CABG surgery

systematic review meta-analysis network meta-analysis

Select off-pump CABGradial graftvein grafts pretreatmentcholesterol lowering interventionantiplatelets drugpreconditioning All type of patientuncoded clinical condition ***       artery graftsCABGclopidogrelE2F transcription factor decoyplatelet aggregation inhibitorspreconditioningstatins atorvastatinsimvastatinaspirincangrelorclopidogreldipyridamolsulfinpyrazonesulotrobanticlopidine vs controlvs on pump CABGvs placebovs placebo or controlvs saphenous vein grafts      

Filter

Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (57)stroke (fatal and non fatal) (47)myocardial infarction (fatal and non fatal) (41)atrial fibrillation (30)Cardiovascular death (28)cardiovascular events (27)Non vascular death (23)Non fatal MI (19)Non fatal stroke (18)new cardiac revascularization (17)graft occlusion (12)graft patency (6)cardiac event (fatal and non fatal ) (3)Long term death (2)Myocardial ischemia (1)death or vein graft failure (1)cardiac death (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	stroke (fatal and non fatal)
antiplatelets drug
not classified
VA Co-op CABG, 1988	various	placebo			Low risk of bias	negative
Guiteras, 1989	various	placebo			Low risk of bias	negative
aspirin
McEnany, 1982	aspirin	placebo			Low risk of bias	negative
Lorenz, 1984	aspirin	placebo			Low risk of bias	negative
GESIC (aspirin), 1990	aspirin	placebo			Low risk of bias	negative
Sydney, 1991	aspirin	placebo			Low risk of bias	-
Hockings, 1993	aspirin	placebo			Low risk of bias	-
clopidogrel
CASCADE, 2009      NCT	clopidogrel+aspirin	aspirin			Low risk of bias	-
dipyridamol
Pantely, 1979	aspirin + dipyridamol	control				negative
Brussels, 1987	aspirin + dipyridamol	control				negative
Czech, 1986	aspirin + dipyridamol	control				-
Des Moines, 1980	aspirin + dipyridamol	control				-
Toronto dipyridamole, 1987	dipyridamol	control				-
Brooks, 1985	aspirin + dipyridamol	placebo			Low risk of bias	negative
Mayo-A, 1984	aspirin + dipyridamol	placebo			Low risk of bias	negative
Wadsworth, 1985	aspirin + dipyridamol	placebo			Low risk of bias	negative
Basel, 1989	aspirin + dipyridamol	placebo			Low risk of bias	negative
Leeds-B, 1985	aspirin + dipyridamol	placebo			Low risk of bias	-
Thaulow, 1987	aspirin + dipyridamol	placebo			Low risk of bias	-
GESIC (aspirin+dipyridamol), 1990	aspirin + dipyridamol	placebo			Low risk of bias	negative
Ekestrom, 1990	dipyridamol	placebo			Low risk of bias	-
sulfinpyrazone
Baur, 1982	sulfinpyrazone	placebo			Low risk of bias	-
sulotroban
German sulotroban, 1989	sulotroban	control				-
ticlopidine
Zurich, 1982	ticlopidine	control				-
Knudsen-B, 1983	ticlopidine	control				-
Romeo, 1983	ticlopidine	control				-
Kohn, 1990	ticlopidine	control				-
Liège-I, 1984	ticlopidine	placebo			Low risk of bias	negative
Liège-II, 1987	ticlopidine	placebo			Low risk of bias	negative
cholesterol lowering intervention
not classified
Song, 2008      NCT						negative
atorvastatin
Chello et al., 2006	preoperative atorvastatin	placebo			Low risk of bias	negative
Patti et al., 2006	preoperative atorvastatin	placebo			Low risk of bias	suggesting
simvastatin
Christenson, 1999	preoperative simvastatin	no treatment				negative
off-pump CABG
not classified
BBS (Moller), 2010          NCT	off-pump	on-pump			Risk of bias	suggesting
DOORS, 2009    NCT	off-pump	on-pump			Risk of bias	negative
PRAGUE 4 (Widimsky), 2004	off-pump	on-pump			Risk of bias	negative
BHACAS I (Ascione), 1999	off-pump	on-pump			Risk of bias	suggesting
BHACAS II (Angelini), 2002	off-pump	on-pump			Risk of bias	suggesting
OCTOPUS (van Dijk), 2002	off-pump	on-pump			Risk of bias	negative
SMART (Staton), 2003	off-pump	on-pump			Risk of bias	negative
Al-Ruzzeh b, 2006	off-pump	on-pump			Risk of bias	negative
Gu, 1998	off-pump	on-pump			Exploratory	negative
Diegeler, 2000	off-pump	on-pump			Exploratory	negative
Gulielmos, 1999	off-pump	on-pump			Exploratory	negative
Matata, 2000	off-pump	on-pump			Exploratory	negative
Covino, 2001	off-pump	on-pump			Exploratory	negative
Penttila, 2001	off-pump	on-pump			Exploratory	negative
Caputo, 2002	off-pump	on-pump			Exploratory	negative
Zamvar, 2002	off-pump	on-pump			Exploratory	negative
Carrier, 2003	off-pump	on-pump			Exploratory	negative
Raja b, 2003	off-pump	on-pump			Exploratory	suggesting
Alwan, 2004	off-pump	on-pump			Exploratory	negative
Gerola, 2001	off-pump	on-pump			Exploratory	negative
Khan, 2004	off-pump	on-pump			Exploratory	suggesting
Legare, 2004          NCT	off-pump	on-pump			Exploratory	negative
Lingaas, 2003	off-pump	on-pump			Exploratory	negative
Motallebzadeh, 2004	off-pump	on-pump			Exploratory	negative
Selvanayagam, 2004	off-pump	on-pump			Exploratory	negative
Ascionee, 2005	off-pump	on-pump			Exploratory	negative
Kobayashi, 2005	off-pump	on-pump			Exploratory	negative
Ascione, 2006	off-pump	on-pump			Exploratory	negative
Michaux, 2006	off-pump	on-pump			Exploratory	negative
Motallebzadeh b, 2006	off-pump	on-pump			Exploratory	negative
Niranjan, 2006	off-pump	on-pump			Exploratory	negative
Paparella, 2006	off-pump	on-pump			Exploratory	negative
Tatoulis, 2006	off-pump	on-pump			Exploratory	negative
Jares, 2006	off-pump	on-pump			Exploratory	negative
Kunes, 2007	off-pump	on-pump			Exploratory	negative
Ozkara, 2007	off-pump	on-pump			Exploratory	negative
ROOBY (Shroyer), 2009    NCT	off-pump	on-pump			Risk of bias	suggesting
Baker, 2001	off-pump	on-pump			Exploratory	negative
Lee, 2003	off-pump	on-pump			Exploratory	negative
Vedin, 2006	off-pump	on-pump			Exploratory	negative
Czerny, 2000	off-pump	on-pump			Exploratory	negative
Czerny b, 2001	off-pump	on-pump			Exploratory	negative
Dorman, 2004	off-pump	on-pump			Exploratory	-
Gasz, 2004	off-pump	on-pump			Exploratory	negative
Guler, 2001	off-pump	on-pump			Exploratory	negative
Muneretto, 2003	off-pump	on-pump			Exploratory	suggesting
Parolari, 2003	off-pump	on-pump			Exploratory	negative
Parolari b, 2003	off-pump	on-pump			Exploratory	-
Puskas, 2004	off-pump	on-pump			Exploratory	negative
Sahlman, 2003	off-pump	on-pump			Exploratory	negative
Syed, 2004	off-pump	on-pump			Exploratory	-
Tang, 2002	off-pump	on-pump			Exploratory	negative
Velisaris, 2003	off-pump	on-pump			Exploratory	negative
Vural, 1995	off-pump	on-pump			Exploratory	negative
Wan, 2004	off-pump	on-pump			Exploratory	-
Wandschneider, 2000	off-pump	on-pump			Exploratory	negative
PROMISS (Uva), 2010	off-pump	on-pump			Risk of bias	negative
preconditioning
not classified
Cheung, 2006	remote ischemic preconditioning	control				-
Gunaydin, 2000	remote ischemic preconditioning	control				-
Hausenloy, 2007      NCT	remote ischemic preconditioning	control				-
Ali, 2007	remote ischemic preconditioning	no RIPC				-
radial graft
not classified
CARRPO, 2009      NCT	artery grafts	saphenous vein grafts			Exploratory	negative
RAPS (Desai), 2004          NCT	radial artery grafts	saphenous vein grafts			Exploratory	suggesting
RSVP, 2008      NCT	radial artery grafts	saphenous vein grafts			Risk of bias	suggesting
Gaudino (radial A), 2005	radial artery grafts	saphenous vein grafts			Risk of bias	suggesting
VA CABG, 2010    NCT	radial artery grafts	saphenous vein grafts			Exploratory	negative
Gaudino (RITA), 2005	right internal thoracic artery grafts	saphenous vein grafts			Exploratory	suggesting
vein grafts pretreatment
not classified
PREVENT IV, 2005    NCT	edifoligide pretreatment	placebo			Low risk of bias	negative