PCI

systematic review meta-analysis network meta-analysis

Select acute myocardial infarction All type of patientelderly patientsuncoded clinical condition ***patient ineligible for thrombolysispatients with inducible post MI ischemia       deferred angioplasty (>3 days) after thrombolysisdrug-eluting stentsearly angioplasty (<3 days) after thrombolysisimmediate PCI after thrombolysisprimary PCIrepeat fibrinolysisrescue PCItransfer for primary angioplasty drug-eluting stentspaclitaxelPCIprimary angioplastyPTCAsirolimus eluting stentzotarolimus eluting stent vs bare-metalvs no systematic PCIvs ballon angioplastyvs drug-eluting stentsvs thrombolytic      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	reinfarction (47)All cause death (45)stroke (fatal and non fatal) (26)Long term death (23)In-hospital death (19)MACE (17)In-hospital death (15)Major bleeding (15)Revascularization (15)long term revascularization (12)long term MI (12)Stent thrombosis (any, end of follow up) (10)myocardial infarction (fatal and non fatal) (9)death, reinfarctus, stroke (8)target-vessel revascularization (8)CABG (7)Bleeding (7)target lesion revascularisation (6)Minor bleeding (5)angiographic restenosis (4)4y stent thrombosis (ARC) (4)Heart failure (4)cardiac death (3)2 yr MACE (3)4 yr MI (2)4 yr TLR (2)4 yr stent thrombosis (2)recurrent angina (2)sub acute stent thrombosis (1-30 days) (2)2 yr TLR (2)2 yr Death (all cause) (2)Emergency CABG (1)late stent thrombosis (31days - 1year) (1)Acute stent thrombosis (<=24h) (1)Reocclusion (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	reinfarction	All cause death
acute myocardial infarction
drug-eluting stents
DEDICATION, 2008      NCT	drug-eluting stents	bare-metal stent			Risk of bias	suggesting
PASEO, 2009	drug-eluting stents	bare-metal stent				-
paclitaxel
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent				suggesting
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
PCI
PRAGUE, 2000	systematic PCI (+stent)	no systematic PCI				negative
WEST, 2006	systematic PCI (+stent)	no systematic PCI				negative
CAPITAL AMI, 2005	systematic PCI (+stent)	no systematic PCI				negative
GRACIA-1, 2004	systematic PCI (+stent)	no systematic PCI			Risk of bias	negative
SIAM III, 2002	systematic PCI (+stent)	no systematic PCI				negative
C-PORT, 2002	primary PCI	accelerated t-PA				-
STAT, 2001	primary stenting	accelerated t-PA				-
STOPAMI 3, 2004	primary stenting	balloon angioplasty				-
ZWOLLE 6, 2005	primary stenting	balloon angioplasty				-
CADILLAC (no abciximab), 2002	primary stenting	balloon angioplasty				-
CADILLAC abciximab., 2002	primary stenting	balloon angioplasty				-
FRESCO, 1998	primary stenting	balloon angioplasty				-
Zwolle 5 (Suryapranata), 1998	primary stenting	balloon angioplasty				suggesting
Jaksch, 1998	primary stenting	balloon angioplasty				suggesting
GRAMI (Rodriguez), 1998	primary stenting	balloon angioplasty				negative
stent-PAMI (Grines), 1999	primary stenting	balloon angioplasty				suggesting
PASTA (Saito), 1999	primary stenting	balloon angioplasty				suggesting
PRISAM (Kawashima), 1999	primary stenting	balloon angioplasty				negative
STENTIM-2 (Maillard), 2000	primary stenting	balloon angioplasty				negative
PSSAAMI (Scheller), 2001	primary stenting	balloon angioplasty				suggesting
STOPAMI 2, 2002	primary stenting	immediate thrombolysis				-
senior PAMI, 2005    NCT	primary PCI	Thrombolysis			Risk of bias	suggesting
primary angioplasty
DANAMI-2, 1997	primary ballon angioplasty	accelerated t-PA				-
Ribichini, 1996	primary ballon angioplasty	accelerated t-PA				-
Garcia, 1997	primary ballon angioplasty	accelerated t-PA				-
GUSTO 2B, 1997	primary ballon angioplasty	accelerated t-PA				-
DeWood, 1989	primary ballon angioplasty	duteplase				-
Gibbons, 1993	primary ballon angioplasty	duteplase				-
O'Neill, 1986	primary ballon angioplasty	intracoronary streptokinase				-
Ribeiro, 1993	primary ballon angioplasty	streptokinase				-
Grinfeld, 1996	primary ballon angioplasty	streptokinase				-
Zijlstra, 1997	primary ballon angioplasty	streptokinase				-
Akhras, 1997	primary ballon angioplasty	streptokinase				-
Zwolle, 1994	primary ballon angioplasty	streptokinase				negative
Zijlstra , 1993	primary ballon angioplasty	streptokinase				-
PAMI, 1993	primary ballon angioplasty	t-PA				-
TRIANA, 2009    NCT	primary ballon angioplasty	tenecteplase			Risk of bias	negative
PTCA
PRAGUE-1, 2000	primary angioplasty	immediate thrombolysis				suggesting
DANAMI-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
MAASTRICHT (Vermeer), 1999	primary angioplasty	immediate thrombolysis				negative
CAPTIM, 2002	primary angioplasty	immediate thrombolysis				negative
PRAGUE-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
AIR-PAMI, 2002	primary angioplasty	immediate thrombolysis				negative
ECSG, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TAMI 1 pilot, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	suggesting
Belenkie, 1991	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Topol, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Ellis, 1994	immediate systematic ballon angioplastyte	no immediate angioplasty				-
TAMI-5 (Califf), 1991	immediate systematic ballon angioplastyte	no immediate angioplasty				-
Erbel, 1989	immediate systematic ballon angioplastyte	no immediate angioplasty				-
MERLIN (Sutton), 2004	immediate systematic ballon angioplastyte	no immediate angioplasty				-
SWISS-SMASH, 1999	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TIMI 2A, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Belenkie, 1992	rescue PTCA	no rescue PTCA			Risk of bias	negative
REACT (rescue PCI), 2005	rescue PTCA	no rescue PTCA				suggesting
MERLIN, 2004	rescue PTCA	no rescue PTCA				negative
RESCUE II, 2000	rescue PTCA	no rescue PTCA				negative
RESCUE, 1994	rescue PTCA	no rescue PTCA				negative
SWIFT, 1991	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
SIAM, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI II-A (defered)	systematic ballon angioplasty	no systematic angioplasty				-
Vermeer, 1999	systematic ballon angioplasty	no systematic angioplasty				-
TAMI 6, 1992	systematic ballon angioplasty	no systematic angioplasty				-
Barbash, 1990	systematic ballon angioplasty	no systematic angioplasty				-
TOPS, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
Van den Brand, 1991	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
Guerci, 1987	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI 2, 1989	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
sirolimus eluting stent
SESAMI, 2007        NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
TYPHOON, 2006      NCT	sirolimus eluting stent	bare-metal stent				suggesting
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent				-
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent				suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent				negative
zotarolimus eluting stent
ZEST AMI (vs PES), 2009      NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009      NCT	zotarolimus eluting stent	sirolimus eluting stent				negative