Drug eluting stent

systematic review meta-analysis network meta-analysis

Select coronary artery disease Acute myocardial infarctionAll type of patientbifurcation lesionbypass graft lesionDiabetic patientsin stent restenosislong or complex lesionsmall vesselstotal occlusionUnparticular patientsunprotected left main artery stenosis       abciximab-coated stentbioabsorbable polymer stentdouble stentingdrug-eluting stentsnon-polymeric ESPCIprovisional T-stenting with drug-eluting stentsresordabletitanium-nitride-oxide coated stent candesartanabciximabbiolimus eluting stentdactinomycin eluting stentdrug-eluting stentseverolimus eluting stentpaclitaxelPCIsirolimus eluting stentzotarolimus eluting stent vs ballon angioplastyvs bare-metalvs no kissing balloonvs PTCAvs brachytherapyvs drug-eluting stentsvs single stentingvs surgery      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (156)myocardial infarction (fatal and non fatal) (144)target lesion revascularisation (144)Stent thrombosis (any, end of follow up) (132)MACE (119)angiographic restenosis (72)target-vessel revascularization (70)4y stent thrombosis (ARC) (57)late stent thrombosis (31days - 1year) (49)cardiac death (48)CABG (35)sub acute stent thrombosis (1-30 days) (27)Acute stent thrombosis (<=24h) (22)2 yr MACE (19)2 yr TLR (16)in-lesion binary restenosis (10)4 yr stent thrombosis (10)2 yr Death (all cause) (9)4 yr MI (8)4 yr TLR (8)4 yr mortality from all causes (5)4 yr death or MI (5)Long term death (1)long term cardiovascular events (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	myocardial infarction (fatal and non fatal)
coronary artery disease
abciximab
Kim, 2010	abciximab-coated stent	bare-metal stent			Exploratory	-
biolimus eluting stent
LEADERS, 2008      NCT	biolimus eluting stent	sirolimus eluting stent				negative
candesartan
SYNTAX (unprotected left main sub group), 2009	DES	CABG			Risk of bias	suggesting
dactinomycin eluting stent
ACTION, 2004	dactinomycin eluting stent	bare-metal stent				suggesting
drug-eluting stents
PASEO, 2009	drug-eluting stents	bare-metal stent				-
DEDICATION, 2008      NCT	drug-eluting stents	bare-metal stent			Risk of bias	suggesting
GENIUS-STEMI, 2009	Genous stent	bare-metal stent			Exploratory	negative
Boudriot, 2008	DES	CABG			Exploratory	negative
FREEDOM, 2012      NCT	PCI with drug-eluting stents	CABG			Risk of bias	negative
Hong, 2005	PCI withdrug-eluting stents	CABG			Risk of bias	-
everolimus eluting stent
FUTURE I, 2004	everolimus eluting stent	bare-metal stent				negative
FUTURE II, 2006	everolimus eluting stent	bare-metal stent			Low risk of bias	-
SPIRIT I, 2005    NCT	everolimus eluting stent	bare-metal stent			Exploratory	negative
BASKET-PROVE (EES), 2010	everolimus eluting stent	bare-metal stent				suggesting
RESET, 2011    NCT	everolimus eluting stent	sirolimus eluting stent				-
PLATINUM, 2011      NCT	everolimus eluting stent	everolimus eluting stent				-
SPIRIT II, 2006      NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
SPIRIT IV, 2010          NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III, 2008        NCT	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
COMPARE, 2009        NCT	everolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SPIRIT III (small vessel subgroup), 2009	everolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
SORT OUT IV, 2012      NCT	everolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ISAR-TEST 4 (EES vs SES)	everolimus eluting stent	sirolimus eluting stent				suggesting
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005	paclitaxel eluting stent	balloon angioplasty				suggesting
TAXUS I, 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS II, 2003      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV, 2004        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SCORE, 2004	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS V (all patients), 2005    NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI, 2005        NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
Erglis, 2007	paclitaxel eluting stent	bare-metal stent				suggesting
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent				suggesting
TAXUS II (diabetics), 2003	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS IV (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS V (diabetics), 2005	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
TAXUS VI (diabetics), 2005      NCT	paclitaxel eluting stent	bare-metal stent			Low risk of bias	suggesting
SOS, 2008        NCT	paclitaxel eluting stent	bare-metal stent			Exploratory	suggesting
TAXUS V small vessels sub groups	paclitaxel eluting stent	bare-metal stent				-
ASPECT, 2003      NCT	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	suggesting
ELUTES, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent				negative
DELIVER, 2004	paclitaxel, non-polymeric eluting stent	bare-metal stent			Risk of bias	negative
PATENCY, 2002	paclitaxel, non-polymeric eluting stent	bare-metal stent			Low risk of bias	negative
TAXUS V ISR, 2006      NCT	paclitaxel eluting balloon	brachytherapy			Risk of bias	-
SYNTAX, 2009          NCT	paclitaxel eluting stent	CABG			Risk of bias	suggesting
ISAR-test (diabetics), 2006	paclitaxel eluting stent	sirolimus eluting stent			Risk of bias	-
sirolimus eluting stent
ISAR-DESIRE (SES vs PTCA), 2005	sirolimus eluting stent	balloon angioplasty				suggesting
Kochiadakis, 2007	sirolimus eluting stent	bare-metal stent			Exploratory	-
RAVEL, 2002      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
SIRIUS, 2003            NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
C-SIRIUS, 2004      NCT	sirolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
E-SIRIUS, 2003      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMART, 2004	sirolimus eluting stent	bare-metal stent				suggesting
DIABETES, 2005	sirolimus eluting stent	bare-metal stent				suggesting
Pache et al, 2005	sirolimus eluting stent	bare-metal stent				suggesting
PRISON II, 2006      NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
TYPHOON, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007        NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
DECODE, 2005      NCT	sirolimus eluting stent	bare-metal stent				suggesting
SCORPIUS, 2007    NCT	sirolimus eluting stent	bare-metal stent				suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Ortolani et al, 2007	sirolimus eluting stent	bare-metal stent				-
Pasceri, 2003	sirolimus eluting stent	bare-metal stent				-
GISSOC II, 2010      NCT	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent				suggesting
BASKET-PROVE (SES), 2010	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Ravel (diabetics), 2004	sirolimus eluting stent	bare-metal stent				suggesting
SES-SMARt (diabetics), 2005	sirolimus eluting stent	bare-metal stent				suggesting
DESSERT, 2008	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
SIRIUS (diabetics), 2003	sirolimus eluting stent	bare-metal stent			Low risk of bias	-
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent				-
RRISC, 2006    NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
SCANDSTENT (subgroup), 2006	sirolimus eluting stent	bare-metal stent			Exploratory	suggesting
CRISTAL    NCT	sirolimus eluting stent	PTCA				-
RIBS-II, 2008	sirolimus eluting stent	PTCA				suggesting
SISR, 2007        NCT	sirolimus eluting stent	brachytherapy			Risk of bias	suggesting
PRECOMBAT, 2011    NCT	sirolimus eluting stent	CABG				-
Thiele, 2009    NCT	PCI withsirolimus ES	MIDCAB			Risk of bias	-
Tomai, 2008	sirolimus eluting stent	paclitaxel eluting stent				-
TAXi, 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-DESIRE (SES vs PES), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
ISAR-DIABETES, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
SIRTAX (Windecker), 2005	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
CORPAL, 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
REALITY, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ISAR-SMART 3, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Zhang (SES vs PES), 2006	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	negative
LONG DES II, 2006	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
SORT OUT II, 2008      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Cervinka, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Petronio et al, 2007	sirolimus eluting stent	paclitaxel eluting stent				negative
Han, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
BASKET (vs paclitaxel), 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-TEST-1, 2006      NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ISAR-LEFT-MAIN, 2009      NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
Kim, 2008	sirolimus eluting stent	paclitaxel eluting stent				negative
Pan, 2007	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	suggesting
DES-DIABETES, 2008	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
SIRTAX diabetics, 2005        NCT	sirolimus eluting stent	paclitaxel eluting stent				negative
TAxi (diabetics)	sirolimus eluting stent	paclitaxel eluting stent				-
REALITY (diabetics), 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
ISAR-DESIRE-2, 2010    NCT	sirolimus eluting stent	paclitaxel eluting stent			Risk of bias	-
Wessely, 2008	sirolimus eluting stent	paclitaxel eluting stent			Exploratory	-
SIRTAX (small vessels subgroup), 2005	sirolimus eluting stent	paclitaxel eluting stent				suggesting
zotarolimus eluting stent
ENDEAVOR II, 2006	zotarolimus eluting stent	bare-metal stent			Low risk of bias	suggesting
RESOLUTE All comers, 2010        NCT	zotarolimus eluting stent	everolimus eluting stent			Risk of bias	negative
TWENTE, 2012      NCT	zotarolimus eluting stent	everolimus eluting stent	click to display paper's table" >			-
ENDEAVOR IV, 2009        NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	suggesting
ZEST AMI (vs PES), 2009      NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZoMaxx I, 2008	zotarolimus eluting stent	paclitaxel eluting stent				-
ZEST (vs PES), 2009    NCT	zotarolimus eluting stent	paclitaxel eluting stent				suggesting
ENDEAVOR III, 2006        NCT	zotarolimus eluting stent	sirolimus eluting stent				suggesting
PROTECT, 2012    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	-
ZEST (vs SES), 2009    NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative
SORT-OUT-3, 2010      NCT	zotarolimus eluting stent	sirolimus eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009      NCT	zotarolimus eluting stent	sirolimus eluting stent				negative