Clinical trials in peripheral vascular diseases

Trial	Studied treatment	Control treatment	patients	ROB	Result
antiplatelets drug
aspirin
CLIPS, 2007	aspirin	placebo		Low risk of bias	Suggesting
antithrombotics
acenocoumarol
APIC, 1989	acenocoumarol	placebo			-
aspirin
Munich B, 1975	aspirin	placebo			-
Munich A, 1975	aspirin	placebo			-
Schoop, 1983	aspirin	placebo			-
Hess, 1985	aspirin	placebo			-
Lassila R, 1991	aspirin	contrôle			-
BOA, 2000	aspirin				-
clopidogrel
CAPRIE (PAD subgroup), 1996	clopidogrel	aspirin			Suggesting
AFFIRM ongoing	clopidogrel				-
dipyridamol
Schoop (2), 1983	aspirin + dipyridamol	placebo			-
Hess (2), 1985	aspirin + dipyridamol	placebo			-
VA study, 1986	aspirin + dipyridamol	placebo			-
ketanserine
Thulesius, 1987	ketanserine	placebo			-
Walden, 1991	ketanserine	placebo			-
PACK, 1996	ketanserine	placebo			-
picotamide
Coto, 1989	picotamide	placebo			-
ADEP, 1993	picotamide	placebo			-
Neirotti, 1994	picotamide	placebo			-
suloctidil
Adriaensen, 1976	suloctidil	placebo			-
Verhaeghe, 1981	suloctidil	placebo			-
Jones, 1982	suloctidil	placebo			-
Holm, 1984	suloctidil	placebo			-
ticlopidine
Hurlow, 1980	ticlopidine	placebo			-
Krause, 1980	ticlopidine	placebo			-
Katsumara, 1982	ticlopidine	placebo			-
Aukland, 1982	ticlopidine	placebo			-
Stiegler, 1984	ticlopidine	placebo			-
Cloarec, 1986	ticlopidine	placebo			-
Ellis, 1986	ticlopidine	placebo			-
Arcan, 1988	ticlopidine	placebo			-
Balsano, 1989	ticlopidine	placebo			-
STIMS, 1990	ticlopidine	placebo			-
EMATAP, 1993	ticlopidine	placebo			-
Becquemin, 1997	ticlopidine	contrôle			-
UFH
Tesi, 1989	HNF	placebo			-
Antonicelli, 1999	HNF	placebo			-
various
CRAMPS, 2000	cloricromene	placebo			-
warfarin
Sarac, 1998	warfarin	contrôle			-
Johnson, 2002	warfarin	contrôle			-
cholesterol lowering intervention
atorvastatin
Mohler III, 2003	atorvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
bezafibrate
LEADER trial, 2000	bezafibrate	placebo	Peripheral Arterial Disease	Low risk of bias	-
niacin
CLAS, 1987	colestipol-niacin	placebo	Peripheral Arterial Disease	Exploratory	-
probucol
PQRST, 1994	probucol	placebo	Peripheral Arterial Disease	Exploratory	-
simvastatin
HPS (sub group), 2002	simvastatin	placebo	Peripheral Arterial Disease	Low risk of bias	-
Mondillo, 2003	simvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
Aronow , 2003	simvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
Exercise Therapy
Exercise Therapy
Larsen OA, 1966	Exercise Therapy	Control			-
Holm J, 1973	Exercise Therapy	Control			-
Dahllof AG, 1974	Exercise Therapy	Control			-
Hiatt WR, 1990	Exercise Therapy	Control			-
Mannarino E, 1991	Exercise Therapy	Control			-
Hiatt WR, 1994	Exercise Therapy	Control			-
Tisi PV, 1997	Exercise Therapy	Control			-
Gelin, 2001	Exercise Therapy	Control			-
Gardner, 2001	Exercise Therapy	Control			-
Fowler, 2002	Exercise Therapy	Control			-
Lear PA ongoing	Exercise Therapy	Control			-
Pockley G ongoing	Exercise Therapy	Control			-
Stewart A ongoing	Exercise Therapy	Control			-
McCloskey B ongoing	Exercise Therapy	Control			-
Jayatunga AP ongoing	Exercise Therapy	Control			-
vasodilators therapy
buflomedil
Diamantopoulos, 2001	buflomédil	placebo			-
LIMB, 2008	buflomedil	placebo		Low risk of bias	Suggesting
cilostazol
Otsuka 21-95-201	cilostazol	placebo			-
Dawson, 1998	cilostazol	placebo			-
Money, 1998	cilostazol	placebo			-
Elam, 1998	cilostazol	placebo			-
Beebe, 1999	cilostazol	placebo			-
Dawson (cilostazol), 2000	cilostazol	placebo			-
Strandness, 2002	cilostazol	placebo			-
ginko biloba
Bauer, 1984	ginko biloba	placebo			-
Peters, 1998	ginko biloba	placebo			-
naftidrofuryl
Clyne, 1980	naftidrofuryl	placebo			-
Meehan, 1982	naftidrofuryl IV	control			-
Negus, 1987	naftidrofuryl IV	prostacyclin			-
Testart, 1994	naftidrofuryl IV	placebo			-
NIQOL germany, 1999	Naftidrofuryl	placebo			-
NIQOL belgium, 2001	naftidrofuryl	placebo			-
NCIS, 2001	naftidrofuryl	placebo			-
D'Hooge D, 2001	naftidrofuryl IV	placebo			-
pentoxifylline
Porter, 1982	pentoxifylline	placebo			-
Donaldson, 1984	pentoxifylline	placebo			-
APIC, 1989	pentoxifylline	placebo			-
Dawson (pentoxifylline), 2000	pentoxifylline	placebo			-
Belcaro, 2002	pentoxifylline	placebo			-

peripheral vascular diseases Description Results

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peripheral vascular diseases
Description Results