insulin sensitizer - biguanides

systematic review meta-analysis network meta-analysis

Select diabetes type 2 uncoded clinical condition ***       biguanide metformin vs placebo or controlvs SU or insulinvs Sulfonylureas      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (39)myocardial infarction (fatal and non fatal) (33)stroke (fatal and non fatal) (28)microvascular events (3)Any diabetes-related outcomes (2)Diabetes-related death (2)Peripheral vascular events (2)macrovascular or microvascular events (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	myocardial infarction (fatal and non fatal)
diabetes type 2
metformin
Teupe, 1991	metformin	placebo				negative
Kooy (HOME), 2009	metformin	placebo			Low risk of bias	suggesting
Campbell, 1994	metformin	Glipizide				negative
UKPDS (vs SU or INS)	metformin	SU/Insulin				suggesting