patients at high risk for cardiovascular events

systematic review meta-analysis network meta-analysis

Select angiotensin-Converting Enzyme Inhibitorsangiotensin-receptor blockersinhibition of the renin-angiotensin system (ACEI or ARB) All type of patientpatients intolerant to ACE inhibitors       angiotensin receptor blockerangiotensin-converting enzyme inhibitorsendopeptidase inhibitors enalaprilperindoprilquinaprilramipriltrandolaprillosartantelmisartancandesartan vs placebo or controlvs beta-blockersvs calcium-channel blockers      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (27)Cardiovascular death (27)cardiovascular events (26)stroke (fatal and non fatal) (25)Revascularization (21)Coronary event (20)Adverse events leading to treatment discontinuation (15)Cough (15)Hypotension (15)angiodema (13)Non fatal MI (10)cardiovascular death, MI, stroke (7)myocardial infarction (fatal and non fatal) (6)Heart failure (5)Diabetes onset (5)Cancer (5)cardiac death (2)lung cancer (2)Coronary death (2)cancer related death (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Cardiovascular death
angiotensin-Converting Enzyme Inhibitors
enalapril
CAMELOT (enalapril), 2004	enalapril	placebo			Low risk of bias	negative
perindopril
EUROPA, 2003	perindopril	placebo			Low risk of bias	suggesting
quinapril
QUIET, 2001	quinapril	placebo			Low risk of bias	negative
ramipril
HOPE, 2000	ramipril	placebo			Low risk of bias	suggesting
ONTARGET (association vs ramipril), 2008    NCT	telmisartan + ramipril	ramipril			Low risk of bias	negative
ONTARGET (association vs telmisartan), 2008    NCT	telmisartan + ramipril	telmisartan			Low risk of bias	suggesting
trandolapril
PEACE, 2004      NCT	trandolapril	placebo			Low risk of bias	suggesting
angiotensin-receptor blockers
not classified
Ruilope, 2010	LCZ696	placebo			Low risk of bias	-
VALUE, 2004      NCT	valsartan	amlodipine			Low risk of bias	suggesting
candesartan
SCOPE, 2003	candesartan	placebo			Low risk of bias	negative
losartan
RENAAL, 2001	losartan	placebo			Low risk of bias	-
LIFE, 2002	losartan	atenolol			Low risk of bias	suggesting
ramipril
ONTARGET (association vs ramipril), 2008    NCT	telmisartan + ramipril	ramipril			Low risk of bias	negative
ONTARGET (association vs telmisartan), 2008    NCT	telmisartan + ramipril	telmisartan			Low risk of bias	suggesting
telmisartan
TRANSCEND, 2008    NCT	telmisartan	placebo			Low risk of bias	suggesting
PROPHESS, 2008      NCT	telmisartan	placebo			Low risk of bias	negative
ONTARGET (telmisartan alone), 2008      NCT	telmisartan	ramipril			Low risk of bias	suggesting
inhibition of the renin-angiotensin system (ACEI or ARB)
enalapril
CAMELOT (enalapril), 2004	enalapril	placebo			Low risk of bias	negative
perindopril
EUROPA, 2003	perindopril	placebo			Low risk of bias	suggesting
quinapril
QUIET, 2001	quinapril	placebo			Low risk of bias	negative
ramipril
HOPE, 2000	ramipril	placebo			Low risk of bias	suggesting
ONTARGET (association vs ramipril), 2008    NCT	telmisartan + ramipril	ramipril			Low risk of bias	negative
ONTARGET (association vs telmisartan), 2008    NCT	telmisartan + ramipril	telmisartan			Low risk of bias	suggesting
telmisartan
TRANSCEND, 2008    NCT	telmisartan	placebo			Low risk of bias	suggesting
ONTARGET (telmisartan alone), 2008      NCT	telmisartan	ramipril			Low risk of bias	suggesting
trandolapril
PEACE, 2004      NCT	trandolapril	placebo			Low risk of bias	suggesting