obesity and overweight

systematic review meta-analysis network meta-analysis

Select All mechanism All type of patient       BupropionFluoxetineglucagon-like peptide-1lipase inhibitorphentermine and topiramateserotonin 5HT2C-receptor agonistserotonin-norepinephrine reuptake inhibitortesofensineTopiramate Bupropionliraglutidelorcaserinorlistatphentermine and topiramateSibutramine topiramate vs placebo or control      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	weight loss equal to or greater than 5 percent (3)weight loss equal to or greater than 10 percent (3)cardiovascular events (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	weight loss equal to or greater than 5 percent	weight loss equal to or greater than 10 percent
All mechanism
not classified
Gray, 1992	Fluoxetine	placebo				-
Breum, 1995	Fluoxetine	placebo				-
Connolly, 1995	Fluoxetine	placebo				-
Darga, 1991	Fluoxetine	placebo				-
Goldstein, 1994	Fluoxetine	placebo				-
Marcus, 1990	Fluoxetine	placebo				-
Mendoza Espejo, 1995	Fluoxetine	placebo				-
Michelson 50wk, 1999	Fluoxetine	placebo				-
O’Kane, 1994	Fluoxetine	placebo				-
APD356-004, 2009	lorcaserin	placebo				-
Astrup	tesofensine	placebo				-
Bupropion
Croft, 2002	Bupropion	placebo				-
Jain, 2002	Bupropion	placebo			Low risk of bias	-
Anderson, 2002	Bupropion	placebo			Low risk of bias	-
liraglutide
Astrup (NN8022-1807 ), 2009    NCT	liraglutide	placebo			Low risk of bias	-
lorcaserin
BLOSSOM (10mg bid), 2009      NCT	lorcaserin	placebo			Low risk of bias	-
BLOOM, 2010    NCT	lorcaserin	placebo			Low risk of bias	-
BLOOM-DM (10mg bid)    NCT	lorcaserin	placebo			Low risk of bias	-
orlistat
Gotfredsen, 2001	Orlistat	placebo				-
Halpern, 2003	Orlistat	placebo			Low risk of bias	-
Hanefeld, 2002	Orlistat	placebo				-
Hauptman, 2000	Orlistat	placebo			Low risk of bias	-
Hill, 1999	Orlistat	placebo			Low risk of bias	-
Hollander, 1998	Orlistat	placebo				-
Karhunen, 2000	Orlistat	placebo				-
Kelley, 2002	Orlistat	placebo			Low risk of bias	-
Krempf, 2005	Orlistat	placebo				-
Lindgarde, 2000	Orlistat	placebo				-
Lucas, 2003	Orlistat	placebo				-
Micic, 1999	Orlistat	placebo			Low risk of bias	-
Miles, 2002	Orlistat	placebo			Low risk of bias	-
Muls, 2001	Orlistat	placebo			Low risk of bias	-
Naumov, 2002	Orlistat	placebo				-
Reaven, 2001	Orlistat	placebo				-
Rissanen, 2001	Orlistat	placebo			Low risk of bias	-
Rosenfalck, 2002	Orlistat	placebo				-
Rossner, 2000	Orlistat	placebo			Low risk of bias	-
Shi Yi, 2001	Orlistat	placebo				-
Sjostrom, 1998	Orlistat	placebo			Low risk of bias	-
Vidgren, 1999	Orlistat	placebo				-
Bakris, 2002	Orlistat	placebo			Low risk of bias	-
Broom, 2002	Orlistat	placebo			Low risk of bias	-
Broom,, 2001	Orlistat	placebo				-
Davidson, 1999	Orlistat	placebo			Low risk of bias	-
Deerochanawong,, 2001	Orlistat	placebo				-
Derosa, 2003	Orlistat	placebo			Low risk of bias	-
phentermine and topiramate
OB 301 (high-dose)	PHEN/TPM high dose	placebo				-
CONQUER (high-dose) (OB 303)      NCT	PHEN/TPM high dose	placebo				-
OB 302 (high-dose)	PHEN/TPM high dose	placebo				-
OB 302 (low-dose)	PHEN/TPM low-dose	placebo				-
OB 301 (mid-dose)	PHEN/TPM mid-dose	placebo				-
CONQUER (mid-dose) (OB 303)      NCT	PHEN/TPM mid-dose	placebo				-
Sibutramine
McMahon, 2000	Sibutramine	placebo				-
Smith, 2001	Sibutramine	placebo				-
McMahon, 2002	Sibutramine	placebo				-
SCOUT, 2010        NCT	sibutramine	placebo			Low risk of bias	-
topiramate
Bray, 2003	Topiramate	placebo				-
Caterson, 2003	Topiramate	placebo				-
Pud’homme, 2003	Topiramate	placebo				-
Rissanen, 2003	Topiramate	placebo				-
Stenlof, 2003	Topiramate	placebo				-
Tonstad, 2003	Topiramate	placebo				-