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Carvedilol
beta-blockers
systematic review
meta-analysis
network meta-analysis
BM-14190 - BM 14190 - Eucardic - Coropres - Kredex - Dilatrend - Coreg - Querto - carvedilol
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acute myocardial infarction
heart failure
hypertension
beta-blockers
Long term treatment
vs placebo or control
vs beta-blockers
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Description
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Risk of bias
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NCT results
All cause death (21)
Cardiovascular death (19)
cardiovascular events (19)
Sudden death (17)
hospitalisation for heart failure (16)
Death from any cause or hospitalization for any reason (16)
NYHA class improvement (16)
Coronary event (16)
Coronary death (16)
CV death, MI hospitalization for HF (2)
Total exercise duration (s) (2)
Time to limiting angina (s) (2)
Time to angina onset (s) (2)
Time to 1 mm ST depression (s) (2)
Angina episodes per week (2)
Nitroglycerin use per week (2)
cardiac event (fatal and non fatal ) (1)
reinfarction (1)
myocardial infarction (fatal and non fatal) (1)
cardiac death (1)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
All cause death
Cardiovascular death
acute myocardial infarction
Basu , 1997
Carvedilol
placebo
Low risk of bias
suggesting
-37%
heart failure
ANZ-HeFT, 1997
carvedilol
placebo
Low risk of bias
negative
-23%
-10%
COPERNICUS, 2002
carvedilol
placebo
Low risk of bias
suggesting
-33%
CAPRICORN, 2001
carvedilol
placebo
Low risk of bias
suggesting
-22%
-24%
Metra, 1994
carvedilol
placebo
-
Olsen, 1995
carvedilol
placebo
-
Krum, 1995
carvedilol
placebo
-
Bristow (MOCHA), 1996
carvedilol
placebo
Low risk of bias
-
Parker, 1996
carvedilol
placebo
Low risk of bias
negative
-30%
Colucci, 1996
carvedilol
placebo
Low risk of bias
-
Cohn, 1997
carvedilol
placebo
-
Carvedilol U.S. Trials (elderly subgroup), 1996
Carvedilol
placebo
suggesting
-55%
COPERNICUS (elderly subgroup), 2001
Carvedilol
placebo
suggesting
-25%
CARMEN (carvedilol alone), 2004
carvedilol
enalapril
negative
-1%
-8%
COMET, 2003
carvedilol
metoprolol
Low risk of bias
suggesting
-14%
-18%
hypertension
Cice et al, 2003
carvedilol
placebo
suggesting
-57%
Nakao et al, 2007
carvedilol
placebo
-
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