Clinical trials in thrombosis prevention

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
antithrombotics
acenocoumarol
van Geloven, 1977	Acenocoumarol	unfractionated heparin			-
Hamulyak, 1994	Acenocoumarol	Nadroparin			Negative
Samama, 2001	Acenocoumarol	Reviparin			Negative
apixaban
APROPOS 2.5mg, 2007	apixaban	enoxaparin (US regimen)	knee surgery	Exploratory	Negative	NCT00097357
ADVANCE-1, 2008	apixaban	enoxaparin (US regimen)	knee surgery	Low risk of bias	Suggesting	NCT00371683
ADVANCE 3, 2010	apixaban	enoxaparin	hip surgery	Low risk of bias	Suggesting	NCT00423319
ADVANCE 2, 2010	apixaban	enoxaparin (europe regimen)	knee surgery	Low risk of bias	Suggesting	NCT00452530
ADOPT, 2011	apixaban	enoxaparin	medical patients	Low risk of bias	Suggesting	NCT00457002
CV185-027 ongoing	apixaban	placebo			-	NCT00320255
ardeparin
Godwin, 1993	ardeparin	unfractionated heparin	abdominal surgery		-
Levine, 1996	ardeparin	placebo	knee surgery		Suggesting
Heit, 2000	out of hospital Ardeparin	standard prophylaxis			Negative
aspirin
MRC, 1972	aspirin	placebo		Low risk of bias	Negative
Loew DVT, 1974	aspirin	placebo		Low risk of bias	-
Clagett, 1975	aspirin	control		Risk of bias	-
Stockholm-I, 1975	Aspirin	placebo		Exploratory	Negative
Pasteyer, 1977	Aspirin	no treatment		Exploratory	Negative
Vinazzer II, 1977	aspirin	placebo		Low risk of bias	-
Harris-I, 1977	Aspirin	placebo		Low risk of bias	Suggesting
Erfurt-A, 1979	aspirin	placebo		Low risk of bias	-
Zekert V, 1980	aspirin	placebo		Low risk of bias	-
Vinazzer I, 1980	aspirin	placebo		Low risk of bias	-
McKenna-I, 1980	Aspirin	placebo		Exploratory	Suggesting
Zekert VI, 1982	aspirin	control		Risk of bias	-
Sautter, 1983	Aspirin	placebo		Exploratory	Suggesting
McBride, 1983	Aspirin	placebo		Exploratory	Negative
Rocha, 1986	Aspirin	no treatment		Exploratory	Suggesting
PEP hip-fracture, 2000	aspirin	placebo		Low risk of bias	Suggesting
PEP elective arthroplasty, 2000	aspirin	placebo		Low risk of bias	-
betrixaban
APEX, 2016	betrixaban	enoxaparin	medical patients	Low risk of bias	Suggesting	NCT01583218
candesartan
Eriksson, 1996	desirudin	UFH			-
Ericksson, 1997	desirudin	enoxaparin			-
REVASC, 1997	desirudin	UFH			-
Certoparin
Schmitz-Huebner, 1984	certoparin	unfractionated heparin	abdominal surgery		Negative
Sasahara, 1986	certoparin	unfractionated heparin	abdominal surgery		Suggesting
Voigt, 1986	certoparin	unfractionated heparin	abdominal surgery		Negative
Haas , 1987	certoparine + DHE	Unfractionated heparin	hip surgery		Negative
Lassen, 1988	certoparine + DHE	Unfractionated heparin	hip surgery		Suggesting
Welzel, 1988	certoparin	unfractionated heparin	abdominal surgery		Suggesting
Lassen, 1989	certoparine + DHE	Unfractionated heparin	hip surgery		Negative
Kakkar, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Adolf, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Heilmann, 1989	certoparin	unfractionated heparin	gynaecological surgery		Negative
Baumgartner, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Hoffmann and Largiade, 1990	certoparin	unfractionated heparin	abdominal surgery		Negative
Koppenhagen, 1990	certoparin	unfractionated heparin	abdominal surgery		-
Schielke, 1991	certoparin	unfractionated heparin	abdominal surgery		-
Koppenhagen, 1992	certoparin	unfractionated heparin	abdominal surgery		-
Hoffmann and Largiader, 1992	certoparin	unfractionated heparin	abdominal surgery		-
Kock, 1995	certoparin	control		Risk of bias	Negative
Heilmann, 1997	certoparin	unfractionated heparin	gynaecological surgery		-
Haas, 1999	certoparin	unfractionated heparin	general surgery		-
CERTIFY, 2010	certoparin	UFH	medical patients		-
dabigatran
RE-NOVATE 2	dabigatran 220mg	enoxaparin	hip surgery	Low risk of bias	Negative	NCT00657150
RE-NOVATE (220mg), 2007	dabigatran 220mg	enoxaparin	hip surgery	Low risk of bias	Negative	NCT00168818
RE-NOVATE (150mg), 2007	dabigatran 150mg	enoxaparin	hip surgery	Low risk of bias	Negative	NCT00168818
RE-MODEL (220mg), 2007	dabigatran 220mg	enoxaparin (europe regimen)	knee surgery	Low risk of bias	Negative
RE-MODEL (150mg), 2007	dabigatran 150mg	enoxaparin (europe regimen)	knee surgery	Low risk of bias	Negative
RE-MOBILIZE (220mg), 2008	dabigatran 220mg	enoxaparin (US regimen)	knee surgery	Low risk of bias	Negative
RE-MOBILIZE (150mg), 2008	dabigatran 150mg	enoxaparin (US regimen)	knee surgery	Low risk of bias	Negative
dalteparin
Haas , 1985	dalteparin	Unfractionated heparin	hip surgery		Negative
Binsack , 1986	dalteparin	Unfractionated heparin	hip surgery		Negative
Bergqvist, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Onarheim, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Barre , 1987	dalteparin	Unfractionated heparin	hip surgery		Negative
Eriksson , 1988	dalteparin	Dextran	hip surgery		Suggesting
Matzsch , 1988	dalteparin	Dextran	hip surgery		Negative
Fricker, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Bergqvist, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Caen, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Borstad, 1988	dalteparin	unfractionated heparin	gynaecological surgery		Negative
Briel, 1988	dalteparin	unfractionated heparin	non orthopedic surgery		Negative
Ockelford , 1989	dalteparin	placebo			Suggesting
Jorgensen, 1989	dalteparin	placebo	hip surgery		Suggesting
Dechavanne , 1989	dalteparin	Unfractionated heparin	hip surgery		Negative
Eriksson , 1989	dalteparin	Unfractionated heparin	hip surgery		Suggesting
Monreal , 1989	dalteparin	Unfractionated heparin	hip surgery		Negative
Scala, 1990	dalteparin	UFH		Risk of bias	Negative
Creperio, 1990	dalteparin	unfractionated heparin	general surgery		Negative
Hartl, 1990	dalteparin	unfractionated heparin	abdominal surgery		Suggesting
Matzsch , 1991	dalteparin	Dextran	hip surgery		Suggesting
Torholm, 1991	dalteparin	placebo	hip surgery		Suggesting
Borstad, 1992	dalteparin	unfractionated heparin	gynaecological surgery		-
Kakkar, 1993	dalteparin	unfractionated heparin	abdominal surgery		-
Dahl, 1997	out of hospital Dalteparin	standard prophylaxis			Suggesting
Lassen, 1998	out of hospital Dalteparin	standard prophylaxis			Negative
Hull, 2000	out of hospital Dalteparin	standard prophylaxis			Suggesting
Leizorovicz, 2004	dalteparin	placebo	medical patients		Suggesting
Lapidus, 2007	dalteparin	placebo		Low risk of bias	Negative
Lapidus, 2007	dalteparin	placebo		Low risk of bias	Negative
D-KAf (Selby), 2007	dalteparin	placebo			Negative	NCT00187408
PROTECT, 2011	dalteparin	UFH	medical patients	Low risk of bias	Suggesting	NCT00182143
deltaparin
Michot, 2002	deltaparin	control		Risk of bias	Suggesting
dipyridamol
Parodi I, 1973	dipyridamol + aspirin	control		Exploratory	Suggesting
Parodi II, 1973	dipyridamol + aspirin	control		Risk of bias	-
Australian I, 1975	dipyridamol + aspirin	control		Risk of bias	-
Lyon-I, 1975	aspirin + dipyridamol	no treatment		Exploratory	Suggesting
Australian II, 1976	dipyridamol + aspirin	control		Risk of bias	-
Encke IA, 1976	dipyridamol + aspirin	placebo		Exploratory	-
Encke IB, 1976	dipyridamol + aspirin	placebo		Exploratory	-
Hamburg, 1976	aspirin + dipyridamol	placebo		Exploratory	Negative
Zekert-III, 1977	dipyridamol + aspirin	control		Risk of bias	-
Weiss, 1977	dipyridamol + aspirin	control		Exploratory	-
Toulouse I, 1979	dipyridamol + aspirin	control		Risk of bias	-
Frankfurt, 1981	aspirin + dipyridamol	placebo		Exploratory	Negative
Harjola DVT, 1982	dipyridamol + aspirin	control		Risk of bias	-
Chicago, 1982	aspirin + dipyridamol	control		Exploratory	Negative
edoxaban
STARS J-V	edoxaban	enoxaparin (short duration)	hip surgery	Low risk of bias	Suggesting	NCT01181167
DU176b-B-J302 ongoing	edoxaban	enoxaparin	knee surgery		-	NCT01181102
DU176b-B-J303 ongoing	edoxaban	enoxaparin	hip surgery		-	NCT01181141
DU176b-B-J304 ongoing	edoxaban	enoxaparin	hip surgery		-	NCT01181167
DU176b-04 ongoing	edoxaban	placebo	knee surgery		-	NCT01203072
enoxaparin
Ho [43]	enoxaparin	no treatment			Negative
Turpie, 1986	enoxaparin	placebo	hip surgery		Suggesting
LeGagneux , 1987	enoxaparin	placebo			Negative
Melon, 1987	enoxaparin	placebo			Negative
Planes , 1988	enoxaparin	Unfractionated heparin	hip surgery		Suggesting
Samama 1, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Samama 2, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Samama 3, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
DES Group , 1991	enoxaparin	Dextran	hip surgery		Suggesting
Leclerc, 1991	enoxaparin	placebo	knee surgery		Suggesting
Levine , 1991	enoxaparin	Unfractionated heparin	hip surgery		Negative
Kaaja, 1992	enoxaparin	unfractionated heparin	gynaecological surgery		-
Gazzaniga (ISG), 1993	enoxaparin	unfractionated heparin	general surgery		-
Warwick, 1995	enoxaparin	no treatment	hip surgery		Negative
Nurmohamed, 1995	enoxaparin	unfractionated heparin	general surgery		-
McLeod (Canadian), 1995	enoxaparin	unfractionated heparin	abdominal surgery		-
Kalodiki, 1996	enoxaparin	placebo	hip surgery		-
Bergqvist, 1996	out of hospital Enoxaparin	standard prophylaxis			Suggesting
Planes, 1996	out of hospital Enoxaparin	standard prophylaxis			Negative
Bergmann and Neuhart, 1996	enoxaparin	UFH	medical patients		Negative
Lechler, 1996	enoxaparin	UFH	medical patients		Negative
Gonzalez, 1996	enoxaparin	unfractionated heparin	abdominal surgery		-
Samama, 1997	enoxaparin	placebo	hip surgery		Suggesting
ENOXACAN, 1997	enoxaparin	unfractionated heparin	abdominal surgery		-
Agnelli, 1998	enoxaparin	placebo			Suggesting
MEDENOX, 1999	Enoxaparin	placebo	medical patients	Low risk of bias	Suggesting
Comp, 2001	out of hospital Enoxaparin	standard prophylaxis			Suggesting
Canata, 2003	enoxaparin	control		Exploratory	Negative
Kleber, 2003	enoxaparin	UFH	medical patients		Negative
Lederle, 2006	Enoxaparin	placebo	medical patients		Negative
LIFENOX, 2011	enoxaparin	placebo	medical patients	Low risk of bias	Negative	NCT00622648
fondaparinux
BRiEF	fondaparinux	enoxaparin	medical patients		-	NCT00521885
L8541	fondaparinux	enoxaparin	orthopaedic surgery	Low risk of bias	Negative
L8635	fondaparinux	enoxaparin	knee surgery	Exploratory	Negative
DRI4757	fondaparinux	placebo	knee surgery	Exploratory	-
PENTAMAKS (Bauer), 2001	fondaparinux	enoxaparin	knee surgery	Low risk of bias	Suggesting
PENTHIFRA (Eriksson), 2001	fondaparinux	enoxaparin	hip surgery	Low risk of bias	Suggesting
Turpie, 2001	fondaparinux	enoxaparin	hip surgery	Exploratory	-
PENTATHLON (Turpie), 2002	fondaparinux	enoxaparin	hip surgery	Low risk of bias	Suggesting
EPHESUS (Lassen), 2002	fondaparinux	enoxaparin	hip surgery		Suggesting
PEGASUS, 2005	fondaparinux	enoxaparin	abdominal surgery	Low risk of bias	Negative
ARTEMIS (Cohen), 2006	fondaparinux	placebo	medical patients		Negative
APOLLO (Turpie), 2007	fondaparinux	placebo (on top intermittent pneumatic comp.)	abdominal surgery	Low risk of bias	Suggesting
NCT00333021 ongoing	fondaparinux	control			-	NCT00333021
FONDACAST ongoing	fondaparinux	nadroparin			-	NCT00843492
PROTECT (fundaparinux) ongoing	fondaparinux	no treatment			-	NCT00881088
NCT00320398 ongoing	fondaparinux	control			-	NCT00320398
fraxiparin
Pezzuoli, 1989	nadroparin	placebo			Suggesting
Leyvraz, 1991	nadroparin	Unfractionated heparin	hip surgery		Negative
Roth, 1995	nadroparin	control			Negative
LMWH
Harenberg, 1990	LMWH	UFH	medical patients		Negative
Harenberg, 1996	LMWH	UFH	medical patients		Negative
nadroparin
Marassi [41]	nadroparin	no treatment			Negative
Balas [40]	nadroparin	placebo			Negative
Kakkar and Murray, 1985	nadroparin	unfractionated heparin	general surgery		Suggesting
EFS, 1988	nadroparin	unfractionated heparin	abdominal surgery		Suggesting
Dahan, 1989	nadroparin	unfractionated heparin	thoracic surgery		Negative
Barbui, 1990	nadroparin	unfractionated heparin	general surgery		-
Kujath, 1993	nadroparin	control		Risk of bias	Suggesting
Eurin, 1994	nadroparin	unfractionated heparin	abdominal surgery		-
Sourmelis, 1995	nadroparin	placebo	hip surgery		Suggesting
Nurmohamed, 1996	nadroparin	placebo			Negative
Bergmann, 1996	nadroparin	placebo	medical patients		Negative
Yoo, 1997	nadroparin	no treatment	hip surgery		Negative
NPHDO, 1998	out of hospital Nadroparin	standard prophylaxis			Negative
Fraisse, 2000	Nadroparin	placebo	medical patients		Negative
Mahe, 2005	Nadroparin	placebo	medical patients		Negative
KANT (7 days), 2008	nadroparin	control		Risk of bias	Suggesting
KANT (14 days), 2008	nadroparin 14d	control		Risk of bias	Suggesting
PROTECT (nadroparin) ongoing	nadroparin	no treatment			-	NCT00881088
phenindione
Eskeland, 1966	Phenindione	no treatment			-
Hamilton, 1970	Phenindione	no treatment			-
reviparin
Kakkar, 1993	reviparin	unfractionated heparin	general surgery		-
Wirth, 2001	reviparin	control		Low risk of bias	Negative
Lassen, 2002	reviparin	placebo		Low risk of bias	Suggesting
rivaroxaban
ODIXa-KNEE, 2005	rivaroxaban	enoxaparin (US regimen)	knee surgery	Exploratory	Negative
ODIXa-HIP 10mg, 2006	rivaroxaban	enoxaparin (short duration)	hip surgery	Exploratory	Suggesting
RECORD 1, 2008	rivaroxaban	enoxaparin	hip surgery	Low risk of bias	Suggesting	NCT00329628
RECORD 3, 2008	rivaroxaban	enoxaparin (europe regimen)	knee surgery	Low risk of bias	Suggesting	NCT00361894
RECORD 2, 2008	rivaroxaban (long duration)	enoxaparin (short duration)	hip surgery	Low risk of bias	Suggesting	NCT00332020
RECORD 4, 2009	rivaroxaban	enoxaparin (US regimen)	knee surgery	Low risk of bias	Suggesting	NCT00362232
MARINER, 2018	rivaroxaban	placebo	medical patients		Suggesting	NCT02111564
suloctidil
Turpie, 1985	Suloctidil	placebo		Low risk of bias	-
ticlopidine
Walker, 1974	ticlopidine	placebo		Exploratory	-
Lasierra, 1982	ticlopidine	placebo		Exploratory	-
McKenna-II, 1983	Ticlopidine	placebo		Exploratory	Negative
McKenna-II , 1983	ticlopidine	placebo			Negative
Lyon-II	Ticlopidine	placebo		Exploratory	Negative
Gardecki	Ticlopidine	placebo		Exploratory	Negative
tinzaparin
Bergqvist [42]	tinzaparin	placebo			Negative
Lassen, 1991	tinzaparin	placebo	hip surgery		Suggesting
Leizorovicz, 1991	tinzaparin	unfractionated heparin	abdominal surgery		-
Jorgensen, 2002	tinzaparin	control		Risk of bias	Negative
UFH
Cade	UFH	control	medical patients		-
Kakkar (IMT)	UFH	no treatment			-
Gruber	UFH	no treatment			-
Torngren	UFH	placebo			-
Handley (low dose), 1972	UFH	control		Risk of bias	Negative
Handley, 1972	UFH	control		Risk of bias	Negative
Gordon-Smith, 1972	UFH	no treatment			-
Nicolaides, 1972	UFH	no treatment			-
Kakkar, 1972	UFH	placebo			-
Gallus, 1973	UFH	control		Risk of bias	Negative
Emerson, 1973	UFH	control		Risk of bias	Suggesting
Warlow, 1973	UFH	control		Low risk of bias	Suggesting
Gallus , 1973	UFH	no treatment			Negative
Gallus , 1973	UFH	no treatment			Suggesting
Gallus, 1973	UFH	no treatment			-
Morris, 1974	UFH	no treatment			Suggesting
Dechavanne, 1974	UFH	no treatment			Suggesting
Multiunit, 1974	UFH	no treatment			-
Abernethy, 1974	UFH	no treatment			-
Sagar, 1974	UFH	no treatment			-
Kettunen, 1974	UFH	no treatment			-
Hampson, 1974	UFH	placebo			Negative
VTCSG, 1975	UFH	no treatment			Negative
Dechavanne, 1975	UFH	no treatment			Suggesting
Sebeseri, 1975	UFH	no treatment			-
Abraham-Inpijn , 1975	UFH	placebo			Negative
Lahnborg, 1975	UFH	placebo			-
Covey, 1975	UFH	placebo			-
Strand, 1975	UFH	placebo			-
Roberts, 1975	UFH	placebo			-
Ribaudo, 1975	UFH	placebo			-
Mannucci , 1976	UFH	no treatment			Suggesting
Galasko , 1976	UFH	no treatment			Suggesting
Gallus, 1976	UFH	no treatment			-
Kraytman, 1976	UFH	no treatment			-
Lahnborg, 1976	UFH	placebo			-
Loew, 1977	UFH	aspirin			-
Morris , 1977	UFH	no treatment			Negative
Kraytman, 1977	UFH	no treatment			-
van Geloven, 1977	UFH	oral anticoagulant			-
Xabregas , 1977	UFH	placebo			Negative
Wu, 1977	UFH	placebo			-
Lawrence, 1977	UFH	placebo			-
Kraytman, 1977	UFH	placebo			-
Kutnowski, 1977	UFH	placebo			-
Coe, 1978	UFH	no treatment			-
Allen, 1978	UFH	no treatment			-
Cerrato, 1978	UFH	no treatment			Suggesting
Williams , 1978	UFH	placebo			Negative
Moskovitz, 1978	UFH	placebo			Suggesting
Moskovitz, 1978	UFH	placebo			Negative
Kiil, 1978	UFH	placebo			-
Torngren, 1978	UFH	placebo			-
Taberner, 1978	UFH	placebo			-
Torngren, 1978	UFH	placebo			-
Bergqvist , 1979	UFH	no treatment			Suggesting
Bergqvist, 1979	UFH	no treatment			Suggesting
Plante, 1979	UFH	no treatment			-
Abraham-Inpijn, 1979	UFH	no treatment			-
Groote Schuur, 1979	UFH	no treatment			-
Ziemski, 1979	UFH	no treatment			-
Hedlund, 1979	UFH	placebo			-
Vinazzer, 1980	UFH	aspirin			-
Bergqvist, 1980	UFH	no treatment			-
Lahnborg, 1980	UFH	placebo			Suggesting
Belch, 1980	UFH	placebo			-
Kruse-Blinkenberg, 1980	UFH	placebo			-
Vandendris, 1980	UFH	placebo			-
Pitt, 1980	UFH	placebo		Risk of bias	Negative
Blech, 1981	UFH	control	medical patients		Suggesting
Spebar, 1981	UFH	no treatment			-
Lowe , 1981	UFH	placebo			Suggesting
Svend-Hansen, 1981	UFH	placebo			Suggesting
Welin-Berger, 1982	UFH	no treatment			Negative
Koppenhagen, 1982	UFH	no treatment			-
Marchetti, 1982	UFH	placebo			-
Clarke-Pearson, 1983	UFH	no treatment			-
Marchelli, 1983	UFH	no treatment			-
Bejjani, 1983	UFH	placebo			-
Muiticentre 53,S4, 1984	UFH	DHE			-
Muiticentre, 1984	UFH	DHE			-
Caloghera, 1984	UFH	no treatment			-
Muiticentre, 1984	UFH	placebo			-
Jourdan, 1984	UFH	placebo			-
Zawilska, 1989	UFH	control		Risk of bias	Suggesting
Gardlund, 1996	UFH	control	medical patients		Suggesting
Manganelli, 1998	out of hospital UFH	standard prophylaxis			Negative
warfarin
Myrhe, 1969	Warfarin	Dextran			-
Myrhe, 1969	Warfarin	placebo			-
Pinto, 1970	Warfarin	no treatment			-
Harris, 1972	Warfarin	Dextran			-
Hume, 1973	Warfarin	no treatment			-
Hume, 1973	Warfarin	Sudoxicam			-
Hume, 1973	Warfarin	unfractionated heparin			-
Morris, 1976	Warfarin	no treatment			-
Barber, 1977	Warfarin	Dextran			-
Barber, 1977	Warfarin	unfractionated heparin			-
Francis, 1983	Warfarin	Dextran			-
Paiement, 1987	Warfarin	Intermittent pneumatic compression			-
Powers, 1989	Warfarin	Aspirin			-
Powers, 1989	Warfarin	no treatment			-
Gerhart, 1991	Warfarin	Danaparoid			-
Bailey, 1991	Warfarin	Intermittent pneumatic compression			-
Kaempffe, 1991	Warfarin	Intermittent pneumatic compression			-
Francis, 1992	Warfarin	Intermittent pneumatic compression			-
Hull, 1993	Warfarin	Logiparin			Suggesting
RD Heparin, 1994	Warfarin	Ardeparin			Suggesting
Leclerc, 1996	Warfarin	Enoxaparin			Suggesting
Heit, 1997	Warfarin	Ardeparin			Suggesting
Lotke, 1997	Warfarin	Aspirin			-
Francis, 1997	Warfarin	Dalteparin			Suggesting
van Comp, 1998	Warfarin	Danaparoid			-
Colwell, 1999	Warfarin	Enoxaparin			Suggesting
Hull, 2000	Warfarin	Dalteparin			Suggesting
Fitzgerald, 2001	Warfarin	Enoxaparin			Suggesting
ximelagatran
Phase II (Heit), 2001	ximelagatran	Enoxaparin			Negative
METHRO I, 2002	ximelagatran	Dalteparin			Negative
METHRO II, 2002	ximelagatran	Dalteparin			Suggesting
METHRO III, 2002	ximelagatran	Enoxaparin			Negative
Platinum (Colwell), 2003	ximelagatran	Enoxaparin			Negative
EXPRESS, 2003	ximelagatran	Enoxaparin			Suggesting
graduated compression stockings
UFH
Torngren, 1980	GCS + UFH	UFH			Suggesting
Wille-Jorgensen, 1985	GCS + UFH	UFH			Suggesting
*Rasmussen (adj), 1988	GCS + UFH	UFH			Negative
Wille-Jorgensen, 1991	GCS + UFH	UFH			Suggesting
mechanical devices for thromboprophylaxis
aspirin
Hull (+asp), 1979	IPC + aspirin	aspirin			Negative
Hull 2 (+asp), 1979	IPC + aspirin	aspirin			-
Lieberman (A), 1994	IPC + aspirin	aspirin			Negative
Gelfer, 2006	CECT + aspirin	LMWH			-
UFH
Siragusa (H), 1994	IPC + UFH	UFH			Negative
Ramos, 1996	IPC + UFH	UFH			Suggesting
Killewich, 1997	IPC + UFH	control			Negative

thrombosis prevention Description Results

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thrombosis prevention
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