Clinical trials in acute myocardial infarction

Trial	Studied treatment	Control treatment	ROB	Result	NCT
angiotensin-Converting Enzyme Inhibitors
captopril
Sharpe, 1991	captopril	placebo	Exploratory	-
Nabel, 1991	captopril	placebo	Exploratory	-
Bussmann, 1992	captopril	placebo	Exploratory	-
Hargreaves, 1992	captopril	placebo	Exploratory	-
Ray, 1993	captopril	placebo	Exploratory	-
Galcera, 1993	captopril	placebo	Exploratory	-
PRACTICAL (captopril), 1994	captopril or enalapril	placebo	Exploratory	-
Di Pasquale, 1994	captopril	placebo	Exploratory	-
ISIS-4, 1995	captopril	placebo	Low risk of bias	-
CCS-1, 1995	captopril	placebo	Low risk of bias	-
CATS, 1996	captopril	placebo	Exploratory	-
ECCE, 1997	captopril	placebo	Exploratory	-
Di Pasquale, 1997	captopril	placebo	Exploratory	-
French, 1999	captopril	placebo	Exploratory	-
enalapril
CONSENSUS 2, 1992	enalapril	placebo	Low risk of bias	-
Schulman, 1995	enalapril	placebo	Exploratory	-
fosinopril
FAMIS, 1998	fosinopril	placebo	Exploratory	-
irbesartan
GLOBAL ongoing	irbesartan	control	Exploratory	-	NCT00125645
lisinopril
GISSI 3, 1994	lisinopril	placebo	Risk of bias	-
ramipril
Wagner, 2002	ramipril	placebo	Exploratory	-
zofenopril
SMILE, 1995	zofenopril	placebo	Low risk of bias	Suggesting
angiotensin-receptor blockers
losartan
OPTIMAAL, 2002	Losartan	Captopril		Suggesting
valsartan
VALIANT (valsartan+capropril), 2003	Valsartan+ACE inhibitor	ACE inhibitor only		Negative
VALIANT (valsartan alone), 2003	Valsartan	Captopril		Negative
antiarrythmic drugs
amiodarone
Hockings, 1987	early amiodarone	placebo		Negative
BASIS, 1990	early amiodarone	control		Suggesting
CAMIAT , 1991	early amiodarone	placebo		Negative
Ceremuzynski, 1992	early amiodarone	placebo		Negative
Navarro-Lopez, 1993	early amiodarone	control		Negative
magnesium
Morton, 1984	magnesium	placebo		Negative
Rasmussen, 1986	magnesium	placebo		Negative
Smith, 1986	magnesium	placebo		Negative
Abraham, 1987	magnesium	placebo		Negative
Ceremuzynski, 1989	magnesium	placebo		Suggesting
Ising, 1990	magnesium	placebo		-
Parikka, 1990	magnesium	placebo		Negative
Shechter, 1990	magnesium	placebo		Suggesting
Singh, 1990	magnesium	placebo		Suggesting
Chen, 1991	magnesium	placebo		Suggesting
Feldstedt, 1991	magnesium	placebo		Negative
Shechter, 1991	magnesium	placebo		Negative
Wu, 1992	magnesium	control		Suggesting
Woods, 1992	magnesium	placebo		Suggesting
ISIS-4, 1995	magnesium	control		Suggesting
Bhargava, 1995	magnesium	placebo		Suggesting
Shechter, 1995	magnesium	placebo		Suggesting
Thogersen, 1995	magnesium	placebo		Negative
Urek, 1996	magnesium	placebo		Negative
Raghu, 1999	magnesium	placebo		Suggesting
MAGIC, 2000	magnesium	placebo		Negative	NCT00000610
Gyamlani, 2000	magnesium	placebo		Suggesting
Santoro, 2000	magnesium	placebo		Negative
Zhu, 2002	magnesium	control		Suggesting
Nakashima, 2004	magnesium	placebo		Negative
anticoagulant
coumadin
ASPECT, 1994	coumadin	placebo		Suggesting
ASPECT-2 (coumadin alone), 2002	coumadin	aspirin		Suggesting
ASPECT-2 (coumadin+ASA vs ASA), 2002	coumadin	control (on top of aspirin)		Negative
warfarin
CARS (warafrin 3mg), 1997	warfarin	control (on top of aspirin)		Suggesting
CARS (warfarin 1mg), 1997	warfarin	control (on top of aspirin)		Negative
Williams, 1997	warfarin	placebo (on top of aspirin)		Suggesting
WARIS, 1999	warfarin	control (on top of aspirin)		-
WARIS II (warfarin alone), 2002	warfarin	aspirin		Suggesting
APRICOT-2, 2002	warfarin	control (on top of aspirin)		Suggesting
CHAMP, 2002	warfarin	control (on top of aspirin)		Negative
WARIS II (warfarin+ASA), 2002	warfarin	control (on top of aspirin)		Suggesting
Zibaeenezhad, 2004	warfarin	control (on top of aspirin)		Negative
LoWASA, 2004	warfarin	control (on top of aspirin)	Risk of bias	Suggesting
antithrombotics
aspirin
Frankfurt, 1976	aspirin	control		Negative
ISIS-pilot, 1987	aspirin	placebo		Negative
Huddinge, 1988	aspirin	control		Negative
ISIS-2, 1988	aspirin	placebo		Suggesting
Dutch-aspirin, 1990	aspirin	placebo		Negative
APRICOT, 1993	aspirin	placebo		Suggesting
clopidogrel
COMMIT, 2005	clopidogrel	placebo		Suggesting	NCT00222573
CLARITY-TIMI 28, 2005	clopidogrel	placebo		-
dalteparin
FRAMI, 1997	Dalteparin	placebo		-
BIOMACS II, 1999	Dalteparin	placebo		-
ASSENT Plus, 2003	Dalteparin	UFH		Negative
elinogrel
ERASE-MI, 2009	elinogrel	placebo	Exploratory	Negative
INNOVATE ongoing	elinogrel	error		-	NCT00751231
enoxaparin
ASSENT 3, 2001	Enoxaparin	UFH		Suggesting
HART II, 2001	Enoxaparin	UFH		Negative
AMI-SK, 2002	Enoxaparin	placebo		-
Baird, 2002	Enoxaparin	UFH		Negative
ENTIRE-TIMI 2, 2002	Enoxaparin	UFH		Suggesting
ASSENT 3 Plus, 2003	Enoxaparin	UFH		Negative
fondaparinux
MICHELANGELO OASIS-6, 2006	fondaparinux	placebo	Low risk of bias	Suggesting	NCT00064428
reviparin
CREATE, 2005	Reviparin	placebo		-
sulfinpyrazone
Wilcox, 1980	sulfinpyrazone	placebo		Negative
Louvain sulphinpyrazone, 1983	sulfinpyrazone	placebo		Negative
Dutch sulphinpyrazone, 1986	sulfinpyrazone	control		Negative
ticlopidine
Knudsen-A, 1985	ticlopidine	control		Negative
UFH
ISIS-2 Pilot, 1987	UFH	no heparin		Negative
ECSG, 1992	UFH	placebo		Negative
OSIRIS, 1992	UFH	placebo		Negative
DUCCS, 1994	UFH	no heparin		Negative
beta-blockers
acebutolol
Azancot, 1982	Acebutolol	placebo		Negative
APSI, 1990	Acebutolol	placebo		Suggesting
alprenolol
Wilhelmsson , 1974	Alprenolol	placebo		Negative
Andersen , 1979	Alprenolol	placebo		Negative
atenolol
Yusuf , 1980	Atenolol	placebo		Negative
ISIS1 Collaborative Group , 1986	Atenolol	placebo		Negative
Van de Werf , 1993	Atenolol	placebo		Negative
betaxolol
Yang , 1987	Betaxolol	placebo		Negative
carvedilol
Basu , 1997	Carvedilol	placebo		Suggesting
labetalol
Heber , 1987	Labetalol	placebo		Negative
metoprolol
Waagstein , 1975	Practololormetoprolol	placebo		Negative
Hjalmarson , 1981	Metoprolol	placebo		Suggesting
Von Essen , 1982		placebo		Negative
Manger Cats , 1983	Metoprolol	placebo		Negative
Rehnqvist , 1983	Metoprolol	placebo		Suggesting
MIAMI Trial Research Group , 1985		placebo		Negative
Salathia , 1985	Metoprolol	placebo		Suggesting
LIT Research Group , 1987	Metoprolol	placebo		Negative
TIMI IIB, 1989		placebo		Negative
oxprenolol
Fuccella , 1968	Oxprenolol	placebo		Negative
Lombardo , 1979	Oxprenolol	placebo		Negative
Wilcox , 1980	Oxprenolol	placebo		Negative
CPRG , 1981	Oxprenolol	placebo		Negative
Taylor , 1982	Oxprenolol	placebo		Negative
EIS , 1984	Oxprenolol	placebo		Negative
Schwartz (high risk and low risk) , 1992	Oxprenolol	placebo		Suggesting
pindolol
Australian and Swedish study, 1983	Pindolol	placebo		Negative
Owensby , 1984	Pindolol	placebo		Negative
practolol
Multicentre international , 1975	Practolol	placebo		Suggesting
Evemy , 1978	Practolol	placebo		Negative
Thompson , 1979	Practolol	placebo		Negative
Johansson , 1980	Practolol	placebo		Negative
Macleod , 1980	Practolol	placebo		Negative
Snow , 1980	Practolol	placebo		Negative
propranolol
Balcon , 1966	Propranolol	placebo		Negative
Clausen , 1966	Propranolol	placebo		Negative
Multicentre , 1966	Propranolol	placebo		Negative
Sloman , 1967	Propranolol	placebo		Negative
Dotremont , 1968	Propranolol	placebo		Negative
Kahler , 1968	Propranolol	placebo		Negative
Ledwich , 1968	Propranolol	placebo		Negative
Norris , 1968	Propranolol	placebo		Negative
Barber , 1976	Propranolol	placebo		Negative
Pitt , 1976	Propranolol	placebo		Negative
Norris , 1978	Propranolol	placebo		Negative
Peter , 1978	Propranolol	placebo		Negative
Hutton , 1979	Propranolol	placebo		Negative
Mueller , 1980	Propranolol	placebo		Negative
Baber , 1980	Propranolol	placebo		Negative
Wilcox , 1980	Propranolol or atenolol	placebo		Suggesting
Gupta , 1982	Propranolol	placebo		Negative
BHAT , 1982	Propranolol	placebo		Suggesting	NCT00000492
Hansteen , 1982	Propranolol	placebo		Suggesting
Nigam , 1983	Propranolol	placebo		Negative
Gupta , 1984	Propranolol	placebo		Negative
Norris , 1984	Propranolol	placebo		Negative
Roberts , 1984	Propranolol	placebo		Negative
Singh , 1985	Propranolol	placebo		Negative
Curtis , 1991	Propranolol	placebo		Negative
Aronow , 1997	Propranolol	control		Suggesting
sotalol
Lloyd , 1988	Sotalol	placebo		Negative
timolol
Tonkin , 1981	Timolol	placebo		Negative
Norwegian Multicentre Study Group , 1981	Timolol	placebo		Suggesting
UKCSG , 1983	Timolol	placebo		Negative
Campbell , 1984	Timolol	placebo		Negative
Federman , 1984	Timolol	placebo		Negative
ICSG , 1984	Timolol	placebo		Negative
Ranganathan , 1988	Timolol	placebo		Negative
xamoterol
McMurray , 1991	Xamoterol	placebo		Negative
calcium channel blockers
diltiazem
Machecourt, 1986	diltiazem			Negative
Gibson, 1986	diltiazem	placebo		Negative
MDPIT, 1988	diltiazem	placebo		Negative
Zannad, 1988	diltiazem	placebo		Negative
nifedipine
MI study group, 1979	nifedipine			-
Muller, 1984	nifedipine			Negative
Gordon, 1984	nifedipine			Negative
Sirnes, 1984	nifedipine	placebo		Negative
Eisenberg, 1985	nifedipine	placebo		Negative
Loogna, 1985	nifedipine	placebo		Negative
Bradagan, 1986	nifedipine	placebo		Negative
TRENT (Wilcox), 1986	nifedipine	placebo		Negative
Jaffe, 1987	nifedipine	placebo		Negative
Gottlieb, 1988	nifedipine	placebo		Negative
Erbel, 1988	nifedipine	placebo		Negative
SPRINT I, 1988	nifedipine	placebo		Negative
Walker, 1988	nifedipine	placebo		Negative
SPRINT II, 1993	nifedipine	placebo		Negative
verapamil
Bussman, 1984	verapamil	control		Negative
DAVIT I, 1984	verapamil	placebo		-
Danish study, 1984	verapamil	placebo		Negative
Crea, 1985	verapamil	placebo		Negative
DAVIT II, 1990	verapamil	placebo		Negative
CRIS, 1996	verapamil	placebo		Negative
increasing hemoglobin concentration
taspoglutide
HEBE III, 2010	epoetin alfa	placebo	Exploratory	Negative
Late revascularisation
PTCA
TOMIIS, 1994	late PTCA	no PTCA		Negative
Horie et al, 1998	late PTCA	no PTCA		Suggesting
TOAT, 2002	late PTCA	no PTCA		Negative
DECOPI, 2004	late PTCA	no PTCA		Negative
Silva et al, 2005	late PTCA	no PTCA		Negative
OAT, 2006	late PTCA	no PTCA		Negative
TOSCA-2, 2006	late PTCA	no PTCA		-	NCT00025766
myocardial revascularization
abciximab
Zorman, 2002	Abciximab	primary intervention		Negative
ERAMI (Mesquita Gabriel), 2003	Abciximab	primary intervention		Negative
REOMOBILE (Arntz), 2003	Abciximab	primary intervention		Negative
BRAVE (Kastrati), 2004	Abciximab + reteplase	primary intervention		-
ReoPro-BRIDGING (Gyongyosi), 2004	Abciximab	primary intervention		Negative
Bellandi, 2006	Abciximab	primary intervention		Negative
FINESSE (combination-facilitated PCI), 2008	Abciximab + reteplase	primary intervention		Negative	NCT00046228
alteplase
LIMI (Vermeer), 1999	alteplase	primary intervention		Negative
PACT (Ross,), 1999	alteplase	primary intervention		Negative
anistreplase
TEAM 2, 1991	anistreplase	streptokinase		-
APSAC
AIMS, 1988	APSAC	placebo		Suggesting
German Multicenter Trial, 1988	APSAC	placebo		Suggesting
APSIM, 1989	APSAC	control		Negative
ISIS III (SK/APSAC), 1992	APSAC	streptokinase		Negative
TEAM 3, 1992	APSAC	t-PA		-
eptifibatide
INTAMI (Zeymer), 2005	Eptifibatide	primary intervention		Negative
lanoteplase
InTIME-II, 2000	lanoteplase	accelerated t-PA		Negative
PCI
Jaksch, 1998	primary stenting	balloon angioplasty		Suggesting
GRAMI (Rodriguez), 1998	primary stenting	balloon angioplasty		Negative
Zwolle 5 (Suryapranata), 1998	primary stenting	balloon angioplasty		Suggesting
FRESCO, 1998	primary stenting	balloon angioplasty		-
stent-PAMI (Grines), 1999	primary stenting	balloon angioplasty		Suggesting
PASTA (Saito), 1999	primary stenting	balloon angioplasty		Suggesting
PRISAM (Kawashima), 1999	primary stenting	balloon angioplasty		Negative
STENTIM-2 (Maillard), 2000	primary stenting	balloon angioplasty		Negative
PRAGUE, 2000	systematic PCI (+stent)	no systematic PCI		Negative
STAT, 2001	primary stenting	accelerated t-PA		-
PSSAAMI (Scheller), 2001	primary stenting	balloon angioplasty		Suggesting
C-PORT, 2002	primary PCI	accelerated t-PA		-
CADILLAC abciximab., 2002	primary stenting	balloon angioplasty		-
CADILLAC (no abciximab), 2002	primary stenting	balloon angioplasty		-
STOPAMI 2, 2002	primary stenting	immediate thrombolysis		-
SIAM III, 2002	systematic PCI (+stent)	no systematic PCI		Negative
STOPAMI 3, 2004	primary stenting	balloon angioplasty		-
GRACIA-1, 2004	systematic PCI (+stent)	no systematic PCI	Risk of bias	Negative
ZWOLLE 6, 2005	primary stenting	balloon angioplasty		-
CAPITAL AMI, 2005	systematic PCI (+stent)	no systematic PCI		Negative
senior PAMI, 2005	primary PCI	Thrombolysis	Risk of bias	Suggesting	NCT00136929
WEST, 2006	systematic PCI (+stent)	no systematic PCI		Negative
primary angioplasty
O'Neill, 1986	primary ballon angioplasty	intracoronary streptokinase		-
DeWood, 1989	primary ballon angioplasty	duteplase		-
Gibbons, 1993	primary ballon angioplasty	duteplase		-
Ribeiro, 1993	primary ballon angioplasty	streptokinase		-
Zijlstra , 1993	primary ballon angioplasty	streptokinase		-
PAMI, 1993	primary ballon angioplasty	t-PA		-
Zwolle, 1994	primary ballon angioplasty	streptokinase		Negative
Ribichini, 1996	primary ballon angioplasty	accelerated t-PA		-
Grinfeld, 1996	primary ballon angioplasty	streptokinase		-
Garcia, 1997	primary ballon angioplasty	accelerated t-PA		-
GUSTO 2B, 1997	primary ballon angioplasty	accelerated t-PA		-
DANAMI-2, 1997	primary ballon angioplasty	accelerated t-PA		-
Zijlstra, 1997	primary ballon angioplasty	streptokinase		-
Akhras, 1997	primary ballon angioplasty	streptokinase		-
TRIANA, 2009	primary ballon angioplasty	tenecteplase	Risk of bias	Negative	NCT00257309
PTCA
TIMI II-A (defered)	systematic ballon angioplasty	no systematic angioplasty		-
TAMI 1 pilot, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	Suggesting
Topol, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	-
Guerci, 1987	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
ECSG, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	Negative
TIMI 2A, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	-
Erbel, 1989	immediate systematic ballon angioplastyte	no immediate angioplasty		-
TIMI 2, 1989	systematic ballon angioplasty	no systematic angioplasty	Risk of bias	Negative
Barbash, 1990	systematic ballon angioplasty	no systematic angioplasty		-
TAMI-5 (Califf), 1991	immediate systematic ballon angioplastyte	no immediate angioplasty		-
Belenkie, 1991	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	-
SWIFT, 1991	systematic ballon angioplasty	no systematic angioplasty	Risk of bias	Negative
Van den Brand, 1991	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
Belenkie, 1992	rescue PTCA	no rescue PTCA	Risk of bias	Negative
SIAM, 1992	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
TOPS, 1992	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
TAMI 6, 1992	systematic ballon angioplasty	no systematic angioplasty		-
Ellis, 1994	immediate systematic ballon angioplastyte	no immediate angioplasty		-
RESCUE, 1994	rescue PTCA	no rescue PTCA		Negative
MAASTRICHT (Vermeer), 1999	primary angioplasty	immediate thrombolysis		Negative
SHOCK (Hochman), 1999	immediate systematic ballon angioplastyte	no immediate angioplasty	Risk of bias	Suggesting	NCT00000552
SWISS-SMASH, 1999	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	Negative
Vermeer, 1999	systematic ballon angioplasty	no systematic angioplasty		-
PRAGUE-1, 2000	primary angioplasty	immediate thrombolysis		Suggesting
RESCUE II, 2000	rescue PTCA	no rescue PTCA		Negative
AIR-PAMI, 2002	primary angioplasty	immediate thrombolysis		Negative
CAPTIM, 2002	primary angioplasty	immediate thrombolysis		Negative
DANAMI-2, 2003	primary angioplasty	immediate thrombolysis		Suggesting
PRAGUE-2, 2003	primary angioplasty	immediate thrombolysis		Suggesting
MERLIN (Sutton), 2004	immediate systematic ballon angioplastyte	no immediate angioplasty		-
MERLIN, 2004	rescue PTCA	no rescue PTCA		Negative
REACT (rescue PCI), 2005	rescue PTCA	no rescue PTCA		Suggesting
reteplase
INJECT, 1995	reteplase	streptokinase		Negative
RAPID-2, 1996	reteplase	accelerated t-PA	Exploratory	Suggesting
GUSTO III, 1997	reteplase	accelerated t-PA		Negative
saruplase
PRIMI (vs SK), 1989	saruplase	streptokinase		-
PRIMI (vs UK), 1989	saruplase	urokinase		-
SESAM, 1997	saruplase	t-PA	Exploratory	Negative
COMPASS, 1998	saruplase	streptokinase		Negative
streptokinase
ISAM, 1986	streptokinase	placebo		Negative
GISSI I, 1986	streptokinase	placebo		Suggesting
ISIS 2 pilot, 1987	streptokinase	placebo		-
ISIS-2 (SK), 1988	streptokinase	placebo		Suggesting
Western Washington Intravenous Trial, 1988	streptokinase	placebo		Negative	NCT00000507
SAMI (O’Neill), 1992	streptokinase	primary intervention		Negative
EMERAS (all delay), 1993	streptokinase	placebo		Negative
EMERAS (7-12h), 1993	streptokinase	placebo		-
GUSTO tPA-SK Hiv, 1993	t-PA + streptokinase	streptokinase		Negative
PRAGUE (Widimisky), 2000	streptokinase	primary intervention		Negative
t-pa
ECSG, 1985	t-PA	streptokinase		Negative
TIMI-1, 1987	t-PA	streptokinase		-	NCT00000505
ASSET, 1988	t-PA	placebo		Suggesting
PAIMS, 1989	t-PA	streptokinase		-
White, 1989	t-PA	streptokinase		-
GISSI II, 1990	t-PA	streptokinase		Suggesting
International Study Group, 1990	t-PA	streptokinase		Suggesting
KAMIT, 1991	t-PA half dose	t-PA	Exploratory	Negative
TAMI 5 (t-PA vs uroK), 1991	t-PA	urokinase		-
TAPS, 1992	accelerated t-PA	APSAC		Negative
TAMI 6, 1992	t-PA	placebo		Negative
ISIS III (SK/tPA), 1992	t-PA	streptokinase		Suggesting
Cherng, 1992	t-PA	streptokinase		Negative
RAAMI, 1992	accelerated t-PA	t-PA		-
LATE, 1993	t-PA	placebo	Low risk of bias	Negative
GUSTO tPA Hiv, 1993	accelerated t-PA	streptokinase		Suggesting
Centre Illinois, 1993	t-PA	streptokinase		-
TIMI 4, 1994	accelerated t-PA	APSAC		-
COBALT, 1997	bolus t-PA	accelerated t-PA		Negative
tenecteplase
ASSENT-2, 1999	tenecteplase	accelerated t-PA		Suggesting
GRACIA (Fernandez-Aviles,), 2004	tenecteplase	primary intervention		Negative
ADVANCE-MI, 2005	Eptifibatide + tenecteplase	primary intervention		-
ASSENT-4 PCI (Van de Werf), 2006		primary intervention		Negative	NCT00168792
tirofiban
TIGER-PA (Lee), 2003	Tirofiban	primary intervention		Negative
Cutlip, 2003	Tirofiban	primary intervention		Negative
On-Time (van’t Hof), 2004	Tirofiban	primary intervention		Negative
urokinase
USIM, 1991	urokinase	control		-
nitrates
isosorbide dinitrate
Fitzgerald, 1990	isosorbide mononitrate	placebo	Exploratory	Negative
Hildebrandt, 1992	isosorbide dinitrate	placebo	Exploratory	Negative
Hargreaves, 1992	isosorbide mononitrate	placebo	Exploratory	Negative
ISIS-4, 1995	isosorbide mononitrate	placebo	Low risk of bias	Suggesting
molsidomine
Beaufils, 1988	molsidomine	placebo	Exploratory	Negative
ESPRIM, 1994	molsidomine	placebo	Low risk of bias	Negative
nitroglycerin
Chiche, 1979	nitroglycerin	control	Risk of bias	Negative
Bussman, 1981	nitroglycerin	control	Exploratory	Suggesting
Nelson, 1983	nitroglycerin	control	Risk of bias	Negative
Jugdutt, 1983	nitroglycerin	control	Exploratory	Suggesting
Flaherty, 1983	nitroglycerin	placebo	Risk of bias	Negative
Jaffe, 1983	nitroglycerin	placebo	Low risk of bias	Negative
Lis, 1984	nitroglycerin	placebo	Low risk of bias	Negative
Jugdutt, 1988	nitroglycerin	control	Exploratory	Suggesting
Charvat, 1990	nitroglycerin	placebo	Exploratory	Negative
GISSI-3, 1994	nitroglycerin	control	Risk of bias	Suggesting
thrombectomy
divers
PIHRATE, 2004	Diver	conventional PCI		Negative
REMEDIA, 2005	Diver	conventional PCI		Suggesting
Sardella, 2005	Diver	conventional PCI		-
De Luca, 2006	Diver	conventional PCI		Suggesting

acute myocardial infarction Description Results

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acute myocardial infarction
Description Results