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Eplerenone
aldosterone blockade
systematic review
meta-analysis
network meta-analysis
Inspra - eplerenon
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heart failure
aldosterone-receptor blockers
vs placebo or control
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NCT results
All cause death (4)
Cardiovascular death (4)
hospitalisation for cardiovascular causes (4)
death from cardiovascular causes or hospitalization for cardiovascular causes (4)
NYHA change (4)
LV ejection fraction (4)
Adverse events (4)
Adverse events leading to treatment discontinuation (4)
serious hyperkalemia (4)
Sudden death (4)
exacerbation of heart failure (4)
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exercise capacity (4)
death from cardiovascular causes or hospitalization for heart failure (4)
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hospitalisation for heart failure (4)
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Trial
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tags
ROB
Trial result
All cause death
Cardiovascular death
heart failure
EPHESUS, 2003
eplerenone
placebo
Low risk of bias
suggesting
-14%
-16%
EMPHASIS-HF, 2010
NCT
eplerenone
placebo
Low risk of bias
suggesting
-19%
-20%
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