Clinical trials of antiplatelets drug - TrialResults-center.org

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
acute coronary syndrome
aspirin
VA-pilot	aspirin	placebo			Negative
ALDUSA-pilot	aspirin	placebo			Negative
Frankfurt, 1976	aspirin	control			Negative
VA-main, 1983	aspirin	placebo			Suggesting
Canadian (Aspirin + sulfinpyrazone), 1985	aspirin + sulfinpyrazone	placebo			Negative
Canadian (Aspirin vs PBO), 1985	aspirin	placebo			-
ISIS-pilot, 1987	aspirin	placebo			Negative
Huddinge, 1988	aspirin	control			Negative
Théroux, 1988	aspirin	placebo			Suggesting
ISIS-2, 1988	aspirin	placebo			Suggesting
ATACS-pilot, 1990	aspirin	control			Negative
RISC, 1990	aspirin	placebo			Suggesting
Dutch-aspirin, 1990	aspirin	placebo			Negative
APRICOT, 1993	aspirin	placebo			Suggesting
atopaxar
LANCELOT ACS	atopaxar	placebo		Exploratory	-
J-LANCELOT, 2010	atopaxar	placebo		Exploratory	-
clopidogrel
CURE, 2001	clopidogrel + aspirin	aspirin			Suggesting
COMMIT, 2005	clopidogrel	placebo			Suggesting	NCT00222573
CLARITY-TIMI 28, 2005	clopidogrel	placebo			-
CURRENT OASIS 7 (clopidogrel), 2010	clopidogrel high-dose regimen	clopidogrel standard-dose		Low risk of bias	Negative	NCT00335452
dipyridamol
Prandoni, 1991	aspirin + dipyridamol	placebo			Negative
elinogrel
ERASE-MI, 2009	elinogrel	placebo		Exploratory	Negative
INNOVATE ongoing	elinogrel	error			-	NCT00751231
prasugrel
TRITON-TIMI 38, 2007	prasugrel	clopidogrel		Low risk of bias	Suggesting	NCT00097591
TRILOGY ACS (overall population), 2012	prasugrel	clopidogrel		Low risk of bias	Negative	NCT00699998
ACAPULCO ongoing	prasugrel	clopidogrel			-
sulfinpyrazone
Wilcox, 1980	sulfinpyrazone	placebo			Negative
Louvain sulphinpyrazone, 1983	sulfinpyrazone	placebo			Negative
Canadian (sulfinpyrazone alone), 1985	sulfinpyrazone	placebo			-
Dutch sulphinpyrazone, 1986	sulfinpyrazone	control			Negative
ticagrelor
DISPERSE-2 (90mg), 2007	ticagrelor	clopidogrel		Exploratory	Negative
PLATO, 2009	ticagrelor	clopidogrel		Low risk of bias	Suggesting	NCT00391872
ticlopidine
Florida UA	ticlopidine	placebo			Negative
Knudsen-A, 1985	ticlopidine	control			Negative
STAI, 1990	ticlopidine	control			Suggesting
trapidil
Modena	trapidil	placebo			Suggesting
triflusal
Plaza, 1993	triflusal	placebo			Suggesting
vorapaxar
TRACER, 2011	vorapaxar	placebo (on top standard therapy)		Low risk of bias	-	NCT00527943
acute myocardial infarction
aspirin
Frankfurt, 1976	aspirin	control			Negative
ISIS-pilot, 1987	aspirin	placebo			Negative
Huddinge, 1988	aspirin	control			Negative
ISIS-2, 1988	aspirin	placebo			Suggesting
Dutch-aspirin, 1990	aspirin	placebo			Negative
APRICOT, 1993	aspirin	placebo			Suggesting
clopidogrel
COMMIT, 2005	clopidogrel	placebo			Suggesting	NCT00222573
CLARITY-TIMI 28, 2005	clopidogrel	placebo			-
elinogrel
ERASE-MI, 2009	elinogrel	placebo		Exploratory	Negative
INNOVATE ongoing	elinogrel	error			-	NCT00751231
sulfinpyrazone
Wilcox, 1980	sulfinpyrazone	placebo			Negative
Louvain sulphinpyrazone, 1983	sulfinpyrazone	placebo			Negative
Dutch sulphinpyrazone, 1986	sulfinpyrazone	control			Negative
ticlopidine
Knudsen-A, 1985	ticlopidine	control			Negative
CABG surgery
aspirin
McEnany, 1982	aspirin	placebo			Negative
Lorenz, 1984	aspirin	placebo			Negative
GESIC (aspirin), 1990	aspirin	placebo			Negative
Sydney, 1991	aspirin	placebo			-
Hockings, 1993	aspirin	placebo			-
cangrelor
Bridge ongoing	cangrelor	placebo			-	NCT00767507
clopidogrel
CASCADE, 2009	clopidogrel+aspirin	aspirin		Exploratory	-	NCT00228423
dipyridamol
Pantely, 1979	aspirin + dipyridamol	control			Negative
Des Moines, 1980	aspirin + dipyridamol	control			-
Mayo-A, 1984	aspirin + dipyridamol	placebo			Negative
Brooks, 1985	aspirin + dipyridamol	placebo			Negative
Wadsworth, 1985	aspirin + dipyridamol	placebo			Negative
Leeds-B, 1985	aspirin + dipyridamol	placebo			-
Czech, 1986	aspirin + dipyridamol	control			-
Brussels, 1987	aspirin + dipyridamol	control			Negative
Toronto dipyridamole, 1987	dipyridamol	control			-
Thaulow, 1987	aspirin + dipyridamol	placebo			-
Basel, 1989	aspirin + dipyridamol	placebo			Negative
Ekestrom, 1990	dipyridamol	placebo			-
GESIC (aspirin+dipyridamol), 1990	aspirin + dipyridamol	placebo			Negative
sulfinpyrazone
Baur, 1982	sulfinpyrazone	placebo			-
sulotroban
German sulotroban, 1989	sulotroban	control			-
ticlopidine
Zurich, 1982	ticlopidine	control			-
Knudsen-B, 1983	ticlopidine	control			-
Romeo, 1983	ticlopidine	control			-
Liège-I, 1984	ticlopidine	placebo			Negative
Liège-II, 1987	ticlopidine	placebo			Negative
Kohn, 1990	ticlopidine	control			-
cardiovascular prevention
aspirin
Cardiff I, 1974	aspirin	placebo			Negative
Munich A, 1975	aspirin	placebo			-
Munich B, 1975	aspirin	placebo			-
CDPA, 1976	aspirin	placebo			Negative
Cardiff II, 1979	aspirin	placebo			Negative
Vogel, 1979	aspirin	placebo			Suggesting
AMIS, 1980	aspirin	placebo			Suggesting	NCT00000491
GAMIS, 1980	aspirin	placebo			Negative
PARIS, 1980	aspirin	placebo			Negative
Schoop, 1983	aspirin	placebo			-
Hess, 1985	aspirin	placebo			-
British Doctor’s Trial, 1988	aspirin	no treatment	primary prevention	Risk of bias	Negative
DAMAD, 1989	aspirin	placebo		Low risk of bias	Negative
PHS (diabetics sub group), 1989	aspirin	placebo		Low risk of bias	Suggesting
Physicians Health Study, 1989	aspirin	placebo	primary prevention	Low risk of bias	Suggesting	NCT00000500
ETDRS, 1992	aspirin	placebo		Low risk of bias	Suggesting
SAPAT, 1992	aspirin	placebo		Low risk of bias	Suggesting
Thrombosis Prevention Trial, 1998	aspirin	placebo	primary prevention	Low risk of bias	Suggesting	NCT00000614
HOT, 1998	aspirin	placebo	primary prevention	Low risk of bias	Suggesting
JAMIS, 1999	aspirin	placebo			Suggesting
Primary Prevention Project, 2001	aspirin	no treatment	primary prevention	Risk of bias	Negative
PPP (diabetics sub group), 2003	aspirin	no treatment		Exploratory	Negative
WHS (diabetics sub group), 2005	aspirin	placebo		Exploratory	Suggesting
Women’s Health Study, 2005	aspirin	placebo	primary prevention	Low risk of bias	Suggesting
CLIPS, 2007	aspirin	placebo		Low risk of bias	Suggesting
JPAD, 2008	aspirin	no treatment		Risk of bias	Suggesting	NCT00110448
POPADAD aspirin, 2008	aspirin	placebo		Low risk of bias	Negative	ISRCTN53295293
AAA, 2009	aspirin	placebo	secondary prevention	Low risk of bias	Negative	ISRCTN66587262
ASPREE, 2018	aspirin	placebo			-	NCT01038583
ASCEND, 2018	aspirin	placebo			Suggesting	NCT00135226
JPPP ongoing	aspirin	no aspirin	primary prevention	Risk of bias	-	NCT00225849
ASCEND (aspirin) ongoing	aspirin	placebo			-	NCT00135226
ACCEPT-D ongoing	aspirin	placebo		Risk of bias	-	ISRCTN48110081
clopidogrel
ASCET	clopidogrel	aspirin		Risk of bias	Negative	NCT00222261
CAPRIE, 1996	clopidogrel	aspirin	secondary prevention	Low risk of bias	Suggesting
CAPRIE (PAD subgroup), 1996	clopidogrel	aspirin			Suggesting
CHARISMA, 2006	clopidogrel	placebo (on top aspirin)	secondary prevention	Low risk of bias	Suggesting	NCT00050817
dipyridamol
Foulds, 1960	dipyridamol	placebo		Exploratory	-
Zion, 1961	dipyridamol	placebo		Exploratory	-
Dewar, 1961	dipyridamol	placebo		Exploratory	-
Kinsella, 1962	dipyridamol	placebo		Exploratory	-
Leiberman, 1964	dipyridamol	placebo		Exploratory	-
Neumann, 1964	dipyridamol	placebo		Exploratory	-
Atlanta (Sbar), 1967	dipyridamol	control		Exploratory	Negative
Becker, 1967	dipyridamol	control		Exploratory	Negative
Wirecki, 1967	dipyridamol	control		Exploratory	Negative
Igloe, 1970	dipyridamol	placebo		Exploratory	-
PARIS, 1980	dipyridamol + aspirin	aspirin			Negative
PARIS, 1980	dipyridamol + aspirin	placebo			Negative
Schoop (2), 1983	aspirin + dipyridamol	placebo			-
Hess (2), 1985	aspirin + dipyridamol	placebo			-
VA study, 1986	aspirin + dipyridamol	placebo			-
PARIS-II, 1986	dipyridamol + aspirin	placebo			Negative
ketanserine
Thulesius, 1987	ketanserine	placebo			-
Walden, 1991	ketanserine	placebo			-
PACK, 1996	ketanserine	placebo			-
picotamide
Coto, 1989	picotamide	placebo			-
ADEP, 1993	picotamide	placebo			-
Neirotti, 1994	picotamide	placebo			-
Cocozza, 1995	picotamide	placebo		Exploratory	Negative
sulfinpyrazone
Dutch, 1980	sulfinyrazone	placebo			Negative
suloctidil
Adriaensen, 1976	suloctidil	placebo			-
Verhaeghe, 1981	suloctidil	placebo			-
Jones, 1982	suloctidil	placebo			-
Holm, 1984	suloctidil	placebo			-
ticagrelor
PEGASUS 60mg, 2015	ticagrelor	placebo (on top aspirin)	secondary prevention	Low risk of bias	Suggesting	NCT01225562
PEGASUS 90mg, 2015	ticagrelor	placebo (on top aspirin)	secondary prevention		Suggesting	NCT01225562
EUCLID, 2016	ticagrelor	clopidogrel		Low risk of bias	-	NCT01732822
ticlopidine
Birmingham-A, 1979	ticlopidine	placebo			Negative
Hurlow, 1980	ticlopidine	placebo			-
Krause, 1980	ticlopidine	placebo			-
Katsumara, 1982	ticlopidine	placebo			-
Aukland, 1982	ticlopidine	placebo			-
London diabetes, 1983	ticlopidine	placebo			Negative
TIMAD, 1984	ticlopidine	placebo			Negative
Nyberg, 1984	ticlopidine	placebo		Low risk of bias	Negative
Stiegler, 1984	ticlopidine	placebo			-
Berglund, 1985	ticlopidine	placebo		Exploratory	Negative
Ellis, 1986	ticlopidine	placebo			-
Cloarec, 1986	ticlopidine	placebo			-
Arcan, 1988	ticlopidine	placebo			-
Balsano, 1989	ticlopidine	placebo			-
STIMS, 1990	ticlopidine	placebo			-
BTRS, 1992	ticlopidine	placebo			Negative
EMATAP, 1993	ticlopidine	placebo			-
various
CRAMPS, 2000	cloricromene	placebo			-
vorapaxar
TRA-2P TIMI 50, 2012	vorapaxar	placebo (on top aspirin)	secondary prevention	Low risk of bias	Suggesting	NCT00526474
TRA-2P TIMI 50 (no prior stroke sub group), 2012	vorapaxar	placebo (on top aspirin)	secondary prevention	Exploratory	Suggesting
TRA-2P TIMI 50 (MI subgroup), 2012	vorapaxar	placebo (on top aspirin)	secondary prevention	Exploratory	Suggesting	NCT00526474
diabetes type 2
aspirin
DAMAD, 1989	aspirin	placebo		Low risk of bias	Negative
PHS (diabetics sub group), 1989	aspirin	placebo		Low risk of bias	Suggesting
ETDRS, 1992	aspirin	placebo		Low risk of bias	Suggesting
PPP (diabetics sub group), 2003	aspirin	no treatment		Exploratory	Negative
WHS (diabetics sub group), 2005	aspirin	placebo		Exploratory	Suggesting
JPAD, 2008	aspirin	no treatment		Risk of bias	Suggesting	NCT00110448
POPADAD aspirin, 2008	aspirin	placebo		Low risk of bias	Negative	ISRCTN53295293
ASCEND (aspirin) ongoing	aspirin	placebo			-	NCT00135226
ACCEPT-D ongoing	aspirin	placebo		Risk of bias	-	ISRCTN48110081
picotamide
Cocozza, 1995	picotamide	placebo		Exploratory	Negative
sulfinpyrazone
Dutch, 1980	sulfinyrazone	placebo			Negative
ticlopidine
Birmingham-A, 1979	ticlopidine	placebo			Negative
London diabetes, 1983	ticlopidine	placebo			Negative
TIMAD, 1984	ticlopidine	placebo			Negative
Nyberg, 1984	ticlopidine	placebo		Low risk of bias	Negative
BTRS, 1992	ticlopidine	placebo			Negative
hypertension
aspirin
HOT, 1998	aspirin	placebo	primary prevention	Low risk of bias	Suggesting
percutaneous coronary intervention
cilostazol
Kunishima, 1997	cilostazol	aspirin			Negative
Sekiya, 1998	cilostazol + aspirin	aspirin			Negative
Ochiai, 1999	cilostazol + aspirin	ticlopidine + aspirin			Negative
Park, 1999	cilostazol + aspirin	ticlopidine + aspirin			Negative
Yoon, 1999	cilostazol + aspirin	ticlopidine + aspirin			Negative
Kozuma, 2001	cilostazol + aspirin	ticlopidine + aspirin			Negative
Kamishirado, 2002	cilostazol + aspirin	ticlopidine + aspirin			Negative
clopidogrel
Müller, 2000	clopidogrel + aspirin	ticlopidine + aspirin			Negative
CLASSICS, 2000	clopidogrel + aspirin	ticlopidine + aspirin			Negative
TOPPS, 2001	clopidogrel + aspirin	ticlopidine + aspirin			Negative
Piamsomboon, 2001	clopidogrel + aspirin	ticlopidine + aspirin			Negative
REAL-LATE, ZEST-LATE, 2010	clopidogrel+aspirin	aspirin			Negative	NCT00484926
GRAVITAS, 2011	high-dose clopidogrel	normal-dose clopidogrel		Risk of bias	Negative	NCT00645918
ticlopidine
Hall, 1996	ticlopidine + aspirin	aspirin			Negative
ISAR, 1996	ticlopidine + aspirin	coumadin + aspirin			Suggesting
STARS (vs aspirin), 1998	ticlopidine + aspirin	aspirin			Suggesting
FANTASTIC, 1998	ticlopidine + aspirin	coumadin + aspirin			Negative
MATTIS, 1998	ticlopidine + aspirin	coumadin + aspirin			Negative
STARS (vs coumadin+asp), 1998	ticlopidine + aspirin	coumadin + aspirin			Suggesting
Foussas, 2000	ticlopidine + aspirin	coumadin + aspirin			Suggesting
peripheral vascular diseases
aspirin
Munich A, 1975	aspirin	placebo			-
Munich B, 1975	aspirin	placebo			-
Schoop, 1983	aspirin	placebo			-
Hess, 1985	aspirin	placebo			-
CLIPS, 2007	aspirin	placebo		Low risk of bias	Suggesting
clopidogrel
CAPRIE (PAD subgroup), 1996	clopidogrel	aspirin			Suggesting
dipyridamol
Schoop (2), 1983	aspirin + dipyridamol	placebo			-
Hess (2), 1985	aspirin + dipyridamol	placebo			-
VA study, 1986	aspirin + dipyridamol	placebo			-
ketanserine
Thulesius, 1987	ketanserine	placebo			-
Walden, 1991	ketanserine	placebo			-
PACK, 1996	ketanserine	placebo			-
picotamide
Coto, 1989	picotamide	placebo			-
ADEP, 1993	picotamide	placebo			-
Neirotti, 1994	picotamide	placebo			-
suloctidil
Adriaensen, 1976	suloctidil	placebo			-
Verhaeghe, 1981	suloctidil	placebo			-
Jones, 1982	suloctidil	placebo			-
Holm, 1984	suloctidil	placebo			-
ticagrelor
EUCLID, 2016	ticagrelor	clopidogrel		Low risk of bias	-	NCT01732822
ticlopidine
Hurlow, 1980	ticlopidine	placebo			-
Krause, 1980	ticlopidine	placebo			-
Katsumara, 1982	ticlopidine	placebo			-
Aukland, 1982	ticlopidine	placebo			-
Stiegler, 1984	ticlopidine	placebo			-
Ellis, 1986	ticlopidine	placebo			-
Cloarec, 1986	ticlopidine	placebo			-
Arcan, 1988	ticlopidine	placebo			-
Balsano, 1989	ticlopidine	placebo			-
STIMS, 1990	ticlopidine	placebo			-
EMATAP, 1993	ticlopidine	placebo			-
various
CRAMPS, 2000	cloricromene	placebo			-
post myocardial infarction
aspirin
Cardiff I, 1974	aspirin	placebo			Negative
CDPA, 1976	aspirin	placebo			Negative
Cardiff II, 1979	aspirin	placebo			Negative
Vogel, 1979	aspirin	placebo			Suggesting
AMIS, 1980	aspirin	placebo			Suggesting	NCT00000491
GAMIS, 1980	aspirin	placebo			Negative
PARIS, 1980	aspirin	placebo			Negative
JAMIS, 1999	aspirin	placebo			Suggesting
clopidogrel
CAPRIE, 1996	clopidogrel	aspirin			-
dipyridamol
PARIS, 1980	dipyridamol + aspirin	aspirin			Negative
PARIS, 1980	dipyridamol + aspirin	placebo			Negative
PARIS-II, 1986	dipyridamol + aspirin	placebo			Negative
ticagrelor
PEGASUS 60mg, 2015	ticagrelor	placebo (on top aspirin)	secondary prevention	Low risk of bias	Suggesting	NCT01225562
PEGASUS 90mg, 2015	ticagrelor	placebo (on top aspirin)	secondary prevention		Suggesting	NCT01225562
vorapaxar
TRA-2P TIMI 50, 2012	vorapaxar	placebo (on top aspirin)	secondary prevention	Low risk of bias	Suggesting	NCT00526474
post stroke
aspirin
AITA, 1975	aspirin	placebo			Negative
Reuther , 1976	aspirin	placebo			Negative
Canadian study (CCSG), 1978	aspirin	placebo			Negative
DCS, 1980	aspirin	placebo			Negative
AICLA, 1981	aspirin	placebo			Negative
Danish low-dose, 1986	aspirin	placebo			Negative
Swedish study , 1987	aspirin	placebo			Negative
UK-TIA low dose , 1988	aspirin	placebo			Negative
UK-TIA high dose , 1988	aspirin	placebo			Suggesting
SALT , 1991	aspirin	placebo			Negative
Lindblad , 1991	aspirin	placebo			Suggesting
ESPS 2 , 1996	aspirin	placebo			Suggesting
thrombosis prevention
aspirin
MRC, 1972	aspirin	placebo		Low risk of bias	Negative
Zekert-I , 1974	Aspirin	placebo		Exploratory	Suggesting
Loew DVT, 1974	aspirin	placebo		Low risk of bias	-
Clagett, 1975	aspirin	control		Risk of bias	-
Stockholm-I, 1975	Aspirin	placebo		Exploratory	Negative
Powers , 1976	Aspirin	placebo		Exploratory	Suggesting
Pasteyer, 1977	Aspirin	no treatment		Exploratory	Negative
Harris-I, 1977	Aspirin	placebo		Low risk of bias	Suggesting
Vinazzer II, 1977	aspirin	placebo		Low risk of bias	-
Erfurt-B , 1979	Aspirin	placebo		Exploratory	Negative
Erfurt-A, 1979	aspirin	placebo		Low risk of bias	-
McKenna-I, 1980	Aspirin	placebo		Exploratory	Suggesting
Zekert V, 1980	aspirin	placebo		Low risk of bias	-
Vinazzer I, 1980	aspirin	placebo		Low risk of bias	-
Zekert VI, 1982	aspirin	control		Risk of bias	-
Sautter, 1983	Aspirin	placebo		Exploratory	Suggesting
McBride, 1983	Aspirin	placebo		Exploratory	Negative
Rocha, 1986	Aspirin	no treatment		Exploratory	Suggesting
PEP hip-fracture, 2000	aspirin	placebo		Low risk of bias	Suggesting
PEP elective arthroplasty, 2000	aspirin	placebo		Low risk of bias	-
dipyridamol
Parodi I, 1973	dipyridamol + aspirin	control		Exploratory	Suggesting
Parodi II, 1973	dipyridamol + aspirin	control		Risk of bias	-
Australian I, 1975	dipyridamol + aspirin	control		Risk of bias	-
Lyon-I, 1975	aspirin + dipyridamol	no treatment		Exploratory	Suggesting
Australian II, 1976	dipyridamol + aspirin	control		Risk of bias	-
Hamburg, 1976	aspirin + dipyridamol	placebo		Exploratory	Negative
Encke-II , 1976	aspirin + dipyridamol	placebo		Exploratory	Negative
Encke IA, 1976	dipyridamol + aspirin	placebo		Exploratory	-
Encke IB, 1976	dipyridamol + aspirin	placebo		Exploratory	-
Zekert-III, 1977	dipyridamol + aspirin	control		Risk of bias	-
Weiss, 1977	dipyridamol + aspirin	control		Exploratory	-
Morris-A , 1977	dipyridamol	no treatment		Exploratory	Negative
Morris-B , 1977	aspirin + dipyridamol	no treatment		Exploratory	Negative
Toulouse I, 1979	dipyridamol + aspirin	control		Risk of bias	-
Frankfurt, 1981	aspirin + dipyridamol	placebo		Exploratory	Negative
Harjola DVT, 1982	dipyridamol + aspirin	control		Risk of bias	-
Chicago, 1982	aspirin + dipyridamol	control		Exploratory	Negative
suloctidil
Turpie, 1985	Suloctidil	placebo		Low risk of bias	-
ticlopidine
Walker, 1974	ticlopidine	placebo		Exploratory	-
Lasierra, 1982	ticlopidine	placebo		Exploratory	-
McKenna-II, 1983	Ticlopidine	placebo		Exploratory	Negative
McKenna-II , 1983	ticlopidine	placebo			Negative
Lyon-II	Ticlopidine	placebo		Exploratory	Negative
Gardecki	Ticlopidine	placebo		Exploratory	Negative
UFH
Gallus , 1973	UFH	no treatment			Suggesting
Morris, 1974	UFH	no treatment			Suggesting
Dechavanne, 1974	UFH	no treatment			Suggesting
Hampson, 1974	UFH	placebo			Negative
VTCSG, 1975	UFH	no treatment			Negative
Dechavanne, 1975	UFH	no treatment			Suggesting
Abraham-Inpijn , 1975	UFH	placebo			Negative
Mannucci , 1976	UFH	no treatment			Suggesting
Galasko , 1976	UFH	no treatment			Suggesting
Morris , 1977	UFH	no treatment			Negative
Xabregas , 1977	UFH	placebo			Negative
Williams , 1978	UFH	placebo			Negative
Moskovitz, 1978	UFH	placebo			Suggesting
Moskovitz, 1978	UFH	placebo			Negative
Bergqvist , 1979	UFH	no treatment			Suggesting
Bergqvist, 1979	UFH	no treatment			Suggesting
Lahnborg, 1980	UFH	placebo			Suggesting
Svend-Hansen, 1981	UFH	placebo			Suggesting
Welin-Berger, 1982	UFH	no treatment			Negative

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