Clinical trials of simvastatin - TrialResults-center.org

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
acute coronary syndrome
A to Z, 2004	simvastatin	placebo	acute coronary syndrome		Negative
aortic stenosis
SEAS, 2008	ezetimibe+simvastatin	placebo	aortic stenosis	Low risk of bias	Negative	NCT00092677
CABG surgery
Christenson, 1999	preoperative simvastatin	no treatment			Negative
cardiovascular prevention
MAAS, 1994	simvastatin	placebo	secondary prevention	Exploratory	Negative
4S, 1994	simvastatin	placebo	secondary prevention	Low risk of bias	Conclusive
CIS, 1997	simvastatin	placebo	secondary prevention	Exploratory	Negative
4S (elderly subgroup), 1997	simvastatin	placebo	elderly	Exploratory	Suggesting
4S (diabetic sub group), 1999	simvastatin	placebo	diabetic patients	Exploratory	Suggesting
HPS (diabetic sub group), 2002	simvastatin	placebo	diabetic patients	Exploratory	Suggesting
HPS, 2002	simvastatin	placebo	secondary prevention	Low risk of bias	Conclusive
HPS (elderly subgroup), 2002	simvastatin	placebo	elderly	Exploratory	Suggesting
HPS (women subgroup) , 2002	Simvastatin	placebo	women	Exploratory	Suggesting
Mondillo, 2003	simvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
Aronow , 2003	simvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
Node, 2003	simvastatin	placebo	heart failure		Negative
HPS (diabetic primary prevention sub group), 2003	simvastatin	placebo	diabetic	Exploratory	-
A to Z, 2004	simvastatin	placebo	acute coronary syndrome		Negative
HPS (post troke sub group), 2004	simvastatin	placebo	post stroke	Exploratory	Suggesting
Hong, 2005	simvastatin	control	heart failure	Risk of bias	Negative
Landmesser, 2005	simvastatin	ezetimibe	heart failure		-
SEAS, 2008	ezetimibe+simvastatin	placebo	aortic stenosis	Low risk of bias	Negative	NCT00092677
SEARCH, 2010	simvastatin high dose	simvastatin	secondary prevention	Low risk of bias	Suggesting	NCT00124072
diabetes type 2
4S (diabetic sub group), 1999	simvastatin	placebo	diabetic patients	Exploratory	Suggesting
HPS (diabetic sub group), 2002	simvastatin	placebo	diabetic patients	Exploratory	Suggesting
heart failure
Node, 2003	simvastatin	placebo	heart failure		Negative
Hong, 2005	simvastatin	control	heart failure	Risk of bias	Negative
Landmesser, 2005	simvastatin	ezetimibe	heart failure		-
peripheral vascular diseases
HPS (sub group), 2002	simvastatin	placebo	Peripheral Arterial Disease	Low risk of bias	-
Mondillo, 2003	simvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
Aronow , 2003	simvastatin	placebo	Peripheral Arterial Disease	Exploratory	-
post myocardial infarction
4S, 1994	simvastatin	placebo	secondary prevention	Low risk of bias	Conclusive
post stroke
HPS (post troke sub group), 2004	simvastatin	placebo	post stroke	Exploratory	Suggesting

Simvastatin cholesterol lowering intervention Description Results

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Simvastatin cholesterol lowering intervention
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