angiotensin-Converting Enzyme Inhibitors

systematic review meta-analysis network meta-analysis

Select acute myocardial infarctionheart failurepatients at high risk for cardiovascular events all type of heart failureAll type of patientelderly patientsMI patients with LV dysfunction without clinical evidence of HFuncoded clinical condition ***patients with or without HFpatients with preserved-LVEF heart failuresystematic early treatment (with or without sign of HF)       angiotensin receptor blockerAngiotensin-Converting Enzyme Inhibitorsintravenous ACEI captoprilenalaprilfosinoprillisinoprilperindoprilquinaprilramipriltrandolaprilzofenoprilirbesartanbenazeprilcilazapril vs placebo or controlvs placebo or no treatmentvs angiotensin-converting enzyme inhibitorsvs vasodilators      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (86)Death from any cause or hospitalization for any reason (34)NYHA class improvement (16)Long term death (14)Cardiovascular death (7)cardiovascular events (7)Revascularization (7)stroke (fatal and non fatal) (6)hospitalisation for heart failure (5)Non fatal MI (5)Coronary event (5)Adverse events leading to treatment discontinuation (4)Cough (4)Hypotension (4)angiodema (3)cardiovascular death, MI, stroke (2)death or severe congestive heart failure (2)death or severe congestive heart failure (1)Coronary death (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Death from any cause or hospitalization for any reason
acute myocardial infarction
captopril
Bussmann, 1992	captopril	placebo			Low risk of bias	-
Mortarino, 1990	captopril	placebo			Low risk of bias	-
Sogaard, 1994	captopril	placebo			Low risk of bias	-
Pfeffer, 1988	captopril	placebo			Low risk of bias	-
ISIS-4, 1995	captopril	placebo			Low risk of bias	-
CATS, 1996	captopril	placebo			Low risk of bias	-
CCS-1, 1995	captopril	placebo			Low risk of bias	-
Sharpe, 1988	captopril	placebo			Low risk of bias	-
French, 1999	captopril	placebo			Low risk of bias	-
ECCE, 1997	captopril	placebo			Low risk of bias	-
Sharpe, 1991	captopril	placebo			Low risk of bias	-
Ray, 1993	captopril	placebo			Low risk of bias	-
SAVE, 1992	captopril	placebo			Low risk of bias	-
Hargreaves, 1992	captopril	placebo			Low risk of bias	-
Galcera, 1993	captopril	placebo			Low risk of bias	-
Di Pasquale, 1997	captopril	placebo			Low risk of bias	-
Di Pasquale, 1994	captopril	placebo			Low risk of bias	-
Nabel, 1991	captopril	placebo			Low risk of bias	-
PRACTICAL (captopril), 1994	captopril or enalapril	placebo			Low risk of bias	-
enalapril
CONSENSUS 2, 1992	enalapril	placebo			Low risk of bias	-
Schulman, 1995	enalapril	placebo			Low risk of bias	-
fosinopril
FAMIS, 1998	fosinopril	placebo			Low risk of bias	-
lisinopril
GISSI 3, 1994	lisinopril	placebo			Risk of bias	-
ramipril
AIRE, 1993	ramipril	placebo			Low risk of bias	-
Wagner, 2002	ramipril	placebo			Low risk of bias	-
trandolapril
TRACE, 1995	trandolapril	placebo			Low risk of bias	-
zofenopril
SMILE, 1995	zofenopril	placebo			Low risk of bias	suggesting
heart failure
benazepril
McGany, 1991	benazepril	control				negative
Colfer, 1992	benazepril	placebo			Low risk of bias	negative
captopril
Captopril Digoxin Multicenter Research Group, 1988	captopril	placebo			Low risk of bias	negative
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995	captopril	placebo			Low risk of bias	-
Magnani, 1990	captopril	placebo			Low risk of bias	-
CMRG, 1983	captopril	placebo			Low risk of bias	-
Munich MHFT (Kleber), 1992	captopril	placebo			Low risk of bias	negative
Barabino, 1991	captopril	placebo			Low risk of bias	suggesting
Bussmann, 1987	captopril	placebo			Low risk of bias	negative
Magnani, 1986	captopril	placebo			Low risk of bias	-
SAVE, 1992	captopril	placebo			Low risk of bias	-
Pfeffer, 1988	captopril	placebo			Low risk of bias	-
Sogaard, 1994	captopril	placebo			Low risk of bias	-
Sharpe, 1988	captopril	placebo			Low risk of bias	-
Mortarino, 1990	captopril	placebo			Low risk of bias	-
packer, 1986	captopril	enalapril			Exploratory	-
cilazapril
Drexler, 1989	cilazapril	placebo			Low risk of bias	negative
Dosseger, 1993	cilazapril	placebo			Low risk of bias	-
Cilazapril-Captopril Multi-centre Group, 1995	cilazapril	placebo			Low risk of bias	-
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995	cilazapril	captopril			Low risk of bias	-
enalapril
Rucinska-a (enalapril), 1991	enalapril	control				negative
Enalapril CHF investigators, 1987	enalapril	control				negative
Rucinska-b (enalapril), 1991	enalapril	control				negative
SOLVD treatment, 1991    NCT	enalapril	placebo			Low risk of bias	suggesting
SOLVD prevention, 1992    NCT	enalapril	placebo			Low risk of bias	-
Cleland, 1985	enalapril	placebo			Low risk of bias	negative
Dickstein, 1991	enalapril	placebo			Low risk of bias	negative
Sharpe, 1984	enalapril	placebo			Low risk of bias	-
McGrath, 1985	enalapril	placebo			Low risk of bias	-
Chrysant, 1985	enalapril	placebo			Low risk of bias	-
CONSENSUS, 1987	enalapril	placebo			Low risk of bias	negative
CASSIS (enalapril), 1995	enalapril	placebo			Low risk of bias	-
NETWORK (2.5 bid vs 10 bid), 1998	enalapril	enalapril			Low risk of bias	-
NETWORK (5 bid vs 10 bid), 1998	enalapril	enalapril			Low risk of bias	-
V-HeFT II, 1991	enalapril	hydralazine+ISDN			Low risk of bias	-
fosinopril
FEST (Erhardt), 1996	fosinopril	placebo			Low risk of bias	-
Brown, 1995	fosinopril	placebo			Low risk of bias	-
lisinopril
Rucinska-c (lisinopril), 1000	lisinopril	control				negative
Zwehl, 1990	lisinopril	control				negative
Giles, 1990	lisinopril	control				negative
International Study Group (Lewis), 1989	lisinopril	placebo			Low risk of bias	-
Gilbert, 1993	lisinopril	placebo			Low risk of bias	negative
ATLAS, 1999	lisinopril	lisinopril			Low risk of bias	-
perindopril
Lechat, 1993	perindopril	placebo			Low risk of bias	negative
PEP CHF, 2006	perindopril	placebo			Low risk of bias	negative
quinapril
Uprichard-c, 1994		control				negative
Uprichard-a, 1994		control				negative
Uprichard-b, 1994		control				negative
Northridge, 1991		placebo			Low risk of bias	negative
Riegger, 1990		placebo			Low risk of bias	negative
Quinapril Heart Failure Trial Investigators, 1993		placebo			Low risk of bias	-
Nussberger, 1994		placebo			Low risk of bias	-
Rieger, 1991		placebo			Low risk of bias	negative
ramipril
Swedberg, 1991	ramipril	control				negative
Maass-c, 1991	ramipril	placebo			Low risk of bias	negative
Gundersen, 1994	ramipril	placebo			Low risk of bias	-
Lemarie, 1992	ramipril	placebo			Low risk of bias	negative
Maass-a, 1991	ramipril	placebo				negative
Gordon, 1991	ramipril	placebo			Low risk of bias	suggesting
AIRE, 1993	ramipril	placebo			Low risk of bias	-
Maass-b, 1991	ramipril	placebo			Low risk of bias	negative
trandolapril
Hampton, 1998	trandolapril	placebo			Low risk of bias	-
TRACE, 1995	trandolapril	placebo			Low risk of bias	-
patients at high risk for cardiovascular events
enalapril
CAMELOT (enalapril), 2004	enalapril	placebo			Low risk of bias	negative
perindopril
EUROPA, 2003	perindopril	placebo			Low risk of bias	suggesting
quinapril
QUIET, 2001	quinapril	placebo			Low risk of bias	negative
ramipril
HOPE, 2000	ramipril	placebo			Low risk of bias	suggesting
ONTARGET (association vs ramipril), 2008    NCT	telmisartan + ramipril	ramipril			Low risk of bias	negative
ONTARGET (association vs telmisartan), 2008    NCT	telmisartan + ramipril	telmisartan			Low risk of bias	suggesting
trandolapril
PEACE, 2004      NCT	trandolapril	placebo			Low risk of bias	suggesting