cardiac arrest

systematic review meta-analysis network meta-analysis

Select Public Access Defibrillation active compression-decompression CPRantiarrythmic drugscompression-only CPRfibrinolysismodified resuscitation protocolomega-3 fatty acids vasopressin All type of patientuncoded clinical condition ***out hospital patientspatients with an implantable cardioverter defibrillator       active compression-decompression CPRamiodaroneAutomatic External Defibrillationchest compressions before defibrillationcompression-only CPRfibrinolyticfish oilvasopressin amiodaronefish oilt-patenecteplase vs Cardiopulmonary Resuscitationvs control or placebovs defibrillation firstvs epinephrinevs placebovs placebo or controlvs lidocainevs standard CPR      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	Survival to hospital discharge (18)Return of spontaneous circulation (12)favorable neurologic outcome at discharge (10)long-term survival (8)All cause death (7)Death before hospital discharge (7)Failure of return of spontaneous circulation (7)Death before hospital admission (3)implantable cardioverter defibrillator discharge (3)survival to hospital admission (2)Death within 24 hours (2)intracranial hemorrhage (1)ischemic stroke (1)survivors of definite out of hospital cardiac arrest (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	Survival to hospital discharge	Return of spontaneous circulation
active compression-decompression CPR
not classified
Aufderheide, 2011	active compression-decompression CPR	standard CPR			Risk of bias	suggesting
antiarrythmic drugs
amiodarone
ARREST, 1999	amiodarone	placebo			Low risk of bias	suggesting
ALIVE, 2002	amiodarone	lidocaine			Low risk of bias	suggesting
compression-only CPR
not classified
Rea, 2010    NCT	compression-only CPR	standard CPR				negative
Svensson, 2010	compression-only CPR	standard CPR				negative
Hallstrom, 2000	compression-only CPR	standard CPR			Risk of bias	negative
Hallstrom + preliminary study	compression-only CPR	standard CPR				-
fibrinolysis
t-pa
Abu-Laban, 2002	t-PA	placebo			Low risk of bias	negative
tenecteplase
TROICA, 2008      NCT	tenecteplase	placebo			Low risk of bias	negative
TICA, 2004	tenecteplase	placebo			Low risk of bias	negative
modified resuscitation protocol
not classified
Jost, 2010	compressions first	defibrillation first				negative
Baker, 2008	compressions first	defibrillation first				negative
Jacobs, 2005	compressions first	defibrillation first				negative
Wik, 2003	compressions first	defibrillation first				negative
Aufderheide, 2011	active compression-decompression CPR	standard CPR			Risk of bias	suggesting
Rea, 2010    NCT	compression-only CPR	standard CPR				negative
Svensson, 2010	compression-only CPR	standard CPR				negative
Hallstrom, 2000	compression-only CPR	standard CPR			Risk of bias	negative
Hallstrom + preliminary study	compression-only CPR	standard CPR				-
omega-3 fatty acids
fish oil
Raitt , 2006    NCT	fish oil	placebo			Low risk of bias	negative
SOFA , 2006      NCT	fish oil	placebo			Low risk of bias	negative
Leaf, 2005	fish oil	placebo				suggesting
Public Access Defibrillation
not classified
HAT      NCT	Automatic External Defibrillation	Cardiopulmonary Resuscitation				-
PAD (Hallstrom), 2004	Automatic External Defibrillation	Cardiopulmonary Resuscitation				negative
vasopressin
not classified
Lindner, 1997	vasopressin	epinephrine			Low risk of bias	suggesting
Li, 1999	vasopressin	epinephrine				suggesting
Lee, 2000	vasopressin	epinephrine				negative
Stiell, 2001	vasopressin	epinephrine			Low risk of bias	negative
Wenzel, 2004	vasopressin	epinephrine				negative