Clinical trials of sirolimus eluting stent

Trial	Studied trt	Control trt	ROB	Trial result	2 yr MACE
Group by... in first in second in third	Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation			Global trial result Main results All results All result tag NCT results	Numeric bar chart forest plot medians
acute myocardial infarction
TYPHOON, 2006 NCT	sirolimus eluting stent	bare-metal stent		suggesting
SESAMI, 2007 NCT	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent		-
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent		suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent		negative
coronary artery disease
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty		suggesting
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent	Exploratory	-
RAVEL, 2002 NCT	sirolimus eluting stent	bare-metal stent	Low risk of bias	suggesting
SIRIUS, 2003 NCT	sirolimus eluting stent	bare-metal stent	Low risk of bias	suggesting
C-SIRIUS, 2004 NCT	sirolimus eluting stent	bare-metal stent	Low risk of bias	suggesting
E-SIRIUS, 2003 NCT	sirolimus eluting stent	bare-metal stent		suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent		suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent		suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent		suggesting
PRISON II, 2006 NCT	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
SCANDSTENT, 2006 NCT	sirolimus eluting stent	bare-metal stent		suggesting
TYPHOON, 2006 NCT	sirolimus eluting stent	bare-metal stent		suggesting
SESAMI, 2007 NCT	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
DECODE, 2005 NCT	sirolimus eluting stent	bare-metal stent		suggesting
SCORPIUS, 2007 NCT	sirolimus eluting stent	bare-metal stent		suggesting
RRISC, 2006 NCT	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent		-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent		-
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent		suggesting
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent		suggesting
GISSOC II, 2010 NCT	sirolimus eluting stent	bare-metal stent	Exploratory	suggesting
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent		-
DESSERT, 2008	sirolimus eluting stent	bare-metal stent	Exploratory	suggesting
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent	Low risk of bias	-
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent		suggesting
SCANDSTENT (subgroup), 2006	sirolimus eluting stent	bare-metal stent	Exploratory	suggesting
BASKET-PROVE (SES), 2010	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
CRISTAL NCT	sirolimus eluting stent	PTCA		-
RIBS-II, 2008	sirolimus eluting stent	PTCA		suggesting
SISR, 2007 NCT	sirolimus eluting stent	brachytherapy	Risk of bias	suggesting
PRECOMBAT, 2011 NCT	sirolimus eluting stent	CABG		-
Thiele, 2009 NCT	PCI withsirolimus ES	MIDCAB	Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent		-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent		suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
REALITY, 2006 NCT	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
ISAR-SMART 3, 2006 NCT	sirolimus eluting stent	paclitaxel eluting stent		negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
SORT OUT II, 2008 NCT	sirolimus eluting stent	paclitaxel eluting stent		negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent		negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
ISAR-TEST-1, 2006 NCT	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	negative
ISAR-DESIRE-2, 2010 NCT	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	-
ISAR-LEFT-MAIN, 2009 NCT	sirolimus eluting stent	paclitaxel eluting stent		negative
SIRTAX (small vessels subgroup), 2005	sirolimus eluting stent	paclitaxel eluting stent		suggesting
Wessely, 2008	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	-
SIRTAX diabetics, 2005 NCT	sirolimus eluting stent	paclitaxel eluting stent		negative
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent		negative
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent		-
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	suggesting
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
stable angina
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent	Exploratory	-
RAVEL, 2002 NCT	sirolimus eluting stent	bare-metal stent	Low risk of bias	suggesting
SIRIUS, 2003 NCT	sirolimus eluting stent	bare-metal stent	Low risk of bias	suggesting
C-SIRIUS, 2004 NCT	sirolimus eluting stent	bare-metal stent	Low risk of bias	suggesting
E-SIRIUS, 2003 NCT	sirolimus eluting stent	bare-metal stent		suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent		suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent		suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent		suggesting
PRISON II, 2006 NCT	sirolimus eluting stent	bare-metal stent	Risk of bias	suggesting
SCANDSTENT, 2006 NCT	sirolimus eluting stent	bare-metal stent		suggesting
DECODE, 2005 NCT	sirolimus eluting stent	bare-metal stent		suggesting
SCORPIUS, 2007 NCT	sirolimus eluting stent	bare-metal stent		suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent		-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent		-
GISSOC II, 2010 NCT	sirolimus eluting stent	bare-metal stent	Exploratory	suggesting
DESSERT, 2008	sirolimus eluting stent	bare-metal stent	Exploratory	suggesting
Thiele, 2009 NCT	PCI withsirolimus ES	MIDCAB	Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent		-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent		suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
REALITY, 2006 NCT	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
ISAR-SMART 3, 2006 NCT	sirolimus eluting stent	paclitaxel eluting stent		negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent	Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	suggesting
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent		negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent		negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent		negative
ISAR-TEST-1, 2006 NCT	sirolimus eluting stent	paclitaxel eluting stent	Risk of bias	negative
ISAR-LEFT-MAIN, 2009 NCT	sirolimus eluting stent	paclitaxel eluting stent		negative
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent		negative

Sirolimus eluting stent Drug eluting stent systematic review meta-analysis network meta-analysis

Group by...

acute myocardial infarction

coronary artery disease

stable angina

Sirolimus eluting stent Drug eluting stent
systematic review meta-analysis network meta-analysis