aldosterone blockade

systematic review meta-analysis network meta-analysis

Select heart failure All type of patient       aldosterone-receptor blockers eplerenonespironolactone vs placebo or controlvs active treatment      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (3)Cardiovascular death (3)Adverse events (3)serious hyperkalemia (3)Sudden death (3)hospitalisation for cardiovascular causes (2)Adverse events leading to treatment discontinuation (1)exacerbation of heart failure (1)NYHA class improvement (1)death from cardiovascular causes or hospitalization for cardiovascular causes (1)Death from any cause or hospitalization for heart failure (1)Hospitalization for any reason (1)hospitalisation for heart failure (1)Death from any cause or hospitalization for any reason (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Cardiovascular death
heart failure
eplerenone
EPHESUS, 2003	eplerenone	placebo			Low risk of bias	suggesting
EMPHASIS-HF, 2010        NCT	eplerenone	placebo			Low risk of bias	suggesting
spironolactone
Cicoira, 2004	spironolactone	control				-
Cicoira, 2002	spironolactone	control			Exploratory	-
Ramires, 2000	spironolactone	control			Exploratory	-
RALES, 1998	spironolactone	placebo			Risk of bias	suggesting
Agostoni, 2005	spironolactone	placebo			Exploratory	-
Mottram, 2004	spironolactone	placebo			Low risk of bias	-
Macdonald, 2004	spironolactone	placebo			Low risk of bias	-
Yee, 2001	spironolactone	placebo			Low risk of bias	-
Tsutamoto, 2001	spironolactone	placebo			Low risk of bias	-
Farquharson, 2000	spironolactone	placebo			Low risk of bias	-
MacFadyen, 1997	spironolactone	placebo			Low risk of bias	-
Han, 1994	spironolactone+captopril	captopril			Exploratory	-
Bednarz, 2000	aldactone	furosemide			Exploratory	-
Mauersberger, 1985	spironolactone+furosemide	spironolactone+butizide			Exploratory	-