new version V2017

Atorvastatin cholesterol lowering intervention
Description Results

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

MIRACL, 2001atorvastatinplaceboacute coronary syndrome Low risk of bias Suggesting
Colivicchi, 2002atorvastatinusual careacute coronary syndrome Exploratory Negative
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndromeSuggesting
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome Exploratory Negative

acute myocardial infarction

PROVE-IT, 2004atorvastatin high dosepravastatindiabetic Low risk of bias Suggesting

aortic stenosis

SALTIRE, 2005atorvastatinplaceboaortic stenosis Exploratory Negative

atrial fibrillation

MIRACL (AF ancillary study), 2001atorvastatinplacebo Exploratory Negative
MIRACL (sub-group) (Schwartz), 2004atorvastatinplacebo Exploratory Suggesting
Ozaydin, 2006atorvastatincontrol Exploratory Suggesting
ARMYDA-3 (AF ancillary study), 2006atorvastatinplaceboSuggesting
Dernellis, 2006atorvastatinplacebo Exploratory Suggesting
Chello, 2006atorvastatinplacebo Exploratory Negative
Almroth, 2009atorvastatin placebo Risk of bias Suggesting
STOP-AF ongoing atorvastatinplacebo - NCT00252967

CABG surgery

Patti et al., 2006preoperative atorvastatinplaceboSuggesting
Chello et al., 2006preoperative atorvastatinplaceboNegative

cardiovascular prevention

AVERT, 1999atorvastatin high doseangioplastysecondary prevention Risk of bias Negative
MIRACL, 2001atorvastatinplaceboacute coronary syndrome Low risk of bias Suggesting
Colivicchi, 2002atorvastatinusual careacute coronary syndrome Exploratory Negative
GREACE, 2002atorvastatinusual caresecondary prevention Risk of bias Suggesting
ASCOT (women subgroup) , 2003Atorvastatinplacebowomen Exploratory Negative
Mohler, 2003atorvastatinplacebosecondary prevention Low risk of bias -
Mohler III, 2003atorvastatinplaceboPeripheral Arterial Disease Exploratory -
ASCOT (diabetics sub group), 2003atorvastatinplacebodiabetic patients Exploratory Negative
ASCOT, 2003atorvastatinplaceboat risk hypertensive Low risk of bias Conclusive
CARDS, 2004atorvastatinplacebodiabetic Low risk of bias ConclusiveNCT00327418
REVERSAL, 2004atorvastatin high dosepravastatinsecondary prevention Exploratory Negative
PROVE-IT, 2004atorvastatin high dosepravastatindiabetic Low risk of bias Suggesting
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndromeSuggesting
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome Exploratory Negative
TNT, 2005atorvastatin high doseatorvastatinsecondary prevention Low risk of bias Conclusive NCT00327691
Vascular basis, 2005atorvastatin high doselovastatinsecondary prevention Exploratory Negative
SALTIRE, 2005atorvastatinplaceboaortic stenosis Exploratory Negative
Deutsche Diabetes Dialyse Studie (4D), 2005atorvastatinplacebo Low risk of bias Suggesting
Strey, 2005atorvastatinplaceboheart failure -
IDEAL, 2005atorvastatin high dosesimvastatinsecondary prevention Risk of bias Suggesting NCT00159835
TNT (diabetic sub group), 2006atorvastatin high doseatorvastatindiabetic patients Exploratory Suggesting
ASPEN (primary prevention sub group), 2006atorvastatinplacebodiabetic Exploratory Negative
SPARCL, 2006atorvastatinplacebopost stroke Low risk of bias SuggestingNCT00147602
ASPEN, 2006atorvastatinplacebodiabetic patients Low risk of bias Negative
ASPEN, 2006atorvastatinplacebodiabetic Low risk of bias Negative
SAGE, 2007atorvastatin high dosepravastatinsecondary prevention Exploratory Suggesting

diabetes type 2

ASCOT (diabetics sub group), 2003atorvastatinplacebodiabetic patients Exploratory Negative
CARDS, 2004atorvastatinplacebodiabetic Low risk of bias ConclusiveNCT00327418
TNT (diabetic sub group), 2006atorvastatin high doseatorvastatindiabetic patients Exploratory Suggesting
ASPEN, 2006atorvastatinplacebodiabetic patients Low risk of bias Negative
ASPEN (primary prevention sub group), 2006atorvastatinplacebodiabetic Exploratory Negative

heart failure

Strey, 2005atorvastatinplaceboheart failure -
Wojnicz, 2006atorvastatincontrolheart failureNegative
Sola, 2006atorvastatinplaceboheart failureNegative
Yamada, 2007atorvastatincontrolheart failureNegative

hypertension

ASCOT, 2003atorvastatinplaceboat risk hypertensive Low risk of bias Conclusive

percutaneous coronary intervention

GAIN, 2001atorvastatinusual careNegative
ARMYDA, 2004atorvastatinplaceboSuggesting
NAPLES II (Briguori), 2009atorvastatincontrolSuggesting
ARMYDA-RECAPTURE, 2009atorvastatin reloadplacebo Low risk of bias Suggesting
ESTATE ongoing Atorvastatincontrol - NCT00979940

peripheral vascular diseases

Mohler III, 2003atorvastatinplaceboPeripheral Arterial Disease Exploratory -

post myocardial infarction

REVERSAL, 2004atorvastatin high dosepravastatinsecondary prevention Exploratory Negative
TNT, 2005atorvastatin high doseatorvastatinsecondary prevention Low risk of bias Conclusive NCT00327691
Vascular basis, 2005atorvastatin high doselovastatinsecondary prevention Exploratory Negative
IDEAL, 2005atorvastatin high dosesimvastatinsecondary prevention Risk of bias Suggesting NCT00159835
SAGE, 2007atorvastatin high dosepravastatinsecondary prevention Exploratory Suggesting

post stroke

SPARCL, 2006atorvastatinplacebopost stroke Low risk of bias SuggestingNCT00147602



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