Clinical trials of myocardial revascularization

Trial	Studied treatment	Control treatment	ROB	Result	NCT
acute coronary syndrome
anistreplase
UNASEM, 1992	anistreplase	placebo	Exploratory	-
t-pa
Gold, 1987	t-PA	placebo	Exploratory	-
Topol, 1988	t-PA	placebo	Exploratory	Negative
Nicklas, 1989	t-PA	placebo	Exploratory	Negative
Williams, 1990	t-PA	placebo	Exploratory	Negative
Ardissino, 1990	t-PA	placebo	Exploratory	Negative
van der Brand, 1991	t-PA	placebo	Exploratory	Negative
Freeman, 1992	t-PA	placebo	Low risk of bias	Negative
charbonnier, 1992	t-PA	placebo	Exploratory	-
TIMI 3A, 1993	t-PA	placebo	Exploratory	-
TIMI 3B, 1995	t-PA	placebo	Low risk of bias	-
acute myocardial infarction
abciximab
Zorman, 2002	Abciximab	primary intervention		Negative
ERAMI (Mesquita Gabriel), 2003	Abciximab	primary intervention		Negative
REOMOBILE (Arntz), 2003	Abciximab	primary intervention		Negative
BRAVE (Kastrati), 2004	Abciximab + reteplase	primary intervention		-
ReoPro-BRIDGING (Gyongyosi), 2004	Abciximab	primary intervention		Negative
Bellandi, 2006	Abciximab	primary intervention		Negative
FINESSE (combination-facilitated PCI), 2008	Abciximab + reteplase	primary intervention		Negative	NCT00046228
FINESSE (abciximab-facilitated PCI), 2008	Abciximab	primary intervention		Negative	NCT00046228
alteplase
LIMI (Vermeer), 1999	alteplase	primary intervention		Negative
PACT (Ross,), 1999	alteplase	primary intervention		Negative
anistreplase
TEAM 2, 1991	anistreplase	streptokinase		-
APSAC
AIMS, 1988	APSAC	placebo		Suggesting
German Multicenter Trial, 1988	APSAC	placebo		Suggesting
APSIM, 1989	APSAC	control		Negative
ISIS III (SK/APSAC), 1992	APSAC	streptokinase		Negative
TEAM 3, 1992	APSAC	t-PA		-
drug-eluting stents
DEDICATION, 2008	drug-eluting stents	bare-metal stent	Risk of bias	Suggesting	NCT00192868
PASEO, 2009	drug-eluting stents	bare-metal stent		-
eptifibatide
INTAMI (Zeymer), 2005	Eptifibatide	primary intervention		Negative
lanoteplase
InTIME-II, 2000	lanoteplase	accelerated t-PA		Negative
paclitaxel
PASSION, 2006	paclitaxel eluting stent	bare-metal stent	Risk of bias	Negative	ISRCTN65027270
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent	Exploratory	Negative
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent		Suggesting
PCI
Jaksch, 1998	primary stenting	balloon angioplasty		Suggesting
GRAMI (Rodriguez), 1998	primary stenting	balloon angioplasty		Negative
Zwolle 5 (Suryapranata), 1998	primary stenting	balloon angioplasty		Suggesting
FRESCO, 1998	primary stenting	balloon angioplasty		-
stent-PAMI (Grines), 1999	primary stenting	balloon angioplasty		Suggesting
PASTA (Saito), 1999	primary stenting	balloon angioplasty		Suggesting
PRISAM (Kawashima), 1999	primary stenting	balloon angioplasty		Negative
STENTIM-2 (Maillard), 2000	primary stenting	balloon angioplasty		Negative
PRAGUE, 2000	systematic PCI (+stent)	no systematic PCI		Negative
STAT, 2001	primary stenting	accelerated t-PA		-
PSSAAMI (Scheller), 2001	primary stenting	balloon angioplasty		Suggesting
C-PORT, 2002	primary PCI	accelerated t-PA		-
CADILLAC abciximab., 2002	primary stenting	balloon angioplasty		-
CADILLAC (no abciximab), 2002	primary stenting	balloon angioplasty		-
STOPAMI 2, 2002	primary stenting	immediate thrombolysis		-
SIAM III, 2002	systematic PCI (+stent)	no systematic PCI		Negative
STOPAMI 3, 2004	primary stenting	balloon angioplasty		-
GRACIA-1, 2004	systematic PCI (+stent)	no systematic PCI	Risk of bias	Negative
ZWOLLE 6, 2005	primary stenting	balloon angioplasty		-
CAPITAL AMI, 2005	systematic PCI (+stent)	no systematic PCI		Negative
senior PAMI, 2005	primary PCI	Thrombolysis	Risk of bias	Suggesting	NCT00136929
WEST, 2006	systematic PCI (+stent)	no systematic PCI		Negative
primary angioplasty
O'Neill, 1986	primary ballon angioplasty	intracoronary streptokinase		-
DeWood, 1989	primary ballon angioplasty	duteplase		-
Gibbons, 1993	primary ballon angioplasty	duteplase		-
Ribeiro, 1993	primary ballon angioplasty	streptokinase		-
Zijlstra , 1993	primary ballon angioplasty	streptokinase		-
PAMI, 1993	primary ballon angioplasty	t-PA		-
Zwolle, 1994	primary ballon angioplasty	streptokinase		Negative
Ribichini, 1996	primary ballon angioplasty	accelerated t-PA		-
Grinfeld, 1996	primary ballon angioplasty	streptokinase		-
Garcia, 1997	primary ballon angioplasty	accelerated t-PA		-
GUSTO 2B, 1997	primary ballon angioplasty	accelerated t-PA		-
DANAMI-2, 1997	primary ballon angioplasty	accelerated t-PA		-
Zijlstra, 1997	primary ballon angioplasty	streptokinase		-
Akhras, 1997	primary ballon angioplasty	streptokinase		-
TRIANA, 2009	primary ballon angioplasty	tenecteplase	Risk of bias	Negative	NCT00257309
PTCA
TIMI II-A (defered)	systematic ballon angioplasty	no systematic angioplasty		-
TAMI 1 pilot, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	Suggesting
Topol, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	-
Guerci, 1987	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
ECSG, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	Negative
TIMI 2A, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	-
Erbel, 1989	immediate systematic ballon angioplastyte	no immediate angioplasty		-
TIMI 2, 1989	systematic ballon angioplasty	no systematic angioplasty	Risk of bias	Negative
Barbash, 1990	systematic ballon angioplasty	no systematic angioplasty		-
TAMI-5 (Califf), 1991	immediate systematic ballon angioplastyte	no immediate angioplasty		-
Belenkie, 1991	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	-
SWIFT, 1991	systematic ballon angioplasty	no systematic angioplasty	Risk of bias	Negative
Van den Brand, 1991	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
Belenkie, 1992	rescue PTCA	no rescue PTCA	Risk of bias	Negative
SIAM, 1992	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
TOPS, 1992	systematic ballon angioplasty	no systematic angioplasty	Exploratory	Negative
TAMI 6, 1992	systematic ballon angioplasty	no systematic angioplasty		-
Ellis, 1994	immediate systematic ballon angioplastyte	no immediate angioplasty		-
TOMIIS, 1994	late PTCA	no PTCA		Negative
RESCUE, 1994	rescue PTCA	no rescue PTCA		Negative
Horie et al, 1998	late PTCA	no PTCA		Suggesting
MAASTRICHT (Vermeer), 1999	primary angioplasty	immediate thrombolysis		Negative
SHOCK (Hochman), 1999	immediate systematic ballon angioplastyte	no immediate angioplasty	Risk of bias	Suggesting	NCT00000552
SWISS-SMASH, 1999	immediate systematic ballon angioplastyte	no immediate angioplasty	Exploratory	Negative
Vermeer, 1999	systematic ballon angioplasty	no systematic angioplasty		-
PRAGUE-1, 2000	primary angioplasty	immediate thrombolysis		Suggesting
RESCUE II, 2000	rescue PTCA	no rescue PTCA		Negative
AIR-PAMI, 2002	primary angioplasty	immediate thrombolysis		Negative
CAPTIM, 2002	primary angioplasty	immediate thrombolysis		Negative
TOAT, 2002	late PTCA	no PTCA		Negative
DANAMI-2, 2003	primary angioplasty	immediate thrombolysis		Suggesting
PRAGUE-2, 2003	primary angioplasty	immediate thrombolysis		Suggesting
MERLIN (Sutton), 2004	immediate systematic ballon angioplastyte	no immediate angioplasty		-
DECOPI, 2004	late PTCA	no PTCA		Negative
MERLIN, 2004	rescue PTCA	no rescue PTCA		Negative
Silva et al, 2005	late PTCA	no PTCA		Negative
REACT (rescue PCI), 2005	rescue PTCA	no rescue PTCA		Suggesting
OAT, 2006	late PTCA	no PTCA		Negative
TOSCA-2, 2006	late PTCA	no PTCA		-	NCT00025766
reteplase
INJECT, 1995	reteplase	streptokinase		Negative
RAPID-2, 1996	reteplase	accelerated t-PA	Exploratory	Suggesting
GUSTO III, 1997	reteplase	accelerated t-PA		Negative
saruplase
PRIMI (vs SK), 1989	saruplase	streptokinase		-
PRIMI (vs UK), 1989	saruplase	urokinase		-
SESAM, 1997	saruplase	t-PA	Exploratory	Negative
COMPASS, 1998	saruplase	streptokinase		Negative
sirolimus eluting stent
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
TYPHOON, 2006	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00232830
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
SESAMI, 2007	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00288210
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent		-
MISSION, 2008	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	ISRCTN62825862
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent		Negative	ISRCTN90526229
streptokinase
ISAM, 1986	streptokinase	placebo		Negative
GISSI I, 1986	streptokinase	placebo		Suggesting
ISIS 2 pilot, 1987	streptokinase	placebo		-
ISIS-2 (SK), 1988	streptokinase	placebo		Suggesting
Western Washington Intravenous Trial, 1988	streptokinase	placebo		Negative	NCT00000507
SAMI (O’Neill), 1992	streptokinase	primary intervention		Negative
EMERAS (all delay), 1993	streptokinase	placebo		Negative
EMERAS (7-12h), 1993	streptokinase	placebo		-
GUSTO tPA-SK Hiv, 1993	t-PA + streptokinase	streptokinase		Negative
PRAGUE (Widimisky), 2000	streptokinase	primary intervention		Negative
t-pa
ECSG, 1985	t-PA	streptokinase		Negative
TIMI-1, 1987	t-PA	streptokinase		-	NCT00000505
ASSET, 1988	t-PA	placebo		Suggesting
PAIMS, 1989	t-PA	streptokinase		-
White, 1989	t-PA	streptokinase		-
GISSI II, 1990	t-PA	streptokinase		Suggesting
International Study Group, 1990	t-PA	streptokinase		Suggesting
KAMIT, 1991	t-PA half dose	t-PA	Exploratory	Negative
TAMI 5 (t-PA vs uroK), 1991	t-PA	urokinase		-
TAPS, 1992	accelerated t-PA	APSAC		Negative
TAMI 6, 1992	t-PA	placebo		Negative
ISIS III (SK/tPA), 1992	t-PA	streptokinase		Suggesting
Cherng, 1992	t-PA	streptokinase		Negative
RAAMI, 1992	accelerated t-PA	t-PA		-
LATE, 1993	t-PA	placebo	Low risk of bias	Negative
GUSTO tPA Hiv, 1993	accelerated t-PA	streptokinase		Suggesting
Centre Illinois, 1993	t-PA	streptokinase		-
TIMI 4, 1994	accelerated t-PA	APSAC		-
COBALT, 1997	bolus t-PA	accelerated t-PA		Negative
tenecteplase
ASSENT-2, 1999	tenecteplase	accelerated t-PA		Suggesting
GRACIA (Fernandez-Aviles,), 2004	tenecteplase	primary intervention		Negative
ADVANCE-MI, 2005	Eptifibatide + tenecteplase	primary intervention		-
ASSENT-4 PCI (Van de Werf), 2006		primary intervention		Negative	NCT00168792
tirofiban
TIGER-PA (Lee), 2003	Tirofiban	primary intervention		Negative
Cutlip, 2003	Tirofiban	primary intervention		Negative
On-Time (van’t Hof), 2004	Tirofiban	primary intervention		Negative
urokinase
USIM, 1991	urokinase	control		-
zotarolimus eluting stent
ZEST AMI (vs PES), 2009	zotarolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00422565
ZEST AMI (vs SES), 2009	zotarolimus eluting stent	sirolimus eluting stent		Negative	NCT00422565
coronary artery disease
abciximab
Kim, 2010	abciximab-coated stent	bare-metal stent	Exploratory	-
angioplasty
AMIST (Reeves), 2004	angioplasty	MIDCAB	Risk of bias	-
biolimus eluting stent
LEADERS, 2008	biolimus eluting stent	sirolimus eluting stent		Negative	NCT00389220
Coronary Artery Bypass Surgery
Texas, 1977	CABG	medical treatment		Negative
Oregon, 1979	CABG	medical treatment		Negative
New zealand 1, 1981	CABG	medical treatment		Negative
CASS, 1983	CABG	medical treatment		Negative	NCT00000489
VA, 1984	CABG	medical treatment		Suggesting
ECSS (European), 1988	CABG	medical treatment		Suggesting
Allen, 2000	TMR+CABG	CABG		-
Loubani, 2003	TMR+CABG	CABG	Exploratory	-
Zhao, 2006	TMR+CABG	CABG	Exploratory	-
MASS II, 2007	CABG	medical treatment		Negative
STICH (ventricular reconstruction), 2009	CABG+surgical ventricular reconstruction	CABG		Negative	NCT00023595
BARI 2D, 2009	CABG or PCI	medical treatment	Risk of bias	Negative	NCT00006305
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent		Suggesting
drug-eluting stents
Hong, 2005	PCI withdrug-eluting stents	CABG	Risk of bias	-
Boudriot, 2008	DES	CABG	Exploratory	Negative
FREEDOM, 2012	PCI with drug-eluting stents	CABG	Risk of bias	Negative	NCT00086450
ISAR-CABG ongoing	drug-eluting stents	bare-metal stent		-	NCT00611910
Leipzig ongoing	drug-eluting stents	CABG		-	NCT00176397
VA CARDS ongoing	PCI withdrug-eluting stents	CABG	Risk of bias	-	NCT00326196
everolimus eluting stent
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent		Suggesting
ESSENCE diabetes	everolimus eluting stent	sirolimus ES		-	NCT00997763
FUTURE I, 2004	everolimus eluting stent	bare-metal stent		Negative
SPIRIT I, 2005	everolimus eluting stent	bare-metal stent	Exploratory	Negative	NCT00180453
FUTURE II, 2006	everolimus eluting stent	bare-metal stent		-
SPIRIT II, 2006	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00180310
SPIRIT III, 2008	everolimus eluting stent	paclitaxel eluting stent	Exploratory	Suggesting	NCT00180479
SPIRIT IV, 2010	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00307047
PLATINUM, 2011	everolimus eluting stent	everolimus eluting stent		-	NCT00823212
RESET, 2011	everolimus eluting stent	sirolimus eluting stent		-	NCT01035450
SORT OUT IV, 2012	everolimus eluting stent	sirolimus eluting stent	Risk of bias	-	NCT00552877
LEFT-MAIN-2 ongoing	everolimus eluting stent	zotarolimus eluting stent		-	NCT00598637
paclitaxel
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent		Negative
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent		Negative
TAXUS II, 2003	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00299026
ASPECT, 2003	paclitaxel, non-polymeric eluting stent	bare-metal stent		Suggesting	NCT00196079
TAXUS II (diabetics), 2003	paclitaxel eluting stent	bare-metal stent		Suggesting
TAXUS IV, 2004	paclitaxel eluting stent	bare-metal stent	Low risk of bias	Suggesting	NCT00292474
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent		Negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent	Risk of bias	Negative
SCORE, 2004	paclitaxel eluting stent	bare-metal stent		Suggesting
ISAR-DESIRE (PES vs PTCA), 2005	paclitaxel eluting stent	balloon angioplasty		Suggesting
TAXUS V (all patients), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00301522
TAXUS VI, 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00297804
TAXUS IV (diabetics), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00292474
TAXUS V (diabetics), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting
TAXUS VI (diabetics), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00297804
PASSION, 2006	paclitaxel eluting stent	bare-metal stent	Risk of bias	Negative	ISRCTN65027270
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent	Exploratory	Negative
ISAR-test (diabetics), 2006	paclitaxel eluting stent	sirolimus eluting stent	Risk of bias	-
SYNTAX, 2009	paclitaxel eluting stent	CABG	Risk of bias	Suggesting	NCT00114972
BASKET-SAVAGE ongoing	paclitaxel eluting stent	bare-metal stent		-	NCT00595647
VELETI ongoing	paclitaxel eluting stent	medical treatment		-	NCT00289835
PEPCAD IV ongoing	paclitaxel eluting balloon	paclitaxel eluting stent		-	NCT00462631
FRE-RACE ongoing	paclitaxel eluting stent	sirolimus eluting stent		-	NCT00130546
PERSEUS Workhorse, 2010 ongoing	paclitaxel eluting stent	paclitaxel eluting stent		-	NCT00484315
PCI
AVERT, 1995	PCI with or without stent	medical treatment	Risk of bias	Negative
Dakik, 1998	PCI with or without stent	medical treatment	Risk of bias	Negative
AWESOME, 2001	PCI	CABG	Risk of bias	-
Bech, 2001	PCI with or without stent	medical treatment	Risk of bias	Negative
TIME, 2001	PCI with or without stent	medical treatment	Risk of bias	-
DEFER, 2001	FFR-guided PCI	no PCI		Negative
ALKK, 2003	PCI with or without stent	medical treatment	Risk of bias	Suggesting
Hambrecht, 2004	PCI with or without stent	medical treatment	Risk of bias	Negative
COURAGE, 2007	PCI with or without stent	medical treatment	Risk of bias	Suggesting	NCT00007657
MASS II, 2007	PCI with or without stent	medical treatment	Risk of bias	Negative
FAME, 2008	FFR-guided PCI	no PCI		Suggesting	NCT00267774
COMBAT ongoing	PCI	CABG		-
Korean Randomized Study ongoing	PCI	CABG		-
REVASCULARIZE ongoing	PCI	CABG		-
PTCA
ERACI, 1992	balloon angioplasty	CABG		Negative
Toulouse, 1992	balloon angioplasty	CABG		Negative
ACME, 1992	balloon angioplasty	medical treatment	Risk of bias	Suggesting
RITA, 1993	balloon angioplasty	CABG		Negative
Sievers, 1993	balloon angioplasty	medical treatment	Risk of bias	Negative
EAST, 1994	balloon angioplasty	CABG		Negative	NCT00000465
GABI, 1994	balloon angioplasty	CABG		Negative
Lausanne, 1994	balloon angioplasty	CABG		Negative
MASS, 1995	balloon angioplasty	CABG		Negative
CABRI, 1995	balloon angioplasty	CABG		Negative
MASS, 1995	balloon angioplasty	medical treatment	Risk of bias	Suggesting
BARI, 1996	balloon angioplasty	CABG		Negative	NCT00000462
RITA 2, 1997	balloon angioplasty	medical treatment	Risk of bias	Suggesting
ACME 2 (Folland), 1997	balloon angioplasty	medical treatment	Risk of bias	Negative
ACIP, 1997	balloon angioplasty	medical treatment	Exploratory	Negative
INSPIRE, 2006	balloon angioplasty	medical treatment	Risk of bias	Negative
SWISSI II, 2007	balloon angioplasty	medical treatment	Exploratory	Suggesting	NCT00387231
sirolimus eluting stent
RAVEL, 2002	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00233805
SIRIUS, 2003	sirolimus eluting stent	bare-metal stent	Low risk of bias	Suggesting	NCT00232765
E-SIRIUS, 2003	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00235144
Pasceri, 2003	sirolimus eluting stent	bare-metal stent		-
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent		-
C-SIRIUS, 2004	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00381420
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent		Suggesting
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent		Suggesting
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty		Suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent		Suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent		Suggesting
DECODE, 2005	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00489164
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent		Suggesting
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent		Suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
SIRTAX diabetics, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00297661
PRISON II, 2006	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00258596
SCANDSTENT, 2006	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00151658
TYPHOON, 2006	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00232830
REALITY, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00235092
ISAR-SMART 3, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00146575
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	Negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
ISAR-TEST-1, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00140530
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent	Exploratory	-
SESAMI, 2007	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00288210
SCORPIUS, 2007	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00495898
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent		-
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent		Negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	Suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	ISRCTN62825862
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent		-
SORT OUT II, 2008	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00388934
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
Thiele, 2009	PCI withsirolimus ES	MIDCAB	Risk of bias	-	NCT00299429
ISAR-LEFT-MAIN, 2009	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00133237
GISSOC II, 2010	sirolimus eluting stent	bare-metal stent	Exploratory	Suggesting	NCT00220558
PRECOMBAT, 2011	sirolimus eluting stent	CABG		-	NCT00422968
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent		-
Gao ongoing	sirolimus eluting stent	Firebird eluting stent		-	NCT00887211
MIDCAB Versus DES in Proximal LAD Lesions ongoing	sirolimus eluting stent	CABG		-	NCT00299429
Munich Study ongoing	sirolimus eluting stent	CABG		-
FOCUS ongoing	sirolimus eluting stent	cutting ballon angioplasty		-	NCT00485004
DES-ISR ongoing	sirolimus eluting stent	paclitaxel eluting stent		-	NCT00485030
Lipsia-Yukon-DM ongoing	sirolimus eluting stent	paclitaxel eluting stent		-	NCT00368953
BASKET-PROVE, 2008 ongoing	sirolimus eluting stent	bare-metal stent		-
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent		Suggesting
ENDEAVOR III, 2006	zotarolimus eluting stent	sirolimus eluting stent		Suggesting	NCT00217256
ZoMaxx I, 2008	zotarolimus eluting stent	paclitaxel eluting stent		-
ENDEAVOR IV, 2009	zotarolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00217269
ZEST AMI (vs PES), 2009	zotarolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00422565
ZEST (vs PES), 2009	zotarolimus eluting stent	paclitaxel eluting stent		Suggesting	NCT00418067
ZEST (vs SES), 2009	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	Negative	NCT00418067
ZEST AMI (vs SES), 2009	zotarolimus eluting stent	sirolimus eluting stent		Negative	NCT00422565
RESOLUTE All comers, 2010	zotarolimus eluting stent	everolimus eluting stent	Risk of bias	Negative	NCT00617084.)
TWENTE, 2012	zotarolimus eluting stent	everolimus eluting stent		-	NCT01066650
PROTECT, 2012	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	-	NCT00476957
ZoMaxx phase 2 ongoing	zotarolimus eluting stent	paclitaxel eluting stent		-	NCT00140101
DIABEDES IV ongoing	zotarolimus eluting stent	sirolimus eluting stent		-	NCT00552994
PRISON III, 2007 ongoing	zotarolimus eluting stent	sirolimus eluting stent		-	NCT00428454
stable angina
angioplasty
AMIST (Reeves), 2004	angioplasty	MIDCAB	Risk of bias	-
biolimus eluting stent
LEADERS, 2008	biolimus eluting stent	sirolimus eluting stent		Negative	NCT00389220
Coronary Artery Bypass Surgery
Texas, 1977	CABG	medical treatment		Negative
Oregon, 1979	CABG	medical treatment		Negative
New zealand 1, 1981	CABG	medical treatment		Negative
CASS, 1983	CABG	medical treatment		Negative	NCT00000489
VA, 1984	CABG	medical treatment		Suggesting
ECSS (European), 1988	CABG	medical treatment		Suggesting
Allen, 2000	TMR+CABG	CABG		-
Loubani, 2003	TMR+CABG	CABG	Exploratory	-
Zhao, 2006	TMR+CABG	CABG	Exploratory	-
MASS II, 2007	CABG	medical treatment		Negative
STICH (ventricular reconstruction), 2009	CABG+surgical ventricular reconstruction	CABG		Negative	NCT00023595
BARI 2D, 2009	CABG or PCI	medical treatment	Risk of bias	Negative	NCT00006305
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent		Suggesting
drug-eluting stents
Hong, 2005	PCI withdrug-eluting stents	CABG	Risk of bias	-
Boudriot, 2008	DES	CABG	Exploratory	Negative
FREEDOM, 2012	PCI with drug-eluting stents	CABG	Risk of bias	Negative	NCT00086450
ISAR-CABG ongoing	drug-eluting stents	bare-metal stent		-	NCT00611910
Leipzig ongoing	drug-eluting stents	CABG		-	NCT00176397
VA CARDS ongoing	PCI withdrug-eluting stents	CABG	Risk of bias	-	NCT00326196
everolimus eluting stent
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent		Suggesting
FUTURE I, 2004	everolimus eluting stent	bare-metal stent		Negative
SPIRIT I, 2005	everolimus eluting stent	bare-metal stent	Exploratory	Negative	NCT00180453
FUTURE II, 2006	everolimus eluting stent	bare-metal stent		-
SPIRIT II, 2006	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00180310
SPIRIT III, 2008	everolimus eluting stent	paclitaxel eluting stent	Exploratory	Suggesting	NCT00180479
COMPARE, 2009	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT01016041
SPIRIT IV, 2010	everolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00307047
SORT OUT IV, 2012	everolimus eluting stent	sirolimus eluting stent	Risk of bias	-	NCT00552877
LEFT-MAIN-2 ongoing	everolimus eluting stent	zotarolimus eluting stent		-	NCT00598637
paclitaxel
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent		Negative
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent		Negative
TAXUS II, 2003	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00299026
ASPECT, 2003	paclitaxel, non-polymeric eluting stent	bare-metal stent		Suggesting	NCT00196079
TAXUS IV, 2004	paclitaxel eluting stent	bare-metal stent	Low risk of bias	Suggesting	NCT00292474
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent		Negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent	Risk of bias	Negative
SCORE, 2004	paclitaxel eluting stent	bare-metal stent		Suggesting
TAXUS V (all patients), 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00301522
TAXUS VI, 2005	paclitaxel eluting stent	bare-metal stent		Suggesting	NCT00297804
SYNTAX, 2009	paclitaxel eluting stent	CABG	Risk of bias	Suggesting	NCT00114972
BASKET-SAVAGE ongoing	paclitaxel eluting stent	bare-metal stent		-	NCT00595647
VELETI ongoing	paclitaxel eluting stent	medical treatment		-	NCT00289835
PEPCAD IV ongoing	paclitaxel eluting balloon	paclitaxel eluting stent		-	NCT00462631
FRE-RACE ongoing	paclitaxel eluting stent	sirolimus eluting stent		-	NCT00130546
PERSEUS Workhorse, 2010 ongoing	paclitaxel eluting stent	paclitaxel eluting stent		-	NCT00484315
PCI
AVERT, 1995	PCI with or without stent	medical treatment	Risk of bias	Negative
Dakik, 1998	PCI with or without stent	medical treatment	Risk of bias	Negative
AWESOME, 2001	PCI	CABG	Risk of bias	-
Bech, 2001	PCI with or without stent	medical treatment	Risk of bias	Negative
TIME, 2001	PCI with or without stent	medical treatment	Risk of bias	-
DEFER, 2001	FFR-guided PCI	no PCI		Negative
ALKK, 2003	PCI with or without stent	medical treatment	Risk of bias	Suggesting
Hambrecht, 2004	PCI with or without stent	medical treatment	Risk of bias	Negative
COURAGE, 2007	PCI with or without stent	medical treatment	Risk of bias	Suggesting	NCT00007657
MASS II, 2007	PCI with or without stent	medical treatment	Risk of bias	Negative
FAME, 2008	FFR-guided PCI	no PCI		Suggesting	NCT00267774
PTCA
ERACI, 1992	balloon angioplasty	CABG		Negative
Toulouse, 1992	balloon angioplasty	CABG		Negative
ACME, 1992	balloon angioplasty	medical treatment	Risk of bias	Suggesting
RITA, 1993	balloon angioplasty	CABG		Negative
Sievers, 1993	balloon angioplasty	medical treatment	Risk of bias	Negative
EAST, 1994	balloon angioplasty	CABG		Negative	NCT00000465
GABI, 1994	balloon angioplasty	CABG		Negative
Lausanne, 1994	balloon angioplasty	CABG		Negative
MASS, 1995	balloon angioplasty	CABG		Negative
CABRI, 1995	balloon angioplasty	CABG		Negative
MASS, 1995	balloon angioplasty	medical treatment	Risk of bias	Suggesting
BARI, 1996	balloon angioplasty	CABG		Negative	NCT00000462
RITA 2, 1997	balloon angioplasty	medical treatment	Risk of bias	Suggesting
ACME 2 (Folland), 1997	balloon angioplasty	medical treatment	Risk of bias	Negative
ACIP, 1997	balloon angioplasty	medical treatment	Exploratory	Negative
INSPIRE, 2006	balloon angioplasty	medical treatment	Risk of bias	Negative
SWISSI II, 2007	balloon angioplasty	medical treatment	Exploratory	Suggesting	NCT00387231
sirolimus eluting stent
RAVEL, 2002	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00233805
SIRIUS, 2003	sirolimus eluting stent	bare-metal stent	Low risk of bias	Suggesting	NCT00232765
E-SIRIUS, 2003	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00235144
Pasceri, 2003	sirolimus eluting stent	bare-metal stent		-
C-SIRIUS, 2004	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00381420
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent		Suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent		Suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent		Suggesting
DECODE, 2005	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00489164
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent		Suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		Negative
PRISON II, 2006	sirolimus eluting stent	bare-metal stent	Risk of bias	Suggesting	NCT00258596
SCANDSTENT, 2006	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00151658
REALITY, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00235092
ISAR-SMART 3, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00146575
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	Negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent		Negative
ISAR-TEST-1, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	Negative	NCT00140530
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent	Exploratory	-
SCORPIUS, 2007	sirolimus eluting stent	bare-metal stent		Suggesting	NCT00495898
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent		-
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent		Negative
DESSERT, 2008	sirolimus eluting stent	bare-metal stent	Exploratory	Suggesting
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent		-
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent		Negative
Thiele, 2009	PCI withsirolimus ES	MIDCAB	Risk of bias	-	NCT00299429
ISAR-LEFT-MAIN, 2009	sirolimus eluting stent	paclitaxel eluting stent		Negative	NCT00133237
GISSOC II, 2010	sirolimus eluting stent	bare-metal stent	Exploratory	Suggesting	NCT00220558
MIDCAB Versus DES in Proximal LAD Lesions ongoing	sirolimus eluting stent	CABG		-	NCT00299429
FOCUS ongoing	sirolimus eluting stent	cutting ballon angioplasty		-	NCT00485004
DES-ISR ongoing	sirolimus eluting stent	paclitaxel eluting stent		-	NCT00485030
Lipsia-Yukon-DM ongoing	sirolimus eluting stent	paclitaxel eluting stent		-	NCT00368953
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent		Suggesting
ENDEAVOR III, 2006	zotarolimus eluting stent	sirolimus eluting stent		Suggesting	NCT00217256
ENDEAVOR IV, 2009	zotarolimus eluting stent	paclitaxel eluting stent	Risk of bias	Suggesting	NCT00217269
ZEST (vs SES), 2009	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	Negative	NCT00418067
RESOLUTE All comers, 2010	zotarolimus eluting stent	everolimus eluting stent	Risk of bias	Negative	NCT00617084.)
PROTECT, 2012	zotarolimus eluting stent	sirolimus eluting stent	Risk of bias	-	NCT00476957
ZoMaxx phase 2 ongoing	zotarolimus eluting stent	paclitaxel eluting stent		-	NCT00140101
DIABEDES IV ongoing	zotarolimus eluting stent	sirolimus eluting stent		-	NCT00552994
PRISON III, 2007 ongoing	zotarolimus eluting stent	sirolimus eluting stent		-	NCT00428454

myocardial revascularization Description Results

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myocardial revascularization
Description Results