new version V2017

antiarrythmic drugs
Description Results

Amiodarone - Dronedarone - Flecainide - Lidocaine - Propafenone      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute myocardial infarction

dofetilide
DIAMOND MI, 1997dofetilideplacebo -
magnesium
Morton, 1984magnesiumplaceboNegative
Rasmussen, 1986magnesiumplaceboNegative
Smith, 1986magnesiumplaceboNegative
Abraham, 1987magnesiumplaceboNegative
Ceremuzynski, 1989magnesiumplaceboSuggesting
Ising, 1990magnesiumplacebo -
Parikka, 1990magnesiumplaceboNegative
Shechter, 1990magnesiumplaceboSuggesting
Singh, 1990magnesiumplaceboSuggesting
Chen, 1991magnesiumplaceboSuggesting
Feldstedt, 1991magnesiumplaceboNegative
Shechter, 1991magnesiumplaceboNegative
Wu, 1992magnesiumcontrolSuggesting
Woods, 1992magnesiumplaceboSuggesting
ISIS-4, 1995magnesiumcontrolSuggesting
Bhargava, 1995magnesiumplaceboSuggesting
Shechter, 1995magnesiumplaceboSuggesting
Thogersen, 1995magnesiumplaceboNegative
Urek, 1996magnesiumplaceboNegative
Raghu, 1999magnesiumplaceboSuggesting
MAGIC, 2000magnesiumplaceboNegativeNCT00000610
Gyamlani, 2000magnesiumplaceboSuggesting
Santoro, 2000magnesiumplaceboNegative
Zhu, 2002magnesiumcontrolSuggesting
Nakashima, 2004magnesiumplaceboNegative
moricizine
CAST II (early treatment), 1992moricizineplacebo -

atrial fibrillation

amiodarone
Vitolo, 1981amiodaronequinidineSuggesting
Villani, 1992amiodaronedisopyramideSuggesting
Kochiadakis (amiodarone vs placebo), 2000amiodaroneplaceboSuggesting
Kochiadakis (amiodarone vs sotalol), 2000amiodaronesotalol -
GEFACA, 2001amiodaroneplaceboSuggesting
AFFIRM Substudy (amiodarone vs class I drugs), 2003amiodaroneclass I drugs Risk of bias Suggesting
AFFIRM Substudy (sotalol vs class I drugs), 2003amiodaroneclass I drugs -
AFFIRM Substudy (amiodarone vs sotalol), 2003amiodaronesotalolSuggesting
Channer, 2004amiodaroneplaceboSuggesting
Kochiadakis a, 2004amiodaronepropafenoneNegative
SAFE-T (amiodarone vs placebo), 2005amiodaroneplacebo Low risk of bias Suggesting
SAFE-T (amiodarone vs sotalol), 2005amiodaronesotalol -
Azimilide
ASAP, 2003AzimilideplaceboNegative
disopyramide
Lloyd (Disopyramide vs placebo), 1984disopyramideplaceboNegative
Lloyd (Disopyramide vs quinidine), 1984disopyramidequinidine -
PRODIS, 1996disopyramidepropafenoneNegative
Karlson, 1998disopyramideplaceboNegative
dofetilide
SAFIRE-D, 2000dofetilideplaceboSuggesting
DIAMOND, 2001dofetilideplaceboSuggesting
dronedarone
DAFNE, 2003dronedaroneplaceboSuggesting
DIONISOS, 2007dronedaroneamiodaroneSuggesting NCT00489736
EURIDIS, 2007dronedaroneplacebo Low risk of bias SuggestingNCT00259428
ADONIS, 2007dronedaroneplacebo Low risk of bias SuggestingNCT00259376
ERATO, 2008dronedaroneplacebo Exploratory Negative18760136
EURIDIS ADONIS (pooled analysis), 2009dronedaroneplaceboNegative
ATHENA, 2009dronedaroneplacebo Low risk of bias Suggesting NCT00174785
PALLAS, 2011dronedaroneplacebo Low risk of bias Negative NCT01151137
flecainide
Steinbeck (flecainide vs digoxin), 1988flecainidedigoxinSuggesting
Van Gelder, 1989flecainideno treatmentNegative
Carunchio (flecainide vs placebo), 1995flecainideplaceboSuggesting
Aliot, 1996flecainidepropafenoneSuggesting
Naccarelli, 1996flecainidequinidineNegative
metoprolol
Kuhlkamp, 2000metoprololplaceboNegative
propafenone
Richiardi, 1992propafenonequinidineNegative
Reimold, 1993propafenonesotalolNegative
FAPIS, 1996propafenoneflecainideNegative
Stroobandt, 1997propafenoneplaceboNegative
Bellandi (propafenone vs placebo), 2001propafenoneplaceboSuggesting
RAFT, 2003propafenoneplaceboSuggesting
Dogan, 2004propafenoneplaceboSuggesting
Kochiadakis b (propafenone vs placebo), 2004propafenoneplaceboSuggesting
quinidine
Hillestad, 1971quinidineno treatmentNegative
Sodermark, 1975quinidineno treatmentSuggesting
Byrne Quinn, 1979quinidineplaceboSuggesting
Lloyd (quinidine vs disopyramide), 1984quinidinedisopyramide -
Lloyd (quinidine vs placebo), 1984quinidineplaceboNegative
Steinbeck (quinidine vs digoxin), 1988quinidinedigoxinNegative
Steinbeck (quinidine vs flecainide), 1988quinidineflecainide -
Juul-Moller, 1990quinidinesotalolNegative
Kalusche, 1994quinidinesotalolNegative
Hohnloser, 1995quinidinesotalolNegative
SOCESP, 1999quinidinesotalolNegative
PAFAC (quinidine vs placebo), 2004quinidineplaceboSuggesting
SOPAT (quinidine vs placebo), 2004quinidineplaceboSuggesting
PAFAC (quinidine vs sotalol), 2004quinidinesotalol -
SOPAT (quinidine vs sotalol), 2004quinidinesotalol -
sotalol
Singh, 1991sotalolplaceboSuggesting
Carunchio (sotalol vs flecianide), 1995sotalolflecainide -
Carunchio (sotalol vs placebo), 1995sotalolplaceboSuggesting
Benditt, 1999sotalolplaceboNegative
Kochiadakis (sotalol vs placebo), 2000sotalolplacebo -
Plewan, 2001sotalolbisoprololNegative
Bellandi (sotalol vs placebo), 2001sotalolplaceboSuggesting
Kochiadakis b (sotalol vs placebo), 2004sotalolplaceboSuggesting
PAFAC (sotalol vs placebo), 2004sotalolplaceboSuggesting
SOPAT (sotalol vs placebo), 2004sotalolplaceboNegative
Kochiadakis b (sotalol vs propafenome), 2004sotalolpropafenone -
SAFE-T (sotalol vs placebo), 2005sotalolplaceboSuggesting

cardiac arrest

amiodarone
ARREST, 1999amiodaroneplaceboSuggesting
ALIVE, 2002amiodaronelidocaineSuggesting

heart failure

amiodarone
EPAMSA, 1985amiodaroneno treatmentSuggesting
Hamer, 1989amiodaroneplaceboSuggesting
Nicklas, 1991amiodaroneplaceboNegative
GESICA, 1994amiodaroneno treatmentSuggesting
STATCHF, 1995amiodaroneplaceboNegative
AMIOVIRT, 2003amiodaroneICDNegative
dronedarone
ANDROMEDA, 2008dronedaroneplaceboNegative NCT00543699

post myocardial infarction

amiodarone
Hockings, 1987early amiodaroneplaceboNegative
BASIS, 1990early amiodaronecontrolSuggesting
CAMIAT , 1991early amiodaroneplaceboNegative
Ceremuzynski, 1992early amiodaroneplaceboNegative
Navarro-Lopez, 1993early amiodaronecontrolNegative
Azimilide
ALIVE, 2004azimilideplacebo -
dofetilide
DIAMOND MI, 1997dofetilideplacebo -
moricizine
CAST II (early treatment), 1992moricizineplacebo -
CAST II (late treatment), 1992moricizineplacebo -



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