new version V2017

Enoxaparin LMWH

Clexane - Lovenox      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

RESCUEenoxaparinunfractionated heparin - NCT00077818
ESSENCE, 1997enoxaparinUFH (on top of aspirin)Suggesting
TIMI 11 B (short term), 1998enoxaparinUFH (on top of aspirin)Suggesting
TIMI 11 B (long term), 1998enoxaparinUFH (on top of aspirin)Negative
EVET, 2005enoxaparintinzaparinSuggesting
SYNERGY, 2005enoxaparinUFH (on top of aspirin)Negative NCT00043784
INTERACT, 2006enoxaparinUFH (on top of aspirin)Suggesting

acute myocardial infarction

HART II, 2001EnoxaparinUFHNegative
ASSENT 3, 2001EnoxaparinUFHSuggesting
AMI-SK, 2002Enoxaparinplacebo -
ENTIRE-TIMI 2, 2002EnoxaparinUFHSuggesting
Baird, 2002EnoxaparinUFHNegative
ASSENT 3 Plus, 2003EnoxaparinUFHNegative

heart failure

THE-PRINCE (Kleber), 2003enoxaparinUFH -

percutaneous coronary intervention

Rabah, 1999enoxaparinUFH Exploratory Negative
Dudek b (enox alone), 2000enoxaparinUFH -
Dudek, 2000enoxaparinUFHNegative
Dubek b (+abciximal), 2001enoxaparin+abciximabUFH -
Drozd, 2001enoxaparinUFHNegative
Galeote, 2001enoxaparinUFHNegative
CRUISE, 2003enoxaparinUFH Exploratory Negative
STEEPLE, 2006enoxaparinUFH Risk of bias - NCT00077844
ATOLL, 2010enoxaparinUFH Risk of bias -
STREAM ongoing enoxaparinunfractionated heparin - NCT00882635

pulmonary embolism

PREPIC, 1998Enoxaparinunfractionated heparin Risk of bias Negative
Merli sub group, 2001Enoxaparinunfractionated heparin Exploratory Negative

superficial thrombophlebitis

STENOX (enoxaparin 1.5mg/hg), 2003enoxaparinplacebo -
Stenox (enoxaparin 40mg), 2003enoxaparinplacebo -

thrombosis prevention

Ho [43]enoxaparinno treatmentNegative
Turpie, 1986enoxaparinplacebohip surgerySuggesting
Melon, 1987enoxaparinplaceboNegative
LeGagneux , 1987enoxaparinplaceboNegative
Samama 1, 1988enoxaparinunfractionated heparingeneral surgeryNegative
Samama 2, 1988enoxaparinunfractionated heparingeneral surgeryNegative
Samama 3, 1988enoxaparinunfractionated heparingeneral surgeryNegative
Planes , 1988enoxaparinUnfractionated heparinhip surgerySuggesting
DES Group , 1991enoxaparinDextranhip surgerySuggesting
Leclerc, 1991enoxaparinplaceboknee surgerySuggesting
Levine , 1991enoxaparinUnfractionated heparinhip surgeryNegative
Kaaja, 1992enoxaparinunfractionated heparingynaecological surgery -
Gazzaniga (ISG), 1993enoxaparinunfractionated heparingeneral surgery -
Warwick, 1995enoxaparinno treatmenthip surgeryNegative
Nurmohamed, 1995enoxaparinunfractionated heparingeneral surgery -
McLeod (Canadian), 1995enoxaparinunfractionated heparinabdominal surgery -
Kalodiki, 1996enoxaparinplacebohip surgery -
Planes, 1996out of hospital Enoxaparinstandard prophylaxisNegative
Bergqvist, 1996out of hospital Enoxaparinstandard prophylaxisSuggesting
Bergmann and Neuhart, 1996enoxaparinUFHmedical patientsNegative
Lechler, 1996enoxaparinUFHmedical patientsNegative
Gonzalez, 1996enoxaparinunfractionated heparinabdominal surgery -
Samama, 1997enoxaparinplacebohip surgerySuggesting
ENOXACAN, 1997enoxaparinunfractionated heparinabdominal surgery -
Agnelli, 1998enoxaparinplaceboSuggesting
MEDENOX, 1999Enoxaparinplacebomedical patients Low risk of bias Suggesting
Comp, 2001out of hospital Enoxaparinstandard prophylaxisSuggesting
Canata, 2003enoxaparincontrol Exploratory Negative
Kleber, 2003enoxaparinUFHmedical patientsNegative
Lederle, 2006Enoxaparinplacebomedical patientsNegative
LIFENOX, 2011enoxaparinplacebomedical patients Low risk of bias NegativeNCT00622648

venous thrombosis

Simonneau et al , 1993Enoxaparinunfractionated heparinNegative
Pini, 1994Enoxaparinwarfarin Risk of bias Negative
Gonzalez-Fajardo, 1999Enoxaparinwarfarin Risk of bias Suggesting
Veiga, 2000Enoxaparinacenocoumarol Risk of bias Negative
Merli, 2001once daily enoxaparintwice daily enoxaparinNegative
Merli (once daily vs UFH), 2001once daily enoxaparinUFH Low risk of bias Negative
Meyer, 2002extended enoxaparinstandard treatmentNegative
Meyer, 2002Enoxaparinwarfarin Risk of bias Negative
Cesarone, 2003extended enoxaparinstandard treatmentNegative
Deitcher, 2003Enoxaparinwarfarin Risk of bias Negative
Deitcher, 2006extended enoxaparinstandard treatmentNegative
González-Fajardo, 2008Enoxaparincoumarin Risk of bias -