Clinical trials in coronary artery disease

Trial	Studied treatment	Control treatment	ROB	Result	NCT
angiotensin-receptor blockers
candesartan
HIJ-CREATE, 2009	Candesartan	usual care	Risk of bias	-
captopril
VALIANT/Val+Cap, 2003	Valsartan + captopril	Captopril	Low risk of bias	Negative
losartan
ELITE, 1997	Losartan	Captopril	Exploratory	Suggesting
ELITE-II, 2000	Losartan	Captopril	Low risk of bias	Negative
OPTIMAAL, 2001	Losartan	Captopril	Risk of bias	Negative
ramipril
ONTARGET/Tel+Ram, 2008	Telmisartan + ramipril	Ramipril	Low risk of bias	Negative
telmisartan
DETAIL, 2004	Telmisartan	Enalapril	Low risk of bias	Negative
ONTARGET/Tel, 2008	Telmisartan	Ramipril	Low risk of bias	Negative
valsartan
VALIANT/Val, 2003	Valsartan	Captopril	Low risk of bias	Negative
cell-based therapies
fibroblast growth factor
AGENT-3	fibroblast growth factor gene	placebo		-	NCT00346437
AGENT-4	fibroblast growth factor gene	placebo		-	NCT00185263
AWARE	fibroblast growth factor gene	placebo		-	NCT00438867
AGENT 3 and 4 pooled	fibroblast growth factor gene	placebo		-
AGENT-1 (Grines), 2002	fibroblast growth factor gene	placebo		-
FIRST (Simons), 2002	fibroblast growth factor	placebo		-
AGENT-2 (Grines), 2003	fibroblast growth factor gene	placebo		-
gene therapy
EUROINJECT-ONE (Gyöngyösi), 2005	gene therapy	placebo		-
NCT00090714 ongoing	gene therapy	placebo		-	NCT00090714
Drug eluting stent
abciximab
Kim, 2010	abciximab-coated stent	bare-metal stent	Exploratory	-
biolimus eluting stent
LEADERS, 2008	biolimus eluting stent	sirolimus eluting stent		Negative	NCT00389220
candesartan
SYNTAX (unprotected left main sub group), 2009	DES	CABG	Risk of bias	Suggesting
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent		Suggesting
drug-eluting stents
DEDICATION, 2008	drug-eluting stents	bare-metal stent	Risk of bias	Suggesting	NCT00192868
Boudriot, 2008	DES	CABG	Exploratory	Negative
GENIUS-STEMI, 2009	Genous stent	bare-metal stent	Exploratory	Negative
PASEO, 2009	drug-eluting stents	bare-metal stent		-
ISAR-CABG ongoing	drug-eluting stents	bare-metal stent		-	NCT00611910
Leipzig ongoing	drug-eluting stents	CABG		-	NCT00176397
everolimus eluting stent
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent		Suggesting
ESSENCE diabetes	everolimus eluting stent	sirolimus ES		-	NCT00997763
FUTURE I, 2004	everolimus eluting stent	bare-metal stent		Negative
SPIRIT I, 2005	everolimus eluting stent	bare-metal stent	Exploratory	Negative	NCT00180453
FUTURE II, 2006	everolimus eluting stent	bare-metal stent		-
SPIRIT II, 2006	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00180310
SPIRIT III, 2008	everolimus eluting stent	paclitaxel eluting stent	Exploratory	Suggesting	NCT00180479
COMPARE, 2009	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT01016041
SPIRIT III (small vessel subgroup), 2009	everolimus eluting stent	paclitaxel eluting stent	Exploratory	Suggesting
BASKET-PROVE (EES), 2010	everolimus eluting stent	bare-metal stent		Suggesting	ISRCTN72444640
SPIRIT IV, 2010	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00307047
PLATINUM, 2011	everolimus eluting stent	everolimus eluting stent		-	NCT00823212
RESET, 2011	everolimus eluting stent	sirolimus eluting stent		-	NCT01035450
SORT OUT IV, 2012	everolimus eluting stent	sirolimus eluting stent	Risk of bias	-	NCT00552877
LEFT-MAIN-2 ongoing	everolimus eluting stent	zotarolimus eluting stent		-	NCT00598637
paclitaxel
TAXUS V small vessels sub groups	paclitaxel eluting stent	bare-metal stent		-
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent		Negative
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent		Negative
TAXUS II, 2003	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00299026
ASPECT, 2003	paclitaxel, non-polymeric eluting stent	bare-metal stent		Suggesting	NCT00196079
TAXUS II (diabetics), 2003	paclitaxel eluting stent	bare-metal stent		Suggesting
TAXUS IV, 2004	paclitaxel eluting stent	bare-metal stent	Low risk of bias	Suggesting	NCT00292474
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent		Negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent	Risk of bias	Negative
SCORE, 2004	paclitaxel eluting stent	bare-metal stent		Suggesting
ISAR-DESIRE (PES vs PTCA), 2005	paclitaxel eluting stent	balloon angioplasty		Suggesting
TAXUS V (all patients), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00301522
TAXUS VI, 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00297804
TAXUS IV (diabetics), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00292474
TAXUS V (diabetics), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting
TAXUS VI (diabetics), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00297804
PASSION, 2006	paclitaxel eluting stent	bare-metal stent	Risk of bias	Negative	ISRCTN65027270
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent	Exploratory	Negative
TAXUS V ISR, 2006	paclitaxel eluting balloon	brachytherapy	Risk of bias	-	NCT00287573
ISAR-test (diabetics), 2006	paclitaxel eluting stent	sirolimus eluting stent	Risk of bias	-
Erglis, 2007	paclitaxel eluting stent	bare-metal stent		Suggesting
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent		Suggesting
SOS, 2008	paclitaxel eluting stent	bare-metal stent	Exploratory	Suggesting	NCT00247208
SYNTAX, 2009	paclitaxel eluting stent	CABG	Risk of bias	Suggesting	NCT00114972
BASKET-SAVAGE ongoing	paclitaxel eluting stent	bare-metal stent		-	NCT00595647
VELETI ongoing	paclitaxel eluting stent	medical treatment		-	NCT00289835
PEPCAD IV ongoing	paclitaxel eluting balloon	paclitaxel eluting stent		-	NCT00462631
FRE-RACE ongoing	paclitaxel eluting stent	sirolimus eluting stent		-	NCT00130546
PERSEUS Workhorse, 2010 ongoing	paclitaxel eluting stent	paclitaxel eluting stent		-	NCT00484315
PCI
COMBAT ongoing	PCI	CABG		-
Korean Randomized Study ongoing	PCI	CABG		-
REVASCULARIZE ongoing	PCI	CABG		-
sirolimus eluting stent
CRISTAL	sirolimus eluting stent	PTCA		-	NCT00323895
RAVEL, 2002	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00233805
SIRIUS, 2003	sirolimus eluting stent	bare-metal stent	Low risk of bias	Suggesting	NCT00232765
E-SIRIUS, 2003	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00235144
Pasceri, 2003	sirolimus eluting stent	bare-metal stent		-
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent		-
C-SIRIUS, 2004	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00381420
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent		Suggesting
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent		Suggesting
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty		Suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent		Suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent		Suggesting
DECODE, 2005	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00489164
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent		Suggesting
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent		Suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
SIRTAX (small vessels subgroup), 2005	sirolimus eluting stent	paclitaxel eluting stent		Suggesting
SIRTAX diabetics, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00297661
PRISON II, 2006	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00258596
SCANDSTENT, 2006	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00151658
TYPHOON, 2006	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00232830
RRISC, 2006	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00263263
SCANDSTENT (subgroup), 2006	sirolimus eluting stent	bare-metal stent	Exploratory	Suggesting
REALITY, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00235092
ISAR-SMART 3, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00146575
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	Negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
ISAR-TEST-1, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00140530
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent	Exploratory	-
SESAMI, 2007	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00288210
SCORPIUS, 2007	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00495898
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent		-
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent		-
SISR, 2007	sirolimus eluting stent	brachytherapy	Risk of bias	Suggesting	NCT00231257
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent		Negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	Suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	ISRCTN62825862
DESSERT, 2008	sirolimus eluting stent	bare-metal stent	Exploratory	Suggesting
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent		-
SORT OUT II, 2008	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00388934
Wessely, 2008	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	-
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent		Negative
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
RIBS-II, 2008	sirolimus eluting stent	PTCA		Suggesting
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent		Suggesting
ISAR-LEFT-MAIN, 2009	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00133237
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent		Negative	ISRCTN90526229
GISSOC II, 2010	sirolimus eluting stent	bare-metal stent	Exploratory	Suggesting	NCT00220558
BASKET-PROVE (SES), 2010	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	ISRCTN72444640
ISAR-DESIRE-2, 2010	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	-	NCT00598715
PRECOMBAT, 2011	sirolimus eluting stent	CABG		-	NCT00422968
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent		-
Gao ongoing	sirolimus eluting stent	Firebird eluting stent		-	NCT00887211
MIDCAB Versus DES in Proximal LAD Lesions ongoing	sirolimus eluting stent	CABG		-	NCT00299429
Munich Study ongoing	sirolimus eluting stent	CABG		-
FOCUS ongoing	sirolimus eluting stent	cutting ballon angioplasty		-	NCT00485004
DES-ISR ongoing	sirolimus eluting stent	paclitaxel eluting stent		-	NCT00485030
Lipsia-Yukon-DM ongoing	sirolimus eluting stent	paclitaxel eluting stent		-	NCT00368953
BASKET-PROVE, 2008 ongoing	sirolimus eluting stent	bare-metal stent		-
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent		Suggesting
ENDEAVOR III, 2006	zotarolimus eluting stent	sirolimus eluting stent		Suggesting	NCT00217256
ZoMaxx I, 2008	zotarolimus eluting stent	paclitaxel eluting stent		-
ENDEAVOR IV, 2009	zotarolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00217269
ZEST AMI (vs PES), 2009	zotarolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00422565
ZEST (vs PES), 2009	zotarolimus eluting stent	paclitaxel eluting stent		Suggesting	NCT00418067
ZEST (vs SES), 2009	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	Negative	NCT00418067
ZEST AMI (vs SES), 2009	zotarolimus eluting stent	sirolimus eluting stent		Negative	NCT00422565
RESOLUTE All comers, 2010	zotarolimus eluting stent	everolimus eluting stent	Risk of bias	Negative	NCT00617084.)
SORT-OUT-3, 2010	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	Negative	NCT00660478
TWENTE, 2012	zotarolimus eluting stent	everolimus eluting stent		-	NCT01066650
PROTECT, 2012	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	-	NCT00476957
ZoMaxx phase 2 ongoing	zotarolimus eluting stent	paclitaxel eluting stent		-	NCT00140101
DIABEDES IV ongoing	zotarolimus eluting stent	sirolimus eluting stent		-	NCT00552994
PRISON III, 2007 ongoing	zotarolimus eluting stent	sirolimus eluting stent		-	NCT00428454
fractional-flow-reserve-guided PCI
PCI
DEFER, 2001	FFR-guided PCI	no PCI		Negative
FAME, 2008	FFR-guided PCI	no PCI		Suggesting	NCT00267774

coronary artery disease Description Results

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coronary artery disease
Description Results