Clinical trials of heparin (UFH or LMWH)

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
acute coronary syndrome
dalteparin
FRISC (long term), 1996	dalteparin	placebo (on top of aspirin)		Exploratory	Suggesting
FRISC (short term), 1996	dalteparin	placebo (on top of aspirin)		Low risk of bias	-
FRIC prolonged treatment phase (LWMH vs PBO), 1997	dalteparin	placebo (on top of aspirin)			Negative
FRIC (acute phase LMWH vs UFH), 1997	dalteparin	UFH (on top of aspirin)		Exploratory	Negative
enoxaparin
RESCUE	enoxaparin	unfractionated heparin			-	NCT00077818
ESSENCE, 1997	enoxaparin	UFH (on top of aspirin)			Suggesting
TIMI 11 B (short term), 1998	enoxaparin	UFH (on top of aspirin)			Suggesting
TIMI 11 B (long term), 1998	enoxaparin	UFH (on top of aspirin)			Negative
EVET, 2005	enoxaparin	tinzaparin			Suggesting
SYNERGY, 2005	enoxaparin	UFH (on top of aspirin)			Negative	NCT00043784
INTERACT, 2006	enoxaparin	UFH (on top of aspirin)			Suggesting
nadroparin
FRAXIS (6days), 1998	nadroparin	UFH (on top of aspirin)		Low risk of bias	Negative
FRAXIS (14 days), 1998	nadroparin	UFH (on top of aspirin)			Negative
UFH
Theroux (heparin+ASP vs ASP), 1988	UFH	control (on top of aspirin)			Suggesting
Theroux (heparin+aspirin vs PBO), 1988	UFH + aspirin	placebo			Suggesting
Theroux (heparin vs PBO), 1988	UFH	placebo			Suggesting
Cohen (ATACS pilot) (heparin vs asp), 1990	UFH, warfarin	aspirin			Negative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990	UFH, warfarin	control (on top of aspirin)			Negative
RISC (heparin+aspirin vs ASP), 1990	UFH	control (on top of aspirin)			Negative
RISC (heparin vs PBO), 1990	UFH	placebo			Negative
RISC (ASP+ heparin vs PBO), 1990	UFH + aspirin	placebo			Suggesting
ATACS (Cohen), 1994	UFH, warfarin	control (on top of aspirin)			Negative
Holdright, 1994	UFH	control (on top of aspirin)			Negative
Gurfinkel (UFH+aspririn vs aspirin), 1995	UFH	placebo (on top of aspirin)			Negative
acute myocardial infarction
enoxaparin
HART II, 2001	Enoxaparin	UFH			Negative
Baird, 2002	Enoxaparin	UFH			Negative
UFH
ECSG, 1992	UFH	placebo			Negative
DUCCS, 1994	UFH	no heparin			Negative
thrombosis prevention
ardeparin
Godwin, 1993	ardeparin	unfractionated heparin	abdominal surgery		-
Levine, 1996	ardeparin	placebo	knee surgery		Suggesting
Certoparin
Schmitz-Huebner, 1984	certoparin	unfractionated heparin	abdominal surgery		Negative
Sasahara, 1986	certoparin	unfractionated heparin	abdominal surgery		Suggesting
Voigt, 1986	certoparin	unfractionated heparin	abdominal surgery		Negative
Haas , 1987	certoparine + DHE	Unfractionated heparin	hip surgery		Negative
Lassen, 1988	certoparine + DHE	Unfractionated heparin	hip surgery		Suggesting
Welzel, 1988	certoparin	unfractionated heparin	abdominal surgery		Suggesting
Lassen, 1989	certoparine + DHE	Unfractionated heparin	hip surgery		Negative
Kakkar, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Adolf, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Heilmann, 1989	certoparin	unfractionated heparin	gynaecological surgery		Negative
Baumgartner, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Hoffmann and Largiade, 1990	certoparin	unfractionated heparin	abdominal surgery		Negative
Koppenhagen, 1990	certoparin	unfractionated heparin	abdominal surgery		-
Schielke, 1991	certoparin	unfractionated heparin	abdominal surgery		-
Koppenhagen, 1992	certoparin	unfractionated heparin	abdominal surgery		-
Hoffmann and Largiader, 1992	certoparin	unfractionated heparin	abdominal surgery		-
Heilmann, 1997	certoparin	unfractionated heparin	gynaecological surgery		-
Haas, 1999	certoparin	unfractionated heparin	general surgery		-
dalteparin
Haas , 1985	dalteparin	Unfractionated heparin	hip surgery		Negative
Binsack , 1986	dalteparin	Unfractionated heparin	hip surgery		Negative
Bergqvist, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Onarheim, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Barre , 1987	dalteparin	Unfractionated heparin	hip surgery		Negative
Eriksson , 1988	dalteparin	Dextran	hip surgery		Suggesting
Matzsch , 1988	dalteparin	Dextran	hip surgery		Negative
Fricker, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Bergqvist, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Caen, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Borstad, 1988	dalteparin	unfractionated heparin	gynaecological surgery		Negative
Briel, 1988	dalteparin	unfractionated heparin	non orthopedic surgery		Negative
Jorgensen, 1989	dalteparin	placebo	hip surgery		Suggesting
Ockelford , 1989	dalteparin	placebo			Suggesting
Dechavanne , 1989	dalteparin	Unfractionated heparin	hip surgery		Negative
Eriksson , 1989	dalteparin	Unfractionated heparin	hip surgery		Suggesting
Monreal , 1989	dalteparin	Unfractionated heparin	hip surgery		Negative
Creperio, 1990	dalteparin	unfractionated heparin	general surgery		Negative
Hartl, 1990	dalteparin	unfractionated heparin	abdominal surgery		Suggesting
Matzsch , 1991	dalteparin	Dextran	hip surgery		Suggesting
Torholm, 1991	dalteparin	placebo	hip surgery		Suggesting
Borstad, 1992	dalteparin	unfractionated heparin	gynaecological surgery		-
Kakkar, 1993	dalteparin	unfractionated heparin	abdominal surgery		-
enoxaparin
Ho [43]	enoxaparin	no treatment			Negative
Turpie, 1986	enoxaparin	placebo	hip surgery		Suggesting
Melon, 1987	enoxaparin	placebo			Negative
Planes , 1988	enoxaparin	Unfractionated heparin	hip surgery		Suggesting
Samama 1, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Samama 2, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Samama 3, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
DES Group , 1991	enoxaparin	Dextran	hip surgery		Suggesting
Leclerc, 1991	enoxaparin	placebo	knee surgery		Suggesting
Levine , 1991	enoxaparin	Unfractionated heparin	hip surgery		Negative
Kaaja, 1992	enoxaparin	unfractionated heparin	gynaecological surgery		-
Gazzaniga (ISG), 1993	enoxaparin	unfractionated heparin	general surgery		-
Warwick, 1995	enoxaparin	no treatment	hip surgery		Negative
Nurmohamed, 1995	enoxaparin	unfractionated heparin	general surgery		-
McLeod (Canadian), 1995	enoxaparin	unfractionated heparin	abdominal surgery		-
Kalodiki, 1996	enoxaparin	placebo	hip surgery		-
Gonzalez, 1996	enoxaparin	unfractionated heparin	abdominal surgery		-
Samama, 1997	enoxaparin	placebo	hip surgery		Suggesting
ENOXACAN, 1997	enoxaparin	unfractionated heparin	abdominal surgery		-
Agnelli, 1998	enoxaparin	placebo			Suggesting
fraxiparin
Pezzuoli, 1989	nadroparin	placebo			Suggesting
Leyvraz, 1991	nadroparin	Unfractionated heparin	hip surgery		Negative
nadroparin
Marassi [41]	nadroparin	no treatment			Negative
Balas [40]	nadroparin	placebo			Negative
Kakkar and Murray, 1985	nadroparin	unfractionated heparin	general surgery		Suggesting
EFS, 1988	nadroparin	unfractionated heparin	abdominal surgery		Suggesting
Dahan, 1989	nadroparin	unfractionated heparin	thoracic surgery		Negative
Barbui, 1990	nadroparin	unfractionated heparin	general surgery		-
Eurin, 1994	nadroparin	unfractionated heparin	abdominal surgery		-
Sourmelis, 1995	nadroparin	placebo	hip surgery		Suggesting
Nurmohamed, 1996	nadroparin	placebo			Negative
Yoo, 1997	nadroparin	no treatment	hip surgery		Negative
reviparin
Kakkar, 1993	reviparin	unfractionated heparin	general surgery		-
tinzaparin
Bergqvist [42]	tinzaparin	placebo			Negative
Lassen, 1991	tinzaparin	placebo	hip surgery		Suggesting
Leizorovicz, 1991	tinzaparin	unfractionated heparin	abdominal surgery		-
UFH
Cerrato, 1978	UFH	no treatment			Suggesting
venous thrombosis
Bemiparin
Kakkar, 2003	Bemiparin	warfarin		Risk of bias	Negative
dalteparin
Bratt et al , 1985	Dalteparin	unfractionated heparin			Negative
Holm et al , 1986	Dalteparin	unfractionated heparin			Negative
Bratt et al, 1990	Dalteparin	unfractionated heparin			Negative
Holmström, 1992	once daily dalteparin	twice daily dalteparin			Negative
Lindmarker et al , 1993	Dalteparin	unfractionated heparin			Negative
Partsch, 1996	once daily dalteparin	twice daily dalteparin			Negative
Das, 1996	Dalteparin	warfarin		Risk of bias	Negative
Lee, 2003	Dalteparin	warfarin		Risk of bias	Suggesting
enoxaparin
Simonneau et al , 1993	Enoxaparin	unfractionated heparin			Negative
Pini, 1994	Enoxaparin	warfarin		Risk of bias	Negative
Gonzalez-Fajardo, 1999	Enoxaparin	warfarin		Risk of bias	Suggesting
Veiga, 2000	Enoxaparin	acenocoumarol		Risk of bias	Negative
Merli, 2001	once daily enoxaparin	twice daily enoxaparin			Negative
Merli (once daily vs UFH), 2001	once daily enoxaparin	UFH		Low risk of bias	Negative
Meyer, 2002	Enoxaparin	warfarin		Risk of bias	Negative
Deitcher, 2003	Enoxaparin	warfarin		Risk of bias	Negative
González-Fajardo, 2008	Enoxaparin	coumarin		Risk of bias	-
heparin
Krahenbuhl, 1979	subcutaneous heparin	intravenous heparin			-
Bentley, 1980	subcutaneous heparin	intravenous heparin			Suggesting
Andersson, 1982	subcutaneous heparin	intravenous heparin			-
Hull, 1986	subcutaneous heparin	intravenous heparin			Negative
Doyle, 1987	subcutaneous heparin	intravenous heparin			Negative
Walker, 1987	subcutaneous heparin	intravenous heparin			Suggesting
Pini, 1990	subcutaneous heparin	intravenous heparin			Negative
Lopaciuk	subcutaneous heparin	intravenous heparin			Negative
logiparin
Siegbahn, 1989	once daily logiparin	twice daily logiparin			Negative
nadroparin
Collaborative European Multicentre, 1991	Nadroparin	unfractionated heparin			Negative
Prandoni et al , 1992	Nadroparin	unfractionated heparin			Suggesting
Lopaciuk et al , 1992	Nadroparin	unfractionated heparin			Negative
Charbonnier, 1998	once daily nadroparin	twice daily nadroparin			Negative
Lopaciuk, 1999	Nadroparin	acenocoumarol		Risk of bias	Negative
Lopez-Beret, 2001	Nadroparin	acenocoumarol		Risk of bias	Negative
tinzaparin
Hull et al , 1992	Tinzaparin	unfractionated heparin			Suggesting
Hull, 2002	Tinzaparin	warfarin		Risk of bias	Negative
Romera, 2009	Tinzaparin	acenocoumarol		Risk of bias	Suggesting
warfarin
Schulman, 1995	6 months	1.5 months			Suggesting
Levine, 1995	warfarin	discontinuation			Suggesting
DURAC (Schulman), 1997	warfarin	discontinuation			Suggesting
LAFIT (Kearon), 1999	warfarin	discontinuation			Suggesting
Pinede, 2001	3-6 months	1.5-3 months			Negative
Agnelli, 2001	warfarin	discontinuation			Negative
Agnelli, 2003	warfarin	discontinuation			Negative
PREVENT (Ridker), 2003	warfarin	discontinuation			Suggesting
ELAET (Kearon), 2004	warfarin	discontinuation			Negative

heparin (UFH or LMWH) Description Results

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heparin (UFH or LMWH)
Description Results