Clinical trials of clopidogrel - TrialResults-center.org

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
acute coronary syndrome
CURE, 2001	clopidogrel + aspirin	aspirin			Suggesting
CURE (PCI sub study), 2001	clopidogrel	placebo		Exploratory	-
COMMIT, 2005	clopidogrel	placebo			Suggesting	NCT00222573
CLARITY-TIMI 28, 2005	clopidogrel	placebo			-
CURRENT OASIS 7 (clopidogrel), 2010	clopidogrel high-dose regimen	clopidogrel standard-dose		Low risk of bias	Negative	NCT00335452
acute myocardial infarction
COMMIT, 2005	clopidogrel	placebo			Suggesting	NCT00222573
CLARITY-TIMI 28, 2005	clopidogrel	placebo			-
atrial fibrillation
ACTIVE W, 2006	aspirin + clopidogrel	anticoagulant		Risk of bias	Suggesting	NCT00243178
ACTIVE A, 2009	aspirin + clopidogrel	aspirin		Low risk of bias	Suggesting	NCT00249873
CABG surgery
CASCADE, 2009	clopidogrel+aspirin	aspirin		Exploratory	-	NCT00228423
cardiovascular prevention
ASCET	clopidogrel	aspirin		Risk of bias	Negative	NCT00222261
CAPRIE (PAD subgroup), 1996	clopidogrel	aspirin			Suggesting
CAPRIE, 1996	clopidogrel	aspirin	secondary prevention	Low risk of bias	Suggesting
CHARISMA, 2006	clopidogrel	placebo (on top aspirin)	secondary prevention	Low risk of bias	Suggesting	NCT00050817
coronary artery disease
ASCET	clopidogrel	aspirin		Risk of bias	Negative	NCT00222261
CAPRIE, 1996	clopidogrel	aspirin			-
heart failure
WATCH (clopidogrel vs aspirin) ongoing	clopidogrel	aspirin			-
percutaneous coronary intervention
CLASSICS, 2000	clopidogrel + aspirin	ticlopidine + aspirin			Negative
Müller, 2000	clopidogrel + aspirin	ticlopidine + aspirin			Negative
TOPPS, 2001	clopidogrel + aspirin	ticlopidine + aspirin			Negative
Piamsomboon, 2001	clopidogrel + aspirin	ticlopidine + aspirin			Negative
REAL-LATE, ZEST-LATE, 2010	clopidogrel+aspirin	aspirin			Negative	NCT00484926
GRAVITAS, 2011	high-dose clopidogrel	normal-dose clopidogrel		Risk of bias	Negative	NCT00645918
peripheral vascular diseases
CAPRIE (PAD subgroup), 1996	clopidogrel	aspirin			Suggesting
AFFIRM ongoing	clopidogrel				-
post myocardial infarction
CAPRIE, 1996	clopidogrel	aspirin			-
stable angina
ASCET	clopidogrel	aspirin		Risk of bias	Negative	NCT00222261
stent
Müller, 2000	clopidogrel + aspirin	ticlopidine + aspirin			Negative
CLASSICS, 2000	clopidogrel + aspirin	ticlopidine + aspirin			Negative
Piamsomboon, 2001	clopidogrel + aspirin	ticlopidine + aspirin			Negative
TOPPS, 2001	clopidogrel + aspirin	ticlopidine + aspirin			Negative
REAL-LATE, ZEST-LATE, 2010	clopidogrel+aspirin	aspirin			Negative	NCT00484926
GRAVITAS, 2011	high-dose clopidogrel	normal-dose clopidogrel		Risk of bias	Negative	NCT00645918

Clopidogrel antiplatelets drug Description Results

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Clopidogrel antiplatelets drug
Description Results