new version V2017

anticoagulant
Description Results

Acenocoumarol - Betrixaban - Phenindione      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009apixabanplacebo Exploratory Negative NCT00313300
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNegativeNCT00313300
APPRAISE 2, 2011apixabanplacebo Low risk of bias Negative NCT00831441
APPRAISE japan ongoing apixabanplacebo Exploratory - NCT00852397
coumadin
ASPECT-2 (coumadin vs aspirin), 2002coumadinaspirinSuggesting
ASPECT-2 (coumadin+asp vs asp), 2002coumadincontrol (on top of aspirin)Suggesting
dabigatran
REDEEM, 2009dabigatranplaceboNegativeNCT00621855
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparin Exploratory SuggestingNCT00317395
rivaroxaban
ATLAS ACS-TIMI 46 (5mg), 2009rivaroxaban 5mgplaceboNegative NCT00402597
ATLAS ACS-TIMI 46 (2.5mg), 2009rivaroxaban 2.5mgplaceboNegativeNCT00402597
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplacebo Low risk of bias Suggesting NCT00809965
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboSuggesting NCT00809965
warfarin
ATACS (pilot study) warfarin vs aspirin, 1990warfarinaspirinNegative
ATACS (pilot study) (warfarin vs control), 1990warfarincontrol (on top of aspirin)Negative
ATACS, 1994warfarincontrol (on top of aspirin)Negative
CARS, 1997warfarincontrol (on top of aspirin)Negative
Williams, 1997warfarinplacebo (on top of aspirin)Negative
OASIS Pilot (phase 1), 1998warfarincontrol (on top of aspirin)Negative
OASIS Pilot (phase 2), 1998warfarincontrol (on top of aspirin)Negative
OASIS-2 Warfarin Substudy, 2001warfarincontrol (on top of aspirin)Negative
Huyhn, 2001warfarinplacebo (on top of aspirin)Negative
APRICOT-2, 2002warfarincontrol (on top of aspirin)Negative
CHAMP, 2002warfarincontrol (on top of aspirin)Negative
WARIS, 2002warfarincontrol (on top of aspirin)Suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Negative
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)Negative
ximelagatran
ESTEEM, 2003ximelagatranplacebo Exploratory -

acute myocardial infarction

coumadin
ASPECT, 1994coumadinplaceboSuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinSuggesting
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)Negative
warfarin
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)Suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)Negative
Williams, 1997warfarinplacebo (on top of aspirin)Suggesting
WARIS, 1999warfarincontrol (on top of aspirin) -
WARIS II (warfarin alone), 2002warfarinaspirinSuggesting
APRICOT-2, 2002warfarincontrol (on top of aspirin)Suggesting
CHAMP, 2002warfarincontrol (on top of aspirin)Negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)Suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)Negative
LoWASA, 2004warfarincontrol (on top of aspirin) Risk of bias Suggesting

cardiovascular prevention

dicoumarol
Apenstrom and Korsan-Bengtsen, 1964dicoumarolno anticoagulant -
rivaroxaban
COMPASS (rivaroxaban alone), 2017rivaroxabanaspirinsecondary prevention - NCT01776424
COMPASS (rivaroxaban + aspirin), 2017rivaroxaban + aspirinaspirinsecondary prevention Low risk of bias - NCT01776424
wafarin
WARIS, 1990warfarinplacebo -
warfarin
Thrombosis Prevention trial (Warfarin), 1998warfarinplaceboprimary prevention Low risk of bias Suggesting NCT00000614
Thrombosis Prevention trial (W plus A), 1998warfarin + aspirinplaceboprimary prevention Exploratory Suggesting NCT00000614

coronary artery disease

dicoumarol
Apenstrom and Korsan-Bengtsen, 1964dicoumarolno anticoagulant -
wafarin
WARIS, 1990warfarinplacebo -

heart failure

rivaroxaban
COMMANDER HF, 2018rivaroxabanplaceboNegativeNCT01877915
warfarin
HELAS (warfarin vs aspirin), 2006warfarinaspirin -
HELAS (warfarin vs placebo), 2006warfarinplacebo -
WATCH (warfarin vs aspirin), 2009warfarinaspirinSuggestingNCT00007683

percutaneous coronary intervention

bivalirudin
ARMYDA BIVALVEbivalirudinUFH -
BAT (Bittl), 1995bivalirudinUFH Low risk of bias Suggesting
Kleiman, 2002bivalirudin + eptifibatideheparin + GP2b3a inhibitors Exploratory -
REPLACE-2, 2003bivalirudinheparin + GP2b3a inhibitors -
REPLACE-1, 2004bivalirudinUFH Exploratory Negative
ACUITY (Stone) (bivalirudin alone), 2006bivalirudinheparin + GP2b3a inhibitors Risk of bias - NCT00093158
HORIZONS-AMI (Stone), 2008bivalirudinheparin + GP2b3a inhibitors Risk of bias SuggestingNCT00433966
ISAR-REACT 3, 2008bivalirudinUFH Low risk of bias - NCT00262054
NAPLES (Tavano), 2009bivalirudinUFH plus tirofiban Risk of bias Suggesting
dalteparin
Natarajan (without antiGp2b3a), 2003dalteparinUFH -
Natarajan (+ antiGp2b3a), 2003dalteparinUFH + anti Gp2b3a -
enoxaparin
Rabah, 1999enoxaparinUFH Exploratory Negative
Dudek, 2000enoxaparinUFHNegative
Dudek b (enox alone), 2000enoxaparinUFH -
Galeote, 2001enoxaparinUFHNegative
Drozd, 2001enoxaparinUFHNegative
Dubek b (+abciximal), 2001enoxaparin+abciximabUFH -
CRUISE, 2003enoxaparinUFH Exploratory Negative
STEEPLE, 2006enoxaparinUFH Risk of bias - NCT00077844
ATOLL, 2010enoxaparinUFH Risk of bias -
fondaparinux
SWITCH III ongoing fondaparinuxunfractionated heparin or bivalirudin - NCT00464087
reviparin
REDUCE, 1996reviparinUFH Low risk of bias Suggesting

peripheral vascular diseases

warfarin
Sarac, 1998warfarincontrôle -
Johnson, 2002warfarincontrôle -

post myocardial infarction

coumadin
ASPECT, 1994coumadinplaceboSuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinSuggesting
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)Negative
warfarin
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)Suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)Negative
Williams, 1997warfarinplacebo (on top of aspirin)Suggesting
WARIS, 1999warfarincontrol (on top of aspirin) -
WARIS II (warfarin alone), 2002warfarinaspirinSuggesting
APRICOT-2, 2002warfarincontrol (on top of aspirin)Suggesting
CHAMP, 2002warfarincontrol (on top of aspirin)Negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)Suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)Negative
LoWASA, 2004warfarincontrol (on top of aspirin) Risk of bias Suggesting

post stroke

dicoumarol
Nat-Coop, 1962dicoumarolplaceboSuggesting
Howard, 1963dicoumarolplaceboNegative
phenindione
Thygesen, 1964phenindioneplaceboNegative
Enger, 1965phenindioneplaceboNegative
rivaroxaban
NAVIGATE ESUS, 2018rivaroxabanaspirin - NCT02313909
warfarin
SWAT, 1998warfarinaspirinNegative

thrombosis prevention

acenocoumarol
van Geloven, 1977Acenocoumarolunfractionated heparin -
Hamulyak, 1994AcenocoumarolNadroparinNegative
Samama, 2001AcenocoumarolReviparinNegative
apixaban
APROPOS 2.5mg, 2007apixabanenoxaparin (US regimen)knee surgery Exploratory NegativeNCT00097357
ADVANCE-1, 2008apixabanenoxaparin (US regimen)knee surgery Low risk of bias SuggestingNCT00371683
ADVANCE 3, 2010apixabanenoxaparinhip surgery Low risk of bias SuggestingNCT00423319
ADVANCE 2, 2010apixabanenoxaparin (europe regimen)knee surgery Low risk of bias SuggestingNCT00452530
dabigatran
RE-NOVATE 2dabigatran 220mgenoxaparinhip surgery Low risk of bias NegativeNCT00657150
RE-NOVATE (220mg), 2007dabigatran 220mgenoxaparinhip surgery Low risk of bias NegativeNCT00168818
RE-NOVATE (150mg), 2007dabigatran 150mgenoxaparinhip surgery Low risk of bias Negative NCT00168818
RE-MODEL (220mg), 2007dabigatran 220mgenoxaparin (europe regimen)knee surgery Low risk of bias Negative
RE-MODEL (150mg), 2007dabigatran 150mgenoxaparin (europe regimen)knee surgery Low risk of bias Negative
RE-MOBILIZE (220mg), 2008dabigatran 220mgenoxaparin (US regimen)knee surgery Low risk of bias Negative
RE-MOBILIZE (150mg), 2008dabigatran 150mgenoxaparin (US regimen)knee surgery Low risk of bias Negative
edoxaban
STARS J-Vedoxabanenoxaparin (short duration)hip surgery Low risk of bias SuggestingNCT01181167
DU176b-B-J302 ongoing edoxabanenoxaparinknee surgery - NCT01181102
DU176b-B-J303 ongoing edoxabanenoxaparinhip surgery - NCT01181141
DU176b-B-J304 ongoing edoxabanenoxaparinhip surgery - NCT01181167
DU176b-04 ongoing edoxabanplaceboknee surgery - NCT01203072
phenindione
Eskeland, 1966Phenindioneno treatment -
Hamilton, 1970Phenindioneno treatment -
rivaroxaban
ODIXa-KNEE, 2005rivaroxabanenoxaparin (US regimen)knee surgery Exploratory Negative
ODIXa-HIP 10mg, 2006rivaroxabanenoxaparin (short duration)hip surgery Exploratory Suggesting
RECORD 1, 2008rivaroxabanenoxaparinhip surgery Low risk of bias SuggestingNCT00329628
RECORD 3, 2008rivaroxabanenoxaparin (europe regimen)knee surgery Low risk of bias SuggestingNCT00361894
RECORD 2, 2008rivaroxaban (long duration)enoxaparin (short duration)hip surgery Low risk of bias SuggestingNCT00332020
RECORD 4, 2009rivaroxabanenoxaparin (US regimen)knee surgery Low risk of bias SuggestingNCT00362232
warfarin
Myrhe, 1969WarfarinDextran -
Myrhe, 1969Warfarinplacebo -
Pinto, 1970Warfarinno treatment -
Harris, 1972WarfarinDextran -
Hume, 1973Warfarinno treatment -
Hume, 1973WarfarinSudoxicam -
Hume, 1973Warfarinunfractionated heparin -
Morris, 1976Warfarinno treatment -
Barber, 1977WarfarinDextran -
Barber, 1977Warfarinunfractionated heparin -
Francis, 1983WarfarinDextran -
Paiement, 1987WarfarinIntermittent pneumatic compression -
Powers, 1989WarfarinAspirin -
Powers, 1989Warfarinno treatment -
Gerhart, 1991WarfarinDanaparoid -
Bailey, 1991WarfarinIntermittent pneumatic compression -
Kaempffe, 1991WarfarinIntermittent pneumatic compression -
Francis, 1992WarfarinIntermittent pneumatic compression -
Hull, 1993WarfarinLogiparinSuggesting
RD Heparin, 1994WarfarinArdeparinSuggesting
Leclerc, 1996WarfarinEnoxaparinSuggesting
Heit, 1997WarfarinArdeparinSuggesting
Lotke, 1997WarfarinAspirin -
Francis, 1997WarfarinDalteparinSuggesting
van Comp, 1998WarfarinDanaparoid -
Colwell, 1999WarfarinEnoxaparinSuggesting
Hull, 2000WarfarinDalteparinSuggesting
Fitzgerald, 2001WarfarinEnoxaparinSuggesting



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