aldosterone blockade
Trials Results

Eplerenone - Spironolactone

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

heart failure

eplerenone
EPHESUS, 2003eplerenoneplacebo Low risk of bias Suggesting
EMPHASIS-HF, 2010eplerenoneplacebo Low risk of bias Suggesting NCT00232180
REMODEL ongoing eplerenoneplacebo - NCT00082589
Weir ongoing eplerenoneplacebo Exploratory - NCT00132093
spironolactone
Mauersberger, 1985spironolactone+furosemidespironolactone+butizide Exploratory -
Han, 1994spironolactone+captoprilcaptopril Exploratory -
MacFadyen, 1997spironolactoneplacebo Exploratory -
RALES, 1998spironolactoneplacebo Risk of bias Suggesting
Bednarz, 2000aldactonefurosemide Exploratory -
Ramires, 2000spironolactonecontrol Exploratory -
Farquharson, 2000spironolactoneplacebo Exploratory -
Yee, 2001spironolactoneplacebo -
Tsutamoto, 2001spironolactoneplacebo Exploratory -
Cicoira, 2002spironolactonecontrol Exploratory -
Mottram, 2004spironolactoneplacebo Exploratory -
Macdonald, 2004spironolactoneplacebo Exploratory -
Cicoira, 2004spironolactonecontrol -
Agostoni, 2005spironolactoneplacebo Exploratory -
PIE II ongoing spironolactoneplacebo - NCT00123955
Nouvel essai ongoing spironolactonespironolactone Exploratory - NCT00125437



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