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Orlistat
weight-loss drugs
systematic review
meta-analysis
network meta-analysis
Xenical - Alli - THLP - tetrahydrolipstatin - orlistat
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diabetes type 2
obesity and overweight
anti-obesity agents
lipase inhibitor
vs placebo or control
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Description
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NCT results
cardiovascular events (30)
weight change from baseline (kg) (28)
weight change from baseline (%) (28)
weight loss equal to or greater than 5 percent (28)
weight loss equal to or greater than 10 percent (28)
Fasting glucose change (mmol/liter) (28)
HbA1c (28)
Diabetes (2)
normoglycemia (2)
All cause death (2)
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cardiovascular death, MI, stroke (2)
myocardial infarction (fatal and non fatal) (2)
stroke (fatal and non fatal) (2)
hospitalisation for heart failure (2)
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Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
cardiovascular events
weight change from baseline (kg)
diabetes type 2
Heymsfield, 2000
orlistat
placebo
Low risk of bias
negative
XENDOS (Chiasson), 2002
orlistat
placebo
Low risk of bias
negative
obesity and overweight
Bakris, 2002
Orlistat
placebo
Low risk of bias
-
Broom, 2002
Orlistat
placebo
Low risk of bias
-
Broom,, 2001
Orlistat
placebo
-
Davidson, 1999
Orlistat
placebo
Low risk of bias
-
Deerochanawong,, 2001
Orlistat
placebo
-
Derosa, 2003
Orlistat
placebo
Low risk of bias
-
Gotfredsen, 2001
Orlistat
placebo
-
Halpern, 2003
Orlistat
placebo
Low risk of bias
-
Hanefeld, 2002
Orlistat
placebo
-
Hauptman, 2000
Orlistat
placebo
Low risk of bias
-
Hill, 1999
Orlistat
placebo
Low risk of bias
-
Hollander, 1998
Orlistat
placebo
-
Karhunen, 2000
Orlistat
placebo
-
Kelley, 2002
Orlistat
placebo
Low risk of bias
-
Krempf, 2005
Orlistat
placebo
-
Lindgarde, 2000
Orlistat
placebo
-
Lucas, 2003
Orlistat
placebo
-
Micic, 1999
Orlistat
placebo
Low risk of bias
-
Miles, 2002
Orlistat
placebo
Low risk of bias
-
Muls, 2001
Orlistat
placebo
Low risk of bias
-
Naumov, 2002
Orlistat
placebo
-
Reaven, 2001
Orlistat
placebo
-
Rissanen, 2001
Orlistat
placebo
Low risk of bias
-
Rosenfalck, 2002
Orlistat
placebo
-
Rossner, 2000
Orlistat
placebo
Low risk of bias
-
Shi Yi, 2001
Orlistat
placebo
-
Sjostrom, 1998
Orlistat
placebo
Low risk of bias
-
Vidgren, 1999
Orlistat
placebo
-
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