coronary artery disease

systematic review meta-analysis network meta-analysis

Select cell-based therapies Drug eluting stentfractional-flow-reserve-guided PCImyocardial revascularizationanticoagulantanti-anginal drugsdeath and events preventiontransmyocardial revacularization Acute myocardial infarctionAll type of patientbifurcation lesionbypass graft lesionDiabetic patientsuncoded clinical condition ***in stent restenosislong or complex lesionmultivessels diseasepatients with left ventricular dysfunctionsingle vessel diseasesmall vesselstotal occlusionUnparticular patientsunprotected left main artery stenosisuntractable angina       abciximab-coated stentanticoagulantaspirinbioabsorbable polymer stentCABG or PCIclopidogreldipyridamoldouble stentingdrug-eluting stentsfractional-flow-reserve-guidedgene therapygrowth factornicorandilnon-polymeric ESPCIprovisional T-stenting with drug-eluting stentsranolazineresordablestem cellssurgeryticlopidinetitanium-nitride-oxide coated stenttransmyocardial revascularization candesartanwafarinabciximabangioplastyaspirinbiolimus eluting stentclopidogrelCoronary Artery Bypass Surgerydactinomycin eluting stentdicoumaroldipyridamoldrug-eluting stentseverolimus eluting stentfibroblast growth factorgene therapynicorandilpaclitaxelPCIPTCAranolazinesirolimus eluting stentticlopidinezotarolimus eluting stent vs angioplastyvs ballon angioplastyvs bare-metalvs control or placebovs medical treatmentvs no kissing balloonvs no PCIvs placebo or controlvs PTCAvs aspirinvs brachytherapyvs drug-eluting stentsvs no TMRvs single stentingvs Surgery      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (295)myocardial infarction (fatal and non fatal) (217)target lesion revascularisation (214)Stent thrombosis (any, end of follow up) (192)MACE (180)angiographic restenosis (109)target-vessel revascularization (98)4y stent thrombosis (ARC) (85)CABG (84)cardiac death (79)late stent thrombosis (31days - 1year) (77)Long term death (46)PTCA (40)sub acute stent thrombosis (1-30 days) (40)Non fatal MI (34)Acute stent thrombosis (<=24h) (32)Deaths or MI (30)2 yr MACE (28)Cardiac death or MI (27)2 yr TLR (22)Cardiovascular death (18)in-lesion binary restenosis (16)long term cardiovascular events (16)4 yr stent thrombosis (15)cardiovascular events (14)4 yr TLR (12)4 yr MI (12)1 year event (12)stroke (fatal and non fatal) (11)1 year death from any cause (11)Angina (10)1 year revascularization (10)long term MI (10)2 yr Death (all cause) (10)5-year death (9)Angina (grade 2 or worse) in first year (8)4 yr mortality from all causes (8)4 yr death or MI (8)6 months death (8)6 months MI (8)Angina relief (8)In-hospital death (7)urgent CABG (6)In-hospital MI (6) (6)1 year MI (6)6 months events (6)7-year death (6)10-year death (6)Non vascular death (6)Non fatal stroke (6)cardiac event (fatal and non fatal ) (4)Repeat revascularization (4)Revascularization (4)Bleeding (3)Fatal MI (3)death or hospitalization for cardiac causes (3)Definite or probable stent thrombosis (2)Urgent revascularization (2)hospitalisation for cardiovascular causes (1)Coronary event (1)Death, MI and stroke (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	myocardial infarction (fatal and non fatal)
anti-anginal drugs
nicorandil
Nishimura, 2009	nicorandil	control			Risk of bias	-
ranolazine
MARIZA, 2004	ranolazine 1000mg	placebo			Low risk of bias	-
RAN080, 2005	ranolazine 1000mg	placebo			Low risk of bias	-
CARISA 1000mg, 2004	ranolazine 1000mg	placebo (on top standard treatment)			Low risk of bias	negative
ERICA, 2006      NCT	ranolazine 1000mg + amlodipine	placebo + amlodipine			Low risk of bias	-
anticoagulant
not classified
MacMillan, 1960	anticoagulant	no anticoagulant				-
Borchegrevink, 1960	anticoagulant	no anticoagulant				-
Clausen, 1961	anticoagulant	no anticoagulant				-
Harvald, 1961	anticoagulant	no anticoagulant				-
Conrad, 1964	anticoagulant	no anticoagulant				-
Wasserman, 1966	anticoagulant	no anticoagulant				-
Loeliger, 1967	anticoagulant	no anticoagulant				-
Lovell, 1967	anticoagulant	no anticoagulant				-
Seaman, 1969	anticoagulant	no anticoagulant				-
Sorensen, 1969	anticoagulant	no anticoagulant				-
Meuwisse,, 1969	anticoagulant	no anticoagulant				-
Drapkin and Merskey, 1972	anticoagulant	no anticoagulant				-
Sixty Plus Reinfarction, 1980	coumarin congeners	placebo			Low risk of bias	-
ASPECT, 1994	nicoumalone or phenprocoumon	placebo				-
Breddin, 1980	phenprocoumon	placebo			Low risk of bias	-
dicoumarol
Apenstrom and Korsan-Bengtsen, 1964	dicoumarol	no anticoagulant				-
wafarin
WARIS, 1990	warfarin	placebo			Low risk of bias	-
cell-based therapies
not classified
REVASC (Stewart), 2006	VEGF gene transfer	control				-
Ramshorst, 2009	autologous bone marrow–derived mononuclear cells	placebo			Low risk of bias	-
Losordo, 2011      NCT	CD34+ cells	placebo			Exploratory	-
Losordo, 2007      NCT	stem cells CD34+	placebo			Low risk of bias	-
VIVA (Henry), 2003	vascular endothelial growth factor	placebo			Low risk of bias	-
fibroblast growth factor
FIRST (Simons), 2002	fibroblast growth factor	placebo			Low risk of bias	-
AGENT-1 (Grines), 2002	fibroblast growth factor gene	placebo				-
AGENT-2 (Grines), 2003	fibroblast growth factor gene	placebo				-
AGENT-3    NCT	fibroblast growth factor gene	placebo				-
AGENT-4    NCT	fibroblast growth factor gene	placebo				-
AWARE    NCT	fibroblast growth factor gene	placebo			Low risk of bias	-
AGENT 3 and 4 pooled	fibroblast growth factor gene	placebo				-
gene therapy
EUROINJECT-ONE (Gyöngyösi), 2005	gene therapy	placebo			Low risk of bias	-
death and events prevention
aspirin
CDPA, 1976	aspirin	placebo			Low risk of bias	negative
Cardiff I, 1974	aspirin	placebo			Low risk of bias	negative
Cardiff II, 1979	aspirin	placebo			Low risk of bias	negative
Vogel, 1979	aspirin	placebo			Low risk of bias	suggesting
AMIS, 1980    NCT	aspirin	placebo			Low risk of bias	suggesting
GAMIS, 1980	aspirin	placebo			Low risk of bias	negative
PARIS, 1980	aspirin	placebo			Low risk of bias	negative
JAMIS, 1999	aspirin	placebo				suggesting
SAPAT, 1992	aspirin	placebo			Low risk of bias	suggesting
clopidogrel
CAPRIE, 1996	clopidogrel	aspirin			Low risk of bias	-
ASCET    NCT	clopidogrel	aspirin			Risk of bias	negative
dipyridamol
Atlanta (Sbar), 1967	dipyridamol	control			Low risk of bias	negative
Becker, 1967	dipyridamol	control			Low risk of bias	negative
Wirecki, 1967	dipyridamol	control			Low risk of bias	negative
Igloe, 1970	dipyridamol	placebo			Low risk of bias	-
Zion, 1961	dipyridamol	placebo			Low risk of bias	-
Kinsella, 1962	dipyridamol	placebo			Low risk of bias	-
Leiberman, 1964	dipyridamol	placebo			Low risk of bias	-
Dewar, 1961	dipyridamol	placebo			Low risk of bias	-
Neumann, 1964	dipyridamol	placebo			Low risk of bias	-
Foulds, 1960	dipyridamol	placebo			Low risk of bias	-
PARIS, 1980	dipyridamol + aspirin	placebo			Low risk of bias	negative
PARIS-II, 1986	dipyridamol + aspirin	placebo			Low risk of bias	negative
PARIS, 1980	dipyridamol + aspirin	aspirin			Low risk of bias	negative
ticlopidine
Berglund, 1985	ticlopidine	placebo			Low risk of bias	negative
Drug eluting stent
not classified
ISAR-CABG, 2011      NCT	DES	bare-metal stent			Risk of bias	suggesting
TINOX, 2005	titanium-nitride-oxide coated stent	bare-metal stent			Exploratory	-
PAINT (sirolimus), 2009      NCT	biodegradable-polymer	BMS			Risk of bias	-
EVOLVE, 2012      NCT	bioabsorbable polymer EES	everolimus eluting stent				-
Nordic-Baltic Bifurcation Study III, 2009    NCT	kissing balloon	no kissing balloon			Risk of bias	negative
NEVO RES-ELUTION I    NCT	Nevo	paclitaxel eluting stent			Exploratory	-
Costar II, 2008      NCT	CoStar stent	paclitaxel eluting stent			Risk of bias	negative
COSTAR II diabetic (sub group), 2008	CoStar stent	paclitaxel eluting stent			Exploratory	negative
TRIAS-HR, 2008	Genous stent	paclitaxel eluting stent				negative
BIOFREEDOM    NCT	polymer-free biolimus a9-eluting stents	paclitaxel eluting stent			Exploratory	-
BBC ONE, 2008      NCT	double stenting with PES	single stenting				negative
CACTUS , 2009	double stenting with SES	single stenting			Risk of bias	negative
Colombo, 2004	double stenting with SES	single stenting			Exploratory	negative
Ferenc, 2008	double stenting with SES	single stenting			Exploratory	negative
NORDIC , 2006	double stenting with SES	single stenting			Risk of bias	negative
Pan, 2004	double stenting with SES	single stenting			Exploratory	negative
ISAR TEST 2 (vs SES), 2009          NCT	dual sirolimus, probucol eluting stent	sirolimus eluting stent			Risk of bias	negative
ISAR TEST 3 (PF), 2009	polymer free sirolimus stent	sirolimus eluting stent				negative
ISAR TEST 3 (BP), 2009	sirolimus biodegradable polymer	sirolimus eluting stent				negative
ISAR-TEST-4 (biodegradable polymer), 2009    NCT	sirolimus biodegradable polymer	sirolimus eluting stent			Risk of bias	negative
ISAR TEST 2 (vs ZES), 2009      NCT	dual sirolimus, probucol eluting stent	zotarolimus eluting stent			Risk of bias	-
ISAR TEST 5    NCT	dual sirolimus, probucol eluting stent	zotarolimus eluting stent	click to display paper's table" >		Risk of bias	negative
abciximab
Kim, 2010	abciximab-coated stent	bare-metal stent			Exploratory	-
biolimus eluting stent
LEADERS, 2008      NCT	biolimus eluting stent	sirolimus eluting stent				negative
candesartan
SYNTAX (unprotected left main sub group), 2009	DES	CABG			Risk of bias	suggesting
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent				suggesting
drug-eluting stents
PASEO, 2009	drug-eluting stents	bare-metal stent				-
DEDICATION, 2008      NCT	drug-eluting stents	bare-metal stent			Risk of bias	suggesting
GENIUS-STEMI, 2009	Genous stent	bare-metal stent			Exploratory	negative
Boudriot, 2008	DES	CABG			Exploratory	negative
FREEDOM, 2012      NCT	PCI with drug-eluting stents	CABG			Risk of bias	negative
Hong, 2005	PCI withdrug-eluting stents	CABG			Risk of bias	-
everolimus eluting stent
FUTURE I, 2004	everolimus eluting stent	bare-metal stent				negative
FUTURE II, 2006	everolimus eluting stent	bare-metal stent			Low risk of bias	-
SPIRIT I, 2005    NCT	everolimus eluting stent	bare-metal stent			Exploratory	negative
BASKET-PROVE (EES), 2010	everolimus eluting stent	bare-metal stent				suggesting
RESET, 2011    NCT	everolimus eluting stent	sirolimus eluting stent				-
PLATINUM, 2011      NCT	everolimus eluting stent	everolimus eluting stent				-
SPIRIT II, 2006      NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
SPIRIT IV, 2010          NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III, 2008        NCT	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
COMPARE, 2009        NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III (small vessel subgroup), 2009	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
SORT OUT IV, 2012      NCT	everolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent				suggesting
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005	paclitaxel eluting stent	balloon angioplasty				suggesting
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS II, 2003      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV, 2004        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SCORE, 2004	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS V (all patients), 2005    NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI, 2005        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
Erglis, 2007	paclitaxel eluting stent	bare-metal stent				suggesting
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS II (diabetics), 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS V (diabetics), 2005	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SOS, 2008        NCT	paclitaxel eluting stent	bare-metal stent			Exploratory	suggesting
TAXUS V small vessels sub groups	paclitaxel eluting stent	bare-metal stent				-
ASPECT, 2003      NCT	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	suggesting
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent				negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent			Risk of bias	negative
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS V ISR, 2006      NCT	paclitaxel eluting balloon	brachytherapy			Risk of bias	-
SYNTAX, 2009          NCT	paclitaxel eluting stent	CABG			Risk of bias	suggesting
ISAR-test (diabetics), 2006	paclitaxel eluting stent	sirolimus eluting stent			Risk of bias	-
sirolimus eluting stent
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty				suggesting
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent			Exploratory	-
RAVEL, 2002      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
SIRIUS, 2003            NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
C-SIRIUS, 2004      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
E-SIRIUS, 2003      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent				suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent				suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent				suggesting
PRISON II, 2006      NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
TYPHOON, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007        NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
DECODE, 2005      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SCORPIUS, 2007    NCT	sirolimus eluting stent	bare-metal stent				suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent				-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent				-
GISSOC II, 2010      NCT	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent				suggesting
BASKET-PROVE (SES), 2010	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent				suggesting
DESSERT, 2008	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent			Low risk of bias	-
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent				-
RRISC, 2006    NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT (subgroup), 2006	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
CRISTAL    NCT	sirolimus eluting stent	PTCA				-
RIBS-II, 2008	sirolimus eluting stent	PTCA				suggesting
SISR, 2007        NCT	sirolimus eluting stent	brachytherapy			Risk of bias	suggesting
PRECOMBAT, 2011    NCT	sirolimus eluting stent	CABG				-
Thiele, 2009    NCT	PCI withsirolimus ES	MIDCAB			Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent				-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
REALITY, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ISAR-SMART 3, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
SORT OUT II, 2008      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent				negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-TEST-1, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-LEFT-MAIN, 2009      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent				negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SIRTAX diabetics, 2005        NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent				-
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-DESIRE-2, 2010    NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	-
Wessely, 2008	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	-
SIRTAX (small vessels subgroup), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
RESOLUTE All comers, 2010        NCT	zotarolimus eluting stent	everolimus eluting stent			Risk of bias	negative
TWENTE, 2012      NCT	zotarolimus eluting stent	everolimus eluting stent	click to display paper's table" >			-
ENDEAVOR IV, 2009        NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ZEST AMI (vs PES), 2009      NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZoMaxx I, 2008	zotarolimus eluting stent	paclitaxel eluting stent				-
ZEST (vs PES), 2009    NCT	zotarolimus eluting stent	paclitaxel eluting stent				suggesting
ENDEAVOR III, 2006        NCT	zotarolimus eluting stent	sirolimus eluting stent				suggesting
PROTECT, 2012    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ZEST (vs SES), 2009    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative
SORT-OUT-3, 2010      NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009      NCT	zotarolimus eluting stent	sirolimus eluting stent				negative
fractional-flow-reserve-guided PCI
not classified
FAME II, 2012        NCT	FFR-guided PCI	no PCI				suggesting
PCI
FAME, 2008            NCT	FFR-guided PCI	no PCI				suggesting
DEFER, 2001	FFR-guided PCI	no PCI				negative
myocardial revascularization
not classified
Serruys Benestent 2, 1998	stent	balloon angioplasty				suggesting
Versaci , 1997	stent	balloon angioplasty				suggesting
Fischman STRESS, 1994	stent	balloon angioplasty				suggesting
Serruys Benestent, 1994	stent	balloon angioplasty				suggesting
Moer, 2001	stent	balloon angioplasty				negative
Doucet, 2001	stent	balloon angioplasty				negative
Koning, 2001	stent	balloon angioplasty				suggesting
Park, 2000	stent	balloon angioplasty				negative
Lotan, 2000	stent	balloon angioplasty				suggesting
Weaver, 2000	stent	balloon angioplasty				suggesting
Dangas, 2000	stent	balloon angioplasty				negative
Fluck, 2000	stent	balloon angioplasty				negative
Lafont, 2000	stent	balloon angioplasty				negative
Witkowski, 2000	stent	balloon angioplasty				negative
Kastrati, 2000	stent	balloon angioplasty				negative
Di Marlo, 2000	stent	balloon angioplasty				negative
Serruys, 2000	stent	balloon angioplasty				negative
Lincoff (EPISTENT), 1999        NCT	stent	balloon angioplasty				suggesting
Buller, 1999	stent	balloon angioplasty				suggesting
Betriu, 1999	stent	balloon angioplasty				suggesting
Hoher, 1999	stent	balloon angioplasty				suggesting
Sievert, 1999	stent	balloon angioplasty				suggesting
Eeckout, 1996	stent	balloon angioplasty				negative
Sirnes, 1996	stent	balloon angioplasty				suggesting
Savage, 1998	stent	balloon angioplasty				negative
Erbel, 1998	stent	balloon angioplasty				suggesting
Rubartelli, 1998	stent	balloon angioplasty				suggesting
Hancock, 1998	stent	balloon angioplasty				suggesting
Rodriguez, 1998	stent	balloon angioplasty				negative
TINOX, 2005	titanium-nitride-oxide coated stent	bare-metal stent			Exploratory	-
PAINT (sirolimus), 2009      NCT	biodegradable-polymer	BMS			Risk of bias	-
EVOLVE, 2012      NCT	bioabsorbable polymer EES	everolimus eluting stent				-
FAME II, 2012        NCT	FFR-guided PCI	no PCI				suggesting
NEVO RES-ELUTION I    NCT	Nevo	paclitaxel eluting stent			Exploratory	-
Leon (high dose), 2005	TMR	placebo			Low risk of bias	negative
Leon (low dose), 2005	TMR	placebo			Low risk of bias	negative
SYNTAX (diabetic), 2010      NCT	PCI with drug-eluting stents	CABG			Exploratory	-
ARTS, 2001	stent	CABG				negative
ERACI II, 2003	stent	CABG			Risk of bias	suggesting
SOS, 2002            NCT	stent	CABG			Risk of bias	suggesting
CARDia (PCI), 2008	stent	CABG			Risk of bias	negative
LEMANS, 2002      NCT	stent	CABG			Exploratory	negative
MASS II, 2007	stent	CABG			Risk of bias	negative
Myoprotect, 2004	stent	CABG			Exploratory	-
Cisowski	stent	E-ACAB				negative
STICH (vs med), 2011    NCT	CABG	medical treatment			Risk of bias	suggesting
CASS subgroup, 1985	CABG	medical treatment			Exploratory	suggesting
Schofield, 1999	TMR	medical treatment			Risk of bias	negative
Allen, 1999	TMR	medical treatment			Risk of bias	negative
Frazier, 1999	TMR	medical treatment			Risk of bias	negative
ATLANTIC (Burkhoff), 1999	TMR	medical treatment			Risk of bias	negative
Aaberge, 2000	TMR	medical treatment			Risk of bias	negative
Huikeshoven, 2003	TMR	medical treatment			Exploratory	-
PACIFIC, 2000	TMR	medical treatment			Risk of bias	negative
Stone, 2002	TMR	medical treatment			Risk of bias	negative
Salem, 2004	TMR	medical treatment			Low risk of bias	negative
van der Sloot, 2004	TMR	medical treatment			Exploratory	negative
March, 1999	TMR	medical treatment			Exploratory	-
Gray, 2003	TMR	medical treatment			Exploratory	negative
Diegeler, 2002	stent	MIDCAB			Risk of bias	negative
Drenth, 2002	stent	MIDCAB			Risk of bias	negative
Grip, 2001	stent	MIDCAB				negative
SIMA, 2000	stent	MIDCAB				negative
Kim, 2005	stent	MIDCAB			Risk of bias	-
OCTOSTENT, 2003        NCT	stent	OPCAB			Risk of bias	negative
Costar II, 2008      NCT	CoStar stent	paclitaxel eluting stent			Risk of bias	negative
COSTAR II diabetic (sub group), 2008	CoStar stent	paclitaxel eluting stent			Exploratory	negative
TRIAS-HR, 2008	Genous stent	paclitaxel eluting stent				negative
BIOFREEDOM    NCT	polymer-free biolimus a9-eluting stents	paclitaxel eluting stent			Exploratory	-
ISAR TEST 2 (vs SES), 2009          NCT	dual sirolimus, probucol eluting stent	sirolimus eluting stent			Risk of bias	negative
ISAR TEST 3 (PF), 2009	polymer free sirolimus stent	sirolimus eluting stent				negative
ISAR TEST 3 (BP), 2009	sirolimus biodegradable polymer	sirolimus eluting stent				negative
ISAR-TEST-4 (biodegradable polymer), 2009    NCT	sirolimus biodegradable polymer	sirolimus eluting stent			Risk of bias	negative
Galiñanes, 2004	TMR	thoracic sympathectomy			Exploratory	negative
ISAR TEST 2 (vs ZES), 2009      NCT	dual sirolimus, probucol eluting stent	zotarolimus eluting stent			Risk of bias	-
ISAR TEST 5    NCT	dual sirolimus, probucol eluting stent	zotarolimus eluting stent	click to display paper's table" >		Risk of bias	negative
abciximab
Kim, 2010	abciximab-coated stent	bare-metal stent			Exploratory	-
angioplasty
AMIST (Reeves), 2004	angioplasty	MIDCAB			Risk of bias	-
biolimus eluting stent
LEADERS, 2008      NCT	biolimus eluting stent	sirolimus eluting stent				negative
Coronary Artery Bypass Surgery
Allen, 2000	TMR+CABG	CABG				-
STICH (ventricular reconstruction), 2009      NCT	CABG+surgical ventricular reconstruction	CABG				negative
Loubani, 2003	TMR+CABG	CABG			Exploratory	-
Zhao, 2006	TMR+CABG	CABG			Exploratory	-
MASS II, 2007	CABG	medical treatment				negative
VA, 1984	CABG	medical treatment				suggesting
ECSS (European), 1988	CABG	medical treatment				suggesting
CASS, 1983    NCT	CABG	medical treatment				negative
Texas, 1977	CABG	medical treatment				negative
Oregon, 1979	CABG	medical treatment				negative
New zealand 1, 1981	CABG	medical treatment				negative
BARI 2D, 2009          NCT	CABG or PCI	medical treatment			Risk of bias	negative
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent				suggesting
drug-eluting stents
Boudriot, 2008	DES	CABG			Exploratory	negative
FREEDOM, 2012      NCT	PCI with drug-eluting stents	CABG			Risk of bias	negative
Hong, 2005	PCI withdrug-eluting stents	CABG			Risk of bias	-
everolimus eluting stent
FUTURE I, 2004	everolimus eluting stent	bare-metal stent				negative
FUTURE II, 2006	everolimus eluting stent	bare-metal stent			Low risk of bias	-
SPIRIT I, 2005    NCT	everolimus eluting stent	bare-metal stent			Exploratory	negative
RESET, 2011    NCT	everolimus eluting stent	sirolimus eluting stent				-
PLATINUM, 2011      NCT	everolimus eluting stent	everolimus eluting stent				-
SPIRIT II, 2006      NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
SPIRIT IV, 2010          NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III, 2008        NCT	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
SORT OUT IV, 2012      NCT	everolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent				suggesting
ESSENCE diabetes      NCT	everolimus eluting stent	sirolimus ES				-
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005	paclitaxel eluting stent	balloon angioplasty				suggesting
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS II, 2003      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV, 2004        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SCORE, 2004	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS V (all patients), 2005    NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI, 2005        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
TAXUS II (diabetics), 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS V (diabetics), 2005	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
ASPECT, 2003      NCT	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	suggesting
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent				negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent			Risk of bias	negative
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	negative
SYNTAX, 2009          NCT	paclitaxel eluting stent	CABG			Risk of bias	suggesting
ISAR-test (diabetics), 2006	paclitaxel eluting stent	sirolimus eluting stent			Risk of bias	-
PCI
AVERT, 1995	PCI with or without stent	medical treatment			Risk of bias	negative
COURAGE, 2007      NCT	PCI with or without stent	medical treatment			Risk of bias	suggesting
MASS II, 2007	PCI with or without stent	medical treatment			Risk of bias	negative
Dakik, 1998	PCI with or without stent	medical treatment			Risk of bias	negative
ALKK, 2003	PCI with or without stent	medical treatment			Risk of bias	suggesting
Hambrecht, 2004	PCI with or without stent	medical treatment			Risk of bias	negative
Bech, 2001	PCI with or without stent	medical treatment			Risk of bias	negative
TIME, 2001	PCI with or without stent	medical treatment			Risk of bias	-
FAME, 2008            NCT	FFR-guided PCI	no PCI				suggesting
DEFER, 2001	FFR-guided PCI	no PCI				negative
AWESOME, 2001	PCI	CABG			Risk of bias	-
PTCA
RITA 2, 1997	balloon angioplasty	medical treatment			Risk of bias	suggesting
ACME, 1992	balloon angioplasty	medical treatment			Risk of bias	suggesting
Sievers, 1993	balloon angioplasty	medical treatment			Risk of bias	negative
MASS, 1995	balloon angioplasty	medical treatment			Risk of bias	suggesting
ACME 2 (Folland), 1997	balloon angioplasty	medical treatment			Risk of bias	negative
ACIP, 1997	balloon angioplasty	medical treatment			Exploratory	negative
INSPIRE, 2006	balloon angioplasty	medical treatment			Risk of bias	negative
SWISSI II, 2007      NCT	balloon angioplasty	medical treatment			Exploratory	suggesting
BARI, 1996      NCT	balloon angioplasty	CABG				negative
MASS, 1995	balloon angioplasty	CABG				negative
CABRI, 1995	balloon angioplasty	CABG				negative
EAST, 1994      NCT	balloon angioplasty	CABG				negative
GABI, 1994	balloon angioplasty	CABG				negative
Lausanne, 1994	balloon angioplasty	CABG				negative
RITA, 1993	balloon angioplasty	CABG				negative
ERACI, 1992	balloon angioplasty	CABG				negative
Toulouse, 1992	balloon angioplasty	CABG				negative
sirolimus eluting stent
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty				suggesting
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent			Exploratory	-
RAVEL, 2002      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
SIRIUS, 2003            NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
C-SIRIUS, 2004      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
E-SIRIUS, 2003      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent				suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent				suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent				suggesting
PRISON II, 2006      NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
TYPHOON, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007        NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
DECODE, 2005      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SCORPIUS, 2007    NCT	sirolimus eluting stent	bare-metal stent				suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent				-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent				-
GISSOC II, 2010      NCT	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent				suggesting
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent			Low risk of bias	-
PRECOMBAT, 2011    NCT	sirolimus eluting stent	CABG				-
Thiele, 2009    NCT	PCI withsirolimus ES	MIDCAB			Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent				-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
REALITY, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ISAR-SMART 3, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
SORT OUT II, 2008      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent				negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-TEST-1, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-LEFT-MAIN, 2009      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
SIRTAX diabetics, 2005        NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent				-
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
RESOLUTE All comers, 2010        NCT	zotarolimus eluting stent	everolimus eluting stent			Risk of bias	negative
TWENTE, 2012      NCT	zotarolimus eluting stent	everolimus eluting stent	click to display paper's table" >			-
ENDEAVOR IV, 2009        NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ZEST AMI (vs PES), 2009      NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZoMaxx I, 2008	zotarolimus eluting stent	paclitaxel eluting stent				-
ZEST (vs PES), 2009    NCT	zotarolimus eluting stent	paclitaxel eluting stent				suggesting
ENDEAVOR III, 2006        NCT	zotarolimus eluting stent	sirolimus eluting stent				suggesting
PROTECT, 2012    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ZEST (vs SES), 2009    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009      NCT	zotarolimus eluting stent	sirolimus eluting stent				negative
transmyocardial revacularization
not classified
Leon (high dose), 2005	TMR	placebo			Low risk of bias	negative
Leon (low dose), 2005	TMR	placebo			Low risk of bias	negative
Schofield, 1999	TMR	medical treatment			Risk of bias	negative
Allen, 1999	TMR	medical treatment			Risk of bias	negative
Frazier, 1999	TMR	medical treatment			Risk of bias	negative
ATLANTIC (Burkhoff), 1999	TMR	medical treatment			Risk of bias	negative
Aaberge, 2000	TMR	medical treatment			Risk of bias	negative
Huikeshoven, 2003	TMR	medical treatment			Exploratory	-
PACIFIC, 2000	TMR	medical treatment			Risk of bias	negative
Stone, 2002	TMR	medical treatment			Risk of bias	negative
Salem, 2004	TMR	medical treatment			Low risk of bias	negative
van der Sloot, 2004	TMR	medical treatment			Exploratory	negative
March, 1999	TMR	medical treatment			Exploratory	-
Gray, 2003	TMR	medical treatment			Exploratory	negative
Galiñanes, 2004	TMR	thoracic sympathectomy			Exploratory	negative
Coronary Artery Bypass Surgery
Allen, 2000	TMR+CABG	CABG				-
Loubani, 2003	TMR+CABG	CABG			Exploratory	-
Zhao, 2006	TMR+CABG	CABG			Exploratory	-