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Metformin
antidiabetic drugs
systematic review
meta-analysis
network meta-analysis
Glucophage - Dimethylbiguanidine - Dimethylguanylguanidine - Metformin
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diabetes type 2
impaired fasting glucose
antidiabetic drugs
biguanide
drugs + lifestyle modification
glitazones
vs placebo or control
vs SU or insulin
vs Sulfonylureas
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Description
Synopsis
Comparison
Treatments
Patients
Characteristics
Method
Risk of bias
References
None
Tools
Indexation
Results
Global trial result
Main results
All results
All result tag
NCT results
All cause death (71)
myocardial infarction (fatal and non fatal) (71)
stroke (fatal and non fatal) (71)
Diabetes (37)
normoglycemia (37)
cardiovascular events (37)
Cardiovascular death (37)
cardiovascular death, MI, stroke (37)
hospitalisation for heart failure (37)
Any diabetes-related outcomes (34)
Diabetes-related death (34)
Peripheral vascular events (34)
microvascular events (34)
macrovascular or microvascular events (34)
Options
Numeric
bar chart
forest plot
medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
All cause death
myocardial infarction (fatal and non fatal)
diabetes type 2
IDDP (Ramachandran), 2006
lifestyle modification + metformin
control
Risk of bias
negative
Jarret, 1979
lifestyle modification + metformin
control
Exploratory
negative
James, 2005
metformin
control
-
Teupe, 1991
metformin
placebo
negative
∞%
Kooy (HOME), 2009
metformin
placebo
Low risk of bias
suggesting
48%
11%
US-DPP (metformin) (Knowler), 2002
metformin
placebo
Low risk of bias
negative
Kay, 2001
metformin
placebo
-
EDIT (Holman), 2003
metformin
placebo
-
Li, 1999
metformin
placebo
Low risk of bias
negative
Baillargeon, 2004
metformin
placebo
-
Bridger, 2006
metformin
placebo
-
Charles, 1998
metformin
placebo
negative
Charles, 2000
metformin
placebo
-
Choux, 2003
metformin
placebo
-
Crave, 1995
metformin
placebo
-
Fleming, 2002
metformin
placebo
-
Freemark, 2001
metformin
placebo
-
Gambineri, 2004
metformin
placebo
-
Giugliano, 1993
metformin
placebo
-
Hoeger, 2004
metformin
placebo
-
Kelly, 2002
metformin
placebo
-
Kocak, 2002
metformin
placebo
-
Lehtovirta, 2001
metformin
placebo
negative
Moghetti, 2000
metformin
placebo
-
Morel, 1999
metformin
placebo
-
Ng, 2001
metformin
placebo
-
Orchard, 2005
metformin
placebo
suggesting
Pasquali, 2000
metformin
placebo
-
Rodriguez, 2004
metformin
placebo
-
Rodriguez-Moctezuma, 2004
metformin
placebo
negative
Sirtori, 1984
metformin
placebo
-
Srinivasan, 2006
metformin
placebo
-
Stakos, 2005
metformin
placebo
-
Sturrock, 2002
metformin
placebo
-
Tang, 2006
metformin
placebo
-
Vitale, 2005
metformin
placebo
-
CANOE, 2010
NCT
rosiglitazone and metformin
placebo
Low risk of bias
suggesting
Campbell, 1994
metformin
Glipizide
negative
UKPDS (vs SU or INS)
metformin
SU/Insulin
suggesting
-27%
-22%
impaired fasting glucose
US-DPP (metformin) (Knowler), 2002
metformin
placebo
Low risk of bias
negative
CANOE, 2010
NCT
rosiglitazone and metformin
placebo
Low risk of bias
suggesting
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