| Diet | cardiovascular prevention, in all type of patients | vs usual diet | by 12% | NS | NS | - | - | NS | NS | - | - | NS | - | - | NS | - | NS | NS | - | - | - | NS | - | - | - | - | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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| All cause death | 1.12 [1.07 1.16] | p=0.04 | 0 | 141524 | 19 | Veterans Ad. (Dayton), MRC Soya, Woodhill, Oslo Diet Heart Study (Leren), Rose, MRC low fat, Singh, STARS (St Thomas, diet), Los Angeles VA (Dayton), Ornish, Kallio, MRFIT, Hjermann, Finnish Mental Hospital (Miettinen), WHO Collaborative, Göteborg (Wilhelmsen), Black, Goteborg, Minnesota coronary survey (Frantz), | | Coronary death | 1.00 [0.86 1.16] | p=1.00 | 0 | 55417 | 7 | Veterans Ad. (Dayton), MRC Soya, Woodhill, Oslo Diet Heart Study (Leren), Rose, WHI low fat, Minnesota coronary survey (Frantz), | | Coronary event | 0.94 [0.86 1.03] | p=1.00 | 0 | 56433 | 8 | Veterans Ad. (Dayton), MRC Soya, Oslo Diet Heart Study (Leren), Rose, MRC low fat, WHI low fat, Finnish Mental Hospital (Miettinen), Minnesota coronary survey (Frantz), | | Adverse events | no data | | Cardiovascular death | no data | | Death from cancer | 1.44 [0.91 2.29] | p=1.00 | 0 | 5632 | 3 | Veterans Ad. (Dayton), MRC Soya, Minnesota coronary survey (Frantz), | | MACE | 0.97 [0.89 1.05] | p=1.00 | 0 | 48835 | 1 | WHI low fat, | | Haemmorhagic stroke | no data | | Fatal stroke | no data | | Non fatal MI | 0.93 [0.83 1.05] | p=1.00 | 0 | 50566 | 5 | Veterans Ad. (Dayton), MRC Soya, Oslo Diet Heart Study (Leren), Rose, WHI low fat, | | Cancer | no data | | Rhabdomyolysis | no data | | stroke (fatal and non fatal) | 1.00 [0.88 1.13] | p=1.00 | 0 | 49681 | 2 | Veterans Ad. (Dayton), WHI low fat, | | myocardial infarction (fatal and non fatal) | no data | | cardiac death | 0.97 [0.91 1.03] | p=1.00 | 0 | 135621 | 15 | MRC Soya, Woodhill, Rose, Singh, STARS (St Thomas, diet), Los Angeles VA (Dayton), Ornish, Kallio, MRFIT, Hjermann, Finnish Mental Hospital (Miettinen), WHO Collaborative, Göteborg (Wilhelmsen), Black, Goteborg, | | cardiovascular events | 0.97 [0.91 1.05] | p=1.00 | 0 | 48835 | 1 | WHI low fat, | | Coronary death and non fatal MI | no data | | Myopathy | no data | | LDL | no data | | non cardiovascular death | 0.99 [0.95 1.05] | p=1.00 | 0 | 136033 | 16 | MRC Soya, Woodhill, Oslo Diet Heart Study (Leren), Rose, Singh, STARS (St Thomas, diet), Los Angeles VA (Dayton), Kallio, MRFIT, Göteborg (Wilhelmsen), Black, Goteborg, Ornish, Hjermann, Finnish Mental Hospital (Miettinen), WHO Collaborative, | | Venous thromboembolism | no data | | new-onset diabetes | no data | | total cholesterol (at 1 y) | no data | | HDL (at 1 y) | no data |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients | Trial | Studied treatment | Control | Patients |
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| Veterans Ad. (Dayton), 1969 | cholesterol lowering diet | usual diet | men in domicilary care, age>55, with or without CHD | | MRC Soya, 1968 | Régime pauvre en graisses saturées + 85 g/j dhuile de soja | usual diet | ambulatory men with recent MI | | Woodhill, 1966 | diet | usual diet | men, 30-59 years | | Oslo Diet Heart Study (Leren), 1966 | diet | usual care | middle-aged ambulatory men with prior MI | | Rose, 1965 | Régime restreint en graisses + 80 g/j huile de maïs | usual diet | men, <70 years | | MRC low fat, 1965 | | | | | WHI low fat, 2005 | dietary modification intervention to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily | usual diet | postmenopausal women, aged 50 to 79 years, without prior breast cancer | | Singh, 1992 | strict diet | usual diet | patients with suspected acute myocardial infarction | | STARS (St Thomas, diet), 1992 | dietary advice | usual diet | patients with angina or past myocardial infarction
| | Los Angeles VA (Dayton), 1969 | diet | usual diet | men in domicilary care, age>55, with or without CHD | | Ornish, 1990 | low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise | usual-care | Patients with angiographically documented coronary artery disease | | Kallio, 1979 | diet (multifactorial intervention programme) | usual diet | patients below 65 years who had an acute myocardial infarction | | MRFIT, 1982 | multifactor intervention program | usual diet | high-risk men aged 35 to 57 years | | Hjermann, 1981 | diet | usual diet | healthy, normotensive men at high risk of coronary heart disease | | Finnish Mental Hospital (Miettinen), 1985 | cholesterol-lowering diet (low in saturated fats and cholesterol and relatively high in polyunsaturated fats) | usual diet | middle-aged institionalized women without CHD | | WHO Collaborative, 1986 | multifactorial prevention | usual diet | middle-aged men | | Göteborg (Wilhelmsen), 1986 | multifactorial intervention programme | usual care | men, 47-55 years old at entry | | Black, 1994 | diet with 20 percent of total caloric intake as fat | usual diet | patients with nonmelanoma skin cancer | | Goteborg, 1986 | multifactorial intervention programme | no intervention | men, 47-55 years old at entry | | Minnesota coronary survey (Frantz), 1975 | cholesterol lowering diet | control diet | Adult residents ofmental hospitals; no illness restrictions, no cholesterol concentration requirements |
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