Clinical trials of fibrinolysis - TrialResults-center.org

Trial	Studied treatment	Control treatment	ROB	Result	NCT
acute coronary syndrome
anistreplase
UNASEM, 1992	anistreplase	placebo	Exploratory	-
t-pa
Gold, 1987	t-PA	placebo	Exploratory	-
Topol, 1988	t-PA	placebo	Exploratory	Negative
Nicklas, 1989	t-PA	placebo	Exploratory	Negative
Ardissino, 1990	t-PA	placebo	Exploratory	Negative
Williams, 1990	t-PA	placebo	Exploratory	Negative
van der Brand, 1991	t-PA	placebo	Exploratory	Negative
Freeman, 1992	t-PA	placebo	Low risk of bias	Negative
charbonnier, 1992	t-PA	placebo	Exploratory	-
TIMI 3A, 1993	t-PA	placebo	Exploratory	-
TIMI 3B, 1995	t-PA	placebo	Low risk of bias	-
acute myocardial infarction
anistreplase
TEAM 2, 1991	anistreplase	streptokinase		-
APSAC
AIMS, 1988	APSAC	placebo		Suggesting
German Multicenter Trial, 1988	APSAC	placebo		Suggesting
APSIM, 1989	APSAC	control		Negative
ISIS III (SK/APSAC), 1992	APSAC	streptokinase		Negative
TEAM 3, 1992	APSAC	t-PA		-
lanoteplase
InTIME-II, 2000	lanoteplase	accelerated t-PA		Negative
reteplase
INJECT, 1995	reteplase	streptokinase		Negative
RAPID-2, 1996	reteplase	accelerated t-PA	Exploratory	Suggesting
GUSTO III, 1997	reteplase	accelerated t-PA		Negative
saruplase
PRIMI (vs SK), 1989	saruplase	streptokinase		-
PRIMI (vs UK), 1989	saruplase	urokinase		-
SESAM, 1997	saruplase	t-PA	Exploratory	Negative
COMPASS, 1998	saruplase	streptokinase		Negative
streptokinase
GISSI I, 1986	streptokinase	placebo		Suggesting
ISAM, 1986	streptokinase	placebo		Negative
ISIS 2 pilot, 1987	streptokinase	placebo		-
Western Washington Intravenous Trial, 1988	streptokinase	placebo		Negative	NCT00000507
ISIS-2 (SK), 1988	streptokinase	placebo		Suggesting
EMERAS (all delay), 1993	streptokinase	placebo		Negative
EMERAS (7-12h), 1993	streptokinase	placebo		-
GUSTO tPA-SK Hiv, 1993	t-PA + streptokinase	streptokinase		Negative
t-pa
ECSG, 1985	t-PA	streptokinase		Negative
TIMI-1, 1987	t-PA	streptokinase		-	NCT00000505
ASSET, 1988	t-PA	placebo		Suggesting
PAIMS, 1989	t-PA	streptokinase		-
White, 1989	t-PA	streptokinase		-
International Study Group, 1990	t-PA	streptokinase		Suggesting
GISSI II, 1990	t-PA	streptokinase		Suggesting
KAMIT, 1991	t-PA half dose	t-PA	Exploratory	Negative
TAMI 5 (t-PA vs uroK), 1991	t-PA	urokinase		-
TAPS, 1992	accelerated t-PA	APSAC		Negative
TAMI 6, 1992	t-PA	placebo		Negative
ISIS III (SK/tPA), 1992	t-PA	streptokinase		Suggesting
Cherng, 1992	t-PA	streptokinase		Negative
RAAMI, 1992	accelerated t-PA	t-PA		-
LATE, 1993	t-PA	placebo	Low risk of bias	Negative
GUSTO tPA Hiv, 1993	accelerated t-PA	streptokinase		Suggesting
Centre Illinois, 1993	t-PA	streptokinase		-
TIMI 4, 1994	accelerated t-PA	APSAC		-
COBALT, 1997	bolus t-PA	accelerated t-PA		Negative
tenecteplase
ASSENT-2, 1999	tenecteplase	accelerated t-PA		Suggesting
urokinase
USIM, 1991	urokinase	control		-
cardiac arrest
t-pa
Abu-Laban, 2002	t-PA	placebo	Exploratory	Negative
tenecteplase
TICA, 2004	tenecteplase	placebo	Exploratory	Negative
TROICA, 2008	tenecteplase	placebo	Low risk of bias	Negative	NCT00157261
pulmonary embolism
candesartan
Tebbe, 2009	desmoteplase	alteplase	Exploratory	-
rt-PA
Levine, 1990	rt-PA	placebo	Low risk of bias	Negative
PIOPED, 1990	rt-PA	placebo	Exploratory	Negative
PAIMS 2, 1992	rt-PA	no fibrinolysis	Exploratory	Negative
Goldhaber, 1993	rt-PA	no fibrinolysis	Exploratory	Negative
Konstantinides, 2002	rt-PA	placebo	Low risk of bias	Negative
streptokinase
Tibbutt, 1974	streptokinase	no fibrinolysis	Exploratory	Negative
Ly, 1978	streptokinase	no fibrinolysis	Exploratory	Negative
Jerjes-Sanchez, 1995	streptokinase	no fibrinolysis	Exploratory	-
tenecteplase
PEITHO ongoing	tenecteplase	placebo		-	NCT00639743
urokinase
UPET, 1973	urokinase	placebo	Low risk of bias	Negative
Marini, 1988	urokinase	no fibrinolysis	Exploratory	-
venous thrombosis
heparin
Schweizer tPA, 1998	tPA+heparin	no fibrinolysis		Negative
streptokinase
Kakkar (streptokinase), 1969	streptokinase	no fibrinolysis		Negative
Tsapogas, 1973	streptokinase	no fibrinolysis		Negative
Common, 1976	streptokinase	no fibrinolysis		Negative
Arneson, 1978	streptokinase	no fibrinolysis		Negative
Schulman, 1986	streptokinase	no fibrinolysis		Negative
Schweizer (systemic SK), 2000	streptokinase	no fibrinolysis		-
Elsharawy, 2002	streptokinase	no fibrinolysis		Negative
t-pa
Verhaeghe (high dose), 1989	tPA	no fibrinolysis		-
Verhaeghe (low dose), 1989	tPA	no fibrinolysis		-
Goldhaber (tPA+heparin), 1990	tPA	no fibrinolysis		-
Turpie, 1990	tPA	no fibrinolysis		Negative
Goldhaber (tPA alone), 1990	tPA	no fibrinolysis		Negative
Schweizer (local tPA), 2000	tPA	no fibrinolysis		-
urokinase
Kiil, 1981	urokinase	no fibrinolysis		Negative
Schweizer (urokinase), 1998	urokinase	no fibrinolysis		Negative
Schweizer (systemic urokinase), 2000	urokinase	no fibrinolysis		-
Schweizer (local urokinase), 2000	urokinase	no fibrinolysis		-

fibrinolysis Description Results

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fibrinolysis
Description Results