aromatase inhibitors

systematic review meta-analysis network meta-analysis

Select advanced breast cancer (metastatic) All type of patient       AI alonecombination including AI aminoglutethimide anastrozoleexemestane fadrozole formestane letrozole vs combinationvs different AIvs estrogen receptor antagonistvs X      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	objective response (ORR) (36)clinical benefit (32)hot flushes (20)nausea (18)rash (15)progression or death (progression free survival PFS) (15)death (overall survival) (13)diarrhoea (10)vomiting (8)vaginal bleeding (6)thromboembolic AE (6)arthralgia (6) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	objective response (ORR)	clinical benefit
advanced breast cancer (metastatic)
aminoglutethimide
Mercer, 1993	aminoglutethimide	hydrocortisone				negative
Canney, 1988	aminoglutethimide	medroxyprogesterone acetate				suggesting
Garcia-Giralt, 1992	aminoglutethimide	medroxyprogesterone acetate				negative
Samonis, 1994	aminoglutethimide	medroxyprogesterone acetate				negative
Lundgren, 1989	aminoglutethimide	megestrol acetate				negative
Russell, 1997	aminoglutethimide	megestrol acetate				negative
Alonso-Munoz, 1988	aminoglutethimide	tamoxifen				negative
Gale, 1994	aminoglutethimide	tamoxifen				negative
Ingle, 1986	aminoglutethimide + tamoxifen	tamoxifen				negative
Powles, 1984	combination of hormone therapies	tamoxifen				negative
anastrozole
Mauriac, 2003	anastrozole	fulvestrant				negative
Buzdar a, 1996	anastrozole	megestrol acetate				negative
TARGET (Bonneterre), 2001	anastrozole	tamoxifen				suggesting
Milla-Santos, 2003	anastrozole	tamoxifen				negative
exemestane
Chia, 2008	exemestane	fulvestrant				negative
Kaufmann, 2000	exemestane	megestrol acetate				negative
Paridaens, 2003	exemestane	tamoxifen				negative
fadrozole
Bezwoda, 1998	fadrozole	megestrol acetate				negative
Buzdar b, 1996	fadrozole	megestrol acetate				negative
Buzdar c, 1996	fadrozole	megestrol acetate				negative
Thuerlimann, 1996	fadrozole	tamoxifen				negative
Falkson, 1996	fadrozole	tamoxifen				negative
formestane
Kleeberg, 1997	formestane	anastrozole				negative
Thuerlimann, 1997	formestane	megestrol acetate				negative
Freue, 2000	formestane	megestrol acetate				suggesting
Perez Carrion, 1994	formestane	tamoxifen				negative
letrozole
Gershanovich, 1998	letrozole	aminoglutethimide				negative
Rose, 2003	letrozole	anastrozole				negative
Goss, 2007	letrozole	atamestane + toremifene				negative
Tominaga, 2003	letrozole	fadrozole				negative
Buzdar, 2001	letrozole	megestrol acetate				suggesting
Dombernowsky, 1998	letrozole	megestrol acetate				negative
Mourisden, 2001	letrozole	tamoxifen				negative