new version V2017

heart failure
Description Results

     

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

All mechanism

serelaxin
RELAX-AHF, 2013serelaxinplacebo - NCT00520806

angiotensin-Converting Enzyme Inhibitors

benazepril
McGany, 1991benazeprilcontrolNegative
Colfer, 1992benazeprilplacebo Exploratory Negative
captopril
CMRG, 1983captoprilplacebo Exploratory -
packer, 1986captoprilenalapril Exploratory -
Magnani, 1986captoprilplacebo Exploratory -
Bussmann, 1987captoprilplacebo Exploratory Negative
Captopril Digoxin Multicenter Research Group, 1988captoprilplacebo Low risk of bias Negative
Magnani, 1990captoprilplacebo Exploratory -
Barabino, 1991captoprilplacebo Exploratory Suggesting
Munich MHFT (Kleber), 1992captoprilplacebo Low risk of bias Negative
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995captoprilplacebo Exploratory -
cilazapril
Drexler, 1989cilazaprilplacebo Exploratory Negative
Dosseger, 1993cilazaprilplacebo Exploratory -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995cilazaprilcaptopril Exploratory -
Cilazapril-Captopril Multi-centre Group, 1995cilazaprilplacebo Exploratory -
enalapril
Sharpe, 1984enalaprilplacebo -
Cleland, 1985enalaprilplacebo Exploratory Negative
McGrath, 1985enalaprilplacebo -
Chrysant, 1985enalaprilplacebo Low risk of bias -
Enalapril CHF investigators, 1987enalaprilcontrolNegative
CONSENSUS, 1987enalaprilplacebo Low risk of bias Negative
Rucinska-b (enalapril), 1991enalaprilcontrolNegative
Rucinska-a (enalapril), 1991enalaprilcontrolNegative
V-HeFT II, 1991enalaprilhydralazine+ISDN Low risk of bias -
SOLVD treatment, 1991enalaprilplacebo Low risk of bias Suggesting NCT00000516
Dickstein, 1991enalaprilplacebo Exploratory Negative
SOLVD prevention, 1992enalaprilplacebo Low risk of bias - NCT00000516
CASSIS (enalapril), 1995enalaprilplacebo Exploratory -
NETWORK (2.5 bid vs 10 bid), 1998enalaprilenalapril Low risk of bias -
NETWORK (5 bid vs 10 bid), 1998enalaprilenalapril Low risk of bias -
fosinopril
Brown, 1995fosinoprilplacebo Exploratory -
FEST (Erhardt), 1996fosinoprilplacebo Exploratory -
lisinopril
Rucinska-c (lisinopril), 1000lisinoprilcontrolNegative
International Study Group (Lewis), 1989lisinoprilplacebo Exploratory -
Zwehl, 1990lisinoprilcontrolNegative
Giles, 1990lisinoprilcontrolNegative
Gilbert, 1993lisinoprilplaceboNegative
ATLAS, 1999lisinoprillisinopril Low risk of bias -
perindopril
Lechat, 1993perindoprilplaceboNegative
PEP CHF, 2006perindoprilplacebo Low risk of bias Negative
quinapril
Riegger, 1990placeboNegative
Northridge, 1991placebo Exploratory Negative
Rieger, 1991placebo Exploratory Negative
Quinapril Heart Failure Trial Investigators, 1993placebo Exploratory -
Uprichard-a, 1994controlNegative
Uprichard-b, 1994controlNegative
Uprichard-c, 1994controlNegative
Nussberger, 1994placebo Exploratory -
ramipril
Swedberg, 1991ramiprilcontrolNegative
Maass-a, 1991ramiprilplaceboNegative
Gordon, 1991ramiprilplacebo Exploratory Suggesting
Maass-b, 1991ramiprilplacebo Exploratory Negative
Maass-c, 1991ramiprilplacebo Exploratory Negative
Lemarie, 1992ramiprilplacebo Exploratory Negative
Gundersen, 1994ramiprilplacebo Exploratory -
trandolapril
Hampton, 1998trandolaprilplacebo Exploratory -

angiotensin-receptor blockers

candesartan
RESOLVD association, 1999candesartan+ACE inhibitorACE inhibitor only Exploratory Negative
RESOLVD (candesartan alone), 1999candesartanenalapril Exploratory Negative
STRETCH, 1999candesartanplacebo Exploratory -
SPICE, 2000candesartanplacebo Exploratory Negative
CHARM-Added, 2003candesartan+ACE inhibitorACE inhibitor only Low risk of bias Negative
ARCH-J, 2003candesartanplacebo Low risk of bias -
CHARM-Alternative, 2003candesartanplacebo Low risk of bias Suggesting
Mitrovic et al., 2003candesartanplacebo Exploratory Suggesting
CHARM preserved, 2003candesartanplacebo Low risk of bias -
irbesartan
Tonkon et al., 2000irbesartan+ACE inhibitorACE inhibitor only Exploratory -
I-PRESERVE (McMurray), 2008ibesartanplacebo Low risk of bias NegativeNCT00095238
losartan
Dickstein et al., 1995losartanenalapril Exploratory -
Losartan Phase III U.S., 1995losartanplacebo Exploratory Negative
Losartan phase II S, 1996losartanenalapril Exploratory -
losartan phase II US, 1996losartanenalapril Exploratory -
Losartan Phase III International, 1996losartanplacebo Exploratory Suggesting
ELITE, 1997losartancaptopril Exploratory Negative
Lang et al., 1997losartanenalapril Exploratory -
Hamroff et al., 1999losartan+ACE inhibitorACE inhibitor only Exploratory -
ELITE II, 2000losartancaptopril Low risk of bias -
HEAAL, 2009losartan 150mglosartan 50mg Low risk of bias SuggestingNCT00090259
NCT00090259 ongoing losartanlosartan - NCT00090259
telmisartan
REPLACE, 2001telmisartanenalapril Exploratory -
valsartan
Mazayev et al. (vs lisinopril, 1998valsartanLisinopril Exploratory -
Mazayev et al. (vs placebo), 1998valsartanplacebo Exploratory -
V-HeFT, 1999valsartan+ACE inhibitorACE inhibitor only Exploratory Negative
Val-HeFT, 2001valsartan+ACE inhibitorACE inhibitor only Low risk of bias Suggesting
HEAVEN, 2002valsartanenalapril Exploratory -
VALIDD, 2007valsartanno valsartan Exploratory NegativeNCT00170924

antiarrythmic drugs

amiodarone
EPAMSA, 1985amiodaroneno treatmentSuggesting
Hamer, 1989amiodaroneplaceboSuggesting
Nicklas, 1991amiodaroneplaceboNegative
GESICA, 1994amiodaroneno treatmentSuggesting
STATCHF, 1995amiodaroneplaceboNegative
AMIOVIRT, 2003amiodaroneICDNegative
dronedarone
ANDROMEDA, 2008dronedaroneplaceboNegative NCT00543699

antithrombotics

aspirin
Barzizza (ASA), 1993aspirinplacebo Exploratory -
WASH (aspirin), 2004aspirinno treatmentNegative
clopidogrel
WATCH (clopidogrel vs aspirin) ongoing clopidogrelaspirin -
enoxaparin
THE-PRINCE (Kleber), 2003enoxaparinUFH -
rivaroxaban
COMMANDER HF, 2018rivaroxabanplaceboNegativeNCT01877915
warfarin
Barzizza (warfarin), 1993warfarinplacebo -
WASH (warfarin), 2004warfarinno treatmentNegative
HELAS (warfarin vs aspirin), 2006warfarinaspirin -
HELAS (warfarin vs placebo), 2006warfarinplacebo -
WATCH (warfarin vs aspirin), 2009warfarinaspirinSuggestingNCT00007683

beta-blockers

bisoprolol
CIBIS, 1994bisoprololplaceboSuggesting
CIBIS II, 1999bisoprololplaceboSuggesting
CIBIS II (elderly subgroup), 1999BisoprololplaceboSuggesting
bucindolol
Pollock, 1990Bucindololplacebo -
Woodley, 1991Bucindololplacebo -
Bristow, 1994Bucindololplacebo -
MERIT-HF (elderly subgroup), 1999BucindololplaceboSuggesting
BEST, 2001bucindololplaceboSuggestingNCT00000560
carvedilol
Metra, 1994carvedilolplacebo -
Olsen, 1995carvedilolplacebo -
Krum, 1995carvedilolplacebo -
Bristow (MOCHA), 1996carvedilolplacebo -
Parker, 1996carvedilolplaceboNegative
Colucci, 1996carvedilolplacebo -
Carvedilol U.S. Trials (elderly subgroup), 1996CarvedilolplaceboSuggesting
ANZ-HeFT, 1997carvedilolplaceboNegative
Cohn, 1997carvedilolplacebo -
CAPRICORN, 2001carvedilolplaceboSuggesting
COPERNICUS (elderly subgroup), 2001CarvedilolplaceboSuggesting
COPERNICUS, 2002carvedilolplaceboSuggesting
COMET, 2003carvedilolmetoprololSuggesting
CARMEN (carvedilol alone), 2004carvedilolenalaprilNegative
CARMEN (carvedilol+enalapril), 2004 ongoing carvedilol+enalaprilenalapril -
metoprolol
Engelmeier, 1985metoprololplacebo -
MDC (Waagstein), 1993metoprololplaceboNegative
Fisher, 1994metoprololplacebo -
Eichhorn, 1994metoprololplacebo -
MERIT-HF, 1999metoprololplaceboSuggesting
RESOLVD, 2000metoprololplacebo -
BEST (elderly subgroup), 2001MetoprololplaceboNegative
nebivolol
Lechat, 1991Nebivololplacebo -
Wisenbaugh, 1993NebivololplaceboNegative
SENIORS, 2005nebivololplacebo -

calcium channel blockers

amlodipine
Packer, 1991amlodipinecontrol Exploratory -
Smith, 1994amlodipinecontrol Exploratory -
Udelson, 1996amlodipinecontrol Exploratory -
Binkley, 1996amlodipinecontrol Exploratory -
PRAISE, 1996amlodipineplacebo Low risk of bias Negative
Ghali, 1997amlodipinecontrol Exploratory -
PRAISE II , 2000Amlodipineplacebo Low risk of bias Negative
diltiazem
DiDi, 1996diltiazemplacebo Low risk of bias Negative
Liao , 1998Diltiazemplacebo Exploratory Suggesting
felodipine
Kassis, 1987felodipineplacebo Exploratory -
Dunselman, 1990felodipineenalapril Exploratory -
Kassis, 1990felodipineplacebo Exploratory -
De Vries, 1995felodipineenalapril Exploratory -
Littler, 1995Felodipineplacebo Exploratory Negative
VHeFT III, 1997felodipineplacebo Exploratory Negative
isradipine
Van den Toren, 1996isradipineplacebo Exploratory -
mibefradil
MACH 1, 2000mibefradilplacebo Low risk of bias Suggesting
nicardipine
Gheorghiade, 1991nicardipinecontrol Exploratory -
Abrams, 1993nicardipinecontrol Exploratory -
nisoldipine
Schofer, 1990nisoldipinecaptopril Exploratory -
Rousseau, 1994nisoldipineplacebo Exploratory -
Gaudron, 1996Nisoldipineplacebo Exploratory -

cholesterol lowering intervention

atorvastatin
Strey, 2005atorvastatinplaceboheart failure -
Wojnicz, 2006atorvastatincontrolheart failureNegative
Sola, 2006atorvastatinplaceboheart failureNegative
Yamada, 2007atorvastatincontrolheart failureNegative
cerivastatin
Laufs, 2004cerivastatinplaceboheart failure -
rosuvastatin
CORONA, 2007rosuvastatinplaceboheart failure Low risk of bias NegativeNCT00206310
Krum, 2007rosuvastatinplaceboheart failure Exploratory Negative
GISSI-HF rosuvastatine, 2008rosuvastatinplaceboheart failure Low risk of bias Negative NCT00336336
simvastatin
Node, 2003simvastatinplaceboheart failureNegative
Hong, 2005simvastatincontrolheart failure Risk of bias Negative
Landmesser, 2005simvastatinezetimibeheart failure -

digitalis glycosides

digoxin
Fleg, 1982digoxinplaceboNegative
Lee, 1982digoxinplaceboNegative
Taggart, 1983digoxinplaceboNegative
Captopril-Digoxin Multicenter Research Group (CDMRG), 1988digoxinplaceboSuggesting
German and Austrian Xamoterol Study, 1988digoxinplaceboNegative
Guyatt, 1988digoxinplaceboNegative
DiBianco, 1989digoxinplaceboSuggesting
Pugh, 1989digoxinplaceboNegative
Blackwood, 1990digoxinplaceboNegative
Radiance, 1993digoxinplaceboSuggesting
Proved, 1993digoxinplaceboNegative
DIMT, 1993digoxinplaceboNegative
Digitalis Investigation Group (DIG), 1997digoxinplaceboSuggestingNCT00000476

diuretics

amiloride
Cheitlin, 1991amilorideplacebo Exploratory -
eplerenone
EPHESUS, 2003eplerenoneplacebo Low risk of bias Suggesting
EMPHASIS-HF, 2010eplerenoneplacebo Low risk of bias Suggesting NCT00232180
REMODEL ongoing eplerenoneplacebo - NCT00082589
Weir ongoing eplerenoneplacebo Exploratory - NCT00132093
furosemide
Boccanelli, 1986furosemidecaptopril Exploratory Negative
Cowley, 1986furosemidecaptopril Exploratory -
hydrochlorothiazide
Sievert, 1989hydrochlorothiazide+triamterenedigoxin Exploratory -
Nordrehaug, 1992hydrochlorothiazidebenazepril Exploratory Suggesting
rolofylline
PROTECT-1rolofyllineplacebo - NCT00328692
spironolactone
Mauersberger, 1985spironolactone+furosemidespironolactone+butizide Exploratory -
Dalhstrom, 1986furosemide + spironolactoneprenalterol Exploratory Negative
Han, 1994spironolactone+captoprilcaptopril Exploratory -
Barr, 1995spironolactoneplacebo Exploratory -
MacFadyen, 1997spironolactoneplacebo Exploratory -
RALES, 1998spironolactoneplacebo Risk of bias Suggesting
Ramires, 2000spironolactonecontrol Exploratory -
Bednarz, 2000aldactonefurosemide Exploratory -
Farquharson, 2000spironolactoneplacebo Exploratory -
Yee, 2001spironolactoneplacebo -
Tsutamoto, 2001spironolactoneplacebo Exploratory -
Cicoira, 2002spironolactonecontrol Exploratory -
Cicoira, 2004spironolactonecontrol -
Mottram, 2004spironolactoneplacebo Exploratory -
Macdonald, 2004spironolactoneplacebo Exploratory -
Agostoni, 2005spironolactoneplacebo Exploratory -
PIE II ongoing spironolactoneplacebo - NCT00123955
Nouvel essai ongoing spironolactonespironolactone Exploratory - NCT00125437

Exercise Therapy

Exercise Therapy
Hambrecht et al, 1995Exercise trainingcontrol -
Dubach et al, 1997Exercise trainingcontrol -
Giannuzzi et al, 1997Exercise trainingcontrol -
Zanelli et al, 1997Exercise trainingcontrol -
Willenheimer et al, 1998Exercise trainingcontrol -
Belardinelli et al, 1999Exercise trainingcontrol -
Wielenga et al, 1999Exercise trainingcontrol -
Kiilavuori et al, 2000Exercise trainingcontrol -
McKelvie et al, 2002Exercise trainingcontrol -
ExTraMATCH, 2004Exercise trainingcontrol -

increasing hemoglobin concentration

taspoglutide
van Veldhuisen, 2007darbepoetin alfaplacebo Exploratory NegativeNCT00086086
Ponikowski, 2007darbepoetin alfaplacebo Exploratory Negative NCT00117234
STAMINA-HeFT (Ghali), 2008darbepoetin alfaplacebo Exploratory NegativeNCT00049985
Parissis, 2008darbepoetin alfaplacebo Exploratory Negative
Kourea, 2008darbepoetin alfaplacebo Exploratory Negative
Parissis, 2009darbepoetin alfaplacebo Exploratory -

Miscellaneous

rolofylline
PROTECT, 2010rolofyllineplacebo Low risk of bias NegativeNCT00328692

phosphodiesterase III inhibitors

amrinone
AMTG, 1985AmrinoneplaceboNegative
Enoximone
Lardoux, 1987EnoximoneplaceboNegative
EMTG, 1990EnoximoneplaceboNegative
WESG, 1991EnoximoneplaceboNegative
Cowley, 1994EnoximoneplaceboNegative
ESG, 2000EnoximoneplaceboNegative
EMOTE, 2007enoximoneplacebo -
ESSENTIAL (I and II), 2009enoximoneplacebo Low risk of bias NegativeNCT00051285
EMPOWER ongoing enoximoneplacebo (on top metoprolol) - NCT00077948
Flosequinan
REFLECT II, 1991FlosequinanplaceboNegative
Cowley, 1993FlosequinanplaceboNegative
FACET, 1993FlosequinanplaceboNegative
REFLECT, 1993FlosequinanplaceboNegative
ibopamine
PRIME II, 1997ibopamineplaceboNegative
Milrinone
MMTG, 1989MilrinoneplaceboNegative
PROMISE, 1991MilrinoneplaceboNegative
vesnarinone
OPC-8212 MRG, 1990VesnarinoneplaceboNegative
VSG, 1993VesnarinoneplaceboSuggesting
VEST, 1998VesnarinoneplaceboNegative

relaxine

serelaxin
Pre-RELAX-AHF, 2009serelaxinplacebo Exploratory - NCT00520806

renin inhibitor

aliskiren
ASTRONAUT, 2013Aliskirenplacebo Low risk of bias - NCT00894387
ATMOSPHERE ongoing aliskirenEnalapril Low risk of bias - NCT00853658

vasodilators therapy

epoprostenol
FIRST, 1997epoprostenolstandard care Exploratory -
hydralazine
Chatterjee, 1980hydralazinecontrol Exploratory -
Franciosa, 1982hydralazineplacebo Exploratory -
Conradson , 1984hydralazineplacebo Exploratory -
Magorien , 1984hydralazineplacebo Exploratory -
hydralazine-ISDN
VHeFT I (hydralazine ISDN), 1986hydralazine-ISDNplacebo Low risk of bias Negative
isosorbide dinitrate
Franciosa , 1978isosorbide dinitrateplacebo Exploratory -
NICE (Lewis), 1999isosorbide dinitrateplacebo -
levosimendan
CASINOlevosimendandobutamine Low risk of bias -
LIDO, 2002levosimendandobutamine Exploratory -
RUSSLAN, 2002levosimendanplacebo Exploratory -
REVIVE-I, 2003levosimendanplacebo Exploratory -
SURVIVE, 2007levosimendandobutamine Low risk of bias NegativeNCT00348504
REVIVE II, 2013levosimendanplacebo Exploratory - NCT00048425
nesiritide
NSGET (comparative trial), 2000nesiritidecontrol Low risk of bias -
NSGET (efficacy trial), 2000nesiritideplacebo Low risk of bias Negative
PRECEDENT, 2002nesiritidedobutamine Exploratory - NCT00270400
VMAC (24h), 2002nesiritidenitroglycerin Risk of bias NegativeNCT00083772
VMAC (intravenous neseritide), 2002nesiritideplacebo Low risk of bias - NCT00083772
PROACTION, 2003nesiritideplacebo Low risk of bias Negative
FUSION 1, 2004nesiritidestandard care Low risk of bias - NCT00270361
BNP-CARDS, 2007nesiritideplacebo Exploratory - NCT00186329
FUSION 2, 2008nesiritideplacebo Low risk of bias - NCT00091520
ASCEND-HF, 2011nesiritideplacebo Low risk of bias Negative NCT00475852

vasopeptidase inhibitor

omapatrilat
IMPRESS, 2000omapatrilatlisinoprilSuggesting
OVERTURE, 2002omapatrilatenalapril -

vasopressin antagonist

tolvaptan
EVEREST Clinical Status , 2007tolvaptanplacebo - NCT00071331
EVEREST Outcome, 2007tolvaptanplacebo -
Udelson, 2007tovalpanplacebo Exploratory SuggestingNCT00043758



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