Mechanism

Diet

cardiovascular prevention, in all type of patients

Endpoint	TE [95% CI]	p val	I2	n	k
Venous thromboembolism	no data
cardiovascular events	0.97 [0.91 1.05]	p=1.00	0	48835	1	WHI low fat,
Cardiovascular death	no data
stroke (fatal and non fatal)	1.00 [0.88 1.13]	p=1.00	0	49681	2	Veterans Ad. (Dayton), WHI low fat,
Coronary event	0.94 [0.86 1.03]	p=1.00	0	56433	8	Veterans Ad. (Dayton), MRC Soya, Oslo Diet Heart Study (Leren), Rose, MRC low fat, WHI low fat, Finnish Mental Hospital (Miettinen), Minnesota coronary survey (Frantz),
Coronary death and non fatal MI	no data
Coronary death	1.00 [0.86 1.16]	p=1.00	0	55417	7	Veterans Ad. (Dayton), MRC Soya, Woodhill, Oslo Diet Heart Study (Leren), Rose, WHI low fat, Minnesota coronary survey (Frantz),
cardiac death	0.97 [0.91 1.03]	p=1.00	0	135621	15	MRC Soya, Woodhill, Rose, Singh, STARS (St Thomas, diet), Los Angeles VA (Dayton), Ornish, Kallio, MRFIT, Hjermann, Finnish Mental Hospital (Miettinen), WHO Collaborative, Göteborg (Wilhelmsen), Black, Goteborg,
MACE	0.97 [0.89 1.05]	p=1.00	0	48835	1	WHI low fat,
Non fatal MI	0.93 [0.83 1.05]	p=1.00	0	50566	5	Veterans Ad. (Dayton), MRC Soya, Oslo Diet Heart Study (Leren), Rose, WHI low fat,
All cause death	1.12 [1.07 1.16]	p=0.04	0	141524	19	Veterans Ad. (Dayton), MRC Soya, Woodhill, Oslo Diet Heart Study (Leren), Rose, MRC low fat, Singh, STARS (St Thomas, diet), Los Angeles VA (Dayton), Ornish, Kallio, MRFIT, Hjermann, Finnish Mental Hospital (Miettinen), WHO Collaborative, Göteborg (Wilhelmsen), Black, Goteborg, Minnesota coronary survey (Frantz),
non cardiovascular death	0.99 [0.95 1.05]	p=1.00	0	136033	16	MRC Soya, Woodhill, Oslo Diet Heart Study (Leren), Rose, Singh, STARS (St Thomas, diet), Los Angeles VA (Dayton), Kallio, MRFIT, Göteborg (Wilhelmsen), Black, Goteborg, Ornish, Hjermann, Finnish Mental Hospital (Miettinen), WHO Collaborative,
Fatal stroke	no data
Haemmorhagic stroke	no data
new-onset diabetes	no data
Death from cancer	1.44 [0.91 2.29]	p=1.00	0	5632	3	Veterans Ad. (Dayton), MRC Soya, Minnesota coronary survey (Frantz),
Rhabdomyolysis	no data
Myopathy	no data
Cancer	no data
Adverse events	no data

Trial	Studied treatment	Control	Patients
Veterans Ad. (Dayton), 1969	cholesterol lowering diet	usual diet	men in domicilary care, age>55, with or without CHD
MRC Soya, 1968	Régime pauvre en graisses saturées + 85 g/j dhuile de soja	usual diet	ambulatory men with recent MI
Woodhill, 1966	diet	usual diet	men, 30-59 years
Oslo Diet Heart Study (Leren), 1966	diet	usual care	middle-aged ambulatory men with prior MI
Rose, 1965	Régime restreint en graisses + 80 g/j huile de maïs	usual diet	men, <70 years
MRC low fat, 1965
WHI low fat, 2005	dietary modification intervention to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily	usual diet	postmenopausal women, aged 50 to 79 years, without prior breast cancer
Singh, 1992	strict diet	usual diet	patients with suspected acute myocardial infarction
STARS (St Thomas, diet), 1992	dietary advice	usual diet	patients with angina or past myocardial infarction
Los Angeles VA (Dayton), 1969	diet	usual diet	men in domicilary care, age>55, with or without CHD
Ornish, 1990	low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise	usual-care	Patients with angiographically documented coronary artery disease
Kallio, 1979	diet (multifactorial intervention programme)	usual diet	patients below 65 years who had an acute myocardial infarction
MRFIT, 1982	multifactor intervention program	usual diet	high-risk men aged 35 to 57 years
Hjermann, 1981	diet	usual diet	healthy, normotensive men at high risk of coronary heart disease
Finnish Mental Hospital (Miettinen), 1985	cholesterol-lowering diet (low in saturated fats and cholesterol and relatively high in polyunsaturated fats)	usual diet	middle-aged institionalized women without CHD
WHO Collaborative, 1986	multifactorial prevention	usual diet	middle-aged men
Göteborg (Wilhelmsen), 1986	multifactorial intervention programme	usual care	men, 47-55 years old at entry
Black, 1994	diet with 20 percent of total caloric intake as fat	usual diet	patients with nonmelanoma skin cancer
Goteborg, 1986	multifactorial intervention programme	no intervention	men, 47-55 years old at entry
Minnesota coronary survey (Frantz), 1975	cholesterol lowering diet	control diet	Adult residents ofmental hospitals; no illness restrictions, no cholesterol concentration requirements

Diet

all NS

diet