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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | cardiovascular events | HbA1c |
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NN2211-1333 | liraglutide other doses | | | | | - | | |
Pratley (1.8 vs 1.2), 2010 | liraglutide 1.8mg | liraglutide 1.2mg | | | | negative | | |
LEADER, 2016 NCT | liraglutide | placebo | | | Low risk of bias | conclusive | | |
NN2211-1571 (Vilsbøll), 2007 NCT | liraglutide other doses | placebo | | | Exploratory | negative | | |
Seino, 2008 NCT | liraglutide other doses | placebo | | | Exploratory | negative | | |
Madsbad (vs placebo), 2004 | liraglutide other doses | placebo | | | | negative | | |
Harder, 2004 | liraglutide other doses | placebo | | | Exploratory | - | | |
Kaku 0.6mg, 2010 | liraglutide other doses | placebo | | | Low risk of bias | suggesting | | |
LEAD-2 (Nauck) (1.2mg vs placebo), 2009 NCT | liraglutide 1.2mg | placebo (add on MET) | | | Low risk of bias | suggesting | | |
LEAD-2 (Nauck) (1.8mg vs placebo), 2009 NCT | liraglutide 1.8mg | placebo (add on MET) | | | Low risk of bias | suggesting | | |
NN2211-1796 NCT | liraglutide other doses | placebo (add on MET) | | | | - | | |
LEAD-1 SU (1.2 mg vs placebo), 2009 NCT | liraglutide 1.2mg | placebo (add on SU) | | | Low risk of bias | suggesting | | |
LEAD-1 SU (1.8 mg vs placebo), 2009 NCT | liraglutide 1.8mg | placebo (add on SU) | | | Low risk of bias | suggesting | | |
LEAD-5 (vs placebo), 2009 NCT | liraglutide 1.8mg | placebo (add on SU+MET) | | | Low risk of bias | suggesting | | |
LEAD-4 (1.2mg), 2009 NCT | liraglutide 1.2mg | placebo (add on TZD+MET) | | | Low risk of bias | suggesting | | |
LEAD-4 (1.8mg), 2009 NCT | liraglutide 1.8mg | placebo (add on TZD+MET) | | | Low risk of bias | suggesting | | |
Kaku 0.9mg, 2010 | liraglutide other doses | placebo (on top SU) | | | Low risk of bias | suggesting | | |
LEAD-6, 2009 NCT | liraglutide 1.8mg | exenatide on top MET/SU/MET+SU | | | Risk of bias | suggesting | | |
Seino, 2010 NCT | liraglutide other doses | glibenclamide | | | Low risk of bias | negative | | |
LEAD-3 mono 1.2mg (Garber), 2009 NCT | liraglutide 1.2mg | glimepiride | | | Low risk of bias | negative | | |
LEAD-3 mono 1.8mg (Garber), 2009 NCT | liraglutide 1.8mg | glimepiride | | | Low risk of bias | negative | | |
Madsbad (vs Glimepiride), 2004 | liraglutide other doses | glimepiride | | | Exploratory | suggesting | | |
LEAD-2 (Nauck) (1.2 mg vs glimepiride), 2009 NCT | liraglutide 1.2mg | glimepiride (add on MET) | | | Low risk of bias | negative | | |
LEAD-2 (Nauck) (1.8 mg vs glimepiride), 2009 NCT | liraglutide 1.8mg | glimepiride (add on MET) | | | Low risk of bias | negative | | |
LEAD-5 (vs Glargine), 2009 NCT | liraglutide 1.8mg | insulin glargine (add on SU+MET) | | | Risk of bias | negative | | |
LEAD 1 (1.8 vs 1.2), 2009 | liraglutide 1.8mg | liraglutide 1.2mg | | | | negative | | |
LEAD 2 (1.8 vs 1.2), 2009 | liraglutide 1.8mg | liraglutide 1.2mg | | | | negative | | |
LEAD 4 (1.8 vs 1.2), 2009 | liraglutide 1.8mg | liraglutide 1.2mg | | | | negative | | |
Feinglos, 2005 | liraglutide other doses | metformin | | | Exploratory | negative | | |
LEAD-1 SU (1.2 vs rosiglitazone), 2009 | liraglutide 1.2mg | rosiflitazone | | | | suggesting | | |
LEAD-1 SU (1.8 vs rosiglitazone), 2009 NCT | liraglutide other doses | rosiglitazone (add on SU) | | | Low risk of bias | suggesting | | |
Pratley 1.2mg, 2010 NCT | liraglutide 1.2mg | sitagliptin | | | Risk of bias | suggesting | | |
Pratley 1.8mg, 2010 NCT | liraglutide 1.8mg | sitagliptin | | | Low risk of bias | suggesting | | |
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Astrup (NN8022-1807 ), 2009 NCT | liraglutide | placebo | | | Low risk of bias | - | | |