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Betrixaban
anticoagulant
systematic review
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PRT054021
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thrombosis prevention
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Description
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Comparison
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Characteristics
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NCT results
Major bleeding (3)
All cause death (3)
stroke (fatal and non fatal) (2)
ischemic stroke (2)
Haemmorhagic stroke (2)
thrombo-embolic event (cerebral or systemic) (2)
Cardiovascular death (2)
Fatal stroke (2)
systemic thrombo-embolic complication (2)
Fatal bleeding (2)
Non fatal stroke (2)
hypertransaminasemia (2)
TE event or ischemic stroke or systemic embolism (2)
Lifethreatening major bleeding (2)
Non-lifethreatening major bleeding (2)
Gastrointestinal major bleeding (2)
major or clinically relevant non-major bleeding (2)
Coronary event (2)
asymptomatic DVT (1)
Symptomatic deep-vein thrombosis (1)
Symptomatic pulmonary embolism (1)
Deep vein thrombosis (1)
pulmonary embolism (symptomatic and asymptomatic) (1)
fatal pulmonary embolism (1)
proximal deep-vein thrombosis (1)
Venous thromboembolism or death (1)
net benefit (1)
Venous thromboembolism (1)
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Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
Major bleeding
All cause death
thrombosis prevention
APEX, 2016
NCT
betrixaban
enoxaparin
medical patients
Low risk of bias
suggesting
19%
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