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angiotensin-receptor blockers
Description Results

Candesartan - Irbesartan - Losartan - Telmisartan - Valsartan      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute myocardial infarction

losartan
OPTIMAAL, 2002LosartanCaptoprilSuggesting
valsartan
VALIANT (valsartan+capropril), 2003Valsartan+ACE inhibitor ACE inhibitor onlyNegative
VALIANT (valsartan alone), 2003ValsartanCaptoprilNegative

diabetes type 2

irbesartan
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipine Low risk of bias Suggesting
IPDM (150mg), 2001irbesartanplacebo Exploratory Suggesting
losartan
RENAAL, 2001losartanplacebo Low risk of bias Suggesting
olmesartan
ORIENTolmesartanplaceboNegativeNCT00141453
ROADMAP, 2010olmesartanplacebo Low risk of bias Suggesting NCT00185159

heart failure

candesartan
RESOLVD association, 1999candesartan+ACE inhibitorACE inhibitor only Exploratory Negative
RESOLVD (candesartan alone), 1999candesartanenalapril Exploratory Negative
STRETCH, 1999candesartanplacebo Exploratory -
SPICE, 2000candesartanplacebo Exploratory Negative
CHARM-Added, 2003candesartan+ACE inhibitorACE inhibitor only Low risk of bias Negative
ARCH-J, 2003candesartanplacebo Low risk of bias -
CHARM-Alternative, 2003candesartanplacebo Low risk of bias Suggesting
CHARM preserved, 2003candesartanplacebo Low risk of bias -
Mitrovic et al., 2003candesartanplacebo Exploratory Suggesting
irbesartan
Tonkon et al., 2000irbesartan+ACE inhibitorACE inhibitor only Exploratory -
I-PRESERVE (McMurray), 2008ibesartanplacebo Low risk of bias NegativeNCT00095238
losartan
Dickstein et al., 1995losartanenalapril Exploratory -
Losartan Phase III U.S., 1995losartanplacebo Exploratory Negative
losartan phase II US, 1996losartanenalapril Exploratory -
Losartan phase II S, 1996losartanenalapril Exploratory -
Losartan Phase III International, 1996losartanplacebo Exploratory Suggesting
ELITE, 1997losartancaptopril Exploratory Negative
Lang et al., 1997losartanenalapril Exploratory -
Hamroff et al., 1999losartan+ACE inhibitorACE inhibitor only Exploratory -
ELITE II, 2000losartancaptopril Low risk of bias -
HEAAL, 2009losartan 150mglosartan 50mg Low risk of bias SuggestingNCT00090259
NCT00090259 ongoing losartanlosartan - NCT00090259
telmisartan
REPLACE, 2001telmisartanenalapril Exploratory -
valsartan
Mazayev et al. (vs lisinopril, 1998valsartanLisinopril Exploratory -
Mazayev et al. (vs placebo), 1998valsartanplacebo Exploratory -
V-HeFT, 1999valsartan+ACE inhibitorACE inhibitor only Exploratory Negative
Val-HeFT, 2001valsartan+ACE inhibitorACE inhibitor only Low risk of bias Suggesting
HEAVEN, 2002valsartanenalapril Exploratory -
VALIDD, 2007valsartanno valsartan Exploratory NegativeNCT00170924

hypertension

candesartan
ALPINE, 2003candesartanhydrochlorothiazide Low risk of bias Suggesting
SCOPE, 2003candesartanplacebo Low risk of bias Negative
E-COST-R, 2005candesartanconventional treatment Risk of bias Negative
E-COST, 2005candesartanconventional treatment Risk of bias Suggesting
Takahashi, 2006candesartancontrol Exploratory Negative
CASE-J, 2008candesartanamlodipine Risk of bias Suggesting
HIJ-CREATE, 2009candesartanconventional treatment Risk of bias Suggesting
HIJ-CREATE, 2009Candesartanusual care Risk of bias -
captopril
VALIANT/Val+Cap, 2003Valsartan + captoprilCaptopril Low risk of bias Negative
irbesartan
IRMA 2, 2001irbesartanplacebo Low risk of bias Negative
IDNT (irbesartan vs pbo), 2001irbesartanplacebo Low risk of bias Negative
losartan
ELITE, 1997LosartanCaptopril Exploratory Suggesting
ELITE-II, 2000LosartanCaptopril Low risk of bias Negative
OPTIMAAL, 2001LosartanCaptopril Risk of bias Negative
RENAAL, 2001losartanplacebo Low risk of bias -
LIFE, 2002losartanatenolol Low risk of bias Suggesting
ramipril
ONTARGET/Tel+Ram, 2008Telmisartan + ramiprilRamipril Low risk of bias Negative
telmisartan
DETAIL, 2004TelmisartanEnalapril Low risk of bias Negative
PROPHESS, 2008telmisartanplacebo Low risk of bias NegativeNCT00153062
ONTARGET/Tel, 2008TelmisartanRamipril Low risk of bias Negative
valsartan
VALIANT/Val, 2003ValsartanCaptopril Low risk of bias Negative

miscellaneous

candesartan
ALPINE, 2003candesartanhydrochlorothiazide Low risk of bias Suggesting
SCOPE, 2003candesartanplacebo Low risk of bias Negative
E-COST-R, 2005candesartanconventional treatment Risk of bias Negative
E-COST, 2005candesartanconventional treatment Risk of bias Suggesting
Takahashi, 2006candesartancontrol Exploratory Negative
TROPHY, 2006candesartanplacebo Exploratory SuggestingNCT00227318
CASE-J, 2008candesartanamlodipine Risk of bias Suggesting
HIJ-CREATE, 2009candesartanconventional treatment Risk of bias Suggesting
irbesartan
IDNT (irbesartan vs pbo), 2001irbesartanplacebo Low risk of bias Negative
IRMA 2, 2001irbesartanplacebo Low risk of bias Negative
losartan
RENAAL, 2001losartanplacebo Low risk of bias -
LIFE, 2002losartanatenolol Low risk of bias Suggesting
olmesartan
ORIENTolmesartanplaceboNegativeNCT00141453
ROADMAP, 2010olmesartanplacebo Low risk of bias Suggesting NCT00185159
ramipril
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNegative NCT00153101
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanSuggesting NCT00153101
telmisartan
TRANSCEND, 2008telmisartanplacebo Low risk of bias SuggestingNCT00153101
PROPHESS, 2008telmisartanplacebo Low risk of bias NegativeNCT00153062
ONTARGET (telmisartan alone), 2008telmisartanramipril Low risk of bias Suggesting NCT00153101

patients at high risk for cardiovascular events

candesartan
SCOPE, 2003candesartanplacebo Low risk of bias Negative
losartan
RENAAL, 2001losartanplacebo Low risk of bias -
LIFE, 2002losartanatenolol Low risk of bias Suggesting
ramipril
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNegative NCT00153101
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanSuggesting NCT00153101
telmisartan
PROPHESS, 2008telmisartanplacebo Low risk of bias NegativeNCT00153062
TRANSCEND, 2008telmisartanplacebo Low risk of bias SuggestingNCT00153101
ONTARGET (telmisartan alone), 2008telmisartanramipril Low risk of bias Suggesting NCT00153101



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