LMWH trial summary

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
thrombosis prevention
ardeparin
Godwin, 1993	ardeparin	unfractionated heparin	abdominal surgery		-
Levine, 1996	ardeparin	placebo	knee surgery		Suggesting
Certoparin
Schmitz-Huebner, 1984	certoparin	unfractionated heparin	abdominal surgery		Negative
Sasahara, 1986	certoparin	unfractionated heparin	abdominal surgery		Suggesting
Voigt, 1986	certoparin	unfractionated heparin	abdominal surgery		Negative
Haas , 1987	certoparine + DHE	Unfractionated heparin	hip surgery		Negative
Lassen, 1988	certoparine + DHE	Unfractionated heparin	hip surgery		Suggesting
Welzel, 1988	certoparin	unfractionated heparin	abdominal surgery		Suggesting
Lassen, 1989	certoparine + DHE	Unfractionated heparin	hip surgery		Negative
Kakkar, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Adolf, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Heilmann, 1989	certoparin	unfractionated heparin	gynaecological surgery		Negative
Baumgartner, 1989	certoparin	unfractionated heparin	abdominal surgery		Negative
Hoffmann and Largiade, 1990	certoparin	unfractionated heparin	abdominal surgery		Negative
Koppenhagen, 1990	certoparin	unfractionated heparin	abdominal surgery		-
Schielke, 1991	certoparin	unfractionated heparin	abdominal surgery		-
Koppenhagen, 1992	certoparin	unfractionated heparin	abdominal surgery		-
Hoffmann and Largiader, 1992	certoparin	unfractionated heparin	abdominal surgery		-
Heilmann, 1997	certoparin	unfractionated heparin	gynaecological surgery		-
Haas, 1999	certoparin	unfractionated heparin	general surgery		-
CERTIFY, 2010	certoparin	UFH	medical patients		-
dalteparin
Haas , 1985	dalteparin	Unfractionated heparin	hip surgery		Negative
Binsack , 1986	dalteparin	Unfractionated heparin	hip surgery		Negative
Bergqvist, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Onarheim, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Koller, 1986	dalteparin	unfractionated heparin	abdominal surgery		Negative
Barre , 1987	dalteparin	Unfractionated heparin	hip surgery		Negative
Eriksson , 1988	dalteparin	Dextran	hip surgery		Suggesting
Matzsch , 1988	dalteparin	Dextran	hip surgery		Negative
Fricker, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Bergqvist, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Caen, 1988	dalteparin	unfractionated heparin	abdominal surgery		Negative
Borstad, 1988	dalteparin	unfractionated heparin	gynaecological surgery		Negative
Briel, 1988	dalteparin	unfractionated heparin	non orthopedic surgery		Negative
Jorgensen, 1989	dalteparin	placebo	hip surgery		Suggesting
Dechavanne , 1989	dalteparin	Unfractionated heparin	hip surgery		Negative
Eriksson , 1989	dalteparin	Unfractionated heparin	hip surgery		Suggesting
Monreal , 1989	dalteparin	Unfractionated heparin	hip surgery		Negative
Ockelford , 1989	dalteparin	placebo			Suggesting
Creperio, 1990	dalteparin	unfractionated heparin	general surgery		Negative
Hartl, 1990	dalteparin	unfractionated heparin	abdominal surgery		Suggesting
Torholm, 1991	dalteparin	placebo	hip surgery		Suggesting
Matzsch , 1991	dalteparin	Dextran	hip surgery		Suggesting
Borstad, 1992	dalteparin	unfractionated heparin	gynaecological surgery		-
Kakkar, 1993	dalteparin	unfractionated heparin	abdominal surgery		-
Leizorovicz, 2004	dalteparin	placebo	medical patients		Suggesting
PROTECT, 2011	dalteparin	UFH	medical patients	Low risk of bias	Suggesting	NCT00182143
enoxaparin
Ho [43]	enoxaparin	no treatment			Negative
Turpie, 1986	enoxaparin	placebo	hip surgery		Suggesting
Melon, 1987	enoxaparin	placebo			Negative
Planes , 1988	enoxaparin	Unfractionated heparin	hip surgery		Suggesting
Samama 1, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Samama 2, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Samama 3, 1988	enoxaparin	unfractionated heparin	general surgery		Negative
Leclerc, 1991	enoxaparin	placebo	knee surgery		Suggesting
DES Group , 1991	enoxaparin	Dextran	hip surgery		Suggesting
Levine , 1991	enoxaparin	Unfractionated heparin	hip surgery		Negative
Kaaja, 1992	enoxaparin	unfractionated heparin	gynaecological surgery		-
Gazzaniga (ISG), 1993	enoxaparin	unfractionated heparin	general surgery		-
Warwick, 1995	enoxaparin	no treatment	hip surgery		Negative
Nurmohamed, 1995	enoxaparin	unfractionated heparin	general surgery		-
McLeod (Canadian), 1995	enoxaparin	unfractionated heparin	abdominal surgery		-
Kalodiki, 1996	enoxaparin	placebo	hip surgery		-
Gonzalez, 1996	enoxaparin	unfractionated heparin	abdominal surgery		-
Bergmann and Neuhart, 1996	enoxaparin	UFH	medical patients		Negative
Lechler, 1996	enoxaparin	UFH	medical patients		Negative
Samama, 1997	enoxaparin	placebo	hip surgery		Suggesting
ENOXACAN, 1997	enoxaparin	unfractionated heparin	abdominal surgery		-
Agnelli, 1998	enoxaparin	placebo			Suggesting
MEDENOX, 1999	Enoxaparin	placebo	medical patients	Low risk of bias	Suggesting
Kleber, 2003	enoxaparin	UFH	medical patients		Negative
Lederle, 2006	Enoxaparin	placebo	medical patients		Negative
LIFENOX, 2011	enoxaparin	placebo	medical patients	Low risk of bias	Negative	NCT00622648
fraxiparin
Pezzuoli, 1989	nadroparin	placebo			Suggesting
Leyvraz, 1991	nadroparin	Unfractionated heparin	hip surgery		Negative
LMWH
Harenberg, 1990	LMWH	UFH	medical patients		Negative
Harenberg, 1996	LMWH	UFH	medical patients		Negative
nadroparin
Balas [40]	nadroparin	placebo			Negative
Marassi [41]	nadroparin	no treatment			Negative
Kakkar and Murray, 1985	nadroparin	unfractionated heparin	general surgery		Suggesting
EFS, 1988	nadroparin	unfractionated heparin	abdominal surgery		Suggesting
Dahan, 1989	nadroparin	unfractionated heparin	thoracic surgery		Negative
Barbui, 1990	nadroparin	unfractionated heparin	general surgery		-
Eurin, 1994	nadroparin	unfractionated heparin	abdominal surgery		-
Sourmelis, 1995	nadroparin	placebo	hip surgery		Suggesting
Nurmohamed, 1996	nadroparin	placebo			Negative
Bergmann, 1996	nadroparin	placebo	medical patients		Negative
Yoo, 1997	nadroparin	no treatment	hip surgery		Negative
Fraisse, 2000	Nadroparin	placebo	medical patients		Negative
Mahe, 2005	Nadroparin	placebo	medical patients		Negative
reviparin
Kakkar, 1993	reviparin	unfractionated heparin	general surgery		-
tinzaparin
Bergqvist [42]	tinzaparin	placebo			Negative
Lassen, 1991	tinzaparin	placebo	hip surgery		Suggesting
Leizorovicz, 1991	tinzaparin	unfractionated heparin	abdominal surgery		-
UFH
Cerrato, 1978	UFH	no treatment			Suggesting
venous thrombosis
Bemiparin
Kakkar, 2003	Bemiparin	warfarin		Risk of bias	Negative
dalteparin
Bratt et al , 1985	Dalteparin	unfractionated heparin			Negative
Holm et al , 1986	Dalteparin	unfractionated heparin			Negative
Bratt et al, 1990	Dalteparin	unfractionated heparin			Negative
Holmström, 1992	once daily dalteparin	twice daily dalteparin			Negative
Lindmarker et al , 1993	Dalteparin	unfractionated heparin			Negative
Partsch, 1996	once daily dalteparin	twice daily dalteparin			Negative
Das, 1996	Dalteparin	warfarin		Risk of bias	Negative
Lee, 2003	Dalteparin	warfarin		Risk of bias	Suggesting
enoxaparin
Simonneau et al , 1993	Enoxaparin	unfractionated heparin			Negative
Pini, 1994	Enoxaparin	warfarin		Risk of bias	Negative
Gonzalez-Fajardo, 1999	Enoxaparin	warfarin		Risk of bias	Suggesting
Veiga, 2000	Enoxaparin	acenocoumarol		Risk of bias	Negative
Merli, 2001	once daily enoxaparin	twice daily enoxaparin			Negative
Merli (once daily vs UFH), 2001	once daily enoxaparin	UFH		Low risk of bias	Negative
Meyer, 2002	Enoxaparin	warfarin		Risk of bias	Negative
Deitcher, 2003	Enoxaparin	warfarin		Risk of bias	Negative
González-Fajardo, 2008	Enoxaparin	coumarin		Risk of bias	-
logiparin
Siegbahn, 1989	once daily logiparin	twice daily logiparin			Negative
nadroparin
Collaborative European Multicentre, 1991	Nadroparin	unfractionated heparin			Negative
Prandoni et al , 1992	Nadroparin	unfractionated heparin			Suggesting
Lopaciuk et al , 1992	Nadroparin	unfractionated heparin			Negative
Charbonnier, 1998	once daily nadroparin	twice daily nadroparin			Negative
Lopaciuk, 1999	Nadroparin	acenocoumarol		Risk of bias	Negative
Lopez-Beret, 2001	Nadroparin	acenocoumarol		Risk of bias	Negative
tinzaparin
Hull et al , 1992	Tinzaparin	unfractionated heparin			Suggesting
Hull, 2002	Tinzaparin	warfarin		Risk of bias	Negative
Romera, 2009	Tinzaparin	acenocoumarol		Risk of bias	Suggesting

LMWH Trials Results

Group by...

thrombosis prevention

ardeparin

Certoparin

dalteparin

enoxaparin

fraxiparin

LMWH

nadroparin

reviparin

tinzaparin

UFH

venous thrombosis

Bemiparin

dalteparin

enoxaparin

logiparin

nadroparin

tinzaparin

LMWH
Trials Results