new version V2017

Rivaroxaban antithrombotics
Description Results

BAY 59-7939 - Xarelto      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

ATLAS ACS-TIMI 46 (5mg), 2009rivaroxaban 5mgplaceboNegative NCT00402597
ATLAS ACS-TIMI 46 (2.5mg), 2009rivaroxaban 2.5mgplaceboNegativeNCT00402597
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplacebo Low risk of bias Suggesting NCT00809965
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboSuggesting NCT00809965

atrial fibrillation

ROCKET-AF, 2010rivaroxabanwarfarin standard dose Low risk of bias Suggesting NCT00403767
ROCKET (2nd prevention subgroup) , 2011rivaroxabanwarfarinNegative
ROCKET J ongoing rivaroxabanwarfarin standard dose - NCT00494871

cardiovascular prevention

COMPASS (rivaroxaban alone), 2017rivaroxabanaspirinsecondary prevention - NCT01776424
COMPASS (rivaroxaban + aspirin), 2017rivaroxaban + aspirinaspirinsecondary prevention Low risk of bias - NCT01776424

heart failure

COMMANDER HF, 2018rivaroxabanplaceboNegativeNCT01877915

post stroke

NAVIGATE ESUS, 2018rivaroxabanaspirin - NCT02313909

pulmonary embolism

Einstein-PE Evaluation, 2012rivaroxaban (without LMWH)LMWH/VKA Risk of bias - NCT00439777

thrombosis prevention

ODIXa-KNEE, 2005rivaroxabanenoxaparin (US regimen)knee surgery Exploratory Negative
ODIXa-HIP 10mg, 2006rivaroxabanenoxaparin (short duration)hip surgery Exploratory Suggesting
RECORD 1, 2008rivaroxabanenoxaparinhip surgery Low risk of bias SuggestingNCT00329628
RECORD 3, 2008rivaroxabanenoxaparin (europe regimen)knee surgery Low risk of bias SuggestingNCT00361894
RECORD 2, 2008rivaroxaban (long duration)enoxaparin (short duration)hip surgery Low risk of bias SuggestingNCT00332020
RECORD 4, 2009rivaroxabanenoxaparin (US regimen)knee surgery Low risk of bias SuggestingNCT00362232
MARINER, 2018rivaroxabanplacebomedical patientsSuggesting NCT02111564

venous thrombosis

Einstein-DVT Dose-Ranging Study, 2008rivaroxaban (without LMWH)LMWH/VKA -
EINSTEIN-extension, 2009rivaroxabandiscontinuation Low risk of bias Suggesting NCT00439725
Einstein-DVT Evaluation, 2010rivaroxaban (without LMWH)LMWH/VKA Low risk of bias SuggestingNCT00440193
Einstein-PE Evaluation, 2012rivaroxaban (without LMWH)LMWH/VKA Risk of bias - NCT00439777
SELECT D, 2018rivaroxabandalteparinpatients with cancerSuggesting
CONKO-011 ongoing rivaroxaban - NCT02583191
CASTA-DIVA ongoing rivaroxaban - NCT02746185



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