treatment |
|
comparator |
All cause death | Bleeding | Major bleeding | Major bleeding | Fatal bleeding | Recurrent thromboembolic event | Symptomatic pulmonary embolism | Deep vein thrombosis | non-fatal pulmonary embolism | asymptomatic DVT | wound haematoma / infection | fatal pulmonary embolism | Symptomatic venous thromboembolism (DVT, PE) | transfusion |
|
|
Enoxaparin | thrombosis prevention, in urologic surgery | vs placebo | - | - | NS | NS | - | - | NS | - | - | NS | - | - | NS | NS | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | no data | Major bleeding | 1.36 [0.43 4.31] | p=1.00 | 0 | 89 | 1 | LeGagneux , | Major bleeding | 1.36 [0.43 4.31] | p=1.00 | 0 | 89 | 1 | LeGagneux , | Fatal bleeding | no data | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | 1.02 [0.02 52.70] | p=1.00 | 0 | 89 | 1 | LeGagneux , | Deep vein thrombosis | no data | non-fatal pulmonary embolism | no data | asymptomatic DVT | 1.02 [0.02 52.70] | p=1.00 | 0 | 89 | 1 | LeGagneux , | wound haematoma / infection | no data | fatal pulmonary embolism | no data | Symptomatic venous thromboembolism (DVT, PE) | 1.02 [0.02 52.70] | p=1.00 | 0 | 89 | 1 | LeGagneux , | transfusion | 1.36 [0.43 4.31] | p=1.00 | 0 | 89 | 1 | LeGagneux , | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
LeGagneux , 1987 | Enoxaparin 6000 anti-Xa units | Placebo | prostatectomy surgery |
|
Heparin | venous thrombosis, in all type of patients | vs intravenous heparin | - | - | NS | NS | - | NS | - | - | - | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | no data | Major bleeding | 0.81 [0.40 1.64] | p=1.00 | 0 | 783 | 6 | Bentley, Hull, Doyle, Walker, Lopaciuk, Pini, | Major bleeding | 0.81 [0.40 1.64] | p=1.00 | 0 | 783 | 6 | Bentley, Hull, Doyle, Walker, Lopaciuk, Pini, | Fatal bleeding | no data | Recurrent thromboembolic event | 0.72 [0.38 1.36] | p=1.00 | 0 | 783 | 6 | Bentley, Hull, Doyle, Walker, Lopaciuk, Pini, | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | no data | non-fatal pulmonary embolism | no data | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | no data | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Krahenbuhl, 1979 | subcutaneous sodic heparin 30 000 U daily (mean) | intravenous sodic heparin 30 000 U daily (mean) | | Bentley, 1980 | subcutaneous calcic heparin 37 000 U daily (mean) | intravenous sodic heparin 36 800 U daily (mean) | | Andersson, 1982 | subcutaneous sodic heparin 36 800 U daily (mean) | intravenous sodic heparin 33 250 U daily (mean) | | Hull, 1986 | subcutaneous sodic heparin 32 300 U daily (mean) | intravenous sodic heparin 29 700 U daily (mean) | | Doyle, 1987 | subcutaneous calcic heparin 29 200 U daily (mean) | intravenous calcic heparin 29 600 U daily (mean) | | Walker, 1987 | subcutaneous calcic heparin 29 375 U daily (mean) | intravenous calcic heparin 24 384 U daily (mean) | | Lopaciuk, 3000 | subcutaneous sodic heparin 34 400 U daily (mean) | intravenous sodic heparin 37 000 U daily (mean) | | Pini, 1990 | subcutaneous calcic heparin 33 800 U daily (mean) | intravenous sodic heparin 31 700 U daily (mean) | |
|
UFH | thrombosis prevention, in general surgery | vs no treatment | - | by 56% | - | - | NS | - | - | by 59% | by 41% | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 1.56 [1.25 1.93] | p=0.04 | 0 | 6998 | 17 | Kakkar (IMT), Gruber, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 1.03 [0.43 2.42] | p=1.00 | 0 | 7248 | 18 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.41 [0.34 0.50] | p=0.04 | 0 | 7246 | 16 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Sagar, Koppenhagen, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Ziemski, | non-fatal pulmonary embolism | 0.59 [0.39 0.88] | p=0.04 | 0 | 8280 | 20 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Koppenhagen, Bergqvist, Gallus, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.69 [0.34 1.40] | p=1.00 | 0 | 7248 | 18 | Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Kakkar (IMT), 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | Gruber, 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | Gordon-Smith, 1972 | UFH twice daily for 5 days | no treatment | all other general surgery | Nicolaides, 1972 | UFH twice daily for 7 days | no treatment | all other general surgery | Multiunit, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | Abernethy, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | Clarke-Pearson, 1983 | UFH twice daily for 7 days | no treatment | all other general surgery | Plante, 1979 | UFH twice daily for 8 days | no treatment | all other general surgery | Abraham-Inpijn, 1979 | UFH twice daily for 7 days | no treatment | all other general surgery | Spebar, 1981 | UFH twice daily for 5-7 days | no treatment | all other general surgery | Sagar, 1974 | UFH twice daily for 5 days | no treatment | all other general surgery | Koppenhagen, 1982 | UFH twice daily | no treatment | all other general surgery | Bergqvist, 1980 | UFH twice daily for 5 days | no treatment | all other general surgery | Gallus, 1973 | UFH 3 times daily for A | no treatment | all other general surgery | Gallus, 1976 | UFH 3 times daily for 7 days | no treatment | all other general surgery | Groote Schuur, 1979 | UFH 3 times daily for 6 days | no treatment | all other general surgery | Kraytman, 1976 | UFH 3 times daily for 6 days | no treatment | all other general surgery | Kraytman, 1977 | UFH 3 times daily for 6 days | no treatment | all other general surgery | Kettunen, 1974 | UFH 3 times daily for 7 days | no treatment | all other general surgery | Caloghera, 1984 | UFH 3 times daily for 7 days | no treatment | all other general surgery | Marchelli, 1983 | UFH 3 times daily for ? | no treatment | all other general surgery | Ziemski, 1979 | UFH 3 times daily for 2 days | no treatment | all other general surgery |
|
UFH | thrombosis prevention, in general surgery | vs placebo | - | NS | - | - | NS | - | - | by 58% | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 1.15 [0.83 1.61] | p=1.00 | 0 | 3010 | 16 | Kiil, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 0.96 [0.43 2.18] | p=1.00 | 0 | 3246 | 19 | Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.42 [0.32 0.56] | p=0.04 | 0 | 1885 | 17 | Kakkar, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | non-fatal pulmonary embolism | 0.83 [0.40 1.70] | p=1.00 | 0 | 3184 | 18 | Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kraytman, Marchetti, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.86 [0.42 1.78] | p=1.00 | 0 | 3246 | 19 | Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Kakkar, 1972 | UFH twice daily for 7 days | placebo | All other general surgery | Kiil, 1978 | UFH twice daily for 7 days | placebo | All other general surgery | Torngren, 1978 | UFH twice daily for 6-8 days | placebo | all other general surgery | Torngren, 0 | UFH twice daily for 6-8 days | placebo | all other general surgery | Lahnborg, 1975 | UFH twice daily for 5 days | placebo | all other general surgery | Lahnborg, 1976 | UFH twice daily for 5 days | placebo | all other general surgery | Covey, 1975 | UFH twice daily for 8 days | placebo | all other general surgery | Belch, 1980 | UFH twice daily for 7 days | placebo | all other general surgery | Taberner, 1978 | UFH twice daily for 7 days | placebo | all other general surgery | Strand, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | Roberts, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | Ribaudo, 1975 | UFH twice daily for A days | placebo | all other general surgery | Wu, 1977 | UFH twice daily for 7 days | placebo | all other general surgery | Lawrence, 1977 | UFH twice daily for 5 days | placebo | all other general surgery | Muiticentre, 1984 | UFH twice daily for 5-7 days | placebo | all other general surgery | Jourdan, 1984 | UFH twice daily for 5 days | placebo | all other general surgery | Torngren, 1978 | UFH 3 times daily for 6-8 days | placebo | all other general surgery | Kruse-Blinkenberg, 1980 | UFH 3 times daily for 8 days | placebo | all other general surgery | Kraytman, 1977 | UFH 3 times daily for 6 days | placebo | all other general surgery | Marchetti, 1982 | UFH 3 times daily | placebo | all other general surgery |
|
UFH | thrombosis prevention, in general surgery | vs aspirin | - | NS | - | - | NS | - | - | NS | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 3.28 [0.97 11.14] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.66 [0.35 1.23] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | non-fatal pulmonary embolism | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.54 [0.05 6.49] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Loew, 1977 | UFH twice daily for 7 days | aspirin | all other general surgery | Vinazzer, 1980 | UFH twice daily for A days | aspirin | all other general surgery |
|
UFH | thrombosis prevention, in general surgery | vs DHE | - | NS | - | - | NS | - | - | NS | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 1.46 [0.46 4.63] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 0.97 [0.08 11.66] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.69 [0.43 1.09] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | non-fatal pulmonary embolism | 0.96 [0.08 11.53] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.50 [0.03 8.04] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Muiticentre 53,S4, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery | Muiticentre, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery |
|
UFH | thrombosis prevention, in general surgery | vs oral anticoagulant | - | NS | - | - | - | - | - | by 72% | NS | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 1.08 [0.07 17.60] | p=1.00 | 0 | 154 | 1 | van Geloven, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | no data | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.28 [0.10 0.81] | p=0.04 | 0 | 154 | 1 | van Geloven, | non-fatal pulmonary embolism | 0.24 [0.05 1.15] | p=1.00 | 0 | 154 | 1 | van Geloven, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | no data | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
van Geloven, 1977 | UFH twice daily for 4 days | Oral anticoagulant | all other general surgery |
|
UFH | thrombosis prevention, in all type of surgery | vs no treatment | - | by 57% | - | - | NS | - | - | by 57% | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 1.57 [1.27 1.93] | p=0.04 | 0 | 7861 | 30 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Morris , Kakkar (IMT), Gruber, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, Coe, Sebeseri, Allen, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 1.01 [0.50 2.04] | p=1.00 | 0 | 7908 | 28 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, Coe, Sebeseri, Allen, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.43 [0.36 0.51] | p=0.04 | 0 | 8108 | 30 | Morris, Welin-Berger, Bergqvist , Gallus , Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Gallus , Morris , Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Sagar, Koppenhagen, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Ziemski, Coe, Sebeseri, Allen, | non-fatal pulmonary embolism | 0.72 [0.51 1.01] | p=1.00 | 0 | 9143 | 33 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Morris , Kakkar (IMT), Gruber, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Koppenhagen, Bergqvist, Marchelli, Ziemski, Coe, Sebeseri, Allen, Nicolaides, Multiunit, Abernethy, Gallus, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.64 [0.37 1.12] | p=1.00 | 0 | 8111 | 31 | Morris, Welin-Berger, Bergqvist , VTCSG, Mannucci , Dechavanne, Dechavanne, Bergqvist, Galasko , Morris , Kakkar (IMT), Gruber, Nicolaides, Multiunit, Abernethy, Clarke-Pearson, Plante, Abraham-Inpijn, Spebar, Sagar, Bergqvist, Groote Schuur, Kraytman, Kraytman, Kettunen, Caloghera, Marchelli, Ziemski, Coe, Sebeseri, Allen, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Morris, 1974 | UFH twice daily for 10 days | no treatment | elective orthopedic surgery | Welin-Berger, 1982 | UFH twice daily for 7 days | no treatment | elective orthopedic surgery | Bergqvist , 1979 | UFH twice daily for 5 days | no treatment | elective orthopedic surgery | Gallus , 1973 | UFH twice daily for A days | no treatment | elective orthopedic surgery | VTCSG, 1975 | UFH twice daily for 10 days | no treatment | elective orthopedic surgery | Mannucci , 1976 | UFH 3 times daily for 7 days | no treatment | elective orthopedic surgery | Dechavanne, 1974 | UFH 3 times daily for 10 days | no treatment | elective orthopedic surgery | Dechavanne, 1975 | UFH 3 times daily for 10 days | no treatment | elective orthopedic surgery | Bergqvist, 1979 | UFH twice daily for 5 days | no treatment | traumatic orthopedic surgery | Galasko , 1976 | UFH twice daily (duration unknown) | no treatment | traumatic orthopedic surgery | Gallus , 1973 | UFH 3 times daily for A | no treatment | traumatic orthopedic surgery | Morris , 1977 | UFH 3 times daily for 10 days | no treatment | traumatic orthopedic surgery | Kakkar (IMT), 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | Gruber, 0 | UFH 3 times daily for 7 days | no treatment | All other general surgery | Gordon-Smith, 1972 | UFH twice daily for 5 days | no treatment | all other general surgery | Nicolaides, 1972 | UFH twice daily for 7 days | no treatment | all other general surgery | Multiunit, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | Abernethy, 1974 | UFH twice daily for 7 days | no treatment | all other general surgery | Clarke-Pearson, 1983 | UFH twice daily for 7 days | no treatment | all other general surgery | Plante, 1979 | UFH twice daily for 8 days | no treatment | all other general surgery | Abraham-Inpijn, 1979 | UFH twice daily for 7 days | no treatment | all other general surgery | Spebar, 1981 | UFH twice daily for 5-7 days | no treatment | all other general surgery | Sagar, 1974 | UFH twice daily for 5 days | no treatment | all other general surgery | Koppenhagen, 1982 | UFH twice daily | no treatment | all other general surgery | Bergqvist, 1980 | UFH twice daily for 5 days | no treatment | all other general surgery | Gallus, 1973 | UFH 3 times daily for A | no treatment | all other general surgery | Gallus, 1976 | UFH 3 times daily for 7 days | no treatment | all other general surgery | Groote Schuur, 1979 | UFH 3 times daily for 6 days | no treatment | all other general surgery | Kraytman, 1976 | UFH 3 times daily for 6 days | no treatment | all other general surgery | Kraytman, 1977 | UFH 3 times daily for 6 days | no treatment | all other general surgery | Kettunen, 1974 | UFH 3 times daily for 7 days | no treatment | all other general surgery | Caloghera, 1984 | UFH 3 times daily for 7 days | no treatment | all other general surgery | Marchelli, 1983 | UFH 3 times daily for ? | no treatment | all other general surgery | Ziemski, 1979 | UFH 3 times daily for 2 days | no treatment | all other general surgery | Coe, 1978 | UFH twice daily for D | no treatment | urologic surgery | Sebeseri, 1975 | UFH twice daily for D | no treatment | urologic surgery | Allen, 1978 | UFH twice daily for D | no treatment | urologic surgery |
|
UFH | thrombosis prevention, in all type of surgery | vs placebo | - | NS | - | - | NS | - | - | by 56% | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 1.16 [0.86 1.59] | p=1.00 | 0 | 3584 | 26 | Abraham-Inpijn , Lowe , Hampson, Moskovitz, Xabregas , Moskovitz, Kiil, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 1.05 [0.52 2.11] | p=1.00 | 0 | 3715 | 27 | Abraham-Inpijn , Lowe , Hampson, Moskovitz, Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.44 [0.36 0.55] | p=0.04 | 0 | 2694 | 28 | Abraham-Inpijn , Lowe , Hampson, Moskovitz, Lahnborg, Xabregas , Moskovitz, Svend-Hansen, Kakkar, Torngren, Torngren, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Hedlund, Kutnowski, Vandendris, | non-fatal pulmonary embolism | 1.25 [0.76 2.05] | p=1.00 | 0 | 4139 | 30 | Williams , Abraham-Inpijn , Lowe , Moskovitz, Lahnborg, Xabregas , Moskovitz, Svend-Hansen, Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.79 [0.44 1.42] | p=1.00 | 0 | 4301 | 32 | Williams , Abraham-Inpijn , Lowe , Hampson, Moskovitz, Lahnborg, Xabregas , Moskovitz, Svend-Hansen, Kakkar, Kiil, Torngren, Torngren, Lahnborg, Lahnborg, Covey, Belch, Taberner, Strand, Roberts, Ribaudo, Wu, Lawrence, Muiticentre, Jourdan, Kruse-Blinkenberg, Kraytman, Marchetti, Bejjani, Hedlund, Kutnowski, Vandendris, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
---|
Williams , 1978 | UFH twice daily for 14 days | placebo | elective orthopedic surgery | Abraham-Inpijn , 1975 | UFH twice daily for 8 days | placebo | elective orthopedic surgery | Lowe , 1981 | UFH twice daily for 16 days | placebo | elective orthopedic surgery | Hampson, 1974 | UFH 3 times daily for 7- 10 days | placebo | elective orthopedic surgery | Moskovitz, 1978 | UFH 3 times daily for 7 days | placebo | elective orthopedic surgery | Lahnborg, 1980 | UFH twice daily for 10 days | placebo | traumatic orthopedic surgery | Xabregas , 1977 | UFH twice daily for 14 days | placebo | traumatic orthopedic surgery | Moskovitz, 1978 | UFH 3 times daily for 7 days | placebo | traumatic orthopedic surgery | Svend-Hansen, 1981 | UFH 3 times daily for 14 days | placebo | traumatic orthopedic surgery | Kakkar, 1972 | UFH twice daily for 7 days | placebo | All other general surgery | Kiil, 1978 | UFH twice daily for 7 days | placebo | All other general surgery | Torngren, 1978 | UFH twice daily for 6-8 days | placebo | all other general surgery | Torngren, 0 | UFH twice daily for 6-8 days | placebo | all other general surgery | Lahnborg, 1975 | UFH twice daily for 5 days | placebo | all other general surgery | Lahnborg, 1976 | UFH twice daily for 5 days | placebo | all other general surgery | Covey, 1975 | UFH twice daily for 8 days | placebo | all other general surgery | Belch, 1980 | UFH twice daily for 7 days | placebo | all other general surgery | Taberner, 1978 | UFH twice daily for 7 days | placebo | all other general surgery | Strand, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | Roberts, 1975 | UFH twice daily for 7 days | placebo | all other general surgery | Ribaudo, 1975 | UFH twice daily for A days | placebo | all other general surgery | Wu, 1977 | UFH twice daily for 7 days | placebo | all other general surgery | Lawrence, 1977 | UFH twice daily for 5 days | placebo | all other general surgery | Muiticentre, 1984 | UFH twice daily for 5-7 days | placebo | all other general surgery | Jourdan, 1984 | UFH twice daily for 5 days | placebo | all other general surgery | Torngren, 1978 | UFH 3 times daily for 6-8 days | placebo | all other general surgery | Kruse-Blinkenberg, 1980 | UFH 3 times daily for 8 days | placebo | all other general surgery | Kraytman, 1977 | UFH 3 times daily for 6 days | placebo | all other general surgery | Marchetti, 1982 | UFH 3 times daily | placebo | all other general surgery | Bejjani, 1983 | UFH twice daily for 2 days | placebo | urologic surgery | Hedlund, 1979 | UFH 3 times daily for 5 days | placebo | urologic surgery | Kutnowski, 1977 | UFH 3 times daily for 6 days | placebo | urologic surgery | Vandendris, 1980 | UFH 3 times daily for 6 days | placebo | urologic surgery |
|
UFH | thrombosis prevention, in all type of surgery | vs aspirin | - | NS | - | - | NS | - | - | NS | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
All cause death | no data | Bleeding | 3.28 [0.97 11.14] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.66 [0.35 1.23] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | non-fatal pulmonary embolism | 1.06 [0.07 17.04] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.54 [0.05 6.49] | p=1.00 | 0 | 933 | 2 | Loew, Vinazzer, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Loew, 1977 | UFH twice daily for 7 days | aspirin | all other general surgery | Vinazzer, 1980 | UFH twice daily for A days | aspirin | all other general surgery |
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UFH | thrombosis prevention, in all type of surgery | vs DHE | - | NS | - | - | NS | - | - | NS | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Bleeding | 1.46 [0.46 4.63] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 0.97 [0.08 11.66] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.69 [0.43 1.09] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | non-fatal pulmonary embolism | 0.96 [0.08 11.53] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.50 [0.03 8.04] | p=1.00 | 0 | 660 | 2 | Muiticentre 53,S4, Muiticentre, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Muiticentre 53,S4, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery | Muiticentre, 1984 | UFH twice daily for 5-7 days | DHE | all other general surgery |
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UFH | thrombosis prevention, in all type of surgery | vs oral anticoagulant | - | NS | - | - | - | - | - | by 72% | NS | - | - | - | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Bleeding | 1.08 [0.07 17.60] | p=1.00 | 0 | 154 | 1 | van Geloven, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | no data | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.28 [0.10 0.81] | p=0.04 | 0 | 154 | 1 | van Geloven, | non-fatal pulmonary embolism | 0.24 [0.05 1.15] | p=1.00 | 0 | 154 | 1 | van Geloven, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | no data | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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van Geloven, 1977 | UFH twice daily for 4 days | Oral anticoagulant | all other general surgery |
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UFH | thrombosis prevention, in urologic surgery | vs no treatment | - | NS | - | - | NS | - | - | NS | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Bleeding | 2.77 [0.99 7.80] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 0.92 [0.09 9.03] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.48 [0.20 1.12] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | non-fatal pulmonary embolism | 0.57 [0.07 4.76] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.92 [0.09 9.03] | p=1.00 | 0 | 177 | 3 | Coe, Sebeseri, Allen, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Coe, 1978 | UFH twice daily for D | no treatment | urologic surgery | Sebeseri, 1975 | UFH twice daily for D | no treatment | urologic surgery | Allen, 1978 | UFH twice daily for D | no treatment | urologic surgery |
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UFH | thrombosis prevention, in urologic surgery | vs placebo | - | NS | - | - | NS | - | - | by 76% | NS | - | - | NS | - | - | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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All cause death | no data | Bleeding | 1.67 [0.40 6.90] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | Major bleeding | no data | Major bleeding | no data | Fatal bleeding | 1.71 [0.26 11.21] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | Recurrent thromboembolic event | no data | Symptomatic pulmonary embolism | no data | Deep vein thrombosis | 0.24 [0.09 0.64] | p=0.04 | 0 | 143 | 3 | Hedlund, Kutnowski, Vandendris, | non-fatal pulmonary embolism | 0.82 [0.13 5.40] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | asymptomatic DVT | no data | wound haematoma / infection | no data | fatal pulmonary embolism | 0.81 [0.12 5.32] | p=1.00 | 0 | 177 | 4 | Bejjani, Hedlund, Kutnowski, Vandendris, | Symptomatic venous thromboembolism (DVT, PE) | no data | transfusion | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients Trial | Studied treatment | Control | Patients |
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Bejjani, 1983 | UFH twice daily for 2 days | placebo | urologic surgery | Hedlund, 1979 | UFH 3 times daily for 5 days | placebo | urologic surgery | Kutnowski, 1977 | UFH 3 times daily for 6 days | placebo | urologic surgery | Vandendris, 1980 | UFH 3 times daily for 6 days | placebo | urologic surgery |
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