new version V2017

stable angina
Description Results

     

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

anti-anginal drugs

ivabradine
BEAUTIFUL (angina subgroup)ivabradine 15mgplacebo (on top standard treatment) Exploratory Suggesting
CL3-023 (20mg)ivabradineamlodipine Low risk of bias -
CL3-023 (15mg)ivabradineamlodipine Low risk of bias -
Borer (CL2-009) 5mg, 2003ivabradine 5mgplacebo -
Borer (CL2-009) 20mg, 2003ivabradine 20mgplacebo -
Borer (CL2-009) 10mg, 2003ivabradine 10mgplacebo -
INITIATIVE (CL3-017, Tardif) 20mg, 2005ivabradine 20mgatenolol Low risk of bias -
INITIATIVE (CL3-017, Tardif) 15mg, 2005ivabradine 15mgatenolol -
Ruzyllo (CL3-023) 15mg, 2007ivabradine 15mgamlodipine Low risk of bias -
Ruzyllo (CL3-023) 20mg, 2007ivabradine 20mgamlodipine Low risk of bias -
BEAUTIFUL, 2008ivabradine 15mgplacebo Low risk of bias NegativeNCT00143507
ASSOCIATE (Tardif), 2009ivabradine 15mgplacebo on top of atenolol Low risk of bias - NCT00202566
CL3-018 10mgivabradine 10mgplacebo on top of amlodipine -
CL3-018 15mgivabradine 15mgplacebo on top of amlodipine -
nicorandil
Nishimura, 2009nicorandilcontrol Risk of bias -
ranolazine
MARIZA, 2004ranolazine 1000mgplacebo -
CARISA 1000mg, 2004ranolazine 1000mgplacebo (on top standard treatment)Negative
RAN080, 2005ranolazine 1000mgplacebo -
ERICA, 2006ranolazine 1000mg + amlodipineplacebo + amlodipine Low risk of bias - NCT00091429

antibiotics

Azithromycin
Gupta et al, 1997AzithromycinplaceboNegative
ACADEMIC, 1999AzithromycinplaceboNegative
STAMINA (Azithromycin), 2002Azithromycinplacebo Low risk of bias Negative
AZACS, 2003AzithromycinplaceboNegative
WIZARD, 2003AzithromycinplaceboNegative
ACES, 2005AzithromycinplaceboNegativeNCT00000617
clarithromycin
CLARIFY, 2001clarithromycinplaceboSuggesting
CLARICOR, 2006clarithromycinplacebo Low risk of bias Negative NCT00121550

antithrombotics

aspirin
SAPAT, 1992aspirinplacebo Low risk of bias Suggesting
clopidogrel
ASCETclopidogrelaspirin Risk of bias NegativeNCT00222261
dipyridamol
Foulds, 1960dipyridamolplacebo Exploratory -
Dewar, 1961dipyridamolplacebo Exploratory -
Zion, 1961dipyridamolplacebo Exploratory -
Kinsella, 1962dipyridamolplacebo Exploratory -
Neumann, 1964dipyridamolplacebo Exploratory -
Leiberman, 1964dipyridamolplacebo Exploratory -
Atlanta (Sbar), 1967dipyridamolcontrol Exploratory Negative
Becker, 1967dipyridamolcontrol Exploratory Negative
Wirecki, 1967dipyridamolcontrol Exploratory Negative
Igloe, 1970dipyridamolplacebo Exploratory -
ticlopidine
Berglund, 1985ticlopidineplacebo Exploratory Negative

HR-slowing agents

ivabradine
SIGNIFY, 2014ivabradine 20mgplaceboNegativeISRCTN61576291

myocardial revascularization

angioplasty
AMIST (Reeves), 2004angioplastyMIDCAB Risk of bias -
Coronary Artery Bypass Surgery
Texas, 1977CABGmedical treatmentNegative
Oregon, 1979CABGmedical treatmentNegative
New zealand 1, 1981CABGmedical treatmentNegative
CASS, 1983CABGmedical treatmentNegativeNCT00000489
VA, 1984CABGmedical treatmentSuggesting
ECSS (European), 1988CABGmedical treatmentSuggesting
Allen, 2000TMR+CABGCABG -
Loubani, 2003TMR+CABGCABG Exploratory -
Zhao, 2006TMR+CABGCABG Exploratory -
MASS II, 2007CABGmedical treatmentNegative
BARI 2D, 2009CABG or PCImedical treatment Risk of bias NegativeNCT00006305
drug-eluting stents
Hong, 2005PCI withdrug-eluting stentsCABG Risk of bias -
FREEDOM, 2012PCI with drug-eluting stentsCABG Risk of bias Negative NCT00086450
VA CARDS ongoing PCI withdrug-eluting stentsCABG Risk of bias - NCT00326196
PCI
AVERT, 1995PCI with or without stentmedical treatment Risk of bias Negative
Dakik, 1998PCI with or without stentmedical treatment Risk of bias Negative
TIME, 2001PCI with or without stentmedical treatment Risk of bias -
Bech, 2001PCI with or without stentmedical treatment Risk of bias Negative
ALKK, 2003PCI with or without stentmedical treatment Risk of bias Suggesting
Hambrecht, 2004PCI with or without stentmedical treatment Risk of bias Negative
MASS II, 2007PCI with or without stentmedical treatment Risk of bias Negative
COURAGE, 2007PCI with or without stentmedical treatment Risk of bias SuggestingNCT00007657
PTCA
Toulouse, 1992balloon angioplastyCABGNegative
ERACI, 1992balloon angioplastyCABGNegative
ACME, 1992balloon angioplastymedical treatment Risk of bias Suggesting
RITA, 1993balloon angioplastyCABGNegative
Sievers, 1993balloon angioplastymedical treatment Risk of bias Negative
Lausanne, 1994balloon angioplastyCABGNegative
GABI, 1994balloon angioplastyCABGNegative
EAST, 1994balloon angioplastyCABGNegative NCT00000465
CABRI, 1995balloon angioplastyCABGNegative
MASS, 1995balloon angioplastyCABGNegative
MASS, 1995balloon angioplastymedical treatment Risk of bias Suggesting
BARI, 1996balloon angioplastyCABGNegativeNCT00000462
RITA 2, 1997balloon angioplastymedical treatment Risk of bias Suggesting
ACME 2 (Folland), 1997balloon angioplastymedical treatment Risk of bias Negative
ACIP, 1997balloon angioplastymedical treatment Exploratory Negative
INSPIRE, 2006balloon angioplastymedical treatment Risk of bias Negative
SWISSI II, 2007balloon angioplastymedical treatment Exploratory Suggesting NCT00387231
sirolimus eluting stent
Thiele, 2009PCI withsirolimus ESMIDCAB Risk of bias - NCT00299429



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