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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | Major bleeding | All cause death |
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APPRAISE-1 (10mg od), 2009 NCT | apixaban | placebo | | | Low risk of bias | negative | | |
APPRAISE-1 (2.5 mg bid), 2009 NCT | apixaban | placebo | | | Low risk of bias | negative | | |
APPRAISE 2, 2011 NCT | apixaban | placebo | | | Low risk of bias | negative | | |
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AVERROES, 2011 NCT | apixaban | aspirin | ineligible for VKA | | Low risk of bias | suggesting | | |
ARISTOTLE, 2011 NCT | apixaban | warfarin standard dose | | | Low risk of bias | conclusive | | |
phase 2 apixaban NCT | apixaban | warfarin standard dose | | | Exploratory | - | | |
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AMPLIFY-EXT 2.5mg, 2012 NCT | apixaban 2.5mg | discontinuation | | | Low risk of bias | suggesting | | |
AMPLIFY-EXT 5mg, 2012 NCT | apixaban 5mg | discontinuation | | | Low risk of bias | suggesting | | |
AMPLIFY, 2013 NCT | apixaban (without LMWH) | LMWH/VKA | | DOAC without heparin | Low risk of bias | suggesting | | |
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ADOPT, 2011 NCT | apixaban | enoxaparin | medical patients | | Low risk of bias | suggesting | | |
ADVANCE 3, 2010 NCT | apixaban | enoxaparin | hip surgery | | Low risk of bias | suggesting | | |
ADVANCE 2, 2010 NCT | apixaban | enoxaparin (europe regimen) | knee surgery | | Low risk of bias | suggesting | | |
APROPOS 2.5mg, 2007 NCT | apixaban | enoxaparin (US regimen) | knee surgery | | Low risk of bias | negative | | |
ADVANCE-1, 2008 NCT | apixaban | enoxaparin (US regimen) | knee surgery | | Low risk of bias | suggesting | | |
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AMPLIFY-EXT 2.5mg, 2012 NCT | apixaban 2.5mg | discontinuation | | | Low risk of bias | suggesting | | |
AMPLIFY-EXT 5mg, 2012 NCT | apixaban 5mg | discontinuation | | | Low risk of bias | suggesting | | |
Botticelli DVT, 2008 NCT | apixaban (without LMWH) | LMWH/VKA | | | Exploratory | - | | |
AMPLIFY, 2013 NCT | apixaban (without LMWH) | LMWH/VKA | | DOAC without heparin | Low risk of bias | suggesting | | |