myocardial revascularization

systematic review meta-analysis network meta-analysis

Select acute coronary syndromeacute myocardial infarctioncoronary artery diseasestable angina >6h from onset of symptomsall indication togetherAll type of patientDiabetic patientselderly patientsuncoded clinical condition ***failed fibrinolysis (rescue revascularisation)multivessels diseasepatient ineligible for thrombolysispatients in cardiogenic shockpatients with inducible post MI ischemiapatients with left ventricular dysfunctionsingle vessel disease       abciximab-coated stentbioabsorbable polymer stentCABG or PCIcombination facilated PCIcooling-off strategydeferred angioplasty (>3 days) after thrombolysisdrug-eluting stentsearly angioplasty (<3 days) after thrombolysisearly invasive strategyfibrinolysisfibrinolyticfractional-flow-reserve-guidedGP IIb/IIIa inhibitor-facilitated PCIimmediate PCI after thrombolysisnon-polymeric ESPCIPrehospital thrombolysisprimary PCIprovisional T-stenting with drug-eluting stentsrepeat fibrinolysisrescue PCIresordablesurgerythrombolysis-facilitated PCItitanium-nitride-oxide coated stenttransfer for primary angioplastytransmyocardial revascularization abciximabalteplaseangioplastyanistreplaseAPSACbiolimus eluting stentCoronary Artery Bypass Surgerydactinomycin eluting stentdrug-eluting stentseptifibatideeverolimus eluting stentlanoteplasepaclitaxelPCIprimary angioplastyPTCAreteplasesaruplasesirolimus eluting stentstreptokinaset-patenecteplasetirofibanurokinasezotarolimus eluting stent vs angioplastyvs bare-metalvs medical treatmentvs no PCIvs no systematic PCIvs placebo or controlvs PTCAvs ballon angioplastyvs drug-eluting stentsvs no TMRvs other fibrinolyticvs Surgeryvs thrombolytic      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (379)myocardial infarction (fatal and non fatal) (211)target lesion revascularisation (178)MACE (171)Stent thrombosis (any, end of follow up) (167)CABG (127)Long term death (105)angiographic restenosis (102)PTCA (91)cardiac death (84)Deaths or MI (78)4y stent thrombosis (ARC) (77)target-vessel revascularization (76)Non fatal MI (75)late stent thrombosis (31days - 1year) (72)Major bleeding (67)Cardiac death or MI (65)stroke (fatal and non fatal) (60)reinfarction (56)short term death (37)sub acute stent thrombosis (1-30 days) (36)long term MI (35)In-hospital death (35)In-hospital death (34)long term cardiovascular events (33)Acute stent thrombosis (<=24h) (27)Angina (26)1 year event (24)Revascularization (23)2 yr MACE (23)1 year death from any cause (22)1 year revascularization (20)2 yr TLR (18)5-year death (18)Initial TIMI 3 flow (17)Bleeding (16)Angina (grade 2 or worse) in first year (16)6 months MI (16)6 months death (16)Final TIMI 3 flow (16)4 yr stent thrombosis (15)urgent target vessel revascularisation (13)in-lesion binary restenosis (12)4 yr MI (12)4 yr TLR (12)10-year death (12)7-year death (12)urgent CABG (12)In-hospital MI (12) (12)6 months events (12)long term revascularization (12)In hospital non fatal MI (11)1 year MI (11)In hospital death or MI (11)rehospitalization (10)Heart failure (10)4 yr mortality from all causes (8)4 yr death or MI (8)Angina relief (8)death, reinfarctus, stroke (8)CCS class III-IV angina (7)2 yr Death (all cause) (6)death or hospitalization for cardiac causes (6)cardiovascular events (6)Minor bleeding (5)Repeat revascularization (4)Cardiovascular death (4)cardiac event (fatal and non fatal ) (3)long term all cause death, MI (3)long term cardiovascular death (3)no angina (at 6 weeks) (2)hospitalisation for cardiovascular causes (2)Urgent revascularization (2)Definite or probable stent thrombosis (2)Repeat intervention (2)Death, MI and stroke (2)Haemmorhagic stroke (2)recurrent angina (2)Adverse events (1)Positive 6-wk ETT (1)Emergency CABG (1)Death or stroke or myocardial infarction (1)Death, MI, stroke, refractory ischemia (1)Reocclusion (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	myocardial infarction (fatal and non fatal)
acute coronary syndrome
anistreplase
UNASEM, 1992	anistreplase	placebo			Low risk of bias	-
t-pa
Nicklas, 1989	t-PA	placebo			Low risk of bias	negative
Gold, 1987	t-PA	placebo			Exploratory	-
Williams, 1990	t-PA	placebo			Low risk of bias	negative
Freeman, 1992	t-PA	placebo			Low risk of bias	negative
van der Brand, 1991	t-PA	placebo			Low risk of bias	negative
charbonnier, 1992	t-PA	placebo			Low risk of bias	-
Ardissino, 1990	t-PA	placebo			Low risk of bias	negative
TIMI 3B, 1995	t-PA	placebo			Low risk of bias	-
Topol, 1988	t-PA	placebo			Exploratory	negative
TIMI 3A, 1993	t-PA	placebo			Low risk of bias	-
acute myocardial infarction
abciximab
BRAVE (Kastrati), 2004	Abciximab + reteplase	primary intervention				-
ERAMI (Mesquita Gabriel), 2003	Abciximab	primary intervention				negative
REOMOBILE (Arntz), 2003	Abciximab	primary intervention				negative
Zorman, 2002	Abciximab	primary intervention				negative
ReoPro-BRIDGING (Gyongyosi), 2004	Abciximab	primary intervention				negative
Bellandi, 2006	Abciximab	primary intervention				negative
FINESSE (abciximab-facilitated PCI), 2008    NCT	Abciximab	primary intervention				negative
FINESSE (combination-facilitated PCI), 2008    NCT	Abciximab + reteplase	primary intervention				negative
alteplase
LIMI (Vermeer), 1999	alteplase	primary intervention				negative
PACT (Ross,), 1999	alteplase	primary intervention				negative
anistreplase
TEAM 2, 1991	anistreplase	streptokinase			Low risk of bias	-
APSAC
APSIM, 1989	APSAC	control				negative
AIMS, 1988	APSAC	placebo			Low risk of bias	suggesting
German Multicenter Trial, 1988	APSAC	placebo				suggesting
ISIS III (SK/APSAC), 1992	APSAC	streptokinase			Low risk of bias	negative
TEAM 3, 1992	APSAC	t-PA			Low risk of bias	-
drug-eluting stents
DEDICATION, 2008      NCT	drug-eluting stents	bare-metal stent			Risk of bias	suggesting
PASEO, 2009	drug-eluting stents	bare-metal stent				-
eptifibatide
INTAMI (Zeymer), 2005	Eptifibatide	primary intervention				negative
lanoteplase
InTIME-II, 2000	lanoteplase	accelerated t-PA			Low risk of bias	negative
paclitaxel
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent				suggesting
PCI
WEST, 2006	systematic PCI (+stent)	no systematic PCI				negative
CAPITAL AMI, 2005	systematic PCI (+stent)	no systematic PCI				negative
GRACIA-1, 2004	systematic PCI (+stent)	no systematic PCI			Risk of bias	negative
SIAM III, 2002	systematic PCI (+stent)	no systematic PCI				negative
PRAGUE, 2000	systematic PCI (+stent)	no systematic PCI				negative
C-PORT, 2002	primary PCI	accelerated t-PA				-
STAT, 2001	primary stenting	accelerated t-PA				-
Jaksch, 1998	primary stenting	balloon angioplasty				suggesting
GRAMI (Rodriguez), 1998	primary stenting	balloon angioplasty				negative
Zwolle 5 (Suryapranata), 1998	primary stenting	balloon angioplasty				suggesting
stent-PAMI (Grines), 1999	primary stenting	balloon angioplasty				suggesting
PASTA (Saito), 1999	primary stenting	balloon angioplasty				suggesting
PRISAM (Kawashima), 1999	primary stenting	balloon angioplasty				negative
STENTIM-2 (Maillard), 2000	primary stenting	balloon angioplasty				negative
PSSAAMI (Scheller), 2001	primary stenting	balloon angioplasty				suggesting
FRESCO, 1998	primary stenting	balloon angioplasty				-
CADILLAC abciximab., 2002	primary stenting	balloon angioplasty				-
CADILLAC (no abciximab), 2002	primary stenting	balloon angioplasty				-
ZWOLLE 6, 2005	primary stenting	balloon angioplasty				-
STOPAMI 3, 2004	primary stenting	balloon angioplasty				-
STOPAMI 2, 2002	primary stenting	immediate thrombolysis				-
senior PAMI, 2005    NCT	primary PCI	Thrombolysis			Risk of bias	suggesting
primary angioplasty
Ribichini, 1996	primary ballon angioplasty	accelerated t-PA				-
Garcia, 1997	primary ballon angioplasty	accelerated t-PA				-
GUSTO 2B, 1997	primary ballon angioplasty	accelerated t-PA				-
DANAMI-2, 1997	primary ballon angioplasty	accelerated t-PA				-
DeWood, 1989	primary ballon angioplasty	duteplase				-
Gibbons, 1993	primary ballon angioplasty	duteplase				-
O'Neill, 1986	primary ballon angioplasty	intracoronary streptokinase				-
Zwolle, 1994	primary ballon angioplasty	streptokinase				negative
Ribeiro, 1993	primary ballon angioplasty	streptokinase				-
Grinfeld, 1996	primary ballon angioplasty	streptokinase				-
Zijlstra, 1997	primary ballon angioplasty	streptokinase				-
Zijlstra , 1993	primary ballon angioplasty	streptokinase				-
Akhras, 1997	primary ballon angioplasty	streptokinase				-
PAMI, 1993	primary ballon angioplasty	t-PA				-
TRIANA, 2009    NCT	primary ballon angioplasty	tenecteplase			Risk of bias	negative
PTCA
MAASTRICHT (Vermeer), 1999	primary angioplasty	immediate thrombolysis				negative
PRAGUE-1, 2000	primary angioplasty	immediate thrombolysis				suggesting
AIR-PAMI, 2002	primary angioplasty	immediate thrombolysis				negative
CAPTIM, 2002	primary angioplasty	immediate thrombolysis				negative
DANAMI-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
PRAGUE-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
TAMI 1 pilot, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	suggesting
ECSG, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TAMI-5 (Califf), 1991	immediate systematic ballon angioplastyte	no immediate angioplasty				-
SHOCK (Hochman), 1999      NCT	immediate systematic ballon angioplastyte	no immediate angioplasty			Risk of bias	suggesting
Ellis, 1994	immediate systematic ballon angioplastyte	no immediate angioplasty				-
Erbel, 1989	immediate systematic ballon angioplastyte	no immediate angioplasty				-
MERLIN (Sutton), 2004	immediate systematic ballon angioplastyte	no immediate angioplasty				-
SWISS-SMASH, 1999	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TIMI 2A, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Belenkie, 1991	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Topol, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
TOMIIS, 1994	late PTCA	no PTCA				negative
Horie et al, 1998	late PTCA	no PTCA				suggesting
TOAT, 2002	late PTCA	no PTCA				negative
DECOPI, 2004	late PTCA	no PTCA				negative
Silva et al, 2005	late PTCA	no PTCA				negative
OAT, 2006	late PTCA	no PTCA				negative
TOSCA-2, 2006      NCT	late PTCA	no PTCA				-
REACT (rescue PCI), 2005	rescue PTCA	no rescue PTCA				suggesting
MERLIN, 2004	rescue PTCA	no rescue PTCA				negative
RESCUE II, 2000	rescue PTCA	no rescue PTCA				negative
RESCUE, 1994	rescue PTCA	no rescue PTCA				negative
Belenkie, 1992	rescue PTCA	no rescue PTCA			Risk of bias	negative
SWIFT, 1991	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
SIAM, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI 2, 1989	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
Guerci, 1987	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
Van den Brand, 1991	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TOPS, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI II-A (defered)	systematic ballon angioplasty	no systematic angioplasty				-
Vermeer, 1999	systematic ballon angioplasty	no systematic angioplasty				-
TAMI 6, 1992	systematic ballon angioplasty	no systematic angioplasty				-
Barbash, 1990	systematic ballon angioplasty	no systematic angioplasty				-
reteplase
GUSTO III, 1997	reteplase	accelerated t-PA				negative
RAPID-2, 1996	reteplase	accelerated t-PA			Exploratory	suggesting
INJECT, 1995	reteplase	streptokinase			Low risk of bias	negative
saruplase
COMPASS, 1998	saruplase	streptokinase			Low risk of bias	negative
PRIMI (vs SK), 1989	saruplase	streptokinase			Low risk of bias	-
SESAM, 1997	saruplase	t-PA			Exploratory	negative
PRIMI (vs UK), 1989	saruplase	urokinase			Low risk of bias	-
sirolimus eluting stent
TYPHOON, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007        NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent				-
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent				negative
streptokinase
ISAM, 1986	streptokinase	placebo			Low risk of bias	negative
ISIS-2 (SK), 1988	streptokinase	placebo			Low risk of bias	suggesting
Western Washington Intravenous Trial, 1988    NCT	streptokinase	placebo				negative
GISSI I, 1986	streptokinase	placebo				suggesting
EMERAS (all delay), 1993	streptokinase	placebo			Low risk of bias	negative
ISIS 2 pilot, 1987	streptokinase	placebo			Low risk of bias	-
EMERAS (7-12h), 1993	streptokinase	placebo			Low risk of bias	-
SAMI (O’Neill), 1992	streptokinase	primary intervention				negative
PRAGUE (Widimisky), 2000	streptokinase	primary intervention				negative
GUSTO tPA-SK Hiv, 1993	t-PA + streptokinase	streptokinase				negative
t-pa
ASSET, 1988	t-PA	placebo			Low risk of bias	suggesting
LATE, 1993	t-PA	placebo			Low risk of bias	negative
TAMI 6, 1992	t-PA	placebo			Low risk of bias	negative
COBALT, 1997	bolus t-PA	accelerated t-PA			Low risk of bias	negative
TAPS, 1992	accelerated t-PA	APSAC				negative
TIMI 4, 1994	accelerated t-PA	APSAC			Low risk of bias	-
GUSTO tPA Hiv, 1993	accelerated t-PA	streptokinase				suggesting
GISSI II, 1990	t-PA	streptokinase				suggesting
International Study Group, 1990	t-PA	streptokinase			Low risk of bias	suggesting
ISIS III (SK/tPA), 1992	t-PA	streptokinase			Low risk of bias	suggesting
Centre Illinois, 1993	t-PA	streptokinase				-
Cherng, 1992	t-PA	streptokinase				negative
ECSG, 1985	t-PA	streptokinase				negative
PAIMS, 1989	t-PA	streptokinase				-
TIMI-1, 1987    NCT	t-PA	streptokinase			Low risk of bias	-
White, 1989	t-PA	streptokinase			Low risk of bias	-
RAAMI, 1992	accelerated t-PA	t-PA				-
KAMIT, 1991	t-PA half dose	t-PA			Exploratory	negative
TAMI 5 (t-PA vs uroK), 1991	t-PA	urokinase				-
tenecteplase
ADVANCE-MI, 2005	Eptifibatide + tenecteplase	primary intervention				-
ASSENT-2, 1999	tenecteplase	accelerated t-PA			Low risk of bias	suggesting
ASSENT-4 PCI (Van de Werf), 2006      NCT		primary intervention				negative
GRACIA (Fernandez-Aviles,), 2004	tenecteplase	primary intervention				negative
tirofiban
On-Time (van’t Hof), 2004	Tirofiban	primary intervention				negative
TIGER-PA (Lee), 2003	Tirofiban	primary intervention				negative
Cutlip, 2003	Tirofiban	primary intervention				negative
urokinase
USIM, 1991	urokinase	control				-
zotarolimus eluting stent
ZEST AMI (vs PES), 2009      NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009      NCT	zotarolimus eluting stent	sirolimus eluting stent				negative
coronary artery disease
abciximab
Kim, 2010	abciximab-coated stent	bare-metal stent			Exploratory	-
angioplasty
AMIST (Reeves), 2004	angioplasty	MIDCAB			Risk of bias	-
biolimus eluting stent
LEADERS, 2008      NCT	biolimus eluting stent	sirolimus eluting stent				negative
Coronary Artery Bypass Surgery
Allen, 2000	TMR+CABG	CABG				-
STICH (ventricular reconstruction), 2009      NCT	CABG+surgical ventricular reconstruction	CABG				negative
Loubani, 2003	TMR+CABG	CABG			Exploratory	-
Zhao, 2006	TMR+CABG	CABG			Exploratory	-
MASS II, 2007	CABG	medical treatment				negative
VA, 1984	CABG	medical treatment				suggesting
ECSS (European), 1988	CABG	medical treatment				suggesting
CASS, 1983    NCT	CABG	medical treatment				negative
Texas, 1977	CABG	medical treatment				negative
Oregon, 1979	CABG	medical treatment				negative
New zealand 1, 1981	CABG	medical treatment				negative
BARI 2D, 2009          NCT	CABG or PCI	medical treatment			Risk of bias	negative
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent				suggesting
drug-eluting stents
Boudriot, 2008	DES	CABG			Exploratory	negative
FREEDOM, 2012      NCT	PCI with drug-eluting stents	CABG			Risk of bias	negative
Hong, 2005	PCI withdrug-eluting stents	CABG			Risk of bias	-
everolimus eluting stent
FUTURE I, 2004	everolimus eluting stent	bare-metal stent				negative
FUTURE II, 2006	everolimus eluting stent	bare-metal stent			Low risk of bias	-
SPIRIT I, 2005    NCT	everolimus eluting stent	bare-metal stent			Exploratory	negative
RESET, 2011    NCT	everolimus eluting stent	sirolimus eluting stent				-
PLATINUM, 2011      NCT	everolimus eluting stent	everolimus eluting stent				-
SPIRIT II, 2006      NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
SPIRIT IV, 2010          NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III, 2008        NCT	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
SORT OUT IV, 2012      NCT	everolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent				suggesting
ESSENCE diabetes      NCT	everolimus eluting stent	sirolimus ES				-
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005	paclitaxel eluting stent	balloon angioplasty				suggesting
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS II, 2003      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV, 2004        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SCORE, 2004	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS V (all patients), 2005    NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI, 2005        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
TAXUS II (diabetics), 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS V (diabetics), 2005	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
ASPECT, 2003      NCT	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	suggesting
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent				negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent			Risk of bias	negative
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	negative
SYNTAX, 2009          NCT	paclitaxel eluting stent	CABG			Risk of bias	suggesting
ISAR-test (diabetics), 2006	paclitaxel eluting stent	sirolimus eluting stent			Risk of bias	-
PCI
AVERT, 1995	PCI with or without stent	medical treatment			Risk of bias	negative
COURAGE, 2007      NCT	PCI with or without stent	medical treatment			Risk of bias	suggesting
MASS II, 2007	PCI with or without stent	medical treatment			Risk of bias	negative
Dakik, 1998	PCI with or without stent	medical treatment			Risk of bias	negative
ALKK, 2003	PCI with or without stent	medical treatment			Risk of bias	suggesting
Hambrecht, 2004	PCI with or without stent	medical treatment			Risk of bias	negative
Bech, 2001	PCI with or without stent	medical treatment			Risk of bias	negative
TIME, 2001	PCI with or without stent	medical treatment			Risk of bias	-
FAME, 2008            NCT	FFR-guided PCI	no PCI				suggesting
DEFER, 2001	FFR-guided PCI	no PCI				negative
AWESOME, 2001	PCI	CABG			Risk of bias	-
PTCA
RITA 2, 1997	balloon angioplasty	medical treatment			Risk of bias	suggesting
ACME, 1992	balloon angioplasty	medical treatment			Risk of bias	suggesting
Sievers, 1993	balloon angioplasty	medical treatment			Risk of bias	negative
MASS, 1995	balloon angioplasty	medical treatment			Risk of bias	suggesting
ACME 2 (Folland), 1997	balloon angioplasty	medical treatment			Risk of bias	negative
ACIP, 1997	balloon angioplasty	medical treatment			Exploratory	negative
INSPIRE, 2006	balloon angioplasty	medical treatment			Risk of bias	negative
SWISSI II, 2007      NCT	balloon angioplasty	medical treatment			Exploratory	suggesting
BARI, 1996      NCT	balloon angioplasty	CABG				negative
MASS, 1995	balloon angioplasty	CABG				negative
CABRI, 1995	balloon angioplasty	CABG				negative
EAST, 1994      NCT	balloon angioplasty	CABG				negative
GABI, 1994	balloon angioplasty	CABG				negative
Lausanne, 1994	balloon angioplasty	CABG				negative
RITA, 1993	balloon angioplasty	CABG				negative
ERACI, 1992	balloon angioplasty	CABG				negative
Toulouse, 1992	balloon angioplasty	CABG				negative
sirolimus eluting stent
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty				suggesting
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent			Exploratory	-
RAVEL, 2002      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
SIRIUS, 2003            NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
C-SIRIUS, 2004      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
E-SIRIUS, 2003      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent				suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent				suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent				suggesting
PRISON II, 2006      NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
TYPHOON, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007        NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
DECODE, 2005      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SCORPIUS, 2007    NCT	sirolimus eluting stent	bare-metal stent				suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent				-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent				-
GISSOC II, 2010      NCT	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent				suggesting
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent			Low risk of bias	-
PRECOMBAT, 2011    NCT	sirolimus eluting stent	CABG				-
Thiele, 2009    NCT	PCI withsirolimus ES	MIDCAB			Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent				-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
REALITY, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ISAR-SMART 3, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
SORT OUT II, 2008      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent				negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-TEST-1, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-LEFT-MAIN, 2009      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
SIRTAX diabetics, 2005        NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent				-
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
RESOLUTE All comers, 2010        NCT	zotarolimus eluting stent	everolimus eluting stent			Risk of bias	negative
TWENTE, 2012      NCT	zotarolimus eluting stent	everolimus eluting stent	click to display paper's table" >			-
ENDEAVOR IV, 2009        NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ZEST AMI (vs PES), 2009      NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZoMaxx I, 2008	zotarolimus eluting stent	paclitaxel eluting stent				-
ZEST (vs PES), 2009    NCT	zotarolimus eluting stent	paclitaxel eluting stent				suggesting
ENDEAVOR III, 2006        NCT	zotarolimus eluting stent	sirolimus eluting stent				suggesting
PROTECT, 2012    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ZEST (vs SES), 2009    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009      NCT	zotarolimus eluting stent	sirolimus eluting stent				negative
stable angina
angioplasty
AMIST (Reeves), 2004	angioplasty	MIDCAB			Risk of bias	-
biolimus eluting stent
LEADERS, 2008      NCT	biolimus eluting stent	sirolimus eluting stent				negative
Coronary Artery Bypass Surgery
Allen, 2000	TMR+CABG	CABG				-
STICH (ventricular reconstruction), 2009      NCT	CABG+surgical ventricular reconstruction	CABG				negative
Loubani, 2003	TMR+CABG	CABG			Exploratory	-
Zhao, 2006	TMR+CABG	CABG			Exploratory	-
MASS II, 2007	CABG	medical treatment				negative
VA, 1984	CABG	medical treatment				suggesting
ECSS (European), 1988	CABG	medical treatment				suggesting
CASS, 1983    NCT	CABG	medical treatment				negative
Texas, 1977	CABG	medical treatment				negative
Oregon, 1979	CABG	medical treatment				negative
New zealand 1, 1981	CABG	medical treatment				negative
BARI 2D, 2009          NCT	CABG or PCI	medical treatment			Risk of bias	negative
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent				suggesting
drug-eluting stents
Boudriot, 2008	DES	CABG			Exploratory	negative
FREEDOM, 2012      NCT	PCI with drug-eluting stents	CABG			Risk of bias	negative
Hong, 2005	PCI withdrug-eluting stents	CABG			Risk of bias	-
everolimus eluting stent
FUTURE I, 2004	everolimus eluting stent	bare-metal stent				negative
FUTURE II, 2006	everolimus eluting stent	bare-metal stent			Low risk of bias	-
SPIRIT I, 2005    NCT	everolimus eluting stent	bare-metal stent			Exploratory	negative
SPIRIT II, 2006      NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
SPIRIT IV, 2010          NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III, 2008        NCT	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
COMPARE, 2009        NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SORT OUT IV, 2012      NCT	everolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent				suggesting
paclitaxel
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS II, 2003      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV, 2004        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SCORE, 2004	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS V (all patients), 2005    NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI, 2005        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
ASPECT, 2003      NCT	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	suggesting
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent				negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent			Risk of bias	negative
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	negative
SYNTAX, 2009          NCT	paclitaxel eluting stent	CABG			Risk of bias	suggesting
PCI
AVERT, 1995	PCI with or without stent	medical treatment			Risk of bias	negative
COURAGE, 2007      NCT	PCI with or without stent	medical treatment			Risk of bias	suggesting
MASS II, 2007	PCI with or without stent	medical treatment			Risk of bias	negative
Dakik, 1998	PCI with or without stent	medical treatment			Risk of bias	negative
ALKK, 2003	PCI with or without stent	medical treatment			Risk of bias	suggesting
Hambrecht, 2004	PCI with or without stent	medical treatment			Risk of bias	negative
Bech, 2001	PCI with or without stent	medical treatment			Risk of bias	negative
TIME, 2001	PCI with or without stent	medical treatment			Risk of bias	-
FAME, 2008            NCT	FFR-guided PCI	no PCI				suggesting
DEFER, 2001	FFR-guided PCI	no PCI				negative
AWESOME, 2001	PCI	CABG			Risk of bias	-
PTCA
RITA 2, 1997	balloon angioplasty	medical treatment			Risk of bias	suggesting
ACME, 1992	balloon angioplasty	medical treatment			Risk of bias	suggesting
Sievers, 1993	balloon angioplasty	medical treatment			Risk of bias	negative
MASS, 1995	balloon angioplasty	medical treatment			Risk of bias	suggesting
ACME 2 (Folland), 1997	balloon angioplasty	medical treatment			Risk of bias	negative
ACIP, 1997	balloon angioplasty	medical treatment			Exploratory	negative
INSPIRE, 2006	balloon angioplasty	medical treatment			Risk of bias	negative
SWISSI II, 2007      NCT	balloon angioplasty	medical treatment			Exploratory	suggesting
BARI, 1996      NCT	balloon angioplasty	CABG				negative
MASS, 1995	balloon angioplasty	CABG				negative
CABRI, 1995	balloon angioplasty	CABG				negative
EAST, 1994      NCT	balloon angioplasty	CABG				negative
GABI, 1994	balloon angioplasty	CABG				negative
Lausanne, 1994	balloon angioplasty	CABG				negative
RITA, 1993	balloon angioplasty	CABG				negative
ERACI, 1992	balloon angioplasty	CABG				negative
Toulouse, 1992	balloon angioplasty	CABG				negative
sirolimus eluting stent
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent			Exploratory	-
RAVEL, 2002      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
SIRIUS, 2003            NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
C-SIRIUS, 2004      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
E-SIRIUS, 2003      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent				suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent				suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent				suggesting
PRISON II, 2006      NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
DECODE, 2005      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SCORPIUS, 2007    NCT	sirolimus eluting stent	bare-metal stent				suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent				-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent				-
GISSOC II, 2010      NCT	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
DESSERT, 2008	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
Thiele, 2009    NCT	PCI withsirolimus ES	MIDCAB			Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent				-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
REALITY, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ISAR-SMART 3, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent				negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-TEST-1, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-LEFT-MAIN, 2009      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent				negative
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
RESOLUTE All comers, 2010        NCT	zotarolimus eluting stent	everolimus eluting stent			Risk of bias	negative
ENDEAVOR IV, 2009        NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ENDEAVOR III, 2006        NCT	zotarolimus eluting stent	sirolimus eluting stent				suggesting
PROTECT, 2012    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ZEST (vs SES), 2009    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative