beta-blockers

systematic review meta-analysis network meta-analysis

Select acute myocardial infarctionheart failure all type of heart failureelderly patientsuncoded clinical condition ***       beta-blockersLong term treatment acebutololalprenololatenololbetaxololbisoprololbucindololcarvedilollabetalolmetoprololnebivololoxprenololpindololpractololpropranololsotaloltimololxamoterol vs placebo or controlvs beta-blockers      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (114)hospitalisation for heart failure (22)Cardiovascular death (20)reinfarction (19)Sudden death (15)Death from any cause or hospitalization for any reason (15)NYHA class improvement (14)cardiac death (13)myocardial infarction (fatal and non fatal) (8)cardiac event (fatal and non fatal ) (4)Coronary death (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	hospitalisation for heart failure
acute myocardial infarction
acebutolol
Azancot, 1982	Acebutolol	placebo				negative
APSI, 1990	Acebutolol	placebo			Low risk of bias	suggesting
alprenolol
Andersen , 1979	Alprenolol	placebo			Low risk of bias	negative
Wilhelmsson , 1974	Alprenolol	placebo			Low risk of bias	negative
atenolol
ISIS1 Collaborative Group , 1986	Atenolol	placebo				negative
Van de Werf , 1993	Atenolol	placebo				negative
Yusuf , 1980	Atenolol	placebo				negative
betaxolol
Yang , 1987	Betaxolol	placebo				negative
carvedilol
Basu , 1997	Carvedilol	placebo			Low risk of bias	suggesting
labetalol
Heber , 1987	Labetalol	placebo				negative
metoprolol
MIAMI Trial Research Group , 1985		placebo				negative
Von Essen , 1982		placebo				negative
TIMI IIB, 1989		placebo				negative
Hjalmarson , 1981	Metoprolol	placebo			Low risk of bias	suggesting
LIT Research Group , 1987	Metoprolol	placebo			Low risk of bias	negative
Manger Cats , 1983	Metoprolol	placebo			Low risk of bias	negative
Rehnqvist , 1983	Metoprolol	placebo			Low risk of bias	suggesting
Salathia , 1985	Metoprolol	placebo			Low risk of bias	suggesting
Waagstein , 1975	Practololormetoprolol	placebo				negative
oxprenolol
CPRG , 1981	Oxprenolol	placebo				negative
Fuccella , 1968	Oxprenolol	placebo				negative
Lombardo , 1979	Oxprenolol	placebo				negative
Wilcox , 1980	Oxprenolol	placebo				negative
EIS , 1984	Oxprenolol	placebo			Low risk of bias	negative
Schwartz (high risk and low risk) , 1992	Oxprenolol	placebo			Low risk of bias	suggesting
Taylor , 1982	Oxprenolol	placebo			Low risk of bias	negative
pindolol
Owensby , 1984	Pindolol	placebo				negative
Australian and Swedish study, 1983	Pindolol	placebo			Low risk of bias	negative
practolol
Evemy , 1978	Practolol	placebo				negative
Johansson , 1980	Practolol	placebo				negative
Macleod , 1980	Practolol	placebo				negative
Snow , 1980	Practolol	placebo				negative
Thompson , 1979	Practolol	placebo				negative
Multicentre international , 1975	Practolol	placebo			Low risk of bias	suggesting
propranolol
Aronow , 1997	Propranolol	control				suggesting
Balcon , 1966	Propranolol	placebo				negative
Barber , 1976	Propranolol	placebo				negative
Clausen , 1966	Propranolol	placebo				negative
Curtis , 1991	Propranolol	placebo				negative
Dotremont , 1968	Propranolol	placebo				negative
Gupta , 1982	Propranolol	placebo				negative
Gupta , 1984	Propranolol	placebo				negative
Hutton , 1979	Propranolol	placebo				negative
Kahler , 1968	Propranolol	placebo				negative
Ledwich , 1968	Propranolol	placebo				negative
Mueller , 1980	Propranolol	placebo				negative
Multicentre , 1966	Propranolol	placebo				negative
Nigam , 1983	Propranolol	placebo				negative
Norris , 1968	Propranolol	placebo				negative
Norris , 1978	Propranolol	placebo				negative
Norris , 1984	Propranolol	placebo				negative
Peter , 1978	Propranolol	placebo				negative
Pitt , 1976	Propranolol	placebo				negative
Roberts , 1984	Propranolol	placebo				negative
Singh , 1985	Propranolol	placebo				negative
Sloman , 1967	Propranolol	placebo				negative
Baber , 1980	Propranolol	placebo			Low risk of bias	negative
BHAT , 1982    NCT	Propranolol	placebo			Low risk of bias	suggesting
Hansteen , 1982	Propranolol	placebo			Low risk of bias	suggesting
Wilcox , 1980	Propranolol or atenolol	placebo			Low risk of bias	suggesting
sotalol
Lloyd , 1988	Sotalol	placebo				negative
timolol
Campbell , 1984	Timolol	placebo				negative
Federman , 1984	Timolol	placebo				negative
ICSG , 1984	Timolol	placebo				negative
Ranganathan , 1988	Timolol	placebo				negative
Tonkin , 1981	Timolol	placebo				negative
UKCSG , 1983	Timolol	placebo				negative
Norwegian Multicentre Study Group , 1981	Timolol	placebo			Low risk of bias	suggesting
xamoterol
McMurray , 1991	Xamoterol	placebo				negative
heart failure
bisoprolol
CIBIS, 1994	bisoprolol	placebo			Low risk of bias	suggesting
CIBIS II, 1999	bisoprolol	placebo			Low risk of bias	suggesting
CIBIS II (elderly subgroup), 1999	Bisoprolol	placebo				suggesting
bucindolol
BEST, 2001    NCT	bucindolol	placebo			Low risk of bias	suggesting
Pollock, 1990	Bucindolol	placebo			Low risk of bias	-
Woodley, 1991	Bucindolol	placebo				-
Bristow, 1994	Bucindolol	placebo				-
MERIT-HF (elderly subgroup), 1999	Bucindolol	placebo				suggesting
carvedilol
ANZ-HeFT, 1997	carvedilol	placebo			Low risk of bias	negative
COPERNICUS, 2002	carvedilol	placebo			Low risk of bias	suggesting
CAPRICORN, 2001	carvedilol	placebo			Low risk of bias	suggesting
Metra, 1994	carvedilol	placebo				-
Olsen, 1995	carvedilol	placebo				-
Krum, 1995	carvedilol	placebo				-
Bristow (MOCHA), 1996	carvedilol	placebo			Low risk of bias	-
Parker, 1996	carvedilol	placebo			Low risk of bias	negative
Colucci, 1996	carvedilol	placebo			Low risk of bias	-
Cohn, 1997	carvedilol	placebo				-
Carvedilol U.S. Trials (elderly subgroup), 1996	Carvedilol	placebo				suggesting
COPERNICUS (elderly subgroup), 2001	Carvedilol	placebo				suggesting
CARMEN (carvedilol alone), 2004	carvedilol	enalapril				negative
COMET, 2003	carvedilol	metoprolol			Low risk of bias	suggesting
metoprolol
MDC (Waagstein), 1993	metoprolol	placebo			Low risk of bias	negative
MERIT-HF, 1999	metoprolol	placebo			Low risk of bias	suggesting
Engelmeier, 1985	metoprolol	placebo				-
Fisher, 1994	metoprolol	placebo				-
Eichhorn, 1994	metoprolol	placebo				-
RESOLVD, 2000	metoprolol	placebo				-
BEST (elderly subgroup), 2001	Metoprolol	placebo				negative
nebivolol
Lechat, 1991	Nebivolol	placebo				-
Wisenbaugh, 1993	Nebivolol	placebo			Low risk of bias	negative
SENIORS, 2005	nebivolol	placebo			Low risk of bias	-