post stroke

systematic review meta-analysis network meta-analysis

Select foramen ovale closure cholesterol lowering interventionanticoagulantantiplatelets druganti hypertensive agentsprevention All type of patientuncoded clinical condition ***       ADOangiotensin receptor blockeranticoagulantaspirinPercutaneous closure of patent foramen ovaleplasma homocysteine lowering interventionstatins atorvastatinsimvastatintelmisartanaspirindicoumarolfolic acidphenindionerivaroxabanwarfarin vs placebo or controlvs folic acid, vit B12 and vit B6vs medical treatment       cerebral vascular disease

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	stroke (fatal and non fatal) (14)All cause death (14)Cardiovascular death (13)cardiovascular events (4)Non fatal stroke (1)Fatal stroke (1)stroke or TIA (1)TIA (1)Coronary event (1)Non fatal MI (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	stroke (fatal and non fatal)	All cause death
anti hypertensive agents
telmisartan
PROFESS, 2008	telmisartan	placebo				-
anticoagulant
not classified
Baker, 1964	anticoagulant	no anticoagulant				negative
Bradshaw, 1975	anticoagulant	no anticoagulant				negative
LHSPS, 1999	anticoagulant	no anticoagulant				negative
VA Study, 1961	anticoagulant	no anticoagulant				negative
Wallace, 1964	anticoagulant	no anticoagulant				suggesting
McDevitt, 1959	anticoagulant	placebo				negative
dicoumarol
Howard, 1963	dicoumarol	placebo				negative
Nat-Coop, 1962	dicoumarol	placebo				suggesting
phenindione
Enger, 1965	phenindione	placebo				negative
Thygesen, 1964	phenindione	placebo				negative
rivaroxaban
NAVIGATE ESUS, 2018      NCT	rivaroxaban	aspirin				-
warfarin
SWAT, 1998	warfarin	aspirin				negative
antiplatelets drug
aspirin
Canadian study (CCSG), 1978	aspirin	placebo			Low risk of bias	negative
Swedish study , 1987	aspirin	placebo				negative
UK-TIA low dose , 1988	aspirin	placebo				negative
UK-TIA high dose , 1988	aspirin	placebo				suggesting
SALT , 1991	aspirin	placebo				negative
Reuther , 1976	aspirin	placebo				negative
AITA, 1975	aspirin	placebo				negative
DCS, 1980	aspirin	placebo				negative
AICLA, 1981	aspirin	placebo				negative
Lindblad , 1991	aspirin	placebo				suggesting
Danish low-dose, 1986	aspirin	placebo				negative
ESPS 2 , 1996	aspirin	placebo				suggesting
cholesterol lowering intervention
atorvastatin
SPARCL, 2006      NCT	atorvastatin	placebo	post stroke	cerebral vascular disease	Low risk of bias	suggesting
simvastatin
HPS (post troke sub group), 2004	simvastatin	placebo	post stroke	cerebral vascular disease	Low risk of bias	suggesting
foramen ovale closure
not classified
CLOSURE I, 2010      NCT	Starflex	medical treatment			Risk of bias	negative
prevention
folic acid
VITATOPS, 2010    NCT	folic acid, vit B12 and vit B6	placebo			Low risk of bias	suggesting
VISP (Toole), 2004	high dose - folic acid, vit B12 and vit B6	low dose - folic acid, vit B12 and vit B6			Low risk of bias	negative