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Eplerenone
aldosterone blockade
Description
Results
Inspra - eplerenon
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heart failure
Synopsis
Synopsis
Results
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Patients_
Method
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All cause death
Adverse events
Cardiovascular death
Death from any cause or hospitalization for any reason
hospitalisation for heart failure
Sudden death
serious hyperkalemia
death from cardiovascular causes or hospitalization for cardiovascular causes
hospitalisation for cardiovascular causes
Adverse events leading to treatment discontinuation
NYHA class improvement
exacerbation of heart failure
Hospitalization for any reason
Death from any cause or hospitalization for heart failure
NYHA change
LV ejection fraction
exercise capacity
death from cardiovascular causes or hospitalization for heart failure
pdf
Trial
Studied treatment
Control treatment
patients
ROB
Result
NCT
heart failure
EPHESUS, 2003
eplerenone
placebo
Low risk of bias
Suggesting
EMPHASIS-HF, 2010
eplerenone
placebo
Low risk of bias
Suggesting
NCT00232180
REMODEL
ongoing
eplerenone
placebo
-
NCT00082589
Weir
ongoing
eplerenone
placebo
Exploratory
-
NCT00132093
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