Simvastatin cholesterol lowering intervention
systematic review meta-analysis network meta-analysis
 

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathCardiovascular death

acute coronary syndrome  

A to Z, 2004     simvastatinplaceboacute coronary syndrome early initiation negative-10%

aortic stenosis  

SEAS, 2008    NCTezetimibe+simvastatinplaceboaortic stenosisLow risk of bias negative

CABG surgery  

Christenson, 1999     preoperative simvastatinno treatmentnegative

cardiovascular prevention  

Hong, 2005     simvastatincontrolheart failureRisk of bias negative-74%
SEAS, 2008    NCTezetimibe+simvastatinplaceboaortic stenosisLow risk of bias negative
HPS (diabetic sub group), 2002   simvastatinplacebodiabetic patientsLow risk of bias suggesting
4S (diabetic sub group), 1999   simvastatinplacebodiabetic patients secondary prevention Low risk of bias suggesting-21%
Mondillo, 2003   simvastatinplaceboPeripheral Arterial DiseaseExploratory -
Aronow , 2003   simvastatinplaceboPeripheral Arterial DiseaseExploratory -
MAAS, 1994   simvastatinplacebosecondary preventionExploratory negative-65%
HPS, 2002         simvastatinplacebosecondary preventionLow risk of bias conclusive-12%-17%
4S, 1994   simvastatinplacebosecondary preventionLow risk of bias conclusive-29%-34%
A to Z, 2004     simvastatinplaceboacute coronary syndrome early initiation negative-10%
Node, 2003     simvastatinplaceboheart failurenegative
CIS, 1997     simvastatinplacebosecondary preventionExploratory negative-76%
4S (elderly subgroup), 1997     simvastatinplaceboelderly elderly Low risk of bias suggesting-32%
HPS (elderly subgroup), 2002     simvastatinplaceboelderly elderly Low risk of bias suggesting-12%
HPS (post troke sub group), 2004     simvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting
HPS (diabetic primary prevention sub group), 2003     simvastatinplacebodiabetic type 2 diabetes Exploratory -
HPS (women subgroup) , 2002     SimvastatinplacebowomenExploratory suggesting
Landmesser, 2005     simvastatinezetimibeheart failure -
SEARCH, 2010    NCTsimvastatin high dosesimvastatinsecondary preventionLow risk of bias suggesting 0%-1%

diabetes type 2  

HPS (diabetic sub group), 2002   simvastatinplacebodiabetic patientsLow risk of bias suggesting
4S (diabetic sub group), 1999   simvastatinplacebodiabetic patients secondary prevention Low risk of bias suggesting-21%

heart failure  

Hong, 2005     simvastatincontrolheart failureRisk of bias negative-74%
Node, 2003     simvastatinplaceboheart failurenegative
Landmesser, 2005     simvastatinezetimibeheart failure -

peripheral vascular diseases  

HPS (sub group), 2002   simvastatinplaceboPeripheral Arterial DiseaseLow risk of bias -
Mondillo, 2003   simvastatinplaceboPeripheral Arterial DiseaseExploratory -
Aronow , 2003   simvastatinplaceboPeripheral Arterial DiseaseExploratory -

post myocardial infarction  

4S, 1994   simvastatinplacebosecondary preventionLow risk of bias conclusive-29%-34%

post stroke  

HPS (post troke sub group), 2004     simvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting



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