new version V2017

Candesartan angiotensin-receptor blockers
Description Results

CV-11974 - CV11974 - CV 11974 - candesartan - Parapres - Amias - Kenzen - Blopress - Atacand - TCV-116 - TCV 116 - candesartan cilexetil      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

atrial fibrillation

CHARM (AF ancillary study), 2005candesartanplaceboSuggesting
CAPRAF (Tveit), 2007candesartanplacebo Risk of bias - NCT00130975

coronary artery disease

SYNTAX (unprotected left main sub group), 2009DESCABG Risk of bias Suggesting

diabetes type 2

SCOPE (diabetic subgroup), 2003candesartancontrol Exploratory Negative

heart failure

RESOLVD association, 1999candesartan+ACE inhibitorACE inhibitor only Exploratory Negative
RESOLVD (candesartan alone), 1999candesartanenalapril Exploratory Negative
STRETCH, 1999candesartanplacebo Exploratory -
SPICE, 2000candesartanplacebo Exploratory Negative
CHARM-Added, 2003candesartan+ACE inhibitorACE inhibitor only Low risk of bias Negative
ARCH-J, 2003candesartanplacebo Low risk of bias -
CHARM-Alternative, 2003candesartanplacebo Low risk of bias Suggesting
Mitrovic et al., 2003candesartanplacebo Exploratory Suggesting
CHARM preserved, 2003candesartanplacebo Low risk of bias -

heart failure with preserved LVEF

CHARM preserved, 2003candesartanplacebo Low risk of bias -

hypertension

HSCS, 1974deserpidine +methylclothiazideplaceboNegative
ALPINE, 2003candesartanhydrochlorothiazide Low risk of bias Suggesting
SCOPE, 2003candesartanplacebo Low risk of bias Negative
E-COST-R, 2005candesartanconventional treatment Risk of bias Negative
E-COST, 2005candesartanconventional treatment Risk of bias Suggesting
Takahashi, 2006candesartancontrol Exploratory Negative
TROPHY, 2006candesartanplacebo Exploratory SuggestingNCT00227318
Takahashi et al, 2006candesartanusual careSuggesting
CASE-J, 2008candesartanamlodipine Risk of bias Suggesting
Suzuki et al, 2008candesartanusual careSuggesting
HIJ-CREATE, 2009candesartanconventional treatment Risk of bias Suggesting
HIJ-CREATE, 2009Candesartanusual care Risk of bias -

miscellaneous

ALPINE, 2003candesartanhydrochlorothiazide Low risk of bias Suggesting
SCOPE, 2003candesartanplacebo Low risk of bias Negative
E-COST, 2005candesartanconventional treatment Risk of bias Suggesting
E-COST-R, 2005candesartanconventional treatment Risk of bias Negative
Takahashi, 2006candesartancontrol Exploratory Negative
TROPHY, 2006candesartanplacebo Exploratory SuggestingNCT00227318
CASE-J, 2008candesartanamlodipine Risk of bias Suggesting
HIJ-CREATE, 2009candesartanconventional treatment Risk of bias Suggesting

patients at high risk for cardiovascular events

SCOPE, 2003candesartanplacebo Low risk of bias Negative

pulmonary embolism

Tebbe, 2009desmoteplasealteplase Exploratory -

superficial thrombophlebitis

Andreozzi (desmin SC vs 100), 1996desmin SCdesmin 100 -
Andreozzi (200 vs 100), 1996desmin 200desmin 100 -

thrombosis prevention

Eriksson, 1996desirudinUFH -
Ericksson, 1997desirudinenoxaparin -
REVASC, 1997desirudinUFH -



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