thrombosis prevention

systematic review meta-analysis network meta-analysis

Select graduated compression stockingsmechanical devices for thromboprophylaxisanticoagulantantiplatelets drugantithromboticsdirect antithrombinsdirect factor Xa inhibitorsdirect oral anticoagulant (DAO)heparin (UFH or LMWH)LMWHpentasaccharideUFH abdominal surgeryAll type of patientall type of surgeryarthroscopyelective hip replacementelective major knee surgerygeneral surgerygynaecological surgeryhip Fracturemedical patientsneurosurgeryorthopaedic surgeryorthopedic surgeryuncoded clinical condition ***urologic surgery       antivitamins Kdirect factor Xa inhibitorsextended prophylaxisExtended-duration prophylaxisFootpump as adjunctive therapyFootpump monotherapyGCS (adjunctive therapy)Graduated compression stockings IPCIPC adjunctive therapyIPC monotherapyLMWHLow molecular weight heparinmechanicalNOACoral direct thrombin inhibitorplatelet aggregation inhibitorsrecombinant hirudinsynthetic oligosaccharideUFHunfractionated heparin candesartanLMWHacenocoumarolapixabanardeparinaspirinbetrixaban CertoparindabigatrandalteparindeltaparindipyridamoledoxabanenoxaparinfondaparinuxfraxiparinnadroparinphenindionereviparinrivaroxabansuloctidilticlopidinetinzaparinUFHwarfarinximelagatran vs controlvs control or placebovs LMWHvs pentascharidevs placebo or controlvs placebo or no treatmentvs antiplatelet drugsvs aspirinvs Danaparoidvs Dextranvs DHEvs fondaparinuxvs GCSvs heparinvs intermittent pneumatic compressionvs IPCvs Low molecular weight heparinvs oral anticoagulantvs UFHvs Unfractionated heparin      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	Deep vein thrombosis (711)non-fatal pulmonary embolism (476)Major bleeding (462)Bleeding (436)fatal pulmonary embolism (429)All cause death (310)asymptomatic DVT (263)Symptomatic pulmonary embolism (256)wound haematoma / infection (243)Fatal bleeding (203)Symptomatic venous thromboembolism (DVT, PE) (189)proximal DVT (173)total VTE and all-cause mortality (123)Symptomatic deep-vein thrombosis (107)transfusion (107)non pulmonary embolism death (104)distal DVT (98)major VTE (fatal and non fatal DVT,PE) (98)pulmonary embolism (symptomatic and asymptomatic) (77)major or clinically relevant non-major bleeding (75)Coronary event (75)Venous thromboembolism (64)myocardial infarction (fatal and non fatal) (33)Minor bleeding (14)Venous thromboembolism or death (8)any bleedings (7)proximal deep-vein thrombosis (6)net benefit (2) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	Deep vein thrombosis	non-fatal pulmonary embolism
anticoagulant
not classified
Borsgtrom, 1965		no treatment				-
acenocoumarol
Hamulyak, 1994	Acenocoumarol	Nadroparin				negative
Samama, 2001	Acenocoumarol	Reviparin				negative
van Geloven, 1977	Acenocoumarol	unfractionated heparin			Low risk of bias	-
apixaban
ADVANCE 3, 2010    NCT	apixaban	enoxaparin	hip surgery		Low risk of bias	suggesting
ADVANCE 2, 2010      NCT	apixaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
APROPOS 2.5mg, 2007    NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
ADVANCE-1, 2008      NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
dabigatran
RE-NOVATE (150mg), 2007      NCT	dabigatran 150mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE (220mg), 2007      NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE 2    NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-MODEL (150mg), 2007	dabigatran 150mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MODEL (220mg), 2007	dabigatran 220mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (150mg), 2008	dabigatran 150mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (220mg), 2008	dabigatran 220mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
edoxaban
STARS J-V    NCT	edoxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
phenindione
Eskeland, 1966	Phenindione	no treatment				-
Hamilton, 1970	Phenindione	no treatment				-
rivaroxaban
RECORD 1, 2008      NCT	rivaroxaban	enoxaparin	hip surgery		Low risk of bias	suggesting
RECORD 3, 2008    NCT	rivaroxaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
ODIXa-HIP 10mg, 2006	rivaroxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
RECORD 2, 2008    NCT	rivaroxaban (long duration)	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
ODIXa-KNEE, 2005	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RECORD 4, 2009    NCT	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
warfarin
Pinto, 1970	Warfarin	no treatment				-
Hume, 1973	Warfarin	no treatment				-
Morris, 1976	Warfarin	no treatment				-
Powers, 1989	Warfarin	no treatment				-
Myrhe, 1969	Warfarin	placebo			Low risk of bias	-
RD Heparin, 1994	Warfarin	Ardeparin				suggesting
Heit, 1997	Warfarin	Ardeparin			Low risk of bias	suggesting
Powers, 1989	Warfarin	Aspirin				-
Lotke, 1997	Warfarin	Aspirin				-
Francis, 1997	Warfarin	Dalteparin				suggesting
Hull, 2000	Warfarin	Dalteparin			Low risk of bias	suggesting
Gerhart, 1991	Warfarin	Danaparoid				-
van Comp, 1998	Warfarin	Danaparoid				-
Myrhe, 1969	Warfarin	Dextran			Low risk of bias	-
Harris, 1972	Warfarin	Dextran				-
Barber, 1977	Warfarin	Dextran				-
Francis, 1983	Warfarin	Dextran				-
Leclerc, 1996	Warfarin	Enoxaparin			Low risk of bias	suggesting
Colwell, 1999	Warfarin	Enoxaparin				suggesting
Fitzgerald, 2001	Warfarin	Enoxaparin				suggesting
Paiement, 1987	Warfarin	Intermittent pneumatic compression				-
Bailey, 1991	Warfarin	Intermittent pneumatic compression				-
Kaempffe, 1991	Warfarin	Intermittent pneumatic compression				-
Francis, 1992	Warfarin	Intermittent pneumatic compression				-
Hull, 1993	Warfarin	Logiparin			Low risk of bias	suggesting
Hume, 1973	Warfarin	Sudoxicam				-
Hume, 1973	Warfarin	unfractionated heparin				-
Barber, 1977	Warfarin	unfractionated heparin				-
antiplatelets drug
not classified
Veth, 1985	sp	control			Risk of bias	-
Mocris-C , 1977	Flurbiprofen	no treatment			Exploratory	negative
Massachusetts-I , 1981	Hydroxychloroquine	no treatment			Exploratory	negative
Denver-Il , 1980	dipyridamol + ASA	placebo			Low risk of bias	negative
Carter IA, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter IB, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter II, 1974	hydroxychloroquine	placebo			Low risk of bias	-
New York, 1977	hydroxychloroquine	placebo			Low risk of bias	-
Vermont, 1975	hydroxychloroquine	placebo			Low risk of bias	-
Massachusetts-II, 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Cooke, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Hume-A, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Stockholm-II, 1981	Hydroxychloroquine	placebo			Exploratory	negative
Danish-A , 1976	Hydroxychloroquine	placebo			Exploratory	negative
Danish-B , 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Wood , 1973	RA233	placebo			Exploratory	negative
Athens, 1981	sp	placebo			Low risk of bias	-
aspirin
Clagett, 1975	aspirin	control			Risk of bias	-
Zekert VI, 1982	aspirin	control			Risk of bias	-
Pasteyer, 1977	Aspirin	no treatment			Exploratory	negative
Rocha, 1986	Aspirin	no treatment			Exploratory	suggesting
Stockholm-I, 1975	Aspirin	placebo			Exploratory	negative
Harris-I, 1977	Aspirin	placebo			Low risk of bias	suggesting
McKenna-I, 1980	Aspirin	placebo			Exploratory	suggesting
Sautter, 1983	Aspirin	placebo			Exploratory	suggesting
McBride, 1983	Aspirin	placebo			Exploratory	negative
Zekert-I , 1974	Aspirin	placebo			Exploratory	suggesting
Powers , 1976	Aspirin	placebo			Exploratory	suggesting
Erfurt-B , 1979	Aspirin	placebo			Exploratory	negative
PEP hip-fracture, 2000	aspirin	placebo			Low risk of bias	suggesting
MRC, 1972	aspirin	placebo			Low risk of bias	negative
Loew DVT, 1974	aspirin	placebo			Low risk of bias	-
Erfurt-A, 1979	aspirin	placebo			Low risk of bias	-
Zekert V, 1980	aspirin	placebo			Low risk of bias	-
Vinazzer I, 1980	aspirin	placebo			Low risk of bias	-
Vinazzer II, 1977	aspirin	placebo			Low risk of bias	-
PEP elective arthroplasty, 2000	aspirin	placebo			Low risk of bias	-
dipyridamol
Chicago, 1982	aspirin + dipyridamol	control			Exploratory	negative
Parodi I, 1973	dipyridamol + aspirin	control			Exploratory	suggesting
Parodi II, 1973	dipyridamol + aspirin	control			Risk of bias	-
Zekert-III, 1977	dipyridamol + aspirin	control			Risk of bias	-
Australian I, 1975	dipyridamol + aspirin	control			Risk of bias	-
Australian II, 1976	dipyridamol + aspirin	control			Risk of bias	-
Toulouse I, 1979	dipyridamol + aspirin	control			Risk of bias	-
Harjola DVT, 1982	dipyridamol + aspirin	control			Risk of bias	-
Weiss, 1977	dipyridamol + aspirin	control			Exploratory	-
Lyon-I, 1975	aspirin + dipyridamol	no treatment			Exploratory	suggesting
Morris-B , 1977	aspirin + dipyridamol	no treatment			Exploratory	negative
Morris-A , 1977	dipyridamol	no treatment			Exploratory	negative
Hamburg, 1976	aspirin + dipyridamol	placebo			Exploratory	negative
Encke-II , 1976	aspirin + dipyridamol	placebo			Exploratory	negative
Frankfurt, 1981	aspirin + dipyridamol	placebo			Low risk of bias	negative
Encke IA, 1976	dipyridamol + aspirin	placebo			Low risk of bias	-
Encke IB, 1976	dipyridamol + aspirin	placebo			Low risk of bias	-
suloctidil
Turpie, 1985	Suloctidil	placebo			Low risk of bias	-
ticlopidine
Lasierra, 1982	ticlopidine	placebo			Low risk of bias	-
Walker, 1974	ticlopidine	placebo			Low risk of bias	-
McKenna-II , 1983	ticlopidine	placebo			Low risk of bias	negative
McKenna-II, 1983	Ticlopidine	placebo			Exploratory	negative
Lyon-II	Ticlopidine	placebo			Exploratory	negative
Gardecki	Ticlopidine	placebo			Exploratory	negative
UFH
Morris, 1974	UFH	no treatment				suggesting
Welin-Berger, 1982	UFH	no treatment				negative
Bergqvist , 1979	UFH	no treatment				suggesting
VTCSG, 1975	UFH	no treatment				negative
Mannucci , 1976	UFH	no treatment				suggesting
Dechavanne, 1974	UFH	no treatment				suggesting
Dechavanne, 1975	UFH	no treatment				suggesting
Bergqvist, 1979	UFH	no treatment				suggesting
Galasko , 1976	UFH	no treatment				suggesting
Gallus , 1973	UFH	no treatment				suggesting
Morris , 1977	UFH	no treatment				negative
Williams , 1978	UFH	placebo				negative
Abraham-Inpijn , 1975	UFH	placebo				negative
Hampson, 1974	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				suggesting
Lahnborg, 1980	UFH	placebo				suggesting
Xabregas , 1977	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				negative
Svend-Hansen, 1981	UFH	placebo				suggesting
antithrombotics
not classified
Veth, 1985	sp	control			Risk of bias	-
Cohen (L8405), 2007	compression stocking group	control (on top fondaparinux)	hip surgery		Risk of bias	negative
SAVE-HIP1, 2012      NCT	semuloparin	enoxaparin	hip surgery			suggesting
SAVE-KNEE, 2012      NCT	semuloparin	enoxaparin	knee surgery			negative
SAVE-HIP 2, 2012      NCT	semuloparin	enoxaparin	hip surgery			negative
EXCLAIM, 2010      NCT	Extended-duration prophylaxis	error	medical patients		Low risk of bias	suggesting
Borsgtrom, 1965		no treatment				-
Mocris-C , 1977	Flurbiprofen	no treatment			Exploratory	negative
Massachusetts-I , 1981	Hydroxychloroquine	no treatment			Exploratory	negative
Denver-Il , 1980	dipyridamol + ASA	placebo			Low risk of bias	negative
Valle , 1988	fluxum	placebo				negative
Massachusetts-II, 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Cooke, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Hume-A, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Stockholm-II, 1981	Hydroxychloroquine	placebo			Exploratory	negative
Danish-A , 1976	Hydroxychloroquine	placebo			Exploratory	negative
Danish-B , 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Carter IA, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter IB, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter II, 1974	hydroxychloroquine	placebo			Low risk of bias	-
New York, 1977	hydroxychloroquine	placebo			Low risk of bias	-
Vermont, 1975	hydroxychloroquine	placebo			Low risk of bias	-
Dahan, 1986	Pharmuka	placebo	medical patients		Low risk of bias	suggesting
Wood , 1973	RA233	placebo			Exploratory	negative
Athens, 1981	sp	placebo			Low risk of bias	-
Marlovits, 2007	extended-duration thromboprophylaxis	standard-duration thromboprophylaxis			Risk of bias	suggesting
DRIVE, 2008    NCT	SR123781A	enoxaparin	hip surgery		Low risk of bias	-
PENTHIFRA–PLUS (Eriksson), 2003	extended prophylaxis	standard prophylaxis	hip surgery		Low risk of bias	-
Lausen, 1998	extended prophylaxis	standard prophylaxis				negative
ENOXACAN II (Bergqvist), 2002	extended prophylaxis	standard prophylaxis			Low risk of bias	suggesting
FAME (Rasmussen), 2006	extended prophylaxis	standard prophylaxis				suggesting
Limmer, 1994	antixarin	unfractionated heparin	general surgery			-
Chiapuzzo , 1988	fluxum	Unfractionated heparin	hip surgery			negative
Pini , 1989	fluxum	Unfractionated heparin	hip surgery			negative
Catania, 1988	parnaparin	unfractionated heparin	abdominal surgery			negative
Salcuni, 1988	parnaparin	unfractionated heparin	abdominal surgery			negative
Verardi, 1989	parnaparin	unfractionated heparin	abdominal surgery			negative
Garcea, 1992	parnaparin	unfractionated heparin	abdominal surgery			-
ToÈrngren, 1984	SSHA	unfractionated heparin	general surgery			negative
acenocoumarol
Hamulyak, 1994	Acenocoumarol	Nadroparin				negative
Samama, 2001	Acenocoumarol	Reviparin				negative
van Geloven, 1977	Acenocoumarol	unfractionated heparin			Low risk of bias	-
apixaban
ADOPT, 2011      NCT	apixaban	enoxaparin	medical patients		Low risk of bias	suggesting
ADVANCE 3, 2010    NCT	apixaban	enoxaparin	hip surgery		Low risk of bias	suggesting
ADVANCE 2, 2010      NCT	apixaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
APROPOS 2.5mg, 2007    NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
ardeparin
Levine, 1996	ardeparin	placebo	knee surgery		Low risk of bias	suggesting
Heit, 2000	out of hospital Ardeparin	standard prophylaxis				negative
Godwin, 1993	ardeparin	unfractionated heparin	abdominal surgery			-
aspirin
Clagett, 1975	aspirin	control			Risk of bias	-
Zekert VI, 1982	aspirin	control			Risk of bias	-
Pasteyer, 1977	Aspirin	no treatment			Exploratory	negative
Rocha, 1986	Aspirin	no treatment			Exploratory	suggesting
PEP hip-fracture, 2000	aspirin	placebo			Low risk of bias	suggesting
Stockholm-I, 1975	Aspirin	placebo			Exploratory	negative
Harris-I, 1977	Aspirin	placebo			Low risk of bias	suggesting
McKenna-I, 1980	Aspirin	placebo			Exploratory	suggesting
Sautter, 1983	Aspirin	placebo			Exploratory	suggesting
McBride, 1983	Aspirin	placebo			Exploratory	negative
Zekert-I , 1974	Aspirin	placebo			Exploratory	suggesting
Powers , 1976	Aspirin	placebo			Exploratory	suggesting
Erfurt-B , 1979	Aspirin	placebo			Exploratory	negative
MRC, 1972	aspirin	placebo			Low risk of bias	negative
Loew DVT, 1974	aspirin	placebo			Low risk of bias	-
Erfurt-A, 1979	aspirin	placebo			Low risk of bias	-
Zekert V, 1980	aspirin	placebo			Low risk of bias	-
Vinazzer I, 1980	aspirin	placebo			Low risk of bias	-
Vinazzer II, 1977	aspirin	placebo			Low risk of bias	-
PEP elective arthroplasty, 2000	aspirin	placebo			Low risk of bias	-
betrixaban
APEX, 2016    NCT	betrixaban	enoxaparin	medical patients		Low risk of bias	suggesting
candesartan
Ericksson, 1997	desirudin	enoxaparin			Low risk of bias	-
REVASC, 1997	desirudin	UFH				-
Eriksson, 1996	desirudin	UFH			Low risk of bias	-
Certoparin
Kock, 1995	certoparin	control			Risk of bias	negative
CERTIFY, 2010	certoparin	UFH	medical patients			-
Schmitz-Huebner, 1984	certoparin	unfractionated heparin	abdominal surgery			negative
Sasahara, 1986	certoparin	unfractionated heparin	abdominal surgery			suggesting
Voigt, 1986	certoparin	unfractionated heparin	abdominal surgery			negative
Welzel, 1988	certoparin	unfractionated heparin	abdominal surgery			suggesting
Kakkar, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Adolf, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Heilmann, 1989	certoparin	unfractionated heparin	gynaecological surgery			negative
Baumgartner, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Hoffmann and Largiade, 1990	certoparin	unfractionated heparin	abdominal surgery			negative
Koppenhagen, 1990	certoparin	unfractionated heparin	abdominal surgery			-
Schielke, 1991	certoparin	unfractionated heparin	abdominal surgery			-
Koppenhagen, 1992	certoparin	unfractionated heparin	abdominal surgery			-
Hoffmann and Largiader, 1992	certoparin	unfractionated heparin	abdominal surgery			-
Heilmann, 1997	certoparin	unfractionated heparin	gynaecological surgery			-
Haas, 1999	certoparin	unfractionated heparin	general surgery			-
Haas , 1987	certoparine + DHE	Unfractionated heparin	hip surgery			negative
Lassen, 1988	certoparine + DHE	Unfractionated heparin	hip surgery		Low risk of bias	suggesting
Lassen, 1989	certoparine + DHE	Unfractionated heparin	hip surgery		Low risk of bias	negative
dabigatran
RE-NOVATE (150mg), 2007      NCT	dabigatran 150mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE (220mg), 2007      NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE 2    NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-MODEL (150mg), 2007	dabigatran 150mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MODEL (220mg), 2007	dabigatran 220mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (150mg), 2008	dabigatran 150mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (220mg), 2008	dabigatran 220mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
dalteparin
Jorgensen, 1989	dalteparin	placebo	hip surgery		Low risk of bias	suggesting
Torholm, 1991	dalteparin	placebo	hip surgery		Low risk of bias	suggesting
Leizorovicz, 2004	dalteparin	placebo	medical patients		Low risk of bias	suggesting
Ockelford , 1989	dalteparin	placebo				suggesting
Lapidus, 2007	dalteparin	placebo			Low risk of bias	negative
Lapidus, 2007	dalteparin	placebo			Low risk of bias	negative
D-KAf (Selby), 2007      NCT	dalteparin	placebo				negative
Eriksson , 1988	dalteparin	Dextran	hip surgery			suggesting
Matzsch , 1988	dalteparin	Dextran	hip surgery			negative
Matzsch , 1991	dalteparin	Dextran	hip surgery			suggesting
Dahl, 1997	out of hospital Dalteparin	standard prophylaxis				suggesting
Lassen, 1998	out of hospital Dalteparin	standard prophylaxis				negative
Hull, 2000	out of hospital Dalteparin	standard prophylaxis				suggesting
PROTECT, 2011    NCT	dalteparin	UFH	medical patients		Low risk of bias	suggesting
Scala, 1990	dalteparin	UFH			Risk of bias	negative
Haas , 1985	dalteparin	Unfractionated heparin	hip surgery			negative
Binsack , 1986	dalteparin	Unfractionated heparin	hip surgery			negative
Barre , 1987	dalteparin	Unfractionated heparin	hip surgery			negative
Dechavanne , 1989	dalteparin	Unfractionated heparin	hip surgery			negative
Eriksson , 1989	dalteparin	Unfractionated heparin	hip surgery			suggesting
Monreal , 1989	dalteparin	Unfractionated heparin	hip surgery			negative
Bergqvist, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Onarheim, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Fricker, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Bergqvist, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Caen, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Borstad, 1988	dalteparin	unfractionated heparin	gynaecological surgery			negative
Briel, 1988	dalteparin	unfractionated heparin	non orthopedic surgery			negative
Creperio, 1990	dalteparin	unfractionated heparin	general surgery			negative
Hartl, 1990	dalteparin	unfractionated heparin	abdominal surgery			suggesting
Borstad, 1992	dalteparin	unfractionated heparin	gynaecological surgery			-
Kakkar, 1993	dalteparin	unfractionated heparin	abdominal surgery			-
deltaparin
Michot, 2002	deltaparin	control			Risk of bias	suggesting
dipyridamol
Chicago, 1982	aspirin + dipyridamol	control			Exploratory	negative
Parodi I, 1973	dipyridamol + aspirin	control			Exploratory	suggesting
Parodi II, 1973	dipyridamol + aspirin	control			Risk of bias	-
Zekert-III, 1977	dipyridamol + aspirin	control			Risk of bias	-
Australian I, 1975	dipyridamol + aspirin	control			Risk of bias	-
Australian II, 1976	dipyridamol + aspirin	control			Risk of bias	-
Toulouse I, 1979	dipyridamol + aspirin	control			Risk of bias	-
Harjola DVT, 1982	dipyridamol + aspirin	control			Risk of bias	-
Weiss, 1977	dipyridamol + aspirin	control			Exploratory	-
Lyon-I, 1975	aspirin + dipyridamol	no treatment			Exploratory	suggesting
Morris-B , 1977	aspirin + dipyridamol	no treatment			Exploratory	negative
Morris-A , 1977	dipyridamol	no treatment			Exploratory	negative
Hamburg, 1976	aspirin + dipyridamol	placebo			Exploratory	negative
Encke-II , 1976	aspirin + dipyridamol	placebo			Exploratory	negative
Frankfurt, 1981	aspirin + dipyridamol	placebo			Low risk of bias	negative
Encke IA, 1976	dipyridamol + aspirin	placebo			Low risk of bias	-
Encke IB, 1976	dipyridamol + aspirin	placebo			Low risk of bias	-
edoxaban
STARS J-V    NCT	edoxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
enoxaparin
Canata, 2003	enoxaparin	control			Exploratory	negative
Warwick, 1995	enoxaparin	no treatment	hip surgery			negative
Ho [43]	enoxaparin	no treatment				negative
Turpie, 1986	enoxaparin	placebo	hip surgery		Low risk of bias	suggesting
Leclerc, 1991	enoxaparin	placebo	knee surgery		Low risk of bias	suggesting
Samama, 1997	enoxaparin	placebo	hip surgery		Low risk of bias	suggesting
Kalodiki, 1996	enoxaparin	placebo	hip surgery		Low risk of bias	-
MEDENOX, 1999	Enoxaparin	placebo	medical patients		Low risk of bias	suggesting
Lederle, 2006	Enoxaparin	placebo	medical patients		Low risk of bias	negative
LIFENOX, 2011      NCT	enoxaparin	placebo	medical patients		Low risk of bias	negative
LeGagneux , 1987	enoxaparin	placebo				negative
Agnelli, 1998	enoxaparin	placebo				suggesting
Melon, 1987	enoxaparin	placebo				negative
DES Group , 1991	enoxaparin	Dextran	hip surgery			suggesting
Bergqvist, 1996	out of hospital Enoxaparin	standard prophylaxis				suggesting
Planes, 1996	out of hospital Enoxaparin	standard prophylaxis				negative
Comp, 2001	out of hospital Enoxaparin	standard prophylaxis				suggesting
Bergmann and Neuhart, 1996	enoxaparin	UFH	medical patients		Low risk of bias	negative
Lechler, 1996	enoxaparin	UFH	medical patients		Low risk of bias	negative
Kleber, 2003	enoxaparin	UFH	medical patients			negative
Planes , 1988	enoxaparin	Unfractionated heparin	hip surgery			suggesting
Levine , 1991	enoxaparin	Unfractionated heparin	hip surgery			negative
Samama 1, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Samama 2, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Samama 3, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Kaaja, 1992	enoxaparin	unfractionated heparin	gynaecological surgery			-
Gazzaniga (ISG), 1993	enoxaparin	unfractionated heparin	general surgery			-
Nurmohamed, 1995	enoxaparin	unfractionated heparin	general surgery			-
McLeod (Canadian), 1995	enoxaparin	unfractionated heparin	abdominal surgery			-
Gonzalez, 1996	enoxaparin	unfractionated heparin	abdominal surgery			-
ENOXACAN, 1997	enoxaparin	unfractionated heparin	abdominal surgery			-
fondaparinux
DRI4757	fondaparinux	placebo	knee surgery		Low risk of bias	-
ARTEMIS (Cohen), 2006	fondaparinux	placebo	medical patients		Low risk of bias	negative
APOLLO (Turpie), 2007	fondaparinux	placebo (on top intermittent pneumatic comp.)	abdominal surgery		Low risk of bias	suggesting
PENTAMAKS (Bauer), 2001	fondaparinux	enoxaparin	knee surgery		Low risk of bias	suggesting
PENTHIFRA (Eriksson), 2001	fondaparinux	enoxaparin	hip surgery		Low risk of bias	suggesting
PENTATHLON (Turpie), 2002	fondaparinux	enoxaparin	hip surgery		Low risk of bias	suggesting
EPHESUS (Lassen), 2002	fondaparinux	enoxaparin	hip surgery		Low risk of bias	suggesting
Turpie, 2001	fondaparinux	enoxaparin	hip surgery		Low risk of bias	-
L8541	fondaparinux	enoxaparin	orthopaedic surgery		Low risk of bias	negative
L8635	fondaparinux	enoxaparin	knee surgery		Exploratory	negative
BRiEF    NCT	fondaparinux	enoxaparin	medical patients			-
PEGASUS, 2005	fondaparinux	enoxaparin	abdominal surgery		Low risk of bias	negative
fraxiparin
Roth, 1995	nadroparin	control				negative
Pezzuoli, 1989	nadroparin	placebo				suggesting
Leyvraz, 1991	nadroparin	Unfractionated heparin	hip surgery			negative
LMWH
Harenberg, 1990	LMWH	UFH	medical patients		Low risk of bias	negative
Harenberg, 1996	LMWH	UFH	medical patients		Low risk of bias	negative
nadroparin
KANT (7 days), 2008	nadroparin	control			Risk of bias	suggesting
Kujath, 1993	nadroparin	control			Risk of bias	suggesting
KANT (14 days), 2008	nadroparin 14d	control			Risk of bias	suggesting
Yoo, 1997	nadroparin	no treatment	hip surgery			negative
Marassi [41]	nadroparin	no treatment				negative
Sourmelis, 1995	nadroparin	placebo	hip surgery		Low risk of bias	suggesting
Fraisse, 2000	Nadroparin	placebo	medical patients		Low risk of bias	negative
Mahe, 2005	Nadroparin	placebo	medical patients		Low risk of bias	negative
Bergmann, 1996	nadroparin	placebo	medical patients			negative
Balas [40]	nadroparin	placebo				negative
Nurmohamed, 1996	nadroparin	placebo				negative
NPHDO, 1998	out of hospital Nadroparin	standard prophylaxis				negative
Kakkar and Murray, 1985	nadroparin	unfractionated heparin	general surgery			suggesting
EFS, 1988	nadroparin	unfractionated heparin	abdominal surgery			suggesting
Dahan, 1989	nadroparin	unfractionated heparin	thoracic surgery			negative
Barbui, 1990	nadroparin	unfractionated heparin	general surgery			-
Eurin, 1994	nadroparin	unfractionated heparin	abdominal surgery			-
phenindione
Eskeland, 1966	Phenindione	no treatment				-
Hamilton, 1970	Phenindione	no treatment				-
reviparin
Wirth, 2001	reviparin	control			Low risk of bias	negative
Lassen, 2002	reviparin	placebo			Low risk of bias	suggesting
Kakkar, 1993	reviparin	unfractionated heparin	general surgery			-
rivaroxaban
MARINER, 2018        NCT	rivaroxaban	placebo	medical patients		Low risk of bias	suggesting
RECORD 1, 2008      NCT	rivaroxaban	enoxaparin	hip surgery		Low risk of bias	suggesting
RECORD 3, 2008    NCT	rivaroxaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
ODIXa-HIP 10mg, 2006	rivaroxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
RECORD 2, 2008    NCT	rivaroxaban (long duration)	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
ODIXa-KNEE, 2005	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RECORD 4, 2009    NCT	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
suloctidil
Turpie, 1985	Suloctidil	placebo			Low risk of bias	-
ticlopidine
McKenna-II, 1983	Ticlopidine	placebo			Exploratory	negative
Lyon-II	Ticlopidine	placebo			Exploratory	negative
Gardecki	Ticlopidine	placebo			Exploratory	negative
McKenna-II , 1983	ticlopidine	placebo			Low risk of bias	negative
Lasierra, 1982	ticlopidine	placebo			Low risk of bias	-
Walker, 1974	ticlopidine	placebo			Low risk of bias	-
tinzaparin
Jorgensen, 2002	tinzaparin	control			Risk of bias	negative
Lassen, 1991	tinzaparin	placebo	hip surgery		Low risk of bias	suggesting
Bergqvist [42]	tinzaparin	placebo				negative
Leizorovicz, 1991	tinzaparin	unfractionated heparin	abdominal surgery			-
UFH
Blech, 1981	UFH	control	medical patients			suggesting
Cade	UFH	control	medical patients			-
Gardlund, 1996	UFH	control	medical patients			suggesting
Handley (low dose), 1972	UFH	control			Risk of bias	negative
Handley, 1972	UFH	control			Risk of bias	negative
Gallus, 1973	UFH	control			Risk of bias	negative
Emerson, 1973	UFH	control			Risk of bias	suggesting
Zawilska, 1989	UFH	control			Risk of bias	suggesting
Warlow, 1973	UFH	control			Low risk of bias	suggesting
Morris, 1974	UFH	no treatment				suggesting
Welin-Berger, 1982	UFH	no treatment				negative
Bergqvist , 1979	UFH	no treatment				suggesting
VTCSG, 1975	UFH	no treatment				negative
Mannucci , 1976	UFH	no treatment				suggesting
Dechavanne, 1974	UFH	no treatment				suggesting
Dechavanne, 1975	UFH	no treatment				suggesting
Bergqvist, 1979	UFH	no treatment				suggesting
Galasko , 1976	UFH	no treatment				suggesting
Gallus , 1973	UFH	no treatment				suggesting
Morris , 1977	UFH	no treatment				negative
Kakkar (IMT)	UFH	no treatment				-
Gruber	UFH	no treatment				-
Gordon-Smith, 1972	UFH	no treatment				-
Nicolaides, 1972	UFH	no treatment				-
Multiunit, 1974	UFH	no treatment				-
Abernethy, 1974	UFH	no treatment				-
Clarke-Pearson, 1983	UFH	no treatment				-
Plante, 1979	UFH	no treatment				-
Abraham-Inpijn, 1979	UFH	no treatment				-
Spebar, 1981	UFH	no treatment				-
Sagar, 1974	UFH	no treatment				-
Koppenhagen, 1982	UFH	no treatment				-
Bergqvist, 1980	UFH	no treatment				-
Gallus, 1973	UFH	no treatment				-
Gallus, 1976	UFH	no treatment				-
Groote Schuur, 1979	UFH	no treatment				-
Kraytman, 1976	UFH	no treatment				-
Kraytman, 1977	UFH	no treatment				-
Kettunen, 1974	UFH	no treatment				-
Caloghera, 1984	UFH	no treatment				-
Marchelli, 1983	UFH	no treatment				-
Ziemski, 1979	UFH	no treatment				-
Coe, 1978	UFH	no treatment				-
Sebeseri, 1975	UFH	no treatment				-
Allen, 1978	UFH	no treatment				-
Cerrato, 1978	UFH	no treatment				suggesting
Williams , 1978	UFH	placebo				negative
Abraham-Inpijn , 1975	UFH	placebo				negative
Lowe , 1981	UFH	placebo				suggesting
Hampson, 1974	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				suggesting
Lahnborg, 1980	UFH	placebo				suggesting
Xabregas , 1977	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				negative
Svend-Hansen, 1981	UFH	placebo				suggesting
Kakkar, 1972	UFH	placebo				-
Kiil, 1978	UFH	placebo				-
Torngren, 1978	UFH	placebo				-
Torngren	UFH	placebo				-
Lahnborg, 1975	UFH	placebo				-
Lahnborg, 1976	UFH	placebo				-
Covey, 1975	UFH	placebo				-
Belch, 1980	UFH	placebo				-
Taberner, 1978	UFH	placebo				-
Strand, 1975	UFH	placebo				-
Roberts, 1975	UFH	placebo				-
Ribaudo, 1975	UFH	placebo				-
Wu, 1977	UFH	placebo				-
Lawrence, 1977	UFH	placebo				-
Muiticentre, 1984	UFH	placebo				-
Jourdan, 1984	UFH	placebo				-
Torngren, 1978	UFH	placebo				-
Kruse-Blinkenberg, 1980	UFH	placebo				-
Kraytman, 1977	UFH	placebo				-
Marchetti, 1982	UFH	placebo				-
Bejjani, 1983	UFH	placebo				-
Hedlund, 1979	UFH	placebo				-
Kutnowski, 1977	UFH	placebo				-
Vandendris, 1980	UFH	placebo				-
Pitt, 1980	UFH	placebo			Risk of bias	negative
Loew, 1977	UFH	aspirin				-
Vinazzer, 1980	UFH	aspirin				-
Muiticentre 53,S4, 1984	UFH	DHE				-
Muiticentre, 1984	UFH	DHE				-
van Geloven, 1977	UFH	oral anticoagulant				-
Manganelli, 1998	out of hospital UFH	standard prophylaxis				negative
warfarin
Pinto, 1970	Warfarin	no treatment				-
Hume, 1973	Warfarin	no treatment				-
Morris, 1976	Warfarin	no treatment				-
Powers, 1989	Warfarin	no treatment				-
Myrhe, 1969	Warfarin	placebo			Low risk of bias	-
RD Heparin, 1994	Warfarin	Ardeparin				suggesting
Heit, 1997	Warfarin	Ardeparin			Low risk of bias	suggesting
Powers, 1989	Warfarin	Aspirin				-
Lotke, 1997	Warfarin	Aspirin				-
Francis, 1997	Warfarin	Dalteparin				suggesting
Hull, 2000	Warfarin	Dalteparin			Low risk of bias	suggesting
Gerhart, 1991	Warfarin	Danaparoid				-
van Comp, 1998	Warfarin	Danaparoid				-
Myrhe, 1969	Warfarin	Dextran			Low risk of bias	-
Harris, 1972	Warfarin	Dextran				-
Barber, 1977	Warfarin	Dextran				-
Francis, 1983	Warfarin	Dextran				-
Leclerc, 1996	Warfarin	Enoxaparin			Low risk of bias	suggesting
Colwell, 1999	Warfarin	Enoxaparin				suggesting
Fitzgerald, 2001	Warfarin	Enoxaparin				suggesting
Paiement, 1987	Warfarin	Intermittent pneumatic compression				-
Bailey, 1991	Warfarin	Intermittent pneumatic compression				-
Kaempffe, 1991	Warfarin	Intermittent pneumatic compression				-
Francis, 1992	Warfarin	Intermittent pneumatic compression				-
Hull, 1993	Warfarin	Logiparin			Low risk of bias	suggesting
Hume, 1973	Warfarin	Sudoxicam				-
Hume, 1973	Warfarin	unfractionated heparin				-
Barber, 1977	Warfarin	unfractionated heparin				-
ximelagatran
METHRO I, 2002	ximelagatran	Dalteparin				negative
METHRO II, 2002	ximelagatran	Dalteparin			Low risk of bias	suggesting
Phase II (Heit), 2001	ximelagatran	Enoxaparin			Low risk of bias	negative
Platinum (Colwell), 2003	ximelagatran	Enoxaparin			Low risk of bias	negative
METHRO III, 2002	ximelagatran	Enoxaparin			Low risk of bias	negative
EXPRESS, 2003	ximelagatran	Enoxaparin			Low risk of bias	suggesting
direct antithrombins
dabigatran
RE-NOVATE (150mg), 2007      NCT	dabigatran 150mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE (220mg), 2007      NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE 2    NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-MODEL (150mg), 2007	dabigatran 150mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MODEL (220mg), 2007	dabigatran 220mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (150mg), 2008	dabigatran 150mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (220mg), 2008	dabigatran 220mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
ximelagatran
METHRO I, 2002	ximelagatran	Dalteparin				negative
METHRO II, 2002	ximelagatran	Dalteparin			Low risk of bias	suggesting
Phase II (Heit), 2001	ximelagatran	Enoxaparin			Low risk of bias	negative
Platinum (Colwell), 2003	ximelagatran	Enoxaparin			Low risk of bias	negative
METHRO III, 2002	ximelagatran	Enoxaparin			Low risk of bias	negative
EXPRESS, 2003	ximelagatran	Enoxaparin			Low risk of bias	suggesting
direct factor Xa inhibitors
apixaban
ADVANCE 3, 2010    NCT	apixaban	enoxaparin	hip surgery		Low risk of bias	suggesting
ADVANCE 2, 2010      NCT	apixaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
APROPOS 2.5mg, 2007    NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
ADVANCE-1, 2008      NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
edoxaban
STARS J-V    NCT	edoxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
rivaroxaban
RECORD 1, 2008      NCT	rivaroxaban	enoxaparin	hip surgery		Low risk of bias	suggesting
RECORD 3, 2008    NCT	rivaroxaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
ODIXa-HIP 10mg, 2006	rivaroxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
RECORD 2, 2008    NCT	rivaroxaban (long duration)	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
ODIXa-KNEE, 2005	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RECORD 4, 2009    NCT	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
direct oral anticoagulant (DAO)
apixaban
ADOPT, 2011      NCT	apixaban	enoxaparin	medical patients		Low risk of bias	suggesting
ADVANCE 3, 2010    NCT	apixaban	enoxaparin	hip surgery		Low risk of bias	suggesting
ADVANCE 2, 2010      NCT	apixaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
APROPOS 2.5mg, 2007    NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
ADVANCE-1, 2008      NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
betrixaban
APEX, 2016    NCT	betrixaban	enoxaparin	medical patients		Low risk of bias	suggesting
dabigatran
RE-NOVATE (150mg), 2007      NCT	dabigatran 150mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE (220mg), 2007      NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE 2    NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-MODEL (150mg), 2007	dabigatran 150mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MODEL (220mg), 2007	dabigatran 220mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (150mg), 2008	dabigatran 150mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (220mg), 2008	dabigatran 220mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
edoxaban
STARS J-V    NCT	edoxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
rivaroxaban
MARINER, 2018        NCT	rivaroxaban	placebo	medical patients		Low risk of bias	suggesting
RECORD 1, 2008      NCT	rivaroxaban	enoxaparin	hip surgery		Low risk of bias	suggesting
RECORD 3, 2008    NCT	rivaroxaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
ODIXa-HIP 10mg, 2006	rivaroxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
RECORD 2, 2008    NCT	rivaroxaban (long duration)	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
ODIXa-KNEE, 2005	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RECORD 4, 2009    NCT	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
graduated compression stockings
not classified
Cohen (L8405), 2007	compression stocking group	control (on top fondaparinux)	hip surgery		Risk of bias	negative
*Scurr, 1977	GCS	no prophylaxis				suggesting
Holford, 1976	GCS	no prophylaxis				suggesting
Turner, 1984	GCS	no prophylaxis				negative
Turpie (GCS vs crtl), 1989	GCS	no prophylaxis				negative
Allan, 1983	GCS	no prophylaxis				suggesting
*Tsapogas, 1971	GCS	no prophylaxis				-
Barnes, 1978	GCS	no prophylaxis				negative
*Ohlund, 1983	GCS	no prophylaxis				-
*Wille-Jorgensen, 1989	GCS	no prophylaxis				-
*Inada, 1983	GCS	no prophylaxis				-
CLOTS, 2009	GCS	no prophylaxis			Risk of bias	negative
Rosengarten, 1970	GCS	no prophylaxis				negative
Turpie (IPD or GCS), 1989	IPD or GCS	no prophylaxis				negative
Muir, 2000	GCS + asp	aspirin				negative
Kierkegaard, 1993	GCS + asp	aspirin				negative
*Bergqvist, 1984	GCS + dextran	dextran				negative
Fredin, 1989	GCS + dextran	dextran				negative
Scurr (GCS+IPC vs IPC), 1987	GCS +IPC	IPC				negative
Mellbring, 1986	GCS +IPC	IPC				negative
Camporese, 2008	GCS	LMWH				negative
Kalodiki (GCS+LMWH vs LMWH), 1996	GCS + LMWH	LMWH				negative
Porteous, 1989	Knee length GCS	Thigh length GCS				-
Williams, 1988	Knee length GCS	Thigh length GCS				-
Hui THR, 1996	Knee length GCS	Thigh length GCS				-
Hui TKR, 1996	Knee length GCS	Thigh length GCS				-
Howard, 2004	Knee length GCS	Thigh length GCS				-
William, 1996	Knee length GCS	Thigh length GCS				-
Rasmussen (GCS vs UFH), 1998	GCS	UFH				negative
Fasting, 1985	GCS	UFH				negative
Hansberry (vs UFH), 1991	GCS	UFH				negative
UFH
Wille-Jorgensen, 1991	GCS + UFH	UFH				suggesting
Wille-Jorgensen, 1985	GCS + UFH	UFH				suggesting
*Rasmussen (adj), 1988	GCS + UFH	UFH				negative
Torngren, 1980	GCS + UFH	UFH				suggesting
heparin (UFH or LMWH)
not classified
FX140, Simonneau G, 2006	nadroparin	enoxaparin	knee surgery			-
SAVE-HIP1, 2012      NCT	semuloparin	enoxaparin	hip surgery			suggesting
SAVE-KNEE, 2012      NCT	semuloparin	enoxaparin	knee surgery			negative
SAVE-HIP 2, 2012      NCT	semuloparin	enoxaparin	hip surgery			negative
Valle , 1988	fluxum	placebo				negative
Limmer, 1994	antixarin	unfractionated heparin	general surgery			-
Chiapuzzo , 1988	fluxum	Unfractionated heparin	hip surgery			negative
Pini , 1989	fluxum	Unfractionated heparin	hip surgery			negative
Catania, 1988	parnaparin	unfractionated heparin	abdominal surgery			negative
Salcuni, 1988	parnaparin	unfractionated heparin	abdominal surgery			negative
Verardi, 1989	parnaparin	unfractionated heparin	abdominal surgery			negative
Garcea, 1992	parnaparin	unfractionated heparin	abdominal surgery			-
ToÈrngren, 1984	SSHA	unfractionated heparin	general surgery			negative
ardeparin
Levine, 1996	ardeparin	placebo	knee surgery		Low risk of bias	suggesting
Godwin, 1993	ardeparin	unfractionated heparin	abdominal surgery			-
Certoparin
Schmitz-Huebner, 1984	certoparin	unfractionated heparin	abdominal surgery			negative
Sasahara, 1986	certoparin	unfractionated heparin	abdominal surgery			suggesting
Voigt, 1986	certoparin	unfractionated heparin	abdominal surgery			negative
Welzel, 1988	certoparin	unfractionated heparin	abdominal surgery			suggesting
Kakkar, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Adolf, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Heilmann, 1989	certoparin	unfractionated heparin	gynaecological surgery			negative
Baumgartner, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Hoffmann and Largiade, 1990	certoparin	unfractionated heparin	abdominal surgery			negative
Koppenhagen, 1990	certoparin	unfractionated heparin	abdominal surgery			-
Schielke, 1991	certoparin	unfractionated heparin	abdominal surgery			-
Koppenhagen, 1992	certoparin	unfractionated heparin	abdominal surgery			-
Hoffmann and Largiader, 1992	certoparin	unfractionated heparin	abdominal surgery			-
Heilmann, 1997	certoparin	unfractionated heparin	gynaecological surgery			-
Haas, 1999	certoparin	unfractionated heparin	general surgery			-
Haas , 1987	certoparine + DHE	Unfractionated heparin	hip surgery			negative
Lassen, 1988	certoparine + DHE	Unfractionated heparin	hip surgery		Low risk of bias	suggesting
Lassen, 1989	certoparine + DHE	Unfractionated heparin	hip surgery		Low risk of bias	negative
dalteparin
Jorgensen, 1989	dalteparin	placebo	hip surgery		Low risk of bias	suggesting
Torholm, 1991	dalteparin	placebo	hip surgery		Low risk of bias	suggesting
Ockelford , 1989	dalteparin	placebo				suggesting
Eriksson , 1988	dalteparin	Dextran	hip surgery			suggesting
Matzsch , 1988	dalteparin	Dextran	hip surgery			negative
Matzsch , 1991	dalteparin	Dextran	hip surgery			suggesting
Haas , 1985	dalteparin	Unfractionated heparin	hip surgery			negative
Binsack , 1986	dalteparin	Unfractionated heparin	hip surgery			negative
Barre , 1987	dalteparin	Unfractionated heparin	hip surgery			negative
Dechavanne , 1989	dalteparin	Unfractionated heparin	hip surgery			negative
Eriksson , 1989	dalteparin	Unfractionated heparin	hip surgery			suggesting
Monreal , 1989	dalteparin	Unfractionated heparin	hip surgery			negative
Bergqvist, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Onarheim, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Fricker, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Bergqvist, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Caen, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Borstad, 1988	dalteparin	unfractionated heparin	gynaecological surgery			negative
Briel, 1988	dalteparin	unfractionated heparin	non orthopedic surgery			negative
Creperio, 1990	dalteparin	unfractionated heparin	general surgery			negative
Hartl, 1990	dalteparin	unfractionated heparin	abdominal surgery			suggesting
Borstad, 1992	dalteparin	unfractionated heparin	gynaecological surgery			-
Kakkar, 1993	dalteparin	unfractionated heparin	abdominal surgery			-
enoxaparin
Ho [43]	enoxaparin	no treatment				negative
Warwick, 1995	enoxaparin	no treatment	hip surgery			negative
Turpie, 1986	enoxaparin	placebo	hip surgery		Low risk of bias	suggesting
Leclerc, 1991	enoxaparin	placebo	knee surgery		Low risk of bias	suggesting
Samama, 1997	enoxaparin	placebo	hip surgery		Low risk of bias	suggesting
Kalodiki, 1996	enoxaparin	placebo	hip surgery		Low risk of bias	-
Agnelli, 1998	enoxaparin	placebo				suggesting
Melon, 1987	enoxaparin	placebo				negative
DES Group , 1991	enoxaparin	Dextran	hip surgery			suggesting
Planes , 1988	enoxaparin	Unfractionated heparin	hip surgery			suggesting
Levine , 1991	enoxaparin	Unfractionated heparin	hip surgery			negative
Samama 1, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Samama 2, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Samama 3, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Kaaja, 1992	enoxaparin	unfractionated heparin	gynaecological surgery			-
Gazzaniga (ISG), 1993	enoxaparin	unfractionated heparin	general surgery			-
Nurmohamed, 1995	enoxaparin	unfractionated heparin	general surgery			-
McLeod (Canadian), 1995	enoxaparin	unfractionated heparin	abdominal surgery			-
Gonzalez, 1996	enoxaparin	unfractionated heparin	abdominal surgery			-
ENOXACAN, 1997	enoxaparin	unfractionated heparin	abdominal surgery			-
fraxiparin
Pezzuoli, 1989	nadroparin	placebo				suggesting
Leyvraz, 1991	nadroparin	Unfractionated heparin	hip surgery			negative
nadroparin
Yoo, 1997	nadroparin	no treatment	hip surgery			negative
Marassi [41]	nadroparin	no treatment				negative
Balas [40]	nadroparin	placebo				negative
Nurmohamed, 1996	nadroparin	placebo				negative
Sourmelis, 1995	nadroparin	placebo	hip surgery		Low risk of bias	suggesting
Kakkar and Murray, 1985	nadroparin	unfractionated heparin	general surgery			suggesting
EFS, 1988	nadroparin	unfractionated heparin	abdominal surgery			suggesting
Dahan, 1989	nadroparin	unfractionated heparin	thoracic surgery			negative
Barbui, 1990	nadroparin	unfractionated heparin	general surgery			-
Eurin, 1994	nadroparin	unfractionated heparin	abdominal surgery			-
reviparin
Kakkar, 1993	reviparin	unfractionated heparin	general surgery			-
tinzaparin
Bergqvist [42]	tinzaparin	placebo				negative
Lassen, 1991	tinzaparin	placebo	hip surgery		Low risk of bias	suggesting
Leizorovicz, 1991	tinzaparin	unfractionated heparin	abdominal surgery			-
UFH
Cerrato, 1978	UFH	no treatment				suggesting
LMWH
not classified
FX140, Simonneau G, 2006	nadroparin	enoxaparin	knee surgery			-
SAVE-HIP1, 2012      NCT	semuloparin	enoxaparin	hip surgery			suggesting
SAVE-KNEE, 2012      NCT	semuloparin	enoxaparin	knee surgery			negative
SAVE-HIP 2, 2012      NCT	semuloparin	enoxaparin	hip surgery			negative
Valle , 1988	fluxum	placebo				negative
Dahan, 1986	Pharmuka	placebo	medical patients		Low risk of bias	suggesting
Limmer, 1994	antixarin	unfractionated heparin	general surgery			-
Chiapuzzo , 1988	fluxum	Unfractionated heparin	hip surgery			negative
Pini , 1989	fluxum	Unfractionated heparin	hip surgery			negative
Catania, 1988	parnaparin	unfractionated heparin	abdominal surgery			negative
Salcuni, 1988	parnaparin	unfractionated heparin	abdominal surgery			negative
Verardi, 1989	parnaparin	unfractionated heparin	abdominal surgery			negative
Garcea, 1992	parnaparin	unfractionated heparin	abdominal surgery			-
ToÈrngren, 1984	SSHA	unfractionated heparin	general surgery			negative
ardeparin
Levine, 1996	ardeparin	placebo	knee surgery		Low risk of bias	suggesting
Godwin, 1993	ardeparin	unfractionated heparin	abdominal surgery			-
Certoparin
CERTIFY, 2010	certoparin	UFH	medical patients			-
Schmitz-Huebner, 1984	certoparin	unfractionated heparin	abdominal surgery			negative
Sasahara, 1986	certoparin	unfractionated heparin	abdominal surgery			suggesting
Voigt, 1986	certoparin	unfractionated heparin	abdominal surgery			negative
Welzel, 1988	certoparin	unfractionated heparin	abdominal surgery			suggesting
Kakkar, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Adolf, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Heilmann, 1989	certoparin	unfractionated heparin	gynaecological surgery			negative
Baumgartner, 1989	certoparin	unfractionated heparin	abdominal surgery			negative
Hoffmann and Largiade, 1990	certoparin	unfractionated heparin	abdominal surgery			negative
Koppenhagen, 1990	certoparin	unfractionated heparin	abdominal surgery			-
Schielke, 1991	certoparin	unfractionated heparin	abdominal surgery			-
Koppenhagen, 1992	certoparin	unfractionated heparin	abdominal surgery			-
Hoffmann and Largiader, 1992	certoparin	unfractionated heparin	abdominal surgery			-
Heilmann, 1997	certoparin	unfractionated heparin	gynaecological surgery			-
Haas, 1999	certoparin	unfractionated heparin	general surgery			-
Haas , 1987	certoparine + DHE	Unfractionated heparin	hip surgery			negative
Lassen, 1988	certoparine + DHE	Unfractionated heparin	hip surgery		Low risk of bias	suggesting
Lassen, 1989	certoparine + DHE	Unfractionated heparin	hip surgery		Low risk of bias	negative
dalteparin
Jorgensen, 1989	dalteparin	placebo	hip surgery		Low risk of bias	suggesting
Torholm, 1991	dalteparin	placebo	hip surgery		Low risk of bias	suggesting
Ockelford , 1989	dalteparin	placebo				suggesting
Leizorovicz, 2004	dalteparin	placebo	medical patients		Low risk of bias	suggesting
Eriksson , 1988	dalteparin	Dextran	hip surgery			suggesting
Matzsch , 1988	dalteparin	Dextran	hip surgery			negative
Matzsch , 1991	dalteparin	Dextran	hip surgery			suggesting
PROTECT, 2011    NCT	dalteparin	UFH	medical patients		Low risk of bias	suggesting
Bergqvist, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Onarheim, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery			negative
Fricker, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Bergqvist, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Caen, 1988	dalteparin	unfractionated heparin	abdominal surgery			negative
Borstad, 1988	dalteparin	unfractionated heparin	gynaecological surgery			negative
Briel, 1988	dalteparin	unfractionated heparin	non orthopedic surgery			negative
Creperio, 1990	dalteparin	unfractionated heparin	general surgery			negative
Hartl, 1990	dalteparin	unfractionated heparin	abdominal surgery			suggesting
Borstad, 1992	dalteparin	unfractionated heparin	gynaecological surgery			-
Kakkar, 1993	dalteparin	unfractionated heparin	abdominal surgery			-
Haas , 1985	dalteparin	Unfractionated heparin	hip surgery			negative
Binsack , 1986	dalteparin	Unfractionated heparin	hip surgery			negative
Barre , 1987	dalteparin	Unfractionated heparin	hip surgery			negative
Dechavanne , 1989	dalteparin	Unfractionated heparin	hip surgery			negative
Eriksson , 1989	dalteparin	Unfractionated heparin	hip surgery			suggesting
Monreal , 1989	dalteparin	Unfractionated heparin	hip surgery			negative
enoxaparin
Warwick, 1995	enoxaparin	no treatment	hip surgery			negative
Ho [43]	enoxaparin	no treatment				negative
Agnelli, 1998	enoxaparin	placebo				suggesting
Melon, 1987	enoxaparin	placebo				negative
MEDENOX, 1999	Enoxaparin	placebo	medical patients		Low risk of bias	suggesting
Lederle, 2006	Enoxaparin	placebo	medical patients		Low risk of bias	negative
LIFENOX, 2011      NCT	enoxaparin	placebo	medical patients		Low risk of bias	negative
Turpie, 1986	enoxaparin	placebo	hip surgery		Low risk of bias	suggesting
Leclerc, 1991	enoxaparin	placebo	knee surgery		Low risk of bias	suggesting
Samama, 1997	enoxaparin	placebo	hip surgery		Low risk of bias	suggesting
Kalodiki, 1996	enoxaparin	placebo	hip surgery		Low risk of bias	-
DES Group , 1991	enoxaparin	Dextran	hip surgery			suggesting
Bergmann and Neuhart, 1996	enoxaparin	UFH	medical patients		Low risk of bias	negative
Lechler, 1996	enoxaparin	UFH	medical patients		Low risk of bias	negative
Kleber, 2003	enoxaparin	UFH	medical patients			negative
Samama 1, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Samama 2, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Samama 3, 1988	enoxaparin	unfractionated heparin	general surgery			negative
Kaaja, 1992	enoxaparin	unfractionated heparin	gynaecological surgery			-
Gazzaniga (ISG), 1993	enoxaparin	unfractionated heparin	general surgery			-
Nurmohamed, 1995	enoxaparin	unfractionated heparin	general surgery			-
McLeod (Canadian), 1995	enoxaparin	unfractionated heparin	abdominal surgery			-
Gonzalez, 1996	enoxaparin	unfractionated heparin	abdominal surgery			-
ENOXACAN, 1997	enoxaparin	unfractionated heparin	abdominal surgery			-
Planes , 1988	enoxaparin	Unfractionated heparin	hip surgery			suggesting
Levine , 1991	enoxaparin	Unfractionated heparin	hip surgery			negative
fraxiparin
Pezzuoli, 1989	nadroparin	placebo				suggesting
Leyvraz, 1991	nadroparin	Unfractionated heparin	hip surgery			negative
LMWH
Harenberg, 1990	LMWH	UFH	medical patients		Low risk of bias	negative
Harenberg, 1996	LMWH	UFH	medical patients		Low risk of bias	negative
nadroparin
Marassi [41]	nadroparin	no treatment				negative
Yoo, 1997	nadroparin	no treatment	hip surgery			negative
Sourmelis, 1995	nadroparin	placebo	hip surgery		Low risk of bias	suggesting
Balas [40]	nadroparin	placebo				negative
Nurmohamed, 1996	nadroparin	placebo				negative
Fraisse, 2000	Nadroparin	placebo	medical patients		Low risk of bias	negative
Mahe, 2005	Nadroparin	placebo	medical patients		Low risk of bias	negative
Bergmann, 1996	nadroparin	placebo	medical patients			negative
Kakkar and Murray, 1985	nadroparin	unfractionated heparin	general surgery			suggesting
EFS, 1988	nadroparin	unfractionated heparin	abdominal surgery			suggesting
Dahan, 1989	nadroparin	unfractionated heparin	thoracic surgery			negative
Barbui, 1990	nadroparin	unfractionated heparin	general surgery			-
Eurin, 1994	nadroparin	unfractionated heparin	abdominal surgery			-
reviparin
Kakkar, 1993	reviparin	unfractionated heparin	general surgery			-
tinzaparin
Bergqvist [42]	tinzaparin	placebo				negative
Lassen, 1991	tinzaparin	placebo	hip surgery		Low risk of bias	suggesting
Leizorovicz, 1991	tinzaparin	unfractionated heparin	abdominal surgery			-
UFH
Cerrato, 1978	UFH	no treatment				suggesting
mechanical devices for thromboprophylaxis
not classified
Schirai, 1985	GCS	???				suggesting
HAAS I, 1990	IPC	aspirin				suggesting
HAAS II, 1990	IPC	aspirin				negative
McKenna (vs aspirin), 1980	IPC	aspirin				negative
Soderdahl, 1997	thigh Length IPCD	calf Length IPCD			Risk of bias	negative
Scurr, 1981	Footpump (monotherapy)	control				suggesting
Wilson, 1992	Footpump (monotherapy)	control				suggesting
Turpie, 1989	IPC + GCS	control				negative
Blackshear à exclure, 1987	IPC – sequential compression	control			Exploratory	negative
Fisher, 1995	IPC – sequential compression	control			Risk of bias	negative
Hull II, 1990	IPC – sequential compression	control				suggesting
Knudson, 1994	IPC – sequential compression	control				negative
Kosir, 1996	IPC – sequential compression	control			Exploratory	negative
Turple II, 1979	IPC – sequential compression	control				suggesting
Bachmann, 1976	IPC – single compression	control			Risk of bias	suggesting
Butson, 1981	IPC – single compression	control				negative
Bynke, 1987	IPC – single compression	control				negative
Clark, 1974	IPC – single compression	control				negative
Clarke-Pearson I, 1984	IPC – single compression	control				suggesting
Clarke-Pearson II, 1984	IPC – single compression	control				negative
Coe, 1978	IPC – single compression	control				negative
Gallus, 1983	IPC – single compression	control			Risk of bias	negative
Hills, 1972	IPC – single compression	control				suggesting
Hull I, 1979	IPC – single compression	control				suggesting
Skillman, 1978	IPC – single compression	control			Exploratory	suggesting
Turpie I, 1977	IPC – single compression	control				negative
Prasad, 1982	IPC – single compression	control				negative
Weitz, 1986	IPC – unknown type	control			Exploratory	negative
McKenna, 1980	IPCD	control			Exploratory	negative
Smith (D), 1978	IPC + dextran	dextran				negative
Mellbring, 1986	IPC	DHE + low dose heparin				-
Elliott, 1999	IPC – sequential compression	Footpump			Exploratory	-
Fordyce, 1992	IPC + GCS	GCS				suggesting
Caprini, 1983	IPC + GCS	GCS				negative
Turpie, 1989	IPC + GCS	GCS				negative
Wautrecht, 1996	IPC + GCS	GCS				negative
Rokito, 1996	IPC + GCS	GCS				negative
Lacut, 2005	IPC + GCS	GCS			Risk of bias	negative
Pambianco, 1995	IPC + GCS	GCS				negative
Goldhaber, 1995	IPC + GCS	GCS				negative
Dickinson, 1998	IPC + GCS +LMWH	GCS +LMWH				negative
Hansberry, 1991	IPC/FID	GES				negative
Murakami, 2003	CECT	IPC			Exploratory	-
Stone, 1996	Footpump	LMWH			Exploratory	-
Warwick, 1998	Footpump	LMWH			Risk of bias	negative
Blanchard, 1999	Footpump	LMWH			Exploratory	-
Warwick à exclure, 2002	IPC	LMWH				-
Ginzburg, 2003	IPC	LMWH			Exploratory	negative
Kurtoglu, 2004	IPC	LMWH			Exploratory	negative
Norgren, 1998	IPC + GCS	LMWH				negative
*Scurr, 1977	GCS	no prophylaxis				suggesting
Holford, 1976	GCS	no prophylaxis				suggesting
Turner, 1984	GCS	no prophylaxis				negative
Turpie (GCS vs crtl), 1989	GCS	no prophylaxis				negative
Allan, 1983	GCS	no prophylaxis				suggesting
*Tsapogas, 1971	GCS	no prophylaxis				-
Barnes, 1978	GCS	no prophylaxis				negative
*Ohlund, 1983	GCS	no prophylaxis				-
*Wille-Jorgensen, 1989	GCS	no prophylaxis				-
*Inada, 1983	GCS	no prophylaxis				-
CLOTS, 2009	GCS	no prophylaxis			Risk of bias	negative
Rosengarten, 1970	GCS	no prophylaxis				negative
Turpie (IPD or GCS), 1989	IPD or GCS	no prophylaxis				negative
Clarke Pearson, 1993	IPC	UFH				negative
Coe (vs UFH), 1978	IPC	UFH				negative
Kosir, 1998	IPC	UFH				negative
Hansberry (vs UFH), 1991	IPC	UFH				negative
Niolaides, 1983	IPC + GCS	UFH				negative
Santori, 1994	IPC + GCS	UFH				suggesting
Stannard (vs UFH+asp), 1996	Footpump (adjunctive therapy)	UFH then aspirin			Exploratory	negative
Chandhoke, 1992	IPC	vitamin K antagonists				negative
paiement, 1987	IPC	vitamin K antagonists				negative
Kaempffe, 1991	IPC	vitamin K antagonists				negative
Muir, 2000	GCS + asp	aspirin				negative
Kierkegaard, 1993	GCS + asp	aspirin				negative
*Bergqvist, 1984	GCS + dextran	dextran				negative
Fredin, 1989	GCS + dextran	dextran				negative
Scurr (GCS+IPC vs IPC), 1987	GCS +IPC	IPC				negative
Mellbring, 1986	GCS +IPC	IPC				negative
Camporese, 2008	GCS	LMWH				negative
Kalodiki (GCS+LMWH vs LMWH), 1996	GCS + LMWH	LMWH				negative
Porteous, 1989	Knee length GCS	Thigh length GCS				-
Williams, 1988	Knee length GCS	Thigh length GCS				-
Hui THR, 1996	Knee length GCS	Thigh length GCS				-
Hui TKR, 1996	Knee length GCS	Thigh length GCS				-
Howard, 2004	Knee length GCS	Thigh length GCS				-
William, 1996	Knee length GCS	Thigh length GCS				-
Rasmussen (GCS vs UFH), 1998	GCS	UFH				negative
Fasting, 1985	GCS	UFH				negative
Hansberry (vs UFH), 1991	GCS	UFH				negative
aspirin
Lieberman (A), 1994	IPC + aspirin	aspirin				negative
Hull (+asp), 1979	IPC + aspirin	aspirin				negative
Hull 2 (+asp), 1979	IPC + aspirin	aspirin				-
Gelfer, 2006	CECT + aspirin	LMWH				-
UFH
Killewich, 1997	IPC + UFH	control				negative
Siragusa (H), 1994	IPC + UFH	UFH				negative
Ramos, 1996	IPC + UFH	UFH				suggesting
Wille-Jorgensen, 1991	GCS + UFH	UFH				suggesting
Wille-Jorgensen, 1985	GCS + UFH	UFH				suggesting
*Rasmussen (adj), 1988	GCS + UFH	UFH				negative
Torngren, 1980	GCS + UFH	UFH				suggesting
pentasaccharide
not classified
DRIVE, 2008    NCT	SR123781A	enoxaparin	hip surgery		Low risk of bias	-
PENTHIFRA–PLUS (Eriksson), 2003	extended prophylaxis	standard prophylaxis	hip surgery		Low risk of bias	-
fondaparinux
DRI4757	fondaparinux	placebo	knee surgery		Low risk of bias	-
ARTEMIS (Cohen), 2006	fondaparinux	placebo	medical patients		Low risk of bias	negative
APOLLO (Turpie), 2007	fondaparinux	placebo (on top intermittent pneumatic comp.)	abdominal surgery		Low risk of bias	suggesting
PEGASUS, 2005	fondaparinux	enoxaparin	abdominal surgery		Low risk of bias	negative
PENTAMAKS (Bauer), 2001	fondaparinux	enoxaparin	knee surgery		Low risk of bias	suggesting
PENTHIFRA (Eriksson), 2001	fondaparinux	enoxaparin	hip surgery		Low risk of bias	suggesting
PENTATHLON (Turpie), 2002	fondaparinux	enoxaparin	hip surgery		Low risk of bias	suggesting
EPHESUS (Lassen), 2002	fondaparinux	enoxaparin	hip surgery		Low risk of bias	suggesting
Turpie, 2001	fondaparinux	enoxaparin	hip surgery		Low risk of bias	-
L8541	fondaparinux	enoxaparin	orthopaedic surgery		Low risk of bias	negative
L8635	fondaparinux	enoxaparin	knee surgery		Exploratory	negative
UFH
enoxaparin
LeGagneux , 1987	enoxaparin	placebo				negative
UFH
Kettunen, 1974	UFH	no treatment				-
Caloghera, 1984	UFH	no treatment				-
Marchelli, 1983	UFH	no treatment				-
Ziemski, 1979	UFH	no treatment				-
Morris, 1974	UFH	no treatment				suggesting
Welin-Berger, 1982	UFH	no treatment				negative
Bergqvist , 1979	UFH	no treatment				suggesting
Gallus , 1973	UFH	no treatment				negative
VTCSG, 1975	UFH	no treatment				negative
Mannucci , 1976	UFH	no treatment				suggesting
Dechavanne, 1974	UFH	no treatment				suggesting
Dechavanne, 1975	UFH	no treatment				suggesting
Bergqvist, 1979	UFH	no treatment				suggesting
Galasko , 1976	UFH	no treatment				suggesting
Gallus , 1973	UFH	no treatment				suggesting
Morris , 1977	UFH	no treatment				negative
Coe, 1978	UFH	no treatment				-
Sebeseri, 1975	UFH	no treatment				-
Allen, 1978	UFH	no treatment				-
Kakkar (IMT)	UFH	no treatment				-
Gruber	UFH	no treatment				-
Gordon-Smith, 1972	UFH	no treatment				-
Nicolaides, 1972	UFH	no treatment				-
Multiunit, 1974	UFH	no treatment				-
Abernethy, 1974	UFH	no treatment				-
Clarke-Pearson, 1983	UFH	no treatment				-
Plante, 1979	UFH	no treatment				-
Abraham-Inpijn, 1979	UFH	no treatment				-
Spebar, 1981	UFH	no treatment				-
Sagar, 1974	UFH	no treatment				-
Koppenhagen, 1982	UFH	no treatment				-
Bergqvist, 1980	UFH	no treatment				-
Gallus, 1973	UFH	no treatment				-
Gallus, 1976	UFH	no treatment				-
Groote Schuur, 1979	UFH	no treatment				-
Kraytman, 1976	UFH	no treatment				-
Kraytman, 1977	UFH	no treatment				-
Kakkar, 1972	UFH	placebo				-
Kiil, 1978	UFH	placebo				-
Torngren, 1978	UFH	placebo				-
Torngren	UFH	placebo				-
Lahnborg, 1975	UFH	placebo				-
Lahnborg, 1976	UFH	placebo				-
Covey, 1975	UFH	placebo				-
Belch, 1980	UFH	placebo				-
Taberner, 1978	UFH	placebo				-
Strand, 1975	UFH	placebo				-
Roberts, 1975	UFH	placebo				-
Ribaudo, 1975	UFH	placebo				-
Wu, 1977	UFH	placebo				-
Lawrence, 1977	UFH	placebo				-
Muiticentre, 1984	UFH	placebo				-
Jourdan, 1984	UFH	placebo				-
Torngren, 1978	UFH	placebo				-
Kruse-Blinkenberg, 1980	UFH	placebo				-
Kraytman, 1977	UFH	placebo				-
Marchetti, 1982	UFH	placebo				-
Williams , 1978	UFH	placebo				negative
Abraham-Inpijn , 1975	UFH	placebo				negative
Lowe , 1981	UFH	placebo				suggesting
Hampson, 1974	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				suggesting
Lahnborg, 1980	UFH	placebo				suggesting
Xabregas , 1977	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				negative
Svend-Hansen, 1981	UFH	placebo				suggesting
Bejjani, 1983	UFH	placebo				-
Hedlund, 1979	UFH	placebo				-
Kutnowski, 1977	UFH	placebo				-
Vandendris, 1980	UFH	placebo				-
Loew, 1977	UFH	aspirin				-
Vinazzer, 1980	UFH	aspirin				-
Muiticentre 53,S4, 1984	UFH	DHE				-
Muiticentre, 1984	UFH	DHE				-
van Geloven, 1977	UFH	oral anticoagulant				-