| heart failure | versus active treatment No demonstrated result for efficacy | 2 trials | meta-analysis | | | Trial | control | p<0.05 | harm | NS |
|---|
| Boccanelli, 1986 | furosemide vs captopril | | | NYHA functional class improvement 0.71 [0.45; 1.14] worsening heart failure, ∞ [NaN; ∞] | | Cowley, 1986 | furosemide vs captopril | | | |
| Trial | Treatments | Patients | Method |
|---|
| Boccanelli, 1986 | furosemide 25 to 100 mg od (n=8) vs. captopril 12.5 to 50 mg bid +furosemide 25mg od (n=7) | patients with moderate congestive heart failure not completely controlled on digoxin (0.25 mg o.d.) and frusemide (25 mg o.d.), | double blind Parallel groups Sample size: 8/7 Primary endpoint: exercise FU duration: 13 weeks | | Cowley, 1986 | furosemide (increased doses of frusemide) (n=10) vs. captopril (addition) (n=10) introduction | patients with moderate heart failure who still had symptoms despite 40 mg frusemide daily | double blind Cross over Sample size: 10/10 Primary endpoint: exercise tolerance FU duration: |
|
